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[PMID]:27910733
[Au] Autor:Sánchez-Del-Rey A; Sánchez-Fernández JM; Ibargutxi A; Martinez-Ibargüen A; Santaolalla F
[Ad] Endereço:a Otorhinolaryngology Department, School of Medicine , University of the Basque Country , Spain.
[Ti] Título:A comparative morphologic and morphometric study about geniculate ganglion development in man and in rat.
[So] Source:Acta Otolaryngol;137(4):375-383, 2017 Apr.
[Is] ISSN:1651-2251
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONCLUSIONS: Human-rat geniculate ganglion (GG) have multiple origins: (1) An initial proximity (20 µm) to the endocranial foramen of the IAM, suggests neural crest induction; and (2) The influence of epibranchial placodes: the tensor tympani muscle (TTM) and the otic apical coil. OBJECTIVES: This study was undertaken to determine the comparative development of human-rat GG. MATERIALS AND METHODS: A light microscopic study of the GG in human material obtained from spontaneous abortions at 9, 13, 14, 17, 18, and 30 weeks, and one neonate was done. This study examined Webster rat embryos and a post-natal series. Specimens were fixed in Bouin fluid, embedded in paraffin, cut, and stained with H&E. The histomorphometric data were obtained with image analysis software. RESULTS: The human fetus of 9 weeks presents two neuronal groups in the VII nerve: one near (20 µm) the IAM endocranial foramen, foraminal, and the other, tympanic. Neonate GG is located between the TTM and the cochlear apex (inwards). In the 16 day old rat embryo GG is placed within a canal containing the stapedial artery. In the adult rat the GG and the stapedial artery are placed within the IAM.
[Mh] Termos MeSH primário: Gânglio Geniculado/embriologia
[Mh] Termos MeSH secundário: Animais
Biometria
Desenvolvimento Fetal
Seres Humanos
Ratos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1080/00016489.2016.1257867


