Base de dados : MEDLINE
Pesquisa : A08.612.380 [Categoria DeCS]
Referências encontradas : 6186 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 619 ir para página                         

  1 / 6186 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468849
[Au] Autor:Lyle MA; Nichols TR; Kajtaz E; Maas H
[Ad] Endereço:School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia mlyle@ap.gatech.edu.
[Ti] Título:Musculotendon adaptations and preservation of spinal reflex pathways following agonist-to-antagonist tendon transfer.
[So] Source:Physiol Rep;5(9), 2017 May.
[Is] ISSN:2051-817X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tendon transfer surgeries are performed to restore lost motor function, but outcomes are variable, particularly those involving agonist-to-antagonist muscles. Here, we evaluated the possibility that lack of proprioceptive feedback reorganization and musculotendon adaptations could influence outcomes. Plantaris-to-tibialis anterior tendon transfer along with resection of the distal third of the tibialis anterior muscle belly was performed in eight cats. Four cats had concurrent transection of the deep peroneal nerve. After 15-20 weeks, intermuscular length and force-dependent sensory feedback were examined between hindlimb muscles, and the integrity of the tendon-to-tendon connection and musculotendon adaptations were evaluated. Three of the transferred tendons tore. A common finding was the formation of new tendinous connections, which often inserted near the original location of insertion on the skeleton (e.g., connections from plantaris toward calcaneus and from tibialis anterior toward first metatarsal). The newly formed tissue connections are expected to compromise the mechanical action of the transferred muscle. We found no evidence of changes in intermuscular reflexes between transferred plantaris muscle and synergists/antagonists whether the tendon-to-tendon connection remained intact or tore, indicating no spinal reflex reorganization. We propose the lack of spinal reflex reorganization could contribute the transferred muscle not adopting the activation patterns of the host muscle. Taken together, these findings suggest that musculotendon plasticity and lack of spinal reflex circuitry reorganization could limit functional outcomes after tendon transfer surgery. Surgical planning and outcomes assessments after tendon transfer surgery should consider potential consequences of the transferred muscle's intermuscular spinal circuit actions.
[Mh] Termos MeSH primário: Retroalimentação Fisiológica
Músculo Esquelético/fisiologia
Reflexo
Medula Espinal/fisiologia
Tendões/fisiologia
[Mh] Termos MeSH secundário: Animais
Gatos
Vias Eferentes/fisiologia
Feminino
Músculo Esquelético/inervação
Nervo Fibular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  2 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28467898
[Au] Autor:Melzer S; Gil M; Koser DE; Michael M; Huang KW; Monyer H
[Ad] Endereço:Department of Clinical Neurobiology at the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
[Ti] Título:Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity.
[So] Source:Cell Rep;19(5):1045-1055, 2017 May 02.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM ) and parvalbumin-positive (PV ) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV and M2 SOM projecting neurons reduced locomotion, whereas stimulation of M1 SOM projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Neurônios GABAérgicos/metabolismo
Atividade Motora
[Mh] Termos MeSH secundário: Animais
Neurônios Colinérgicos/metabolismo
Neurônios Colinérgicos/fisiologia
Corpo Estriado/citologia
Corpo Estriado/metabolismo
Vias Eferentes/metabolismo
Vias Eferentes/fisiologia
Neurônios GABAérgicos/fisiologia
Interneurônios/metabolismo
Interneurônios/fisiologia
Masculino
Camundongos
Parvalbuminas/genética
Parvalbuminas/metabolismo
Somatostatina/genética
Somatostatina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parvalbumins); 51110-01-1 (Somatostatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  3 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29068990
[Au] Autor:Jang SH; Kwon HG
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu bDepartment of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Republic of Korea.
[Ti] Título:Aggravation of an injured dentato-rubro-thalamic tract in a patient with mild traumatic brain injury: A case report.
