Base de dados : MEDLINE
Pesquisa : A08.675.289 [Categoria DeCS]
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  1 / 1398 MEDLINE  
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[PMID]:29346425
[Au] Autor:Hooper A; Fuller PM; Maguire J
[Ad] Endereço:Tufts University School of Medicine, Department of Neuroscience, Boston, Massachusetts.
[Ti] Título:Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability.
[So] Source:PLoS One;13(1):e0191363, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Corticotropin-releasing hormone (CRH) signaling in the hippocampus has been established to be important for mediating the effects of stress on learning and memory. Given our laboratory's recent characterization of a subset of hippocampal CRH neurons as a novel class of GABAergic interneurons, we hypothesized that these local GABAergic hippocampal CRH neurons may influence hippocampal function. Here we applied an array of molecular tools to selectively label and manipulate hippocampal CRH neurons in mice, in order to assess this interneuron population's impact on hippocampus-dependent behaviors and hippocampal network excitability. Genetically-targeted ablation of hippocampal CRH neurons in vivo impaired object recognition memory and substantially enhanced the severity of kainic acid-induced seizures. Conversely, selective activation of CRH neurons in vitro suppressed the excitability of the mossy fiber-CA3 pathway. Additional experiments are needed to reconcile the functions of GABA and CRH signaling of hippocampal CRH neurons on hippocampal function. However, our results indicate that this interneuron population plays an important role in maintaining adaptive network excitability, and provide a specific circuit-level mechanism for this role.
[Mh] Termos MeSH primário: Região CA3 Hipocampal/metabolismo
Hormônio Liberador da Corticotropina/metabolismo
Neurônios GABAérgicos/metabolismo
Memória
[Mh] Termos MeSH secundário: Animais
Região CA3 Hipocampal/citologia
Eletroencefalografia
Locomoção
Camundongos
Camundongos Transgênicos
Técnicas de Patch-Clamp
Transdução de Sinais
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
56-12-2 (gamma-Aminobutyric Acid); 9015-71-8 (Corticotropin-Releasing Hormone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191363


  2 / 1398 MEDLINE  
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[PMID]:28451637
[Au] Autor:Sun Y; Grieco SF; Holmes TC; Xu X
[Ad] Endereço:Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697-1275.
[Ti] Título:Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hilar mossy cells are the prominent glutamatergic cell type in the dentate hilus of the dentate gyrus (DG); they have been proposed to have critical roles in the DG network. To better understand how mossy cells contribute to DG function, we have applied new viral genetic and functional circuit mapping approaches to quantitatively map and compare local and long-range circuit connections of mossy cells and dentate granule cells in the mouse. The great majority of inputs to mossy cells consist of two parallel inputs from within the DG: an excitatory input pathway from dentate granule cells and an inhibitory input pathway from local DG inhibitory neurons. Mossy cells also receive a moderate degree of excitatory and inhibitory CA3 input from proximal CA3 subfields. Long range inputs to mossy cells are numerically sparse, and they are only identified readily from the medial septum and the septofimbrial nucleus. In comparison, dentate granule cells receive most of their inputs from the entorhinal cortex. The granule cells receive significant synaptic inputs from the hilus and the medial septum, and they also receive direct inputs from both distal and proximal CA3 subfields, which has been underdescribed in the existing literature. Our slice-based physiological mapping studies further supported the identified circuit connections of mossy cells and granule cells. Together, our data suggest that hilar mossy cells are major local circuit integrators and they exert modulation of the activity of dentate granule cells as well as the CA3 region through "back-projection" pathways.
[Mh] Termos MeSH primário: Hipocampo/citologia
Fibras Musgosas Hipocampais/anatomia & histologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Neurônios Colinérgicos/citologia
Feminino
Neurônios GABAérgicos/citologia
Hipocampo/fisiologia
Masculino
Camundongos Endogâmicos C57BL
Fibras Musgosas Hipocampais/fisiologia
Inibição Neural
Vias Neurais/citologia
Vias Neurais/fisiologia
Técnicas de Rastreamento Neuroanatômico
Núcleos Septais/citologia
Sinapses
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  3 / 1398 MEDLINE  
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[PMID]:28463241
[Au] Autor:Wurfel BE; Drevets WC; Bliss SA; McMillin JR; Suzuki H; Ford BN; Morris HM; Teague TK; Dantzer R; Savitz JB
[Ad] Endereço:Laureate Institute for Brain Research, Laureate Institute for Brain Research, Tulsa, OK, USA.
[Ti] Título:Serum kynurenic acid is reduced in affective psychosis.
[So] Source:Transl Psychiatry;7(5):e1115, 2017 May 02.
[Is] ISSN:2158-3188
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites. Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist. In contrast, schizophrenia and psychosis are hypothesized to arise from increased metabolism of the NMDA receptor antagonist, kynurenic acid (KynA), leading to hypofunction of GABAergic interneurons, the disinhibition of pyramidal neurons and striatal hyperdopaminergia. Here we present results that challenge the model of excess KynA production in affective psychosis. After rigorous control of potential confounders and multiple testing we find significant reductions in serum KynA and/or KynA/QA in acutely ill inpatients with major depressive disorder (N=35), bipolar disorder (N=53) and schizoaffective disorder (N=40) versus healthy controls (N=92). No significant difference was found between acutely ill inpatients with schizophrenia (n=21) and healthy controls. Further, a post hoc comparison of patients divided into the categories of non-psychotic affective disorder, affective psychosis and psychotic disorder (non-affective) showed that the greatest decrease in KynA was in the affective psychosis group relative to the other diagnostic groups. Our results are consistent with reports of elevations in proinflammatory cytokines in psychosis, and preclinical work showing that inflammation upregulates the enzyme, kynurenine mono-oxygenase (KMO), which converts kynurenine into 3-hydroxykynurenine and quinolinic acid.
[Mh] Termos MeSH primário: Transtornos Psicóticos Afetivos/metabolismo
Ácido Cinurênico/sangue
Quinurenina 3-Mono-Oxigenase/metabolismo
[Mh] Termos MeSH secundário: Adulto
Transtornos Psicóticos Afetivos/sangue
Transtornos Psicóticos Afetivos/fisiopatologia
Transtorno Bipolar/metabolismo
Corpo Estriado/metabolismo
Citocinas/metabolismo
Depressão/metabolismo
Transtorno Depressivo Maior/metabolismo
Feminino
Neurônios GABAérgicos/metabolismo
Seres Humanos
Inflamação/enzimologia
Ácido Cinurênico/metabolismo
Cinurenina/análogos & derivados
Cinurenina/metabolismo
Masculino
Meia-Idade
Transtornos Psicóticos/metabolismo
Ácido Quinolínico/metabolismo
Receptores de N-Metil-D-Aspartato/metabolismo
Esquizofrenia/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Receptors, N-Methyl-D-Aspartate); 27723548JL (3-hydroxykynurenine); 343-65-7 (Kynurenine); EC 1.14.13.9 (Kynurenine 3-Monooxygenase); F6F0HK1URN (Quinolinic Acid); H030S2S85J (Kynurenic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/tp.2017.88


  4 / 1398 MEDLINE  
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[PMID]:29304042
[Au] Autor:Ntamati NR; Creed M; Achargui R; Lüscher C
[Ad] Endereço:Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
[Ti] Título:Periaqueductal efferents to dopamine and GABA neurons of the VTA.
[So] Source:PLoS One;13(1):e0190297, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.
[Mh] Termos MeSH primário: Dopamina/metabolismo
Neurônios GABAérgicos/metabolismo
Área Tegmentar Ventral/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos
Área Tegmentar Ventral/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190297


  5 / 1398 MEDLINE  
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[PMID]:28467898
[Au] Autor:Melzer S; Gil M; Koser DE; Michael M; Huang KW; Monyer H
[Ad] Endereço:Department of Clinical Neurobiology at the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
[Ti] Título:Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity.
[So] Source:Cell Rep;19(5):1045-1055, 2017 May 02.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM ) and parvalbumin-positive (PV ) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV and M2 SOM projecting neurons reduced locomotion, whereas stimulation of M1 SOM projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Neurônios GABAérgicos/metabolismo
Atividade Motora
[Mh] Termos MeSH secundário: Animais
Neurônios Colinérgicos/metabolismo
Neurônios Colinérgicos/fisiologia
Corpo Estriado/citologia
Corpo Estriado/metabolismo
Vias Eferentes/metabolismo
Vias Eferentes/fisiologia
Neurônios GABAérgicos/fisiologia
Interneurônios/metabolismo
Interneurônios/fisiologia
Masculino
Camundongos
Parvalbuminas/genética
Parvalbuminas/metabolismo
Somatostatina/genética
Somatostatina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parvalbumins); 51110-01-1 (Somatostatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  6 / 1398 MEDLINE  
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[PMID]:29252999
[Au] Autor:Yang S; Govindaiah G; Lee SH; Yang S; Cox CL
[Ad] Endereço:Department of Nano-bioengineering, Incheon National University, Incheon, Korea.
[Ti] Título:Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.
[So] Source:PLoS One;12(12):e0189690, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.
[Mh] Termos MeSH primário: Axônios/fisiologia
Córtex Cerebral/fisiologia
Dendritos/fisiologia
Neurônios/fisiologia
Tálamo/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrofisiologia
Feminino
Neurônios GABAérgicos/fisiologia
Corpos Geniculados/fisiologia
Potenciais Pós-Sinápticos Inibidores
Cinética
Masculino
Inibição Neural/fisiologia
Terminações Pré-Sinápticas/fisiologia
Domínios Proteicos
Ratos
Ratos Sprague-Dawley
Núcleos Talâmicos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189690


