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[PMID]:28456003
[Au] Autor:Röhr D; Halfter H; Schulz JB; Young P; Gess B
[Ad] Endereço:Department of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Muenster, Germany.
[Ti] Título:Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation.
[So] Source:Glia;65(7):1186-1200, 2017 Jul.
[Is] ISSN:1098-1136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peripheral nerve myelination involves rapid production of tightly bound lipid layers requiring cholesterol biosynthesis and myelin protein expression, but also a collagen-containing extracellular matrix providing mechanical stability. In previous studies, we showed a function of ascorbic acid in peripheral nerve myelination and extracellular matrix formation in adult mice. Here, we sought the mechanism of action of ascorbic acid in peripheral nerve myelination using different paradigms of myelination in vivo and in vitro. We found impaired myelination and reduced collagen expression in Sodium-dependent Vitamin C Transporter 2 heterozygous mice (SVCT2 ) during peripheral nerve development and after peripheral nerve injury. In dorsal root ganglion (DRG) explant cultures, hypo-myelination could be rescued by precoating with different collagen types. The activity of the ascorbic acid-dependent demethylating Ten-eleven-translocation (Tet) enzymes was reduced in ascorbic acid deprived and SVCT2 DRG cultures. Further, in ascorbic acid-deprived DRG cultures, methylation of a CpG island in the collagen alpha1 (IV) and alpha2 (IV) bidirectional promoter region was increased compared to wild-type and ascorbic acid treated controls. Taken together, these results provide further evidence for the function of ascorbic acid in myelination and extracellular matrix formation in peripheral nerves and suggest a putative molecular mechanism of ascorbic acid function in Tet-dependent demethylation of collagen promoters.
[Mh] Termos MeSH primário: Colágeno/metabolismo
Desmetilação
Traumatismos dos Nervos Periféricos/genética
Traumatismos dos Nervos Periféricos/fisiopatologia
Remielinização/genética
Transportadores de Sódio Acoplados à Vitamina C/deficiência
[Mh] Termos MeSH secundário: Animais
Ácido Ascórbico/farmacologia
Células Cultivadas
Colágeno/genética
Modelos Animais de Doenças
Feminino
Transtornos Neurológicos da Marcha/etiologia
Gânglios Espinais/citologia
Masculino
Camundongos
Camundongos Transgênicos
Nervos Periféricos/patologia
Nervos Periféricos/ultraestrutura
RNA Mensageiro/metabolismo
Teste de Desempenho do Rota-Rod
Células Receptoras Sensoriais/metabolismo
Células Receptoras Sensoriais/patologia
Transportadores de Sódio Acoplados à Vitamina C/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Slc23a2 protein, mouse); 0 (Sodium-Coupled Vitamin C Transporters); 9007-34-5 (Collagen); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1002/glia.23152


  2 / 12399 MEDLINE  
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[PMID]:29384605
[Au] Autor:Rohde M; van Dam LCJ; Ernst M
[Ti] Título:Statistically Optimal Multisensory Cue Integration: A Practical Tutorial.
[So] Source:Multisens Res;29(4-5):279-317, 2016.
[Is] ISSN:2213-4794
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Humans combine redundant multisensory estimates into a coherent multimodal percept. Experiments in cue integration have shown for many modality pairs and perceptual tasks that multisensory information is fused in a statistically optimal manner: observers take the unimodal sensory reliability into consideration when performing perceptual judgments. They combine the senses according to the rules of Maximum Likelihood Estimation to maximize overall perceptual precision. This tutorial explains in an accessible manner how to design optimal cue integration experiments and how to analyse the results from these experiments to test whether humans follow the predictions of the optimal cue integration model. The tutorial is meant for novices in multisensory integration and requires very little training in formal models and psychophysical methods. For each step in the experimental design and analysis, rules of thumb and practical examples are provided. We also publish Matlab code for an example experiment on cue integration and a Matlab toolbox for data analysis that accompanies the tutorial online. This way, readers can learn about the techniques by trying them out themselves. We hope to provide readers with the tools necessary to design their own experiments on optimal cue integration and enable them to take part in explaining when, why and how humans combine multisensory information optimally.
[Mh] Termos MeSH primário: Teorema de Bayes
Encéfalo/fisiologia
Sinais (Psicologia)
Modelos Neurológicos
Percepção/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Funções Verossimilhança
Teoria Psicológica
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


