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  1 / 929 MEDLINE  
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[PMID]:29208223
[Au] Autor:Donlea JM
[Ad] Endereço:Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095-1763, USA. Electronic address: jdonlea@ucla.edu.
[Ti] Título:Neuronal and molecular mechanisms of sleep homeostasis.
[So] Source:Curr Opin Insect Sci;24:51-57, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sleep is necessary for survival, and prolonged waking causes a homeostatic increase in the need for recovery sleep. Homeostasis is a core component of sleep regulation and has been tightly conserved across evolution from invertebrates to man. Homeostatic sleep regulation was first identified among insects in cockroaches several decades ago, but the characterization of sleep rebound in Drosophila melanogaster opened the use of insect model species to understand homeostatic functions and regulation of sleep. This review describes circuits in two neuropil structures, the central complex and mushroom bodies, that influence sleep homeostasis and neuromodulatory systems that influence the accrual of homeostatic sleep need.
[Mh] Termos MeSH primário: Drosophila melanogaster/fisiologia
Homeostase/fisiologia
Corpos Pedunculados/fisiologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Animais
Neurópilo/fisiologia
Neurotransmissores/metabolismo
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  2 / 929 MEDLINE  
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[PMID]:28752327
[Au] Autor:Boyan G; Liu Y; Khalsa SK; Hartenstein V
[Ad] Endereço:Graduate School of Systemic Neuroscience, Biocenter, Ludwig-Maximilians-Universität, Grosshadernerstrasse 2, 82152, Planegg-Martinsried, Germany.
[Ti] Título:A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila.
[So] Source:Dev Genes Evol;227(4):253-269, 2017 Jul.
[Is] ISSN:1432-041X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The central complex comprises an elaborate system of modular neuropils which mediate spatial orientation and sensory-motor integration in insects such as the grasshopper and Drosophila. The neuroarchitecture of the largest of these modules, the fan-shaped body, is characterized by its stereotypic set of decussating fiber bundles. These are generated during development by axons from four homologous protocerebral lineages which enter the commissural system and subsequently decussate at stereotypic locations across the brain midline. Since the commissural organization prior to fan-shaped body formation has not been previously analyzed in either species, it was not clear how the decussating bundles relate to individual lineages, or if the projection pattern is conserved across species. In this study, we trace the axonal projections from the homologous central complex lineages into the commissural system of the embryonic and larval brains of both the grasshopper and Drosophila. Projections into the primordial commissures of both species are found to be lineage-specific and allow putatively equivalent fascicles to be identified. Comparison of the projection pattern before and after the commencement of axon decussation in both species reveals that equivalent commissural fascicles are involved in generating the columnar neuroarchitecture of the fan-shaped body. Further, the tract-specific columns in both the grasshopper and Drosophila can be shown to contain axons from identical combinations of central complex lineages, suggesting that this columnar neuroarchitecture is also conserved.
[Mh] Termos MeSH primário: Drosophila/crescimento & desenvolvimento
Gafanhotos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Axônios/metabolismo
Evolução Biológica
Padronização Corporal
Encéfalo/citologia
Drosophila/citologia
Drosophila/genética
Drosophila/metabolismo
Gafanhotos/citologia
Gafanhotos/genética
Gafanhotos/metabolismo
Larva/crescimento & desenvolvimento
Larva/metabolismo
Neurônios
Neurópilo/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1007/s00427-017-0587-2


  3 / 929 MEDLINE  
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[PMID]:28533086
[Au] Autor:Ngo KT; Andrade I; Hartenstein V
[Ad] Endereço:Department of Molecular, Cell, and Developmental Biology, United States.
[Ti] Título:Spatio-temporal pattern of neuronal differentiation in the Drosophila visual system: A user's guide to the dynamic morphology of the developing optic lobe.
[So] Source:Dev Biol;428(1):1-24, 2017 08 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Visual information processing in animals with large image forming eyes is carried out in highly structured retinotopically ordered neuropils. Visual neuropils in Drosophila form the optic lobe, which consists of four serially arranged major subdivisions; the lamina, medulla, lobula and lobula plate; the latter three of these are further subdivided into multiple layers. The visual neuropils are formed by more than 100 different cell types, distributed and interconnected in an invariant highly regular pattern. This pattern relies on a protracted sequence of developmental steps, whereby different cell types are born at specific time points and nerve connections are formed in a tightly controlled sequence that has to be coordinated among the different visual neuropils. The developing fly visual system has become a highly regarded and widely studied paradigm to investigate the genetic mechanisms that control the formation of neural circuits. However, these studies are often made difficult by the complex and shifting patterns in which different types of neurons and their connections are distributed throughout development. In the present paper we have reconstructed the three-dimensional architecture of the Drosophila optic lobe from the early larva to the adult. Based on specific markers, we were able to distinguish the populations of progenitors of the four optic neuropils and map the neurons and their connections. Our paper presents sets of annotated confocal z-projections and animated 3D digital models of these structures for representative stages. The data reveal the temporally coordinated growth of the optic neuropils, and clarify how the position and orientation of the neuropils and interconnecting tracts (inner and outer optic chiasm) changes over time. Finally, we have analyzed the emergence of the discrete layers of the medulla and lobula complex using the same markers (DN-cadherin, Brp) employed to systematically explore the structure and development of the central brain neuropil. Our work will facilitate experimental studies of the molecular mechanisms regulating neuronal fate and connectivity in the fly visual system, which bears many fundamental similarities with the retina of vertebrates.
[Mh] Termos MeSH primário: Drosophila melanogaster/embriologia
Neurópilo/citologia
Lobo Óptico de Animais não Mamíferos/anatomia & histologia
Lobo Óptico de Animais não Mamíferos/embriologia
[Mh] Termos MeSH secundário: Animais
Olho/embriologia
Larva/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


  4 / 929 MEDLINE  
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[PMID]:28344111
[Au] Autor:Ramm T; Scholtz G
[Ad] Endereço:Humboldt-Universität zu Berlin, Institut für Biologie, Vergleichende Zoologie, Philippstr. 13, 10115 Berlin, Germany.
[Ti] Título:No sight, no smell? - Brain anatomy of two amphipod crustaceans with different lifestyles.
[So] Source:Arthropod Struct Dev;46(4):537-551, 2017 Jul.
[Is] ISSN:1873-5495
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The brain anatomy of Niphargus puteanus and Orchestia cavimana, two amphipod species with different lifestyles, has been studied using a variety of recent techniques. The general aspects of the brain anatomy of both species correspond to those of other malacostracans. However, both species lack hemiellipsoid bodies. Furthermore, related to their lifestyle certain differences have been observed. The aquatic subterranean species N. puteanus lacks eye structures, the optic nerve, and the two outer optic neuropils lamina and medulla. Only partial remains of the lobula have been detected. In contrast to this, the central complex in the protocerebrum and the olfactory glomeruli in the deutocerebrum are well differentiated. The terrestrial species Orchestia cavimana shows a reduced first antenna, the absence of olfactory neuropils in the deutocerebrum, and a reduction of the olfactory globular tract. The characteristics in defining the hemiellipsoid bodies are critically discussed. Contradictions about presence or absence of this neuropil are due to different conceptualizations. A comparison with other crustaceans that live in dark environments reveal similar patterns of optic system reduction, but to different degrees following a centripetal pattern. Retaining the olfactory system seems a general problem of terrestrialization in crustaceans with the notable exception of terrestrial hermit crabs.
[Mh] Termos MeSH primário: Anfípodes/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/anatomia & histologia
Ecossistema
Estilo de Vida
Neurópilo/citologia
Olfato/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


  5 / 929 MEDLINE  
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[PMID]:28264694
[Au] Autor:Fonseca MI; Chu SH; Hernandez MX; Fang MJ; Modarresi L; Selvan P; MacGregor GR; Tenner AJ
[Ad] Endereço:Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, 92697, USA.
[Ti] Título:Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain.
[So] Source:J Neuroinflammation;14(1):48, 2017 Mar 06.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The complement cascade not only provides protection from infection but can also mediate destructive inflammation. Complement is also involved in elimination of neuronal synapses which is essential for proper development, but can be detrimental during aging and disease. C1q, required for several of these complement-mediated activities, is present in the neuropil, microglia, and a subset of interneurons in the brain. METHODS: To identify the source(s) of C1q in the brain, the C1qa gene was selectively inactivated in the microglia or Thy-1 neurons in both wild type mice and a mouse model of Alzheimer's disease (AD), and C1q synthesis assessed by immunohistochemistry, QPCR, and western blot analysis. RESULTS: While C1q expression in the brain was unaffected after inactivation of C1qa in Thy-1 neurons, the brains of C1qa :Cx3cr1 mice in which C1qa was ablated in microglia were devoid of C1q with the exception of limited C1q in subsets of interneurons. Surprisingly, this loss of C1q occurred even in the absence of tamoxifen by 1 month of age, demonstrating that Cre activity is tamoxifen-independent in microglia in Cx3cr1 mice. C1q expression in C1qa : Cx3cr1 mice continued to decline and remained almost completely absent through aging and in AD model mice. No difference in C1q was detected in the liver or kidney from C1qa : Cx3cr1 mice relative to controls, and C1qa : Cx3cr1 mice had minimal, if any, reduction in plasma C1q. CONCLUSIONS: Thus, microglia, but not neurons or peripheral sources, are the dominant source of C1q in the brain. While demonstrating that the Cx3cr1 deleter cannot be used for adult-induced deletion of genes in microglia, the model described here enables further investigation of physiological roles of C1q in the brain and identification of therapeutic targets for the selective control of complement-mediated activities contributing to neurodegenerative disorders.
[Mh] Termos MeSH primário: Encéfalo/citologia
Complemento C1q/deficiência
Microglia/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Antígeno CD11b/genética
Antígeno CD11b/metabolismo
Receptor 1 de Quimiocina CX3C
Complemento C1q/genética
Regulação da Expressão Gênica/fisiologia
Proteínas Luminescentes/genética
Proteínas Luminescentes/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Neurônios/metabolismo
Neurópilo/metabolismo
RNA Mensageiro/metabolismo
Receptores de Quimiocinas/genética
Receptores de Quimiocinas/metabolismo
Antígenos Thy-1/genética
Antígenos Thy-1/metabolismo
beta-Galactosidase/genética
beta-Galactosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD11b Antigen); 0 (CX3C Chemokine Receptor 1); 0 (Cx3cr1 protein, mouse); 0 (Luminescent Proteins); 0 (RNA, Messenger); 0 (Receptors, Chemokine); 0 (Thy-1 Antigens); 80295-33-6 (Complement C1q); EC 3.2.1.23 (beta-Galactosidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0814-9


  6 / 929 MEDLINE  
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[PMID]:28256708
[Au] Autor:Hsu A; Luebke JI; Medalla M
[Ad] Endereço:Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts.
[Ti] Título:Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey.
[So] Source:J Comp Neurol;525(9):2175-2191, 2017 Jun 15.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The excitatory glutamatergic synapse is the principal site of communication between cortical pyramidal neurons and their targets, a key locus of action of many drugs, and highly vulnerable to dysfunction and loss in neurodegenerative disease. A detailed knowledge of the structure of these synapses in distinct cortical areas and across species is a prerequisite for understanding the anatomical underpinnings of cortical specialization and, potentially, selective vulnerability in neurological disorders. We used serial electron microscopy to assess the ultrastructural features of excitatory (asymmetric) synapses in the layers 2-3 (L2-3) neuropil of visual (V1) and frontal (FC) cortices of the adult mouse and compared findings to those in the rhesus monkey (V1 and lateral prefrontal cortex [LPFC]). Analyses of multiple ultrastructural variables revealed four organizational features. First, the density of asymmetric synapses does not differ between frontal and visual cortices in either species, but is significantly higher in mouse than in monkey. Second, the structural properties of asymmetric synapses in mouse V1 and FC are nearly identical, by stark contrast to the significant differences seen between monkey V1 and LPFC. Third, while the structural features of postsynaptic entities in mouse and monkey V1 do not differ, the size of presynaptic boutons are significantly larger in monkey V1. Fourth, both presynaptic and postsynaptic entities are significantly smaller in the mouse FC than in the monkey LPFC. The diversity of synaptic ultrastructural features demonstrated here have broad implications for the nature and efficacy of glutamatergic signaling in distinct cortical areas within and across species.
[Mh] Termos MeSH primário: Lobo Frontal/ultraestrutura
Macaca mulatta/anatomia & histologia
Camundongos/anatomia & histologia
Sinapses/ultraestrutura
Córtex Visual/ultraestrutura
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Feminino
Lobo Frontal/metabolismo
Imagem Tridimensional
Masculino
Microscopia Imunoeletrônica
Neurônios/metabolismo
Neurônios/ultraestrutura
Neurópilo/metabolismo
Neurópilo/ultraestrutura
Terminações Pré-Sinápticas/ultraestrutura
Especificidade da Espécie
Sinapses/classificação
Sinapses/metabolismo
Córtex Visual/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24196


  7 / 929 MEDLINE  
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[PMID]:28125614
[Au] Autor:Ryan B; Logan BJ; Abraham WC; Williams JM
[Ad] Endereço:Department of Anatomy, University of Otago, Dunedin, New Zealand.
[Ti] Título:MicroRNAs, miR-23a-3p and miR-151-3p, Are Regulated in Dentate Gyrus Neuropil following Induction of Long-Term Potentiation In Vivo.
[So] Source:PLoS One;12(1):e0170407, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Translation of synaptic mRNA contributes to alterations in the proteome necessary to consolidate long-term potentiation (LTP), a model of memory processes. Yet, how this process is controlled is not fully resolved. MicroRNAs are non-coding RNAs that negatively regulate gene expression by suppressing translation or promoting mRNA degradation. As specific microRNAs are synaptically located, we hypothesized that they are ideally suited to couple synaptic activation, translational regulation, and LTP persistence. The aim of this study was to identify LTP-regulated microRNAs at or near synapses. Accordingly, LTP was induced unilaterally at perforant path-dentate gyrus synapses in awake adult Sprague-Dawley rats. Five hours later, dentate gyrus middle molecular layer neuropil, containing potentiated synapses, was laser-microdissected. MicroRNA expression profiling, using TaqMan Low Density MicroRNA Microarrays (n = 4), identified eight regulated microRNAs. Subsequent individual TaqMan assays confirmed upregulation of miR-23a-3p (1.30 ± 0.10; p = 0.015) and miR-151-3p (1.17 ± 0.19; p = 0.045) in a second cohort (n = 7). Interestingly, bioinformatic analysis indicated that miR-151-3p and miR-23a-3p regulate synaptic reorganisation and transcription, respectively. In summary, we have demonstrated for the first time that microRNAs are regulated in isolated neuropil following LTP induction in vivo, supporting the hypothesis that synaptic, LTP-responsive microRNAs contribute to LTP persistence via regulation of the synaptic proteome.
[Mh] Termos MeSH primário: Giro Denteado/metabolismo
Potenciação de Longa Duração/fisiologia
MicroRNAs/metabolismo
Neurópilo/metabolismo
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica
Masculino
MicroRNAs/genética
Ratos
Ratos Sprague-Dawley
Sinapses/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN151 microRNA, rat); 0 (MIRN23 microRNA, rat); 0 (MicroRNAs)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170407


  8 / 929 MEDLINE  
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[PMID]:28077877
[Au] Autor:Erclik T; Li X; Courgeon M; Bertet C; Chen Z; Baumert R; Ng J; Koo C; Arain U; Behnia R; del Valle Rodriguez A; Senderowicz L; Negre N; White KP; Desplan C
[Ad] Endereço:Department of Biology, New York University, New York, New York 10003, USA.
[Ti] Título:Integration of temporal and spatial patterning generates neural diversity.
[So] Source:Nature;541(7637):365-370, 2017 01 19.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: all neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.
[Mh] Termos MeSH primário: Padronização Corporal
Diferenciação Celular
Drosophila melanogaster/citologia
Neurogênese
Neurônios/citologia
Lobo Óptico de Animais não Mamíferos/citologia
[Mh] Termos MeSH secundário: Animais
Padronização Corporal/genética
Encéfalo/citologia
Encéfalo/crescimento & desenvolvimento
Encéfalo/metabolismo
Movimento Celular
Drosophila melanogaster/genética
Drosophila melanogaster/crescimento & desenvolvimento
Feminino
Masculino
Células-Tronco Neurais/citologia
Células-Tronco Neurais/metabolismo
Neurogênese/genética
Neurônios/metabolismo
Neurópilo/citologia
Neurópilo/metabolismo
Lobo Óptico de Animais não Mamíferos/crescimento & desenvolvimento
Lobo Óptico de Animais não Mamíferos/metabolismo
Pupa/citologia
Pupa/genética
Pupa/crescimento & desenvolvimento
Análise Espaço-Temporal
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1038/nature20794


  9 / 929 MEDLINE  
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[PMID]:28074478
[Au] Autor:Glausier JR; Roberts RC; Lewis DA
[Ad] Endereço:Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[Ti] Título:Ultrastructural analysis of parvalbumin synapses in human dorsolateral prefrontal cortex.
[So] Source:J Comp Neurol;525(9):2075-2089, 2017 Jun 15.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coordinated activity of neural circuitry in the primate dorsolateral prefrontal cortex (DLPFC) supports a range of cognitive functions. Altered DLPFC activation is implicated in a number of human psychiatric and neurological illnesses. Proper DLPFC activity is, in part, maintained by two populations of neurons containing the calcium-binding protein parvalbumin (PV): local inhibitory interneurons that form Type II synapses, and long-range glutamatergic inputs from the thalamus that form Type I synapses. Understanding the contributions of each PV neuronal population to human DLPFC function requires a detailed examination of their anatomical properties. Consequently, we performed an electron microscopic analysis of (1) the distribution of PV immunoreactivity within the neuropil, (2) the properties of dendritic shafts of PV-IR interneurons, (3) Type II PV-IR synapses from PV interneurons, and (4) Type I PV-IR synapses from long-range projections, within the superficial and middle laminar zones of the human DLPFC. In both laminar zones, Type II PV-IR synapses from interneurons comprised ∼60% of all PV-IR synapses, and Type I PV-IR synapses from putative thalamocortical terminals comprised the remaining ∼40% of PV-IR synapses. Thus, the present study suggests that innervation from PV-containing thalamic nuclei extends across superficial and middle layers of the human DLPFC. These findings contrast with previous ultrastructural studies in monkey DLPFC where Type I PV-IR synapses were not identified in the superficial laminar zone. The presumptive added modulation of DLPFC circuitry by the thalamus in human may contribute to species-specific, higher-order functions.
[Mh] Termos MeSH primário: Neurônios/ultraestrutura
Parvalbuminas/metabolismo
Córtex Pré-Frontal/citologia
Sinapses/metabolismo
Sinapses/ultraestrutura
[Mh] Termos MeSH secundário: Adulto
Axônios/metabolismo
Axônios/ultraestrutura
Dendritos/metabolismo
Dendritos/ultraestrutura
Feminino
Seres Humanos
Masculino
Microscopia Imunoeletrônica
Meia-Idade
Mitocôndrias/metabolismo
Mitocôndrias/ultraestrutura
Vias Neurais/metabolismo
Vias Neurais/ultraestrutura
Neurônios/metabolismo
Neurópilo/metabolismo
Neurópilo/ultraestrutura
Parvalbuminas/ultraestrutura
Córtex Pré-Frontal/metabolismo
Sinapses/classificação
Núcleos Talâmicos/metabolismo
Núcleos Talâmicos/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parvalbumins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24171


  10 / 929 MEDLINE  
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[PMID]:28074466
[Au] Autor:Immonen EV; Dacke M; Heinze S; El Jundi B
[Ad] Endereço:Nano and Molecular Systems Research Unit, Faculty of Science, University of Oulu, Oulu, Finland.
[Ti] Título:Anatomical organization of the brain of a diurnal and a nocturnal dung beetle.
[So] Source:J Comp Neurol;525(8):1879-1908, 2017 Jun 01.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To avoid the fierce competition for food, South African ball-rolling dung beetles carve a piece of dung off a dung-pile, shape it into a ball and roll it away along a straight line path. For this unidirectional exit from the busy dung pile, at night and day, the beetles use a wide repertoire of celestial compass cues. This robust and relatively easily measurable orientation behavior has made ball-rolling dung beetles an attractive model organism for the study of the neuroethology behind insect orientation and sensory ecology. Although there is already some knowledge emerging concerning how celestial cues are processed in the dung beetle brain, little is known about its general neural layout. Mapping the neuropils of the dung beetle brain is thus a prerequisite to understand the neuronal network that underlies celestial compass orientation. Here, we describe and compare the brains of a day-active and a night-active dung beetle species based on immunostainings against synapsin and serotonin. We also provide 3D reconstructions for all brain areas and many of the fiber bundles in the brain of the day-active dung beetle. Comparison of neuropil structures between the two dung beetle species revealed differences that reflect adaptations to different light conditions. Altogether, our results provide a reference framework for future studies on the neuroethology of insects in general and dung beetles in particular.
[Mh] Termos MeSH primário: Encéfalo/anatomia & histologia
Coleópteros/anatomia & histologia
Neurópilo/citologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Encéfalo/fisiologia
Ritmo Circadiano/fisiologia
Coleópteros/fisiologia
Sinais (Psicologia)
Processamento de Imagem Assistida por Computador
Imagem Tridimensional
Imuno-Histoquímica
Neurópilo/fisiologia
Orientação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24169



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