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[PMID]:28507260
[Au] Autor:Qiang L; Rao AN; Mostoslavsky G; James MF; Comfort N; Sullivan K; Baas PW
[Ad] Endereço:From the Department of Neurobiology and Anatomy (L.Q., A.N.R., P.W.B.), Drexel University, Philadelphia, PA; and Center for Regenerative Medicine (G.M., M.F.J.) and School of Public Health (N.C., K.S.), Boston University, Boston, MA.
[Ti] Título:Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness.
[So] Source:Neurology;88(20):1968-1975, 2017 May 16.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990-1991 war in the Persian Gulf, is thought to be caused by deployment exposures to various neurotoxicants, including pesticides, anti-nerve gas pills, and low-level nerve agents including sarin/cyclosarin. GWI is a multisymptom disorder characterized by fatigue, joint pain, cognitive problems, and gastrointestinal complaints. The most prominent symptoms of GWI (memory problems, poor attention/concentration, chronic headaches, mood alterations, and impaired sleep) suggest that the disease primarily affects the CNS. Development of urgently needed treatments depends on experimental models appropriate for testing mechanistic hypotheses and for screening therapeutic compounds. Rodent models have been useful thus far, but are limited by their inability to assess the contribution of genetic or epigenetic background to the disease, and because disease-vulnerable proteins and pathways may be different in humans relative to rodents. As of yet, no postmortem tissue from the veterans has become available for research. We are moving forward with a paradigm shift in the study of GWI, which utilizes contemporary stem cell technology to convert somatic cells from Gulf War veterans into pluripotent cell lines that can be differentiated into various cell types, including neurons, glia, muscle, or other relevant cell types. Such cell lines are immortal and will be a resource for GWI researchers to pursue mechanistic hypotheses and therapeutics.
[Mh] Termos MeSH primário: Reprogramação Celular
Guerra do Golfo
Neurônios
Síndrome do Golfo Pérsico/patologia
Síndrome do Golfo Pérsico/fisiopatologia
Veteranos
[Mh] Termos MeSH secundário: Animais
Córtex Cerebral
Seres Humanos
Células-Tronco Pluripotentes Induzidas
Camundongos
Neurilema
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000003938


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[PMID]:26224309
[Au] Autor:Miyamoto Y; Torii T; Takada S; Ohno N; Saitoh Y; Nakamura K; Ito A; Ogata T; Terada N; Tanoue A; Yamauchi J
[Ad] Endereço:Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
[Ti] Título:Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.
[So] Source:Mol Biol Cell;26(19):3489-503, 2015 Oct 01.
[Is] ISSN:1939-4586
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During early development of the peripheral nervous system, Schwann cell precursors proliferate, migrate, and differentiate into premyelinating Schwann cells. After birth, Schwann cells envelop neuronal axons with myelin sheaths. Although some molecular mechanisms underlying myelination by Schwann cells have been identified, the whole picture remains unclear. Here we show that signaling through Tyro3 receptor tyrosine kinase and its binding partner, Fyn nonreceptor cytoplasmic tyrosine kinase, is involved in myelination by Schwann cells. Impaired formation of myelin segments is observed in Schwann cell neuronal cultures established from Tyro3-knockout mouse dorsal root ganglia (DRG). Indeed, Tyro3-knockout mice exhibit reduced myelin thickness. By affinity chromatography, Fyn was identified as the binding partner of the Tyro3 intracellular domain, and activity of Fyn is down-regulated in Tyro3-knockout mice, suggesting that Tyro3, acting through Fyn, regulates myelination. Ablating Fyn in mice results in reduced myelin thickness. Decreased myelin formation is observed in cultures established from Fyn-knockout mouse DRG. Furthermore, decreased kinase activity levels and altered expression of myelination-associated transcription factors are observed in these knockout mice. These results suggest the involvement of Tyro3 receptor and its binding partner Fyn in Schwann cell myelination. This constitutes a newly recognized receptor-linked signaling mechanism that can control Schwann cell myelination.
[Mh] Termos MeSH primário: Bainha de Mielina/metabolismo
Proteínas Proto-Oncogênicas c-fyn/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
Células de Schwann/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Neurilema/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (Tyro3 protein, mouse); EC 2.7.10.2 (Fyn protein, mouse); EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151014
[Lr] Data última revisão:
151014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE
[do] DOI:10.1091/mbc.E14-05-1020


  3 / 350 MEDLINE  
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[PMID]:26137552
[Au] Autor:Juang JH; Kuo CH; Peng SJ; Tang SC
[Ad] Endereço:Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan ; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
[Ti] Título:3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration.
[So] Source:EBioMedicine;2(2):109-19, 2015 Feb.
[Is] ISSN:2352-3964
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. The two cell types have shown their plasticity in islet injury, but their roles in transplantation remain unclear. In this research, we applied 3-dimensional neurovascular histology with cell tracing to reveal the participation of Schwann cells and pericytes in mouse islet transplantation. Longitudinal studies of the grafts under the kidney capsule identify that the donor Schwann cells and pericytes re-associate with the engrafted islets at the peri-graft and perivascular domains, respectively, indicating their adaptability in transplantation. Based on the morphological proximity and cellular reactivity, we propose that the new islet microenvironment should include the peri-graft Schwann cell sheath and perivascular pericytes as an integral part of the new tissue.
[Mh] Termos MeSH primário: Imagem Tridimensional/métodos
Transplante das Ilhotas Pancreáticas
Ilhotas Pancreáticas/fisiologia
Neovascularização Fisiológica/fisiologia
Neurogênese/fisiologia
Pericitos/citologia
Células de Schwann/citologia
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/fisiologia
Microambiente Celular/fisiologia
Células Endoteliais
Sobrevivência de Enxerto/fisiologia
Ilhotas Pancreáticas/irrigação sanguínea
Ilhotas Pancreáticas/inervação
Rim/citologia
Camundongos
Camundongos Endogâmicos C57BL
Neurilema/fisiologia
Regeneração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150703
[St] Status:MEDLINE
[do] DOI:10.1016/j.ebiom.2015.01.014


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[PMID]:22434587
[Au] Autor:Rosenbluth J; Petzold C; Peles E
[Ad] Endereço:Department of Physiology & Neuroscience, New York University School of Medicine, New York, New York 10016, USA. rosenj03@med.nyu.edu
[Ti] Título:Dependence of paranodal junctional gap width on transverse bands.
[So] Source:J Comp Neurol;520(12):2774-84, 2012 Aug 15.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mouse mutants with paranodal junctional (PNJ) defects display variable degrees of neurological impairment. In this study we compare control paranodes with those from three mouse mutants that differ with respect to a conspicuous PNJ component, the transverse bands (TBs). We hypothesize that TBs link the apposed junctional membranes together at a fixed distance and thereby determine the width of the junctional gap, which may in turn determine the extent to which nodal action currents can be short-circuited underneath the myelin sheath. Electron micrographs of aldehyde-fixed control PNJs, in which TBs are abundant, show a consistent junctional gap of ∼3.5 nm. In Caspr-null PNJs, which lack TBs entirely, the gap is wider (∼6-7 nm) and more variable. In CST-null PNJs, which have only occasional TBs, the mean PNJ gap width is comparable to that in Caspr-null mice. In the shaking mutant, in contrast, which has approximately 60% of the normal complement of TBs, mean PNJ gap width is not significantly different from that in controls. Correspondingly, shaking mice are much less impaired neurologically than either Caspr-null or CST-null mice. We conclude that in the absence or gross diminution of TBs, mean PNJ gap width increases significantly and suggest that this difference could underlie some of the neurological impairment seen in those mutants. Surprisingly, even in the absence of TBs, paranodes are to some extent maintained in their usual form, implying that in addition to TBs, other factors govern the formation and maintenance of overall paranodal structure.
[Mh] Termos MeSH primário: Junções Comunicantes/fisiologia
Junções Intercelulares/fisiologia
[Mh] Termos MeSH secundário: Animais
Moléculas de Adesão Celular Neuronais/genética
Doenças Desmielinizantes/patologia
Feminino
Junções Comunicantes/química
Junções Comunicantes/patologia
Junções Intercelulares/química
Junções Intercelulares/patologia
Masculino
Camundongos
Camundongos da Linhagem 129
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos Mutantes Neurológicos
Esclerose Múltipla/patologia
Bainha de Mielina/patologia
Neurilema/patologia
Nós Neurofibrosos/patologia
Nós Neurofibrosos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cell Adhesion Molecules, Neuronal); 0 (Cntnap1 protein, mouse)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:120611
[Lr] Data última revisão:
120611
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120322
[St] Status:MEDLINE
[do] DOI:10.1002/cne.23105


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[PMID]:17761152
[Au] Autor:Higo N; Oishi T; Yamashita A; Murata Y; Matsuda K; Hayashi M
[Ad] Endereço:Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono, Tsukuba, Ibaraki, Japan. n.higo@aist.go.jp
[Ti] Título:Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys.
[So] Source:Brain Res;1171:30-41, 2007 Sep 26.
[Is] ISSN:0006-8993
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To understand the molecular and cellular bases of plasticity in the primate motor cortex, we investigated the expression of three protein kinase-C (PKC) substrates: GAP-43, myristoylated alanine-rich C-kinase substrate (MARCKS), and neurogranin, which are key molecules regulating synaptic plasticity. Prominent signals for the three mRNAs were primarily observed in pyramidal cells. Large pyramidal cells in layer V, from which the descending motor tract originates, contained weaker hybridization signals for GAP-43 and neurogranin mRNAs than did the smaller pyramidal cells. We also performed double-label in situ hybridization showing that GAP-43 and neurogranin mRNAs were expressed in a subset of MARCKS-positive neurons. Quantitative analysis showed that the expression was different between the layers: layer VI contained the strongest and layer II the weakest signals for all three mRNAs. The expression levels of GAP-43 and MARCKS mRNA in layer V were higher than in layer III, while the expression level of neurogranin mRNA in layer V was almost the same as in layer III. Developmental analysis from the newborn to adult indicated that the expression levels of the three mRNAs were higher in the infant motor cortex than in the adult. The expression of both GAP-43 and neurogranin mRNAs transiently increased over several months postnatally. The present study showed that the expression of the three PKC substrates was specific to cell types, cortical layers, and postnatal developmental stage. The specific expression may reflect functional specialization for plasticity in the motor cortex of both infants and adults.
[Mh] Termos MeSH primário: Proteína GAP-43/metabolismo
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Proteínas de Membrana/metabolismo
Córtex Motor/enzimologia
Córtex Motor/crescimento & desenvolvimento
Neurilema/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Proteína GAP-43/genética
Hibridização In Situ/métodos
Peptídeos e Proteínas de Sinalização Intracelular/genética
Macaca fascicularis
Macaca mulatta
Proteínas de Membrana/genética
Substrato Quinase C Rico em Alanina Miristoilada
Neurilema/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (GAP-43 Protein); 0 (Intracellular Signaling Peptides and Proteins); 0 (Membrane Proteins); 0 (RNA, Messenger); 125267-21-2 (Myristoylated Alanine-Rich C Kinase Substrate)
[Em] Mês de entrada:0801
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070901
[St] Status:MEDLINE


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[PMID]:17686010
[Au] Autor:Triantafyllou A
[Ad] Endereço:Oral Pathology, Department & School of Dental Studies, The University of Liverpool, Liverpool, UK. a.triantafyllou@liverpool.ac.uk
[Ti] Título:Immunohistochemical characterization of capsular cells in neuromuscular spindles of the neck.
[So] Source:J Oral Pathol Med;36(8):501-4, 2007 Sep.
[Is] ISSN:0904-2512
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To identify capsular components of neuromuscular spindles in man by means of immunohistochemistry. METHODS: Investigation of histologically observed neuromuscular spindles in surgical specimens with the use of markers for sheath cells and basement membranes. RESULTS: Epithelial membrane antigen and CD34 immunoreactivities were found in the outer and inner capsular layers, respectively. S-100 protein was not expressed in the capsules and there was more collagen type IV than laminin. CONCLUSIONS: Cells resembling perineurial cells and endoneurial fibroblasts, and basement membrane rich in collagen type IV comprise the capsules of neuromuscular spindles.
[Mh] Termos MeSH primário: Fusos Musculares/citologia
Músculos do Pescoço/inervação
[Mh] Termos MeSH secundário: Idoso
Antígenos CD34/análise
Membrana Basal/citologia
Biomarcadores/análise
Criança
Colágeno Tipo IV/análise
Feminino
Fibroblastos/citologia
Seres Humanos
Imuno-Histoquímica
Laminina/análise
Masculino
Mucina-1/análise
Neurilema/ultraestrutura
Proteínas S100/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (Biomarkers); 0 (Collagen Type IV); 0 (Laminin); 0 (Mucin-1); 0 (S100 Proteins)
[Em] Mês de entrada:0712
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:070810
[St] Status:MEDLINE


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[PMID]:17515601
[Ti] Título:How good at neurology are you?
[So] Source:Pract Neurol;7(3):202-5, 2007 Jun.
[Is] ISSN:1474-7766
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalopatias/diagnóstico
Encéfalo/patologia
Joelho/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticoagulantes/uso terapêutico
Encéfalo/irrigação sanguínea
Dissecação da Artéria Carótida Interna/tratamento farmacológico
Dissecação da Artéria Carótida Interna/patologia
Angiografia Cerebral
Seres Humanos
Doenças do Nervo Hipoglosso/complicações
Imagem por Ressonância Magnética
Masculino
Neurilema/patologia
Nervo Fibular/patologia
Acidente Vascular Cerebral/etiologia
Acidente Vascular Cerebral/patologia
Varfarina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 5Q7ZVV76EI (Warfarin)
[Em] Mês de entrada:0707
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070523
[St] Status:MEDLINE


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[PMID]:15633052
[Au] Autor:Hickman SJ; Miszkiel KA; Plant GT; Miller DH
[Ad] Endereço:NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
[Ti] Título:The optic nerve sheath on MRI in acute optic neuritis.
[So] Source:Neuroradiology;47(1):51-5, 2005 Jan.
[Is] ISSN:0028-3940
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Optic nerve sheath dilatation or gadolinium-enhancement on magnetic resonance imaging in acute optic neuritis have been previously reported but have been thought to be rare occurrences. This study recruited 33 patients with acute unilateral optic neuritis. All had their optic nerves imaged with fat-saturated fast spin-echo (FSE) imaging, and 28 had imaging before and after triple-dose gadolinium-enhanced fat-saturated T(1)-weighted imaging. Follow-up imaging was performed on 20 patients (15 following gadolinium). A dilated subarachnoid space at the anterior end of the symptomatic optic nerve on FSE imaging was seen in 15/33 cases. In three of these cases, dilatation was visible on short-term follow-up. Optic nerve sheath enhancement was seen in 21/28 cases acutely: seven at the anterior end of the lesion only, five at the posterior end only and nine at both ends. Optic sheath enhancement was seen in 13 patients on follow-up. This study suggests that optic nerve sheath dilatation on FSE images and optic nerve sheath enhancement on triple-dose gadolinium-enhanced images are common findings in acute optic neuritis. Optic nerve sheath dilatation may be due to inflammation of the optic nerve, with its associated swelling, interrupting the communication between the subarachnoid space of the diseased optic nerve and the chiasmal cistern. Optic nerve sheath enhancement suggests that meningeal inflammation occurs in optic neuritis, in agreement with pathological studies of both optic neuritis and multiple sclerosis.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética/métodos
Neurilema/patologia
Nervo Óptico/patologia
Neurite Óptica/diagnóstico
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Meios de Contraste
Dilatação Patológica/diagnóstico
Feminino
Seguimentos
Gadolínio DTPA
Seres Humanos
Aumento da Imagem/métodos
Meningite/diagnóstico
Meia-Idade
Quiasma Óptico/patologia
Estudos Prospectivos
Espaço Subaracnóideo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:0505
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050106
[St] Status:MEDLINE


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[PMID]:14628556
[Au] Autor:Vshivtseva VV; Zamuraev IN; Lukashin VG; Shiriaeva NV
[Ad] Endereço:Laboratory of Regulation of Brain Neurons Functions, Laboratory of Functional Neuromorphology and Neuron Physiology, Laboratory of Genetics of Higher Nervous Activity, RAS I.P. Pavlov Institute of Physiology, St. Petersburg.
[Ti] Título:[Metallophilia in the Ranvier's nodes of nerve fibers in rats of different strains (histochemical study)].
[Ti] Título:Metallofiliia uzlovykh perekhvatov nervnykh volokon u krys razlichnykh linii (gistokhimicheskoe issledovanie).
[So] Source:Morfologiia;124(4):51-2, 2003.
[Is] ISSN:1026-3543
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Myelinated nerve fibers formed by the processes of LV spinal ganglion neurons were studied in two lines of rats selected according to high and low thresholds of nerve system excitability to electric current. Before ultrastructural study the fibres have been treated with potassium pyroantimonate. It was demonstrated that specific dense precipitate was deposited in the nodes of Ranvier of the nerve fibers of rats with low excitability thresholds; this precipitate was not found in the fibers of rats with high thresholds. It is suggested that deposition of precipitate is indicative of a high density of sodium channels in neurilemma, i.e. of high functional activity of nerve fibers.
[Mh] Termos MeSH primário: Gânglios Espinais/metabolismo
Metais/metabolismo
Nós Neurofibrosos/metabolismo
Estresse Psicológico/metabolismo
[Mh] Termos MeSH secundário: Animais
Cátions
Gânglios Espinais/ultraestrutura
Imuno-Histoquímica
Masculino
Microscopia Eletrônica
Neurilema/metabolismo
Neurilema/ultraestrutura
Nós Neurofibrosos/ultraestrutura
Ratos
Ratos Endogâmicos
Canais de Sódio/metabolismo
Estresse Psicológico/patologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Metals); 0 (Sodium Channels)
[Em] Mês de entrada:0404
[Cu] Atualização por classe:110509
[Lr] Data última revisão:
110509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031125
[St] Status:MEDLINE


  10 / 350 MEDLINE  
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[PMID]:11346735
[Au] Autor:Nakamura N; Mitsuyasu T; Higuchi Y; Sandra F; Ohishi M
[Ad] Endereço:First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
[Ti] Título:Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol Endod;91(5):557-62, 2001 May.
[Is] ISSN:1079-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Growth characteristics of ameloblastomas involving the inferior alveolar nerve were examined to determine the most appropriate surgical management of the nerve at the time of the surgical procedure. STUDY DESIGN: Clinical and histopathologic examinations were performed on 22 resected mandibles in which the inferior alveolar nerve was lying adjacent to, or contained within, the tumor. RESULTS: Patterns of tumor involvement of the nerve bundle were evaluated with respect to the presence of bone (11 patients) or connective tissue wall (7 patients) between the tumor and the nerve bundle, and tumor infiltration of perineural connective tissue (4 patients). Neither invasion into the nerve sheath nor invasion into the nerve itself by the ameloblastoma was detected. Tumor infiltration of the tissue surrounding the nerve was identified for the multicystic and solid types but not for the unicystic type. Presence of bone or connective tissue wall between the tumor and the nerve bundle was dominant in the unicystic and plexiform ameloblastomas, whereas tumor infiltration of the perineural tissue was frequently observed in ameloblastomas with the follicular pattern. CONCLUSION: The preservation of the inferior alveolar nerve may be possible in the management of the unicystic type of ameloblastoma. However, a more radical approach is necessary for treatment of multicystic or solid tumors, especially those exhibiting a follicular pattern.
[Mh] Termos MeSH primário: Ameloblastoma/patologia
Neoplasias Mandibulares/patologia
Nervo Mandibular/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ameloblastoma/classificação
Ameloblastoma/cirurgia
Reabsorção Óssea/patologia
Tecido Conjuntivo/patologia
Feminino
Seres Humanos
Masculino
Mandíbula/inervação
Mandíbula/patologia
Neoplasias Mandibulares/cirurgia
Nervo Mandibular/cirurgia
Meia-Idade
Invasividade Neoplásica
Recidiva Local de Neoplasia/patologia
Neurilema/patologia
Planejamento de Assistência ao Paciente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:0107
[Cu] Atualização por classe:041117
[Lr] Data última revisão:
041117
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:010511
[St] Status:MEDLINE



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