  3 / 12399 MEDLINE  
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[PMID]:28451641
[Au] Autor:Yu J; Yang W; Liu H; Hao Y; Zhang Y
[Ad] Endereço:Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138.
[Ti] Título:An Aversive Response to Osmotic Upshift in .
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental osmolarity presents a common type of sensory stimulus to animals. While behavioral responses to osmotic changes are important for maintaining a stable intracellular osmolarity, the underlying mechanisms are not fully understood. In the natural habitat of , changes in environmental osmolarity are commonplace. It is known that the nematode acutely avoids shocks of extremely high osmolarity. Here, we show that also generates gradually increased aversion of mild upshifts in environmental osmolarity. Different from an acute avoidance of osmotic shocks that depends on the function of a transient receptor potential vanilloid channel, the slow aversion to osmotic upshifts requires the cGMP-gated sensory channel subunit TAX-2. TAX-2 acts in several sensory neurons that are exposed to body fluid to generate the aversive response through a motor network that underlies navigation. Osmotic upshifts activate the body cavity sensory neuron URX, which is known to induce aversion upon activation. Together, our results characterize the molecular and cellular mechanisms underlying a novel sensorimotor response to osmotic stimuli and reveal that engages different behaviors and the underlying mechanisms to regulate responses to extracellular osmolarity.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Canais Iônicos/metabolismo
Osmorregulação
Células Receptoras Sensoriais/metabolismo
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans
Locomoção
Pressão Osmótica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Ion Channels); 0 (tax-2 protein, C elegans)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  4 / 12399 MEDLINE  
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[PMID]:29311559
[Au] Autor:Dulin JN; Adler AF; Kumamaru H; Poplawski GHD; Lee-Kubli C; Strobl H; Gibbs D; Kadoya K; Fawcett JW; Lu P; Tuszynski MH
[Ad] Endereço:Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA.
[Ti] Título:Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.
[So] Source:Nat Commun;9(1):84, 2018 01 08.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been reported that axons extending out of neural grafts in the brain form contacts onto phenotypically appropriate host target regions, it is not known whether adult, injured host axons regenerating into NPC grafts also form appropriate connections. We report that spinal cord NPCs grafted into the injured adult rat spinal cord self-assemble organotypic, dorsal horn-like domains. These clusters are extensively innervated by regenerating adult host sensory axons and are avoided by corticospinal axons. Moreover, host axon regeneration into grafts increases significantly after enrichment with appropriate neuronal targets. Together, these findings demonstrate that injured adult axons retain the ability to recognize appropriate targets and avoid inappropriate targets within neural progenitor grafts, suggesting that restoration of complex circuitry after SCI may be achievable.
[Mh] Termos MeSH primário: Axônios/fisiologia
Neurônios Motores/fisiologia
Regeneração Nervosa/fisiologia
Células-Tronco Neurais/transplante
Células Receptoras Sensoriais/fisiologia
Corno Dorsal da Medula Espinal/fisiologia
Traumatismos da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Células-Tronco Neurais/fisiologia
Ratos
Medula Espinal/citologia
Transplante de Células-Tronco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180211
[Lr] Data última revisão:
180211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02613-x