  7 / 1398 MEDLINE  
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[PMID]:27778347
[Au] Autor:Rombo DM; Ribeiro JA; Sebastião AM
[Ad] Endereço:Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
[Ti] Título:Hippocampal GABAergic transmission: a new target for adenosine control of excitability.
[So] Source:J Neurochem;139(6):1056-1070, 2016 12.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Physiological network functioning in the hippocampus is dependent on a balance between glutamatergic cell excitability and the activity of diverse local circuit neurons that release the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Tuners of neuronal communication such as adenosine, an endogenous modulator of synapses, control hippocampal network operations by regulating excitability. Evidence has been recently accumulating on the influence of adenosine on different aspects of GABAergic transmission to shape hippocampal function. This review addresses how adenosine, through its high-affinity A (A R) and A receptors (A R), interferes with different GABA-mediated forms of inhibition in the hippocampus to regulate neuronal excitability. Adenosine-mediated modulation of phasic/tonic inhibitory transmission, of GABA transport mechanisms and its interference with other modulatory systems are discussed together with the putative implications for neuronal function in physiological and pathological conditions. This article is part of a mini review series: 'Synaptic Function and Dysfunction in Brain Diseases'.
[Mh] Termos MeSH primário: Adenosina/metabolismo
Neurônios GABAérgicos/metabolismo
Hipocampo/metabolismo
Transmissão Sináptica/fisiologia
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Adenosina/farmacologia
Animais
Hipocampo/efeitos dos fármacos
Seres Humanos
Rede Nervosa/efeitos dos fármacos
Rede Nervosa/metabolismo
Receptores Purinérgicos P1/metabolismo
Transmissão Sináptica/efeitos dos fármacos
Ácido gama-Aminobutírico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Purinergic P1); 56-12-2 (gamma-Aminobutyric Acid); K72T3FS567 (Adenosine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13872


  8 / 1398 MEDLINE  
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[PMID]:29033363
[Au] Autor:Yu B; Wang X; Wei S; Fu T; Dzakah EE; Waqas A; Walthall WW; Shan G
[Ad] Endereço:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui Province 230027, China.
[Ti] Título:Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.
[So] Source:Dev Cell;43(2):212-226.e7, 2017 Oct 23.
[Is] ISSN:1878-1551
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Both transcriptional regulation and signaling pathways play crucial roles in neuronal differentiation and plasticity. Caenorhabditis elegans possesses 19 GABAergic motor neurons (MNs) called D MNs, which are divided into two subgroups: DD and VD. DD, but not VD, MNs reverse their cellular polarity in a developmental process called respecification. UNC-30 and UNC-55 are two critical transcription factors in D MNs. By using chromatin immunoprecipitation with CRISPR/Cas9 knockin of GFP fusion, we uncovered the global targets of UNC-30 and UNC-55. UNC-30 and UNC-55 are largely converged to regulate over 1,300 noncoding and coding genes, and genes in multiple biological processes, including cAMP metabolism, are co-regulated. Increase in cAMP levels may serve as a timing signal for respecification, whereas UNC-55 regulates genes such as pde-4 to keep the cAMP levels low in VD. Other genes modulating DD respecification such as lin-14, irx-1, and oig-1 are also found to affect cAMP levels.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/metabolismo
AMP Cíclico/metabolismo
Neurônios GABAérgicos/metabolismo
Proteínas de Homeodomínio/metabolismo
Proteínas Nucleares/metabolismo
Receptores de Superfície Celular/metabolismo
Receptores Citoplasmáticos e Nucleares/metabolismo
Transcrição Genética
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados/genética
Animais Geneticamente Modificados/crescimento & desenvolvimento
Animais Geneticamente Modificados/metabolismo
Sistemas CRISPR-Cas
Caenorhabditis elegans/genética
Caenorhabditis elegans/crescimento & desenvolvimento
Proteínas de Caenorhabditis elegans/antagonistas & inibidores
Proteínas de Caenorhabditis elegans/genética
Neurônios GABAérgicos/citologia
Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Homeodomínio/antagonistas & inibidores
Proteínas de Homeodomínio/genética
Proteínas Nucleares/antagonistas & inibidores
Proteínas Nucleares/genética
Receptores de Superfície Celular/antagonistas & inibidores
Receptores de Superfície Celular/genética
Receptores Citoplasmáticos e Nucleares/antagonistas & inibidores
Receptores Citoplasmáticos e Nucleares/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Homeodomain Proteins); 0 (Nuclear Proteins); 0 (Receptors, Cell Surface); 0 (Receptors, Cytoplasmic and Nuclear); 0 (UNC-55 protein, C elegans); 0 (unc-30 protein, C elegans); E0399OZS9N (Cyclic AMP)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE


  9 / 1398 MEDLINE  
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[PMID]:29024654
[Au] Autor:Burke DA; Rotstein HG; Alvarez VA
[Ad] Endereço:Laboratory on Neurobiology of Compulsive Behaviors, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; Department of Neuroscience, Brown University, Providence, Providence, RI 02912, USA.
[Ti] Título:Striatal Local Circuitry: A New Framework for Lateral Inhibition.
[So] Source:Neuron;96(2):267-284, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This Perspective will examine the organization of intrastriatal circuitry, review recent findings in this area, and discuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons. The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. We review some classic studies in combination with more recent anatomical and functional findings to lay out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to the formation of functional units of processing and the integration and filtering of inputs to generate motor patterns and learned behaviors.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Lateralidade Funcional/fisiologia
Neurônios GABAérgicos/fisiologia
Rede Nervosa/fisiologia
Inibição Neural/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpo Estriado/citologia
Seres Humanos
Rede Nervosa/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  10 / 1398 MEDLINE  
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[PMID]:28976974
[Au] Autor:Sawala A; Gould AP
[Ad] Endereço:The Francis Crick Institute, London, United Kingdom.
[Ti] Título:The sex of specific neurons controls female body growth in Drosophila.
[So] Source:PLoS Biol;15(10):e2002252, 2017 Oct.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sexual dimorphisms in body size are widespread throughout the animal kingdom but their underlying mechanisms are not well characterized. Most models for how sex chromosome genes specify size dimorphism have emphasized the importance of gonadal hormones and cell-autonomous influences in mammals versus strictly cell-autonomous mechanisms in Drosophila melanogaster. Here, we use tissue-specific genetics to investigate how sexual size dimorphism (SSD) is established in Drosophila. We find that the larger body size characteristic of Drosophila females is established very early in larval development via an increase in the growth rate per unit of body mass. We demonstrate that the female sex determination gene, Sex-lethal (Sxl), functions in central nervous system (CNS) neurons as part of a relay that specifies the early sex-specific growth trajectories of larval but not imaginal tissues. Neuronal Sxl acts additively in 2 neuronal subpopulations, one of which corresponds to 7 median neurosecretory cells: the insulin-producing cells (IPCs). Surprisingly, however, male-female differences in the production of insulin-like peptides (Ilps) from the IPCs do not appear to be involved in establishing SSD in early larvae, although they may play a later role. These findings support a relay model in which Sxl in neurons and Sxl in local tissues act together to specify the female-specific growth of the larval body. They also reveal that, even though the sex determination pathways in Drosophila and mammals are different, they both modulate body growth via a combination of tissue-autonomous and nonautonomous inputs.
[Mh] Termos MeSH primário: Drosophila/crescimento & desenvolvimento
Neurônios/fisiologia
Processos de Determinação Sexual/genética
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal/genética
Drosophila/genética
Proteínas de Drosophila/genética
Proteínas de Drosophila/metabolismo
Proteínas de Drosophila/fisiologia
Ingestão de Alimentos
Feminino
Neurônios GABAérgicos/fisiologia
Células Secretoras de Insulina/metabolismo
Larva
Masculino
Proteínas de Ligação a RNA/genética
Proteínas de Ligação a RNA/fisiologia
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (ILP2 protein, Drosophila); 0 (RNA-Binding Proteins); 0 (Sxl protein, Drosophila)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2002252



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