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Pesquisa : A08.186.854.443 [Categoria DeCS]
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[PMID]:27061071
[Au] Autor:Hatsuta H; Takao M; Nakano Y; Nogami A; Uchino A; Sumikura H; Kanemaru K; Arai T; Itoh Y; Murayama S
[Ad] Endereço:Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
[Ti] Título:Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia with Lewy Bodies.
[So] Source:J Parkinsons Dis;6(2):325-34, 2016 Apr 02.
[Is] ISSN:1877-718X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Loss of intermediolateral nucleus (IML) neurons is considered to play a major role in orthostatic hypotension (OH) of multiple system atrophy (MSA). In Parkinson disease (PD) and dementia with Lewy bodies (DLB), autonomic phenomena such as OH are common and attributed to dysfunction of sympathetic, parasympathetic, and visceral autonomic neurons. However, apart from MSA, few reports have focused on the neuropathologic aspects in PD and DLB. Here we assessed IML degeneration as well as the fine myelinated fibers (FFs; maximum diameter less than 3 µm) considered to be preganglionic sympathetic nerve fibers derived from IML neurons in PD, DLB, MSA, and age-matched normal controls (NC). METHODS: We counted IML neurons and measured the diameter and number of myelinated fibers of the ventral root at the level of the 12th thoracic segment. RESULTS: Compared to NC, number of IML neurons and density of FF were significantly reduced in PD (53% and 67%), DLB (47% and 71%) and MSA (27% and 42%). Compared to combined group of PD and DLB without OH (OH-), IML neurons in combined group of PD and DLB with OH (OH+) were significantly reduced (77%). Compared to NC, FF densities in OH-, OH+ were significantly reduced (74% and 59%). The mean ratio of small to large myelinated fibers in OH+ (1.18), but not that in OH-(1.58), was significantly lower than that in NC (3.17). CONCLUSIONS: We present neuropathological evidence that IML neurons and FFs in the ventral root are reduced in PD and DLB and that the reduction was more severe in the combined group of OH+ than in OH-.
[Mh] Termos MeSH primário: Doença por Corpos de Lewy/patologia
Neurônios/patologia
Doença de Parkinson/patologia
Corno Lateral da Medula Espinal/patologia
Raízes Nervosas Espinhais/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Hipotensão Ortostática/complicações
Hipotensão Ortostática/patologia
Doença por Corpos de Lewy/complicações
Masculino
Fibras Nervosas/patologia
Doença de Parkinson/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160411
[St] Status:MEDLINE
[do] DOI:10.3233/JPD-150773


  2 / 5 MEDLINE  
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[PMID]:26818039
[Au] Autor:Kawabe T; Iwasa M; Kawabe K; Sapru HN
[Ad] Endereço:a Department of Neurological Surgery , Rutgers New Jersey Medical School , Newark , NJ , USA.
[Ti] Título:Attenuation of angiotensin type 2 receptor function in the rostral ventrolateral medullary pressor area of the spontaneously hypertensive rat.
[So] Source:Clin Exp Hypertens;38(2):209-17, 2016.
[Is] ISSN:1525-6006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We hypothesized that blockade of angiotensin II type 2 receptors (AT2Rs) in the rostral ventrolateral medullary pressor area (RVLM) may elicit sympathoexcitatory responses which are smaller in hypertensive rats compared to normotensive rats. This hypothesis was tested in urethane-anesthetized, artificially ventilated male 14-week-old spontaneously hypertensive rats (SHR). Age-matched male Wistar-Kyoto rats (WKY) and Wistar rats were used as controls. PD123319 (AT2R antagonist) was microinjected into the RVLM and mean arterial pressure (MAP), heart rate (HR) and greater splanchnic nerve activity (GSNA) were recorded. Increases in MAP, HR and GSNA elicited by unilateral microinjections of PD123319 into the RVLM were significantly smaller in SHR when compared with those in WKY and Wistar rats. Unilateral microinjections of l-glutamate (l-Glu) into the RVLM elicited greater increases in MAP and GSNA in SHR compared to those in WKY. AT2R immunoreactivity was demonstrated in the RVLM neurons which were retrogradely labeled from the intermediolateral cell column (IML) of the spinal cord. These results indicate that AT2Rs are present on the RVLM neurons projecting to the IML and their blockade results in sympathoexcitatory responses. Activation of AT2Rs has an inhibitory influence in the RVLM and these receptors are tonically active. Attenuation of the function of AT2Rs in the RVLM may play a role in genesis and/or maintenance of hypertension in SHR.
[Mh] Termos MeSH primário: Bloqueadores do Receptor Tipo 2 de Angiotensina II/farmacologia
Pressão Arterial/efeitos dos fármacos
Ácido Glutâmico/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Imidazóis/farmacologia
Bulbo/efeitos dos fármacos
Piridinas/farmacologia
Nervos Esplâncnicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Hipertensão
Imuno-Histoquímica
Masculino
Bulbo/metabolismo
Microinjeções
Neurônios/metabolismo
Ratos
Ratos Endogâmicos SHR
Ratos Endogâmicos WKY
Ratos Wistar
Receptor Tipo 2 de Angiotensina/metabolismo
Corno Lateral da Medula Espinal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Angiotensin II Type 2 Receptor Blockers); 0 (Imidazoles); 0 (Pyridines); 0 (Receptor, Angiotensin, Type 2); 130663-39-7 (PD 123319); 3KX376GY7L (Glutamic Acid)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE
[do] DOI:10.3109/10641963.2015.1081229


  3 / 5 MEDLINE  
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[PMID]:26463057
[Au] Autor:Sukhoterin AF; Pashchenko PS
[Ad] Endereço:A. A. Vishnevsky Third Central Military Clinical Hospital of Ministry of Defense of the Russian Federation, Odinstovo, Moscow Region, Russia. a.suhoterin@mail.ru.
[Ti] Título:Effects of +Gz Loads on Structural Organization of Central Autonomic Nuclei.
[So] Source:Bull Exp Biol Med;159(5):670-4, 2015 Sep.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Structural alterations in the central autonomic nuclei (dorsal vagal complex and intermediolateral nucleus) of the centrifuged random-bred male rats subjected to +Gz loads were examined. Acute exposure to gravitational loads predominantly produced the reactive changes in these nuclei, while persistently repeated regular loads resulted in cumulation of the destructive alterations. The structural perturbations in the central autonomic nuclei can disturb the autonomic regulation of physiological functions. The character of such disturbances is partially determined by the peculiarities in structural organization of these nuclei.
[Mh] Termos MeSH primário: Área Postrema/ultraestrutura
Gânglios Parassimpáticos/ultraestrutura
Hipergravidade
Neurônios/ultraestrutura
Corno Lateral da Medula Espinal/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Área Postrema/irrigação sanguínea
Área Postrema/patologia
Centrifugação
Gânglios Parassimpáticos/irrigação sanguínea
Gânglios Parassimpáticos/patologia
Masculino
Microscopia Eletrônica de Transmissão
Microtomia
Neurônios/patologia
Ratos
Ratos Wistar
Corno Lateral da Medula Espinal/irrigação sanguínea
Corno Lateral da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160206
[Lr] Data última revisão:
160206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151015
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-3044-0


  4 / 5 MEDLINE  
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[PMID]:26234037
[Au] Autor:Kolos YA; Korzhevskiy DE
[Ti] Título:[THE DISTRIBUTION OF CHOLINERGIC AND NITROXIDERGIC NEURONS IN THE SPINAL CORD OF NEWBORN AND ADULT RATS].
[So] Source:Morfologiia;147(2):32-7, 2015.
[Is] ISSN:1026-3543
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The aim of this study was to examine the distribution of cholinergic and nitroxidergic neurons in the spinal cord (SC) of adult and newborn rats. Using immunohistochemical demonstration of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS), cervical portions of SC were studied in newborn (n=5) and adult (n=5) Wistar rats. It was found that ChAT-positive neurons were localized in the anterior horns of the SC, while individual cells were located in of SC posterior horns, in the central gray matter and at the boundary of VI-VII Rexed laminae. Nitroxidergic neurons were located in the superficial layers of SC posterior horns of grey matter, in the central gray matter and in the area of VI-VII Rexed laminae. It is found that SC of newborn and adult rats contained cholinergic neurons expressing NOS. Detection of cells containing both enzymes already at postnatal Day 1, suggests that they were formed in rat SC during prenatal ontogenesis
[Mh] Termos MeSH primário: Neurônios Colinérgicos
Neurônios Nitrérgicos
Óxido Nítrico Sintase Tipo I/metabolismo
Corno Dorsal da Medula Espinal
Corno Lateral da Medula Espinal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Neurônios Colinérgicos/citologia
Neurônios Colinérgicos/enzimologia
Neurônios Nitrérgicos/citologia
Neurônios Nitrérgicos/enzimologia
Ratos
Ratos Wistar
Corno Dorsal da Medula Espinal/citologia
Corno Dorsal da Medula Espinal/enzimologia
Corno Lateral da Medula Espinal/citologia
Corno Lateral da Medula Espinal/enzimologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.13.39 (Nitric Oxide Synthase Type I); EC 1.14.13.39 (Nos1 protein, rat)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150803
[Lr] Data última revisão:
150803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150804
[St] Status:MEDLINE


  5 / 5 MEDLINE  
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[PMID]:25122704
[Au] Autor:Briant LJ; Stalbovskiy AO; Nolan MF; Champneys AR; Pickering AE
[Ad] Endereço:School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom; and.
[Ti] Título:Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats.
[So] Source:J Neurophysiol;112(11):2756-78, 2014 Dec 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertension is associated with pathologically increased sympathetic drive to the vasculature. This has been attributed to increased excitatory drive to sympathetic preganglionic neurons (SPN) from brainstem cardiovascular control centers. However, there is also evidence supporting increased intrinsic excitability of SPN. To test this hypothesis, we made whole cell recordings of muscle vasoconstrictor-like (MVClike) SPN in the working-heart brainstem preparation of spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. The MVClike SPN have a higher spontaneous firing frequency in the SH rat (3.85 ± 0.4 vs. 2.44 ± 0.4 Hz in WKY; P = 0.011) with greater respiratory modulation of their activity. The action potentials of SH SPN had smaller, shorter afterhyperpolarizations (AHPs) and showed diminished transient rectification indicating suppression of an A-type potassium conductance (IA). We developed mathematical models of the SPN to establish if changes in their intrinsic properties in SH rats could account for their altered firing. Reduction of the maximal conductance density of IA by 15-30% changed the excitability and output of the model from the WKY to a SH profile, with increased firing frequency, amplified respiratory modulation, and smaller AHPs. This change in output is predominantly a consequence of altered synaptic integration. Consistent with these in silico predictions, we found that intrathecal 4-aminopyridine (4-AP) increased sympathetic nerve activity, elevated perfusion pressure, and augmented Traube-Hering waves. Our findings indicate that IA acts as a powerful filter on incoming synaptic drive to SPN and that its diminution in the SH rat is potentially sufficient to account for the increased sympathetic output underlying hypertension.
[Mh] Termos MeSH primário: Potenciais de Ação
Hipertensão/fisiopatologia
Neurônios/fisiologia
Músculos Respiratórios/inervação
Sistema Nervoso Simpático/fisiologia
Vasoconstrição
[Mh] Termos MeSH secundário: Animais
Tronco Encefálico/citologia
Tronco Encefálico/fisiologia
Coração/inervação
Coração/fisiologia
Masculino
Modelos Neurológicos
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Potássio/metabolismo
Bloqueadores dos Canais de Potássio/farmacologia
Canais de Potássio Corretores do Fluxo de Internalização/antagonistas & inibidores
Canais de Potássio Corretores do Fluxo de Internalização/metabolismo
Ratos
Ratos Endogâmicos SHR
Ratos Wistar
Músculos Respiratórios/irrigação sanguínea
Músculos Respiratórios/fisiologia
Corno Lateral da Medula Espinal/citologia
Corno Lateral da Medula Espinal/fisiologia
Sistema Nervoso Simpático/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Potassium Channel Blockers); 0 (Potassium Channels, Inwardly Rectifying); RWP5GA015D (Potassium)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140815
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00350.2014



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