  5 / 12399 MEDLINE  
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[PMID]:28468316
[Au] Autor:Bonior J; Ceranowicz P; Gajdosz R; Kusnierz-Cabala B; Pierzchalski P; Warzecha Z; Dembinski A; Pedziwiatr M; Kot M; Leja-Szpak A; Nawrot-Porabka K; Link-Lenczowski P; Olszanecki R; Bartus K; Jaworek J
[Ad] Endereço:Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michalowskiego St., 31-126 Krakow, Poland. joanna.bonior@uj.edu.pl.
[Ti] Título:Molecular Ghrelin System in the Pancreatic Acinar Cells: The Role of the Polypeptide, Caerulein and Sensory Nerves.
[So] Source:Int J Mol Sci;18(5), 2017 May 02.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Ghrelin (GHRL) is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Experimental studies showed that GHRL protects the stomach and pancreas against acute damage, but the effect of GHRL on pancreatic acinar cells was still undetermined. AIM: To investigate the effect of GHRL and caerulein on the functional ghrelin system in pancreatic acinar cells taking into account the role of sensory nerves (SN). METHODS: Experiments were carried out on isolated pancreatic acinar cells and AR42J cells. Before acinar cells isolation, GHRL was administered intraperitoneally at a dose of 50 µg/kg to rats with intact SN or with capsaicin deactivation of SN (CDSN). After isolation, pancreatic acinar cells were incubated in caerulein-free or caerulein containing solution. AR42J cells were incubated under basal conditions and stimulated with caerulein, GHRL or a combination of the above. RESULTS: Incubation of isolated acinar cells with caerulein inhibited GHS-R and GHRL expression at the level of mRNA and protein in those cells. Either in rats with intact SN or with CDSN, administration of GHRL before isolation of acinar cells increased expression of GHRL and GHS-R in those cells and reversed the caerulein-induced reduction in expression of those parameters. Similar upregulation of GHS-R and GHRL was observed after administration of GHRL in AR42J cells. CONCLUSIONS: GHRL stimulates its own expression and expression of its receptor in isolated pancreatic acinar cells and AR42J cells on the positive feedback pathway. This mechanism seems to participate in the pancreatoprotective effect of GHRL in the course of acute pancreatitis.
[Mh] Termos MeSH primário: Células Acinares/metabolismo
Ceruletídeo/farmacologia
Grelina/metabolismo
Receptores de Grelina/metabolismo
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Células Acinares/efeitos dos fármacos
Animais
Linhagem Celular
Células Cultivadas
Retroalimentação Fisiológica
Grelina/genética
Masculino
Pâncreas/citologia
Pâncreas/inervação
Ratos
Ratos Wistar
Receptores de Grelina/genética
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ghrelin); 0 (Receptors, Ghrelin); 888Y08971B (Ceruletide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  6 / 12399 MEDLINE  
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[PMID]:29304134
[Au] Autor:Jia X; Zhang X; Liu H; Wang R; Zhang T
[Ad] Endereço:Institute of Plant Protection, Hebei Academy of Agriculture and Forestry Sciences/Integrated Pest Management Center of Hebei Province/Key Laboratory of IPM on Crops in Northern Region of North China, Ministry of Agriculture, Baoding, P. R. China.
[Ti] Título:Identification of chemosensory genes from the antennal transcriptome of Indian meal moth Plodia interpunctella.
[So] Source:PLoS One;13(1):e0189889, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Olfaction plays an indispensable role in mediating insect behavior, such as locating host plants, mating partners, and avoidance of toxins and predators. Olfactory-related proteins are required for olfactory perception of insects. However, very few olfactory-related genes have been reported in Plodia interpunctella up to now. In the present study, we sequenced the antennae transcriptome of P. interpunctella using the next-generation sequencing technology, and identified 117 candidate olfactory-related genes, including 29 odorant-binding proteins (OBPs), 15 chemosensory proteins (CSPs), three sensory neuron membrane proteins (SNMPs), 47 odorant receptors (ORs), 14 ionotropic receptors (IRs) and nine gustatory receptors (GRs). Further analysis of qRT-PCR revealed that nine OBPs, three CSPs, two SNMPs, nine ORs and two GRs were specifically expressed in the male antennae, whereas eight OBPs, six CSPs, one SNMP, 16 ORs, two GRs and seven IRs significantly expressed in the female antennae. Taken together, our results provided useful information for further functional studies on insect genes related to recognition of pheromone and odorant, which might be meaningful targets for pest management.
[Mh] Termos MeSH primário: Antenas de Artrópodes/metabolismo
Mariposas/genética
Olfato/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Proteínas de Insetos/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Células Receptoras Sensoriais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insect Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189889


  7 / 12399 MEDLINE  
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[PMID]:29208217
[Au] Autor:Enjin A
[Ad] Endereço:Department of Biology, Lund University, Lund, Sweden. Electronic address: anders.enjin@biol.lu.se.
[Ti] Título:Humidity sensing in insects-from ecology to neural processing.
[So] Source:Curr Opin Insect Sci;24:1-6, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Humidity is an omnipresent climatic factor that influences the fitness, reproductive behavior and geographic distribution of animals. Insects in particular use humidity cues to navigate the environment. Although the sensory neurons of this elusive sense were first described more than fifty years ago, the transduction mechanism of humidity sensing (hygrosensation) remains unknown. Recent work has uncovered some of the key molecules involved, opening up for novel approaches to study hygrosensory transduction. In this review, I will discuss this progress made toward understanding hygrosensation in insects.
[Mh] Termos MeSH primário: Umidade
Proteínas de Insetos/metabolismo
Insetos/fisiologia
Transdução de Sinais
[Mh] Termos MeSH secundário: Animais
Sensação
Células Receptoras Sensoriais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insect Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  8 / 12399 MEDLINE  
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[PMID]:28743797
[Au] Autor:Castillo-Azofeifa D; Losacco JT; Salcedo E; Golden EJ; Finger TE; Barlow LA
[Ad] Endereço:Department of Cell and Developmental Biology and the Rocky Mountain Taste and Smell Center University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
[Ti] Título:Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance.
[So] Source:Development;144(17):3054-3065, 2017 09 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the molecular nature of this dependency is unknown. Here, we show that differentiation of new taste bud cells, but not progenitor proliferation, is interrupted in mice treated with a hedgehog (Hh) pathway inhibitor (HPI), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal. Additionally, epithelial taste precursor cells express Shh transiently, and provide a local supply of Hh ligand that supports taste cell renewal. Taste buds are minimally affected when Shh is lost from either tissue source. However, when both the epithelial and neural supply of Shh are removed, taste buds largely disappear. We conclude Shh supplied by taste nerves and local taste epithelium act in concert to support continued taste bud differentiation. However, although neurally derived Shh is in part responsible for the dependence of taste cell renewal on gustatory innervation, neurotrophic support of taste buds likely involves a complex set of factors.
[Mh] Termos MeSH primário: Epitélio/inervação
Epitélio/metabolismo
Proteínas Hedgehog/metabolismo
Papilas Gustativas/metabolismo
[Mh] Termos MeSH secundário: Animais
Proliferação Celular
Tamanho Celular
Feminino
Deleção de Genes
Masculino
Camundongos
Células Receptoras Sensoriais/metabolismo
Transdução de Sinais
Células-Tronco/citologia
Células-Tronco/metabolismo
Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Hedgehog Proteins); 0 (Shh protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1242/dev.150342


  9 / 12399 MEDLINE  
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[PMID]:28743734
[Au] Autor:Li W; Yi P; Zhu Z; Zhang X; Li W; Ou G
[Ad] Endereço:Tsinghua-Peking Center for Life Sciences, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.
[Ti] Título:Centriole translocation and degeneration during ciliogenesis in neurons.
[So] Source:EMBO J;36(17):2553-2566, 2017 09 01.
[Is] ISSN:1460-2075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neuronal cilia that are formed at the dendritic endings of sensory neurons are essential for sensory perception. However, it remains unclear how the centriole-derived basal body is positioned to form a template for cilium formation. Using fluorescence time-lapse microscopy, we show that the centriole translocates from the cell body to the dendrite tip in the sensory neurons. The centriolar protein SAS-5 interacts with the dynein light-chain LC8 and conditional mutations of cytoplasmic dynein-1 block centriole translocation and ciliogenesis. The components of the central tube are essential for the biogenesis of centrioles, which later drive ciliogenesis in the dendrite; however, the centriole loses these components at the late stage of centriole translocation and subsequently recruits transition zone and intraflagellar transport proteins. Together, our results provide a comprehensive model of ciliogenesis in sensory neurons and reveal the importance of the dynein-dependent centriole translocation in this process.
[Mh] Termos MeSH primário: Centríolos/fisiologia
Cílios/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans
Proteínas de Caenorhabditis elegans/metabolismo
Proteínas de Ciclo Celular/metabolismo
Dineínas/metabolismo
Morfogênese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Cell Cycle Proteins); 0 (SAS-5 protein, C elegans); EC 3.6.4.2 (Dyneins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.15252/embj.201796883


  10 / 12399 MEDLINE  
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[PMID]:27770439
[Au] Autor:Lei Z; Sami Shaikh A; Zheng W; Yu X; Yu J; Li J
[Ad] Endereço:Department of Physiology, School of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China.
[Ti] Título:Non-proton ligand-sensing domain of acid-sensing ion channel 3 is required for itch sensation.
[So] Source:J Neurochem;139(6):1093-1101, 2016 12.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders. However, the molecular mechanisms of itch are unclear. Acid-sensing ion channel 3 (ASIC3) is a sensor of acidic and primary inflammatory pain. The whole-cell patch clamp technique was used to determine the effect of chloroquine (CQ) on ASICs currents in primary sensory neurons or the Chinese hamster ovary cells transfected with rat ASIC1a or ASIC3. Site-directed mutagenesis of plasmid was performed. Scratching behavior was evaluated by measuring the number of bouts during 30 min after injection. CQ, an anti-malarial drug defined as a histamine-independent pruritogen, selectively enhanced the sustained phase of ASIC3 current in a concentration-dependent manner either in ASIC3-transfected Chinese hamster ovary cells or in primary cultured rat dorsal root ganglion neurons. Further studies revealed that the effect of CQ on ASIC3 channels depends on the newly identified non-proton ligand-sensing domain. Importantly, CQ-evoked scratching behavior was largely alleviated by APETx2, a selective ASIC3 channel blocker. Like CQ, other compounds such as amiloride, 2-guanidine-4-methylquinazoline and neuropeptide FF, which have been previously reported to be non-proton ligands that activate ASIC3, undoubtedly evoked the scratching response. In conclusion, ASIC3, a proton-gated ion channel critical for pain sensation, also functions as an essential component of itch transduction.
[Mh] Termos MeSH primário: Canais Iônicos Sensíveis a Ácido/metabolismo
Prurido/metabolismo
Células Receptoras Sensoriais/metabolismo
[Mh] Termos MeSH secundário: Animais
Antimaláricos/farmacologia
Antimaláricos/toxicidade
Células CHO
Células Cultivadas
Cloroquina/farmacologia
Cloroquina/toxicidade
Cricetinae
Cricetulus
Relação Dose-Resposta a Droga
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Prurido/induzido quimicamente
Ratos
Ratos Wistar
Células Receptoras Sensoriais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Accn3 protein, rat); 0 (Acid Sensing Ion Channels); 0 (Antimalarials); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13869



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde