Base de dados : MEDLINE
Pesquisa : A08.713.100 [Categoria DeCS]
Referências encontradas : 391 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 40 ir para página                         

  1 / 391 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28707374
[Au] Autor:Uno T; Furutani M; Sakamoto K; Uno Y; Kanamaru K; Mizoguchi A; Hiragaki S; Takeda M
[Ad] Endereço:Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Hyogo, Japan.
[Ti] Título:Localization and functional analysis of the insect-specific RabX4 in the brain of Bombyx mori.
[So] Source:Arch Insect Biochem Physiol;96(1), 2017 Sep.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rab proteins are small monomeric GTPases/GTP-binding proteins, which form the largest branch of the Ras superfamily. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane trafficking. RabX4 is an insect-specific Rab protein that