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[PMID]:28945740
[Au] Autor:Blum KP; Lamotte D'Incamps B; Zytnicki D; Ting LH
[Ad] Endereço:Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, United States of America.
[Ti] Título:Force encoding in muscle spindles during stretch of passive muscle.
[So] Source:PLoS Comput Biol;13(9):e1005767, 2017 Sep.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Muscle spindle proprioceptive receptors play a primary role in encoding the effects of external mechanical perturbations to the body. During externally-imposed stretches of passive, i.e. electrically-quiescent, muscles, the instantaneous firing rates (IFRs) of muscle spindles are associated with characteristics of stretch such as length and velocity. However, even in passive muscle, there are history-dependent transients of muscle spindle firing that are not uniquely related to muscle length and velocity, nor reproduced by current muscle spindle models. These include acceleration-dependent initial bursts, increased dynamic response to stretch velocity if a muscle has been isometric, and rate relaxation, i.e., a decrease in tonic IFR when a muscle is held at a constant length after being stretched. We collected muscle spindle spike trains across a variety of muscle stretch kinematic conditions, including systematic changes in peak length, velocity, and acceleration. We demonstrate that muscle spindle primary afferents in passive muscle fire in direct relationship to muscle force-related variables, rather than length-related variables. Linear combinations of whole muscle-tendon force and the first time derivative of force (dF/dt) predict the entire time course of transient IFRs in muscle spindle Ia afferents during stretch (i.e., lengthening) of passive muscle, including the initial burst, the dynamic response to lengthening, and rate relaxation following lengthening. Similar to acceleration scaling found previously in postural responses to perturbations, initial burst amplitude scaled equally well to initial stretch acceleration or dF/dt, though later transients were only described by dF/dt. The transient increase in dF/dt at the onset of lengthening reflects muscle short-range stiffness due to cross-bridge dynamics. Our work demonstrates a critical role of muscle cross-bridge dynamics in history-dependent muscle spindle IFRs in passive muscle lengthening conditions relevant to the detection and sensorimotor response to mechanical perturbations to the body, and to previously-described history-dependence in perception of limb position.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Mecanotransdução Celular/fisiologia
Modelos Biológicos
Fusos Musculares/fisiologia
Músculo Esquelético/fisiologia
Reflexo de Estiramento/fisiologia
[Mh] Termos MeSH secundário: Simulação por Computador
Módulo de Elasticidade/fisiologia
Seres Humanos
Estimulação Física
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005767


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[PMID]:28381456
[Au] Autor:Drew RC; Blaha CA; Herr MD; Cui R; Sinoway LI
[Ad] Endereço:Penn State Heart and Vascular Institute, Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania rachel.drew@umb.edu.
[Ti] Título:Muscle mechanoreflex activation via passive calf stretch causes renal vasoconstriction in healthy humans.
[So] Source:Am J Physiol Regul Integr Comp Physiol;312(6):R956-R964, 2017 Jun 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reflex renal vasoconstriction occurs during exercise, and renal vasoconstriction in response to upper-limb muscle mechanoreflex activation has been documented. However, the renal vasoconstrictor response to muscle mechanoreflex activation originating from lower limbs, with and without local metabolite accumulation, has not been assessed. Eleven healthy young subjects (26 ± 1 yr; 5 men) underwent two trials involving 3-min passive calf muscle stretch (mechanoreflex) during 7.5-min lower-limb circulatory occlusion (CO). In one trial, 1.5-min 70% maximal voluntary contraction isometric calf exercise preceded CO to accumulate metabolites during CO and stretch (mechanoreflex and metaboreflex; 70% trial). A control trial involved no exercise before CO (mechanoreflex alone; 0% trial). Beat-to-beat renal blood flow velocity (RBFV; Doppler ultrasound), mean arterial blood pressure (MAP; photoplethysmographic finger cuff), and heart rate (electrocardiogram) were recorded. Renal vascular resistance (RVR), an index of renal vasoconstriction, was calculated as MAP/RBFV. All baseline cardiovascular variables were similar between trials. Stretch increased RVR and decreased RBFV in both trials (change from CO with stretch: RVR - 0% trial = Δ 10 ± 2%, 70% trial = Δ 7 ± 3%; RBFV - 0% trial = Δ -3.8 ± 1.1 cm/s, 70% trial = Δ -2.7 ± 1.5 cm/s; < 0.05 for RVR and RBFV). These stretch-induced changes were of similar magnitudes in both trials, e.g., with and without local metabolite accumulation, as well as when thromboxane production was inhibited. These findings suggest that muscle mechanoreflex activation via passive calf stretch causes renal vasoconstriction, with and without muscle metaboreflex activation, in healthy humans.
[Mh] Termos MeSH primário: Contração Isométrica
Rim/irrigação sanguínea
Fusos Musculares/fisiologia
Exercícios de Alongamento Muscular
Músculo Esquelético/inervação
Reflexo
Artéria Renal/fisiologia
Vasoconstrição
[Mh] Termos MeSH secundário: Adulto
Velocidade do Fluxo Sanguíneo
Pressão Sanguínea
Feminino
Voluntários Saudáveis
Frequência Cardíaca
Seres Humanos
Perna (Membro)
Masculino
Músculo Esquelético/metabolismo
Circulação Renal
Tromboxano B2/metabolismo
Resistência Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
54397-85-2 (Thromboxane B2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00322.2016


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[PMID]:28194098
[Au] Autor:Fujita S; Kaneko M; Nakamura H; Kobayashi M
[Ad] Endereço:Department of Pharmacology, School of Dentistry, Nihon UniversityTokyo, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, School of Dentistry, Nihon UniversityTokyo, Japan.
[Ti] Título:Spatiotemporal Profiles of Proprioception Processed by the Masseter Muscle Spindles in Rat Cerebral Cortex: An Optical Imaging Study.
[So] Source:Front Neural Circuits;11:4, 2017.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Muscle spindles in the jaw-closing muscles, which are innervated by trigeminal mesencephalic neurons (MesV neurons), control the strength of occlusion and the position of the mandible. The mechanisms underlying cortical processing of proprioceptive information are critical to understanding how sensory information from the masticatory muscles regulates orofacial motor function. However, these mechanisms are mostly unknown. The present study aimed to identify the regions that process proprioception of the jaw-closing muscles using optical imaging with a voltage-sensitive dye in rats under urethane anesthesia. First, jaw opening that was produced by mechanically pulling down the mandible evoked an optical response, which reflects neural excitation, in two cortical regions: the most rostroventral part of the primary somatosensory cortex (S1) and the border between the ventral part of the secondary somatosensory cortex (S2) and the insular oral region (IOR). The kinetics of the optical signal, including the latency, amplitude, rise time, decay time and half duration, in the S1 region for the response with the largest amplitude were comparable to those in the region with the largest response in S2/IOR. Second, we visualized the regions responding to electrical stimulation of the masseter nerve, which activates both motor efferent fibers and somatosensory afferent fibers, including those that transmit nociceptive and proprioceptive information. Masseter nerve stimulation initially excited the rostral part of the S2/IOR region, and an adjacent region responded to jaw opening. The caudal part of the region showing the maximum response overlapped with the region responding to jaw opening, whereas the rostral part overlapped with the region responding to electrical stimulation of the maxillary and mandibular molar pulps. These findings suggest that proprioception of the masseter is processed in S1 and S2/IOR. Other sensory information, such as nociception, is processed in a region that is adjacent to these pulpal regions and is located in the rostral part of S2/IOR, which receives nociceptive inputs from the molar pulps. The spatial proximity of these regions may be associated with the mechanisms by which masseter muscle pain is incorrectly perceived as dental pain.
[Mh] Termos MeSH primário: Dor Facial/fisiopatologia
Músculo Masseter/fisiologia
Fusos Musculares/fisiologia
Nociceptividade/fisiologia
Propriocepção/fisiologia
Córtex Somatossensorial/fisiologia
[Mh] Termos MeSH secundário: Animais
Músculo Masseter/fisiopatologia
Imagem Óptica
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2017.00004


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[PMID]:28122055
[Au] Autor:Sonner MJ; Walters MC; Ladle DR
[Ad] Endereço:Department of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, Ohio, United States of America.
[Ti] Título:Analysis of Proprioceptive Sensory Innervation of the Mouse Soleus: A Whole-Mount Muscle Approach.
[So] Source:PLoS One;12(1):e0170751, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Muscle proprioceptive afferents provide feedback critical for successful execution of motor tasks via specialized mechanoreceptors housed within skeletal muscles: muscle spindles, supplied by group Ia and group II afferents, and Golgi tendon organs, supplied by group Ib afferents. The morphology of these proprioceptors and their associated afferents has been studied extensively in the cat soleus, and to a lesser degree, in the rat; however, quantitative analyses of proprioceptive innervation in the mouse soleus are comparatively limited. The present study employed genetically-encoded fluorescent reporting systems to label and analyze muscle spindles, Golgi tendon organs, and the proprioceptive sensory neuron subpopulations supplying them within the intact mouse soleus muscle using high magnification confocal microscopy. Total proprioceptive receptors numbered 11.3 ± 0.4 and 5.2 ± 0.2 for muscle spindles and Golgi tendon organs, respectively, and these receptor counts varied independently (n = 27 muscles). Analogous to findings in the rat, muscle spindles analyzed were most frequently supplied by two proprioceptive afferents, and in the majority of instances, both were classified as primary endings using established morphological criteria. Secondary endings were most frequently observed when spindle associated afferents totaled three or more. The mean diameter of primary and secondary afferent axons differed significantly, but the distributions overlap more than previously observed in cat and rat studies.
[Mh] Termos MeSH primário: Contração Muscular/fisiologia
Fusos Musculares/fisiologia
Músculo Esquelético/inervação
Propriocepção/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Animais
Mecanorreceptores/fisiologia
Camundongos
Camundongos Transgênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170909
[Lr] Data última revisão:
170909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170751


  5 / 3236 MEDLINE  
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[PMID]:28077660
[Au] Autor:Day J; Bent LR; Birznieks I; Macefield VG; Cresswell AG
[Ad] Endereço:School of Human Movement and Nutrition Sciences, University of Queensland, St. Lucia, Queensland, Australia.
[Ti] Título:Muscle spindles in human tibialis anterior encode muscle fascicle length changes.
[So] Source:J Neurophysiol;117(4):1489-1498, 2017 Apr 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Muscle spindles provide exquisitely sensitive proprioceptive information regarding joint position and movement. Through passively driven length changes in the muscle-tendon unit (MTU), muscle spindles detect joint rotations because of their in-parallel mechanical linkage to muscle fascicles. In human microneurography studies, muscle fascicles are assumed to follow the MTU and, as such, fascicle length is not measured in such studies. However, under certain mechanical conditions, compliant structures can act to decouple the fascicles, and, therefore, the spindles, from the MTU. Such decoupling may reduce the fidelity by which muscle spindles encode joint position and movement. The aim of the present study was to measure, for the first time, both the changes in firing of single muscle spindle afferents and changes in muscle fascicle length in vivo from the tibialis anterior muscle (TA) during passive rotations about the ankle. Unitary recordings were made from 15 muscle spindle afferents supplying TA via a microelectrode inserted into the common peroneal nerve. Ultrasonography was used to measure the length of an individual fascicle of TA. We saw a strong correlation between fascicle length and firing rate during passive ankle rotations of varying rates (0.1-0.5 Hz) and amplitudes (1-9°). In particular, we saw responses observed at relatively small changes in muscle length that highlight the sensitivity of the TA muscle to small length changes. This study is the first to measure spindle firing and fascicle dynamics in vivo and provides an experimental basis for further understanding the link between fascicle length, MTU length, and spindle firing patterns. Muscle spindles are exquisitely sensitive to changes in muscle length, but recordings from human muscle spindle afferents are usually correlated with joint angle rather than muscle fascicle length. In this study, we monitored both muscle fascicle length and spindle firing from the human tibialis anterior muscle in vivo. Our findings are the first to measure these signals in vivo and provide an experimental basis for exploring this link further.
[Mh] Termos MeSH primário: Movimento/fisiologia
Fusos Musculares/fisiologia
Músculo Esquelético/fisiologia
Propriocepção/fisiologia
Tendões/fisiologia
[Mh] Termos MeSH secundário: Adulto
Articulação do Tornozelo/inervação
Teorema de Bayes
Biofísica
Estimulação Elétrica
Eletromiografia
Feminino
Seres Humanos
Masculino
Fusos Musculares/diagnóstico por imagem
Músculo Esquelético/diagnóstico por imagem
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00374.2016


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[PMID]:28003412
[Au] Autor:O'Toole SM; Ferrer MM; Mekonnen J; Zhang H; Shima Y; Ladle DR; Nelson SB
[Ad] Endereço:Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts; and.
[Ti] Título:Dicer maintains the identity and function of proprioceptive sensory neurons.
[So] Source:J Neurophysiol;117(3):1057-1069, 2017 Mar 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuronal cell identity is established during development and must be maintained throughout an animal's life (Fishell G, Heintz N. 80: 602-612, 2013). Transcription factors critical for establishing neuronal identity can be required for maintaining it (Deneris ES, Hobert O. 17: 899-907, 2014). Posttranscriptional regulation also plays an important role in neuronal differentiation (Bian S, Sun T. 44: 359-373, 2011), but its role in maintaining cell identity is less established. To better understand how posttranscriptional regulation might contribute to cell identity, we examined the proprioceptive neurons in the dorsal root ganglion (DRG), a highly specialized sensory neuron class, with well-established properties that distinguish them from other neurons in the ganglion. By conditionally ablating Dicer in mice, using parvalbumin (Pvalb)-driven Cre recombinase, we impaired posttranscriptional regulation in the proprioceptive sensory neuron population. Knockout (KO) animals display a progressive form of ataxia at the beginning of the fourth postnatal week that is accompanied by a cell death within the DRG. Before cell loss, expression profiling shows a reduction of proprioceptor specific genes and an increased expression of nonproprioceptive genes normally enriched in other ganglion neurons. Furthermore, although central connections of these neurons are intact, the peripheral connections to the muscle are functionally impaired. Posttranscriptional regulation is therefore necessary to retain the transcriptional identity and support functional specialization of the proprioceptive sensory neurons. We have demonstrated that selectively impairing Dicer in parvalbumin-positive neurons, which include the proprioceptors, triggers behavioral changes, a lack of muscle connectivity, and a loss of transcriptional identity as observed through RNA sequencing. These results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
[Mh] Termos MeSH primário: Ataxia/fisiopatologia
RNA Helicases DEAD-box/fisiologia
Gânglios Espinais/fisiologia
Propriocepção
Processamento de Proteína Pós-Traducional
Ribonuclease III/fisiologia
Células Receptoras Sensoriais/fisiologia
[Mh] Termos MeSH secundário: Animais
Ataxia/genética
Morte Celular
RNA Helicases DEAD-box/genética
RNA Helicases DEAD-box/metabolismo
Gânglios Espinais/metabolismo
Camundongos
Camundongos Knockout
Fusos Musculares/fisiologia
Músculo Esquelético/citologia
Parvalbuminas/metabolismo
Ribonuclease III/genética
Ribonuclease III/metabolismo
Células Receptoras Sensoriais/metabolismo
Proteína Vesicular 1 de Transporte de Glutamato/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parvalbumins); 0 (Slc17a7 protein, mouse); 0 (Vesicular Glutamate Transport Protein 1); EC 3.1.26.3 (Dicer1 protein, mouse); EC 3.1.26.3 (Ribonuclease III); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00763.2016


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[PMID]:27826051
[Au] Autor:Muramatsu K; Niwa M; Tamaki T; Ikutomo M; Masu Y; Hasegawa T; Shimo S; Sasaki SI
[Ad] Endereço:Department of Physical Therapy, Health Science University, Yamanashi, Japan. Electronic address: k.muramatsu@kenkoudai.ac.jp.
[Ti] Título:Effect of streptozotocin-induced diabetes on motoneurons and muscle spindles in rats.
[So] Source:Neurosci Res;115:21-28, 2017 Feb.
[Is] ISSN:1872-8111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:This study examined the alterations in the number and size of motoneurons innervating the medial gastrocnemius (MG) and biceps femoris (BF) motor nuclei in diabetic rats (12 or 22 weeks after injection of streptozotocin) and age-matched controls using retrograde labeling technique. Additionally, morphological alterations of muscle spindles in BF and MG muscles were tested. Significantly fewer labeled MG motoneurons were found in 12- and 22-week diabetic rats as compared with age-matched control animals. In contrast, the number of BF motoneurons was preserved in each group. Compared to control animals, the ratio of larger motoneurons of MG and BF muscle were decreased at 12 weeks, and smaller MG motoneurons were drastically decreased at 22 weeks. Moreover, MG muscle spindle showed reduction of its number and increase of intrafusal muscle fibers; however, BF muscle spindles showed little or no difference from control animals. We conclude that there is an early loss of alpha motoneurons for both MG and BF muscles followed by a later loss of gamma motoneurons in MG muscle in diabetic animals. Moreover, loss of gamma motoneuron might induce atrophy of MG muscle spindles.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/patologia
Diabetes Mellitus Tipo 1/patologia
Neurônios Motores/patologia
Fusos Musculares/patologia
[Mh] Termos MeSH secundário: Animais
Tamanho Celular
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Tipo 1/induzido quimicamente
Masculino
Ratos Wistar
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27643807
[Au] Autor:Villalón E; Jones MR; Sibigtroth C; Zino SJ; Dale JM; Landayan DS; Shen H; Cornelison DD; Garcia ML
[Ad] Endereço:Division of Biological Sciences, Columbia, MO, USA.
[Ti] Título:Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E.
[So] Source:Genes Brain Behav;16(2):260-270, 2017 Feb.
[Is] ISSN:1601-183X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Charcot-Marie-Tooth (CMT) is the most common inherited peripheral neuropathy, affecting approximately 2.8 million people. The CMT leads to distal neuropathy that is characterized by reduced motor nerve conduction velocity, ataxia, muscle atrophy and sensory loss. We generated a mouse model of CMT type 2E (CMT2E) expressing human neurofilament light E396K (hNF-L ), which develops decreased motor nerve conduction velocity, ataxia and muscle atrophy by 4 months of age. Symptomatic hNF-L mice developed phenotypes that were consistent with proprioceptive sensory defects as well as reduced sensitivity to mechanical stimulation, while thermal sensitivity and auditory brainstem responses were unaltered. Progression from presymptomatic to symptomatic included a 50% loss of large diameter sensory axons within the fifth lumbar dorsal root of hNF-L mice. Owing to proprioceptive deficits and loss of large diameter sensory axons, we analyzed muscle spindle morphology in presymptomatic and symptomatic hNF-L and hNF-L control mice. Muscle spindle cross-sectional area and volume were reduced in all hNF-L mice analyzed, suggesting that alterations in muscle spindle morphology occurred prior to the onset of typical CMT pathology. These data suggested that CMT2E pathology initiated in the muscle spindles altering the proprioceptive sensory system. Early sensory pathology in CMT2E could provide a unifying hypothesis for the convergence of pathology observed in CMT.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/fisiopatologia
Fusos Musculares/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Axônios/patologia
Doença de Charcot-Marie-Tooth/genética
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
Camundongos Transgênicos
Atrofia Muscular/genética
Mutação
Condução Nervosa/fisiologia
Proteínas de Neurofilamentos/genética
Córtex Sensório-Motor/metabolismo
Córtex Sensório-Motor/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurofilament Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE
[do] DOI:10.1111/gbb.12341


  9 / 3236 MEDLINE  
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[PMID]:27561829
[Au] Autor:Butler AA; Héroux ME; Gandevia SC
[Ad] Endereço:Neuroscience Research Australia and University of New South Wales, Sydney, NSW, Australia.
[Ti] Título:Body ownership and a new proprioceptive role for muscle spindles.
[So] Source:Acta Physiol (Oxf);220(1):19-27, 2017 May.
[Is] ISSN:1748-1716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Knowledge of which body parts belong to us is referred to as the sense of body ownership. There is increasing evidence that this important aspect of human proprioception is highly malleable. Research into ownership of individual body parts was stimulated by Botvinick and Cohen's rubber-hand illusion (Nature 391,1998, 756), which demonstrated that an artificial body part can be incorporated in one's body representation and can cause real body parts to be sensed erroneously. Here, we review key studies that have advanced our understanding of the sense of body ownership, including the important role played by multisensory integration and spatiotemporal congruence of sensory signals. We also discuss our recent discovery that body ownership can be induced in response to movement stimuli by signals from a single class of sensory receptor, namely muscle spindles.
[Mh] Termos MeSH primário: Fusos Musculares/fisiologia
Propriocepção/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1111/apha.12792


  10 / 3236 MEDLINE  
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[PMID]:27458829
[Au] Autor:Carvalho DZ; Boes CJ
[Ad] Endereço:Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: carvalho.diego@mayo.edu.
[Ti] Título:Absent quadriceps reflex with distant toe flexor response: An underrecognized neurological sign.
[So] Source:Clin Neurol Neurosurg;149:44-5, 2016 Oct.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:As opposed to finger flexion response upon tapping the styloid process with absent brachioradialis reflex (inverted brachioradialis reflex), toe flexion response upon patellar percussion with absent quadriceps reflex is a quite underrecognized neurological sign, and has been reported only once in the literature. Similar to the inverted brachioradialis reflex, this sign can also be useful for neurological localization. We hereby report a patient presenting with signs and symptoms of lumbar radiculopathy in the setting of an anterior epidural mass compressing the cauda equina at L2-L4, without evidence of myelopathy. Upon examination, the patient had bilateral absent quadriceps reflexes with a right toe flexor response when the right patella was percussed. An absent quadriceps reflex with distant toe flexor response is proposed as a lower extremity equivalent of the inverted brachioradialis reflex, likely localizing to L3-L4 levels. Spindle hypersensitivity due to lack of reciprocal inhibition from antagonist muscles is hypothesized as a possible underlying mechanism. Further observations should help clarify the most common underlying etiology (radicular vs. radiculomyelopathy). Neurologists should be able to recognize this sign, as it can be helpful for neurological localization.
[Mh] Termos MeSH primário: Fusos Musculares/fisiopatologia
Exame Neurológico/métodos
Músculo Quadríceps/fisiopatologia
Radiculopatia/diagnóstico
Reflexo Anormal/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Vértebras Lombares
Masculino
Meia-Idade
Patela/fisiologia
Dedos do Pé/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE



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