[So] Source:Medicine (Baltimore);96(43):e8253, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient with mild traumatic brain injury (TBI) by follow-up diffusion tensor tractography (DTT), and observed for approximately nine monthsby serial diffusion tensor tractography (DTT). PATIENT CONCERNS: A 66-year-old male patient was injured in a car crash. Approximately four weeks after the crash, he developed a tremor in the right hand and leg. His symptoms worsened over time. DIAGNOSES: Approximately six months after the crash, he developed a mild tremor in the left hand. Nine months after the crash, he manifested severe tremor in his right hand, mild resting and intentional tremor in his left hand and both legs, and mild trunkal ataxia. INTERVENTIONS: N/A. OUTCOMES: On 3-week DTT, well reconstructed DRTTs were observed in both hemispheres, except for the thinned lower portion of the right DRTT. On 9-month DTT, the right lower DRTT had thinned compared with the 3-week DTT and showed a disruption at the upper portion. The left DRTT showed thinning in the lower portion and tearing in the upper portion compared with 3-week DTT. LESSONS: Aggravation of an injured DRTT was demonstrated in a patient with mild TBI, using serial DTT examination.
[Mh] Termos MeSH primário: Concussão Encefálica/complicações
Núcleos Cerebelares/lesões
Tálamo/lesões
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Idoso
Ataxia/etiologia
Concussão Encefálica/diagnóstico por imagem
Núcleos Cerebelares/diagnóstico por imagem
Imagem de Tensor de Difusão
Vias Eferentes/diagnóstico por imagem
Vias Eferentes/lesões
Seguimentos
Mãos/fisiopatologia
Seres Humanos
Perna (Membro)/fisiopatologia
Masculino
Tálamo/diagnóstico por imagem
Tremor/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008253


  4 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28904231
[Au] Autor:Schulz R; Park E; Lee J; Chang WH; Lee A; Kim YH; Hummel FC
[Ad] Endereço:From the Department of Neurology, University Medical Center Hamburg-Eppendorf, Germany (R.S.); Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Rep
[Ti] Título:Interactions Between the Corticospinal Tract and Premotor-Motor Pathways for Residual Motor Output After Stroke.
[So] Source:Stroke;48(10):2805-2811, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Brain imaging has continuously enhanced our understanding how different brain networks contribute to motor recovery after stroke. However, the present models are still incomplete and do not fit for every patient. The interaction between the degree of damage of the corticospinal tract (CST) and of corticocortical motor connections, that is, the influence of the microstructural state of one connection on the importance of another has been largely neglected. METHODS: Applying diffusion-weighted imaging and probabilistic tractography, we investigated cross-network interactions between the integrity of ipsilesional CST and ipsilesional corticocortical motor pathways for variance in residual motor outcome in 53 patients with subacute stroke. RESULTS: The main finding was a significant interaction between the CST and corticocortical connections between the primary motor and ventral premotor cortex in relation to residual motor output. More specifically, the data indicate that the microstructural state of the connection primary motor-ventral premotor cortex plays only a role in patients with significant damage to the CST. In patients with slightly affected CST, this connection did not explain a relevant amount of variance in motor outcome. CONCLUSIONS: The present data show that patients with stroke with different degree of CST disruption differ in their dependency on structural premotor-motor connections for residual motor output. This finding might have important implications for future research on recovery prediction models and on responses to treatment strategies.
[Mh] Termos MeSH primário: Vias Eferentes/diagnóstico por imagem
Córtex Motor/diagnóstico por imagem
Tratos Piramidais/diagnóstico por imagem
Acidente Vascular Cerebral/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Imagem de Tensor de Difusão/tendências
Vias Eferentes/fisiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Córtex Motor/fisiologia
Tratos Piramidais/fisiologia
Acidente Vascular Cerebral/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.016834


  5 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28576940
[Au] Autor:Smith CC; Paton JFR; Chakrabarty S; Ichiyama RM
[Ad] Endereço:School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom, and calvin.smith@ucl.ac.uk.
[Ti] Título:Descending Systems Direct Development of Key Spinal Motor Circuits.