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[PMID]:27725356
[Au] Autor:Yamauchi M; Yamamoto M; Kitamura K; Kasahara M; Matsunaga S; Murakami G; Abe SI
[Ad] Endereço:Department of Anatomy, Tokyo Dental College.
[Ti] Título:Sympathetic and parasympathetic neurons are likely to be absent in the human vestibular and geniculate ganglia: an immunohistochemical study using elderly cadaveric specimens.
[So] Source:Okajimas Folia Anat Jpn;93(1):1-4, 2016.
[Is] ISSN:1881-1736
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The vestibular and geniculate ganglia of the ear in experimental animals carry both of the tyrosine hydroxylase (TH)-positive sympathetic neurons and the neuronal nitric oxide synthase (nNOS)-positive parasympathetic neurons. With an aid of immunohistochemistry, we examined these ganglia as well as the horizontal part of the facial nerve using specimens from 10 formalin-fixed elderly cadavers. The submandibular ganglion from the same cadavers was used for the positive control for both markers. Although there was a nonspecific reaction in nuclei for the present antibody of nNOS, these ganglia were unlikely to contain either nNOS- or TH-positive neurons. However, we did not deny a possibility that the absence was a result of degeneration with aging. In contrast, the facial nerve horizontal part consistently contained both of TH-positive- and nNOS-positive fibers. These fibers might regulate blood supply to the facial nerve and the dysregulation leads to edema to elevate pressure on the nerve within its osseous canal.
[Mh] Termos MeSH primário: Gânglios Parassimpáticos/citologia
Gânglios Simpáticos/citologia
Gânglio Geniculado/citologia
Neurônios/citologia
Vestíbulo do Labirinto/citologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cadáver
Seres Humanos
Imuno-Histoquímica
Masculino
Fibras Nervosas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27593878
[Au] Autor:Kim MW; Ryu NG; Lim BW; Kim J
[Ad] Endereço:Department of Otorhinolaryngology, Inje University College of Medicine, Goyang, Korea.
[Ti] Título:Temporal Lobe Retraction Provides Better Surgical Exposure of the Peri-Geniculate Ganglion for Facial Nerve Decompression via Transmastoid Approach.
[So] Source:Yonsei Med J;57(6):1482-7, 2016 Nov.
[Is] ISSN:1976-2437
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: For the exposure of the labyrinthine segment of the facial nerve, transmastoid approach is not usually considered due to being situated behind the superior semicircular canal. To obtain a better view and bigger field for manipulation in the peri-geniculate area during facial nerve decompression, retraction of temporal lobe after bony removal of tegmen mastoideum was designed via transmastoid approach. MATERIALS AND METHODS: Fifteen patients with traumatic facial paralysis [House-Brackmann (HB) grade IV-VI], 3 patients with Bell's palsy (HB grade V-VI), and 2 patients with herpes zoster oticus (HB grade V-VI) underwent facial nerve decompression surgery between January 2008 and July 2014. In all patients, we performed temporal lobe retraction for facial nerve decompression via the transmastoid approach. Patients were examined using pre operative tests including high-resolution computed tomography, temporal magnetic resonance imaging, audiometry, and electroneurography (degenerative ratio >90%). Facial function was evaluated by HB grading scale before and 6 months after the surgery. RESULTS: After the surgery, facial function recovered to HB grade I in 9 patients and to grade II in 11 patients. No problems due to surgical retraction of the temporal lobe were noted. Compared to the standard transmastoid approach, our method helped achieve a wider surgical view for improved manipulation in the peri-geniculate ganglion in all cases. CONCLUSION: Facial nerve decompression via the transmastoid approach with temporal lobe retraction provides better exposure to the key areas around the geniculate ganglion without complications.
[Mh] Termos MeSH primário: Descompressão Cirúrgica/métodos
Nervo Facial/cirurgia
Paralisia Facial/cirurgia
Gânglio Geniculado/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Audiometria
Paralisia de Bell/etiologia
Paralisia de Bell/cirurgia
Nervo Facial/diagnóstico por imagem
Paralisia Facial/diagnóstico por imagem
Paralisia Facial/etiologia
Feminino
Gânglio Geniculado/cirurgia
Herpes Zoster da Orelha Externa/cirurgia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Processo Mastoide/cirurgia
Meia-Idade
Procedimentos Neurocirúrgicos/efeitos adversos
Osso Temporal/diagnóstico por imagem
Osso Temporal/cirurgia
Lobo Temporal
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.3349/ymj.2016.57.6.1482


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[PMID]:27484229
[Au] Autor:Lahlou G; Nguyen Y; Russo FY; Ferrary E; Sterkers O; Bernardeschi D
[Ad] Endereço:AP-HP, Pitie-Salpetriere Hospital, Otology, Auditory Implants and Skull Base Surgery Department, Paris, France.
[Ti] Título:Geniculate Ganglion Tumors: Clinical Presentation and Surgical Results.
[So] Source:Otolaryngol Head Neck Surg;155(5):850-855, 2016 Nov.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Facial nerve tumors are rare lesions mostly located in the geniculate ganglion. This study aims to compare those tumors limited to the geniculate ganglion in terms of clinical features and postoperative outcomes. STUDY DESIGN: Case series with chart review. SETTINGS: University tertiary reference center. SUBJECTS AND METHODS: Medical charts were reviewed for 17 patients who had surgery for geniculate ganglion tumor removal (10 hemangiomas, 6 schwannomas, 1 meningioma). Hemangiomas and schwannomas were compared for preoperative facial nerve function, hearing, tumor size, and postoperative outcomes. RESULTS: Facial palsy was observed in all cases. Regarding the preoperative facial nerve function, severe facial palsy (House-Brackmann grades V and VI) was present in 70% of cases for hemangiomas and for no case of schwannoma (P = .01), although hemangiomas were significantly smaller tumors (P = .01). Hearing loss was observed in 4 cases (23.5%) and was related to tumor volume (P < .0001). A complete excision was achieved in all cases, and a facial nerve graft was performed immediately after interruption in 16 patients (94%). Postoperative facial nerve function was improved or stabilized in 94% of cases. A preoperative House-Brackman grade VI was shown as a negative factor for postoperative facial nerve function. CONCLUSIONS: Differences in clinical presentations could help in establishing the good therapeutic option depending on the tumor type. Surgery, when indicated, is safe and effective, and postoperative outcomes are not related to tumor type.
[Mh] Termos MeSH primário: Neoplasias dos Nervos Cranianos/cirurgia
Gânglio Geniculado/cirurgia
Hemangioma/cirurgia
Meningioma/cirurgia
Neurilemoma/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias dos Nervos Cranianos/patologia
Paralisia Facial/patologia
Feminino
Gânglio Geniculado/patologia
Hemangioma/patologia
Seres Humanos
Masculino
Meningioma/patologia
Meia-Idade
Neurilemoma/patologia
Complicações Pós-Operatórias
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


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[PMID]:27340996
[Au] Autor:Tachibana T; Orita Y; Nishizaki K
[Ad] Endereço:Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan. tomoyasutachibana@hotmail.co.jp.
[Ti] Título:Anterior Displacement of the Geniculate Ganglion.
[So] Source:J Int Adv Otol;12(1):113-5, 2016 Apr.
[Is] ISSN:1308-7649
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:We present the case of a 34-year-old Japanese woman with cholesteatoma of the middle ear. During the operation, this patient showed an unusual position of the geniculate ganglion. We reviewed the computed tomography (CT) images targeting the ear of the present case after the operation. We found that the shortest ranges from the ampullated end of the superior semicircular canal to the geniculate ganglion fossa were 5.1 mm on both sides. We did not find any cases with obvious dislocation of the geniculate ganglion among the 67 cases for which we had performed tympanoplasty. Displacement of the geniculate ganglion is either extremely rare or typically unnoticed because this abnormality is asymptomatic. We speculated that the unusual position of the geniculate ganglion was due to an incomplete development of the tympanic tegmen. When surgical treatment such as decompression of the facial nerve or tympanoplasty is performed, close attention should always be paid to the anatomy of the facial nerve from the labyrinthine segment to the geniculate ganglion. In the present case, although connective tissues existed around the anterior epitympanic recess, we left this lesion to avoid iatrogenic facial palsy.
[Mh] Termos MeSH primário: Gânglio Geniculado/anormalidades
Gânglio Geniculado/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Colesteatoma da Orelha Média/diagnóstico por imagem
Colesteatoma da Orelha Média/cirurgia
Diagnóstico Diferencial
Orelha Média/anormalidades
Orelha Média/diagnóstico por imagem
Nervo Facial/anormalidades
Nervo Facial/diagnóstico por imagem
Feminino
Seres Humanos
Valores de Referência
Canais Semicirculares/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE
[do] DOI:10.5152/iao.2016.1559


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[PMID]:27062115
[Au] Autor:Omor Y; Bensouda A; Alard S
[Ad] Endereço:University hospital of Saint-Pierre, Department of medical imaging, Brussels, Belgium. Electronic address: omor.youssef3@gmail.com.
[Ti] Título:"Honeycomb" sign.
[So] Source:Presse Med;45(5):541-3, 2016 May.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias dos Nervos Cranianos/diagnóstico por imagem
Gânglio Geniculado
Hemangioma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160411
[St] Status:MEDLINE


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[PMID]:27030734
[Au] Autor:Yokota Y; Bradley RM
[Ad] Endereço:Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan; and.
[Ti] Título:Receptive field size, chemical and thermal responses, and fiber conduction velocity of rat chorda tympani geniculate ganglion neurons.
[So] Source:J Neurophysiol;115(6):3062-72, 2016 06 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Afferent chorda tympani (CT) fibers innervating taste and somatosensory receptors in fungiform papillae have neuron cell bodies in the geniculate ganglion (GG). The GG/CT fibers branch in the tongue to innervate taste buds in several fungiform papillae. To investigate receptive field characteristics of GG/CT neurons, we recorded extracellular responses from GG cells to application of chemical and thermal stimuli. Receptive field size was mapped by electrical stimulation of individual fungiform papillae. Response latency to electrical stimulation was used to determine fiber conduction velocity. Responses of GG neurons to lingual application of stimuli representing four taste qualities, and water at 4°C, were used to classify neuron response properties. Neurons classified as SALT, responding only to NaCl and NH4Cl, had a mean receptive field size of six papillae. Neurons classified as OTHER responded to salts and other chemical stimuli and had smaller mean receptive fields of four papillae. Neurons that responded to salts and cold stimuli, classified as SALT/THERMAL, and neurons responding to salts, other chemical stimuli and cold, classified as OTHER/THERMAL, had mean receptive field sizes of six and five papillae, respectively. Neurons responding only to cold stimuli, categorized as THERMAL, had receptive fields of one to two papillae located at the tongue tip. Based on conduction velocity most of the neurons were classified as C fibers. Neurons with large receptive fields had higher conduction velocities than neurons with small receptive fields. These results demonstrate that GG neurons can be distinguished by receptive field size, response properties and afferent fiber conduction velocity derived from convergent input of multiple taste organs.
[Mh] Termos MeSH primário: Nervo da Corda do Tímpano/fisiologia
Gânglio Geniculado/citologia
Condução Nervosa/fisiologia
Neurônios/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Cloreto de Amônio/farmacologia
Análise de Variância
Animais
Estimulação Elétrica
Feminino
Condução Nervosa/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Tempo de Reação
Células Receptoras Sensoriais/efeitos dos fármacos
Cloreto de Sódio/farmacologia
Estimulação Química
Paladar/fisiologia
Papilas Gustativas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
01Q9PC255D (Ammonium Chloride); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171127
[Lr] Data última revisão:
171127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00045.2016


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[PMID]:26901525
[Au] Autor:Biggs BT; Tang T; Krimm RF
[Ad] Endereço:Department of Anatomical Sciences and Neurobiology, University of Louisville, School of Medicine, Louisville, Kentucky 40202, United States of America.
[Ti] Título:Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds.
[So] Source:PLoS One;11(2):e0148315, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growth factors regulate cell growth and differentiation in many tissues. In the taste system, as yet unknown growth factors are produced by neurons to maintain taste buds. A number of growth factor receptors are expressed at greater levels in taste buds than in the surrounding epithelium and may be receptors for candidate factors involved in taste bud maintenance. We determined that the ligands of eight of these receptors were expressed in the E14.5 geniculate ganglion and that four of these ligands were expressed in the adult geniculate ganglion. Of these, the insulin-like growth factors (IGF1, IGF2) were expressed in the ganglion and their receptor, insulin-like growth factor receptor 1 (IGF1R), were expressed at the highest levels in taste buds. To determine whether IGF1R regulates taste bud number or structure, we conditionally eliminated IGF1R from the lingual epithelium of mice using the keratin 14 (K14) promoter (K14-Cre::Igf1rlox/lox). While K14-Cre::Igf1rlox/lox mice had significantly fewer taste buds at P30 compared with control mice (Igf1rlox/lox), this difference was not observed by P80. IGF1R removal did not affect taste bud size or cell number, and the number of phospholipase C ß2- (PLCß2) and carbonic anhydrase 4- (Car4) positive taste receptor cells did not differ between genotypes. Taste buds at the back of the tongue fungiform taste field were larger and contained more cells than those at the tongue tip, and these differences were diminished in K14-Cre::Igf1rlox/lox mice. The epithelium was thicker at the back versus the tip of the tongue, and this difference was also attenuated in K14-Cre::Igf1rlox/lox mice. We conclude that, although IGFs are expressed at high levels in the taste system, they likely play little or no role in maintaining adult taste bud structure. IGFs have a potential role in establishing the initial number of taste buds, and there may be limits on epithelial thickness in the absence of IGF1R signaling.
[Mh] Termos MeSH primário: Receptores de Somatomedina/metabolismo
Papilas Gustativas/metabolismo
Língua/metabolismo
[Mh] Termos MeSH secundário: Animais
Gânglio Geniculado/metabolismo
Imuno-Histoquímica
Microdissecção e Captura a Laser
Camundongos
Reação em Cadeia da Polimerase em Tempo Real
Receptor IGF Tipo 1/metabolismo
Receptor IGF Tipo 2/metabolismo
Somatomedinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Receptor, IGF Type 2); 0 (Receptors, Somatomedin); 0 (Somatomedins); EC 2.7.10.1 (Receptor, IGF Type 1)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148315


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[PMID]:26676873
[Au] Autor:Lahlou G; Nguyen Y; Russo FY; Ferrary E; Sterkers O; Bernardeschi D
[Ad] Endereço:Department of Otology, Auditory Implants and Skull Base Surgery, AP-HP, Pitié-Salpêtrière Hospital, 50/52 Bd Vincent Auriol, 75013, Paris, France.
[Ti] Título:Intratemporal facial nerve schwannoma: clinical presentation and management.
[So] Source:Eur Arch Otorhinolaryngol;273(11):3497-3504, 2016 Nov.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Facial nerve schwannoma is the most common facial nerve tumor, but its therapeutic strategy remains debated. The aim of this study is to analyze the facial nerve function and the hearing outcomes after surgery or wait-and-scan policy in a facial nerve schwannoma series. A monocentric retrospective review of medical charts of patients followed for an intratemporal facial nerve schwannoma between 1988 and 2013 was performed. Twenty-two patients were included. Data were extracted pertaining to the following variables: patient demographics, tumor localization, clinical and imaging features, facial nerve function and hearing levels, and details of surgical intervention. The majority of tumors were located at the geniculate ganglion. Initial symptoms were mainly facial palsy and hearing loss. The average follow-up was 4.8 ± 4.5 years. Nineteen patients underwent surgery, and three patients were observed. After surgery, 11 patients had a stable or improved facial nerve function (57.9 %), and 8 patients had a worsened facial nerve function (42.1 %). Facial nerve function was in the majority of cases a HB grade III, depending on surgical strategy. No patient presented a postoperative HB grade V or VI. Regarding the hearing, it remained stable after surgery in 52.6 % of cases, and improved in 10.5 % of cases. Among monitored patients, facial nerve function and hearing remained stable. Surgery for facial nerve schwannoma is a safe and effective option in the treatment of these tumors.
[Mh] Termos MeSH primário: Neoplasias dos Nervos Cranianos/cirurgia
Doenças do Nervo Facial/cirurgia
Nervo Facial/fisiopatologia
Neurilemoma/cirurgia
[Mh] Termos MeSH secundário: Adulto
Paralisia de Bell/etiologia
Neoplasias dos Nervos Cranianos/complicações
Gerenciamento Clínico
Doenças do Nervo Facial/complicações
Paralisia Facial/etiologia
Paralisia Facial/fisiopatologia
Feminino
Gânglio Geniculado/patologia
Audição
Perda Auditiva/etiologia
Seres Humanos
Masculino
Meia-Idade
Neurilemoma/complicações
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE


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[PMID]:26888004
[Au] Autor:Chen D; Cui Y
[Ti] Título:[Geniculate ganglion meningioma: a case report].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;50(11):952-3, 2015 Nov.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Neoplasias dos Nervos Cranianos/patologia
Gânglio Geniculado/patologia
Neoplasias Meníngeas/patologia
Meningioma/patologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160218
[Lr] Data última revisão:
160218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE



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