[So] Source:J Neurosci;37(26):6372-6387, 2017 Jun 28.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The formation of mature spinal motor circuits is dependent on both activity-dependent and independent mechanisms during postnatal development. During this time, reorganization and refinement of spinal sensorimotor circuits occurs as supraspinal projections are integrated. However, specific features of postnatal spinal circuit development remain poorly understood. This study provides the first detailed characterization of rat spinal sensorimotor circuit development in the presence and absence of descending systems. We show that the development of proprioceptive afferent input to motoneurons (MNs) and Renshaw cells (RCs) is disrupted by thoracic spinal cord transection at postnatal day 5 (P5TX). P5TX also led to malformation of GABApre neuron axo-axonic contacts on Ia afferents and of the recurrent inhibitory circuit between MNs and RCs. Using a novel perfused preparation for studying motor control, we show that malformation of these spinal circuits leads to hyperexcitability of the monosynaptic reflex. Our results demonstrate that removing descending input severely disrupts the development of spinal circuits and identifies key mechanisms contributing to motor dysfunction in conditions such as cerebral palsy and spinal cord injury. Acquisition of mature behavior during postnatal development correlates with the arrival and maturation of supraspinal projections to the spinal cord. However, we know little about the role that descending systems play in the maturation of spinal circuits. Here, we characterize postnatal development of key spinal microcircuits in the presence and absence of descending systems. We show that formation of these circuits is abnormal after early (postnatal day 5) removal of descending systems, inducing hyperexcitability of the monosynaptic reflex. The study is a detailed characterization of spinal circuit development elucidating how these mechanisms contribute to motor dysfunction in conditions such as cerebral palsy and spinal cord injury. Understanding these circuits is crucial to developing new therapeutics and improving existing ones in such conditions.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Vias Eferentes/fisiologia
Neurônios Motores/fisiologia
Neurogênese/fisiologia
Reflexo Monosináptico/fisiologia
Medula Espinal/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Rede Nervosa/fisiologia
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0149-17.2017


  6 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28422976
[Au] Autor:Fogel S; Albouy G; King BR; Lungu O; Vien C; Bore A; Pinsard B; Benali H; Carrier J; Doyon J
[Ad] Endereço:Functional Neuroimaging Unit, Centre de Recherche de l'institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.
[Ti] Título:Reactivation or transformation? Motor memory consolidation associated with cerebral activation time-locked to sleep spindles.
[So] Source:PLoS One;12(4):e0174755, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Motor memory consolidation is thought to depend on sleep-dependent reactivation of brain areas recruited during learning. However, up to this point, there has been no direct evidence to support this assertion in humans, and the physiological processes supporting such reactivation are unknown. Here, simultaneous electroencephalographic and functional magnetic resonance imaging (EEG-fMRI) recordings were conducted during post-learning sleep to directly investigate the spindle-related reactivation of a memory trace formed during motor sequence learning (MSL), and its relationship to overnight enhancement in performance (reflecting consolidation). We show that brain regions within the striato-cerebello-cortical network recruited during training on the MSL task, and in particular the striatum, were also activated during sleep, time-locked to spindles. Interestingly, the consolidated trace in the striatum was not simply strengthened, but was transformed/reorganized from rostrodorsal (associative) to caudoventral (sensorimotor) subregions. Moreover, the degree of the reactivation was correlated with overnight improvements in performance. Altogether, the present findings demonstrate that striatal reactivation linked to sleep spindles in the post-learning night, is related to motor memory consolidation.
[Mh] Termos MeSH primário: Cerebelo/fisiologia
Córtex Cerebral/fisiologia
Corpo Estriado/fisiologia
Aprendizagem/fisiologia
Consolidação da Memória/fisiologia
Desempenho Psicomotor/fisiologia
[Mh] Termos MeSH secundário: Adulto
Cerebelo/anatomia & histologia
Córtex Cerebral/anatomia & histologia
Corpo Estriado/anatomia & histologia
Vias Eferentes/anatomia & histologia
Vias Eferentes/fisiologia
Eletroencefalografia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Polissonografia
Sono/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174755


  7 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28421634
[Au] Autor:Bonaz B; Sinniger V; Pellissier S
[Ad] Endereço:University Clinic of Hepato-Gastroenterology, University Hospital, Grenoble, France.
[Ti] Título:Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease.
[So] Source:J Intern Med;282(1):46-63, 2017 Jul.
[Is] ISSN:1365-2796
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel disease (IBD), that is Crohn's disease (CD) and ulcerative colitis, affects about 1.5 million persons in the USA and 2.2 million in Europe. The pathophysiology of IBD involves immunological, genetic and environmental factors. The treatment is medico-surgical but suspensive. Anti-TNFα agents have revolutionized the treatment of IBD but have side effects. In addition, a non-negligible percentage of patients with IBD stop or take episodically their treatment. Consequently, a nondrug therapy targeting TNFα through a physiological pathway, devoid of major side effects and with a good cost-effectiveness ratio, would be of interest. The vagus nerve has dual anti-inflammatory properties through its afferent (i.e. hypothalamic-pituitary-adrenal axis) and efferent (i.e. the anti-TNFα effect of the cholinergic anti-inflammatory pathway) fibres. We have shown that there is an inverse relationship between vagal tone and plasma TNFα level in patients with CD, and have reported, for the first time, that chronic vagus nerve stimulation has anti-inflammatory properties in a rat model of colitis and in a pilot study performed in seven patients with moderate CD. Two of these patients failed to improve after 3 months of vagus nerve stimulation but five were in deep remission (clinical, biological and endoscopic) at 6 months of follow-up and vagal tone was restored. No major side effects were observed. Thus, vagus nerve stimulation provides a new therapeutic option in the treatment of CD.
[Mh] Termos MeSH primário: Doenças Inflamatórias Intestinais/terapia
Estimulação do Nervo Vago
[Mh] Termos MeSH secundário: Vias Aferentes
Animais
Terapias Complementares
Modelos Animais de Doenças
Vias Eferentes
Seres Humanos
Doenças Inflamatórias Intestinais/fisiopatologia
Nervos Esplâncnicos/fisiologia
Baço/inervação
Nervo Vago/anatomia & histologia
Nervo Vago/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1111/joim.12611


  8 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28390599
[Au] Autor:Rocha-Muniz CN; Mamede Carvallo RM; Schochat E
[Ad] Endereço:Universidade de São Paulo School of Medicine (USP), São Paulo, Brazil. Electronic address: Brazil.carolrocha@usp.br.
[Ti] Título:Medial olivocochlear function in children with poor speech-in-noise performance and language disorder.
[So] Source:Int J Pediatr Otorhinolaryngol;96:116-121, 2017 May.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Contralateral masking of transient-evoked otoacoustic emissions is a phenomenon that suggests an inhibitory effect of the olivocochlear efferent auditory pathway. Many studies have been inconclusive in demonstrating a clear connection between this system and a behavioral speech-in-noise listening skill. The purpose of this study was to investigate the activation of a medial olivocochlear (MOC) efferent in children with poor speech-in-noise (PSIN) performance and children with language impairment and PSIN (SLI + PSIN). METHODS: Transient evoked otoacoustic emissions (TEOAEs) with and without contralateral white noise were tested in 52 children (between 6 and 12 years). These children were arranged in three groups: typical development (TD) (n = 25), PSIN (n = 14) and SLI + PSI (n = 13). RESULTS: PSIN and SLI + PSI groups presented reduced otoacoustic emission suppression in comparison with the TD group. CONCLUSION: Our finding suggests differences in MOC function among children with typical development and children with poor SIN and language problems.
[Mh] Termos MeSH primário: Vias Auditivas/fisiopatologia
Cóclea/fisiopatologia
Transtornos da Linguagem/fisiopatologia
Distúrbios da Fala/fisiopatologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Percepção Auditiva
Criança
Vias Eferentes/fisiologia
Feminino
Seres Humanos
Transtornos da Linguagem/complicações
Masculino
Ruído
Emissões Otoacústicas Espontâneas/fisiologia
Fala
Distúrbios da Fala/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  9 / 6186 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28326945
[Au] Autor:Zhuo M
[Ad] Endereço:1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
[Ti] Título:Descending facilitation.
[So] Source:Mol Pain;13:1744806917699212, 2017 Jan.
[Is] ISSN:1744-8069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is documented that sensory transmission, including pain, is subject to endogenous inhibitory and facilitatory modulation at the dorsal horn of the spinal cord. Descending facilitation has received a lot of attention, due to its potentially important roles in chronic pain. Recent investigation using neurobiological approaches has further revealed the link between cortical potentiation and descending facilitation. Cortical-spinal top-down facilitation, including those relayed through brainstem neurons, provides powerful control for pain transmission at the level of the spinal cord. It also provides the neuronal basis to link emotional disorders such as anxiety, depression, and loss of hope to somatosensory pain and sufferings. In this review, I will review a brief history of the discovery of brainstem-spinal descending facilitation and explore new information and hypothesis for descending facilitation in chronic pain.
[Mh] Termos MeSH primário: Dor Crônica/patologia
Dor Crônica/terapia
Vias Eferentes/fisiologia
Pesquisa Médica Translacional
[Mh] Termos MeSH secundário: Animais
Tronco Encefálico/fisiologia
Córtex Cerebral/fisiologia
Seres Humanos
Medula Espinal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1177/1744806917699212


  10 / 6186 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28244847
[Au] Autor:Abou-Elew MH; Hosni NA; Obaid EA; Ewida AH
[Ad] Endereço:Audio-Vestibular Unit,ORL Department,Otorhinolaryngology Department,Faculty of Medicine,Cairo University,Cairo,Egypt.
[Ti] Título:The N3 potential and the efferent cochlear pathway in profound sensorineural hearing loss.
[So] Source:J Laryngol Otol;131(4):334-340, 2017 Apr.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to evaluate the presence of the N3 potential (acoustically evoked short latency negative response) in profound sensorineural hearing loss, its association with the cervical vestibular evoked myogenic potential and the relationship between both potentials and loss of auditory function. METHODS: Otological examinations of 66 ears from 50 patients aged from 4 to 36 years were performed, and the vestibular evoked myogenic potential and auditory brainstem response were measured. RESULTS: The N3 potential was recorded in 36 out of 66 ears (55 per cent) and a vestibular evoked myogenic potential was recorded in 34 (52 per cent). The N3 potential was recorded in 23 out of 34 ears (68 per cent) with a vestibular evoked myogenic potential response and absent in 19 out of 32 ears (59 per cent) without a vestibular evoked myogenic potential response. The presence of an N3 potential was significantly associated with a vestibular evoked myogenic potential response (p = 0.028), but there was no significant difference in the latency or amplitude of the N3 potential in either the presence or absence of a vestibular evoked myogenic potential. CONCLUSION: The presence of an N3 potential in profound sensorineural hearing loss with good or poor vestibular function can be explained by the contribution of the efferent cochlear pathway through olivocochlear fibres that join the inferior vestibular nerve. This theory is supported by its early latency and reversed polarity, which is masked in normal hearing by auditory brainstem response waves.
[Mh] Termos MeSH primário: Cóclea/inervação
Potenciais Evocados/fisiologia
Perda Auditiva Neurossensorial/fisiopatologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
Nervo Vestibular/fisiopatologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Adolescente
Adulto
Audiometria de Resposta Evocada
Criança
Pré-Escolar
Cóclea/fisiopatologia
Estudos Transversais
Vias Eferentes/fisiologia
Feminino
Seres Humanos
Masculino
Tempo de Reação
Testes de Função Vestibular
Vestíbulo do Labirinto/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000317



página 1 de 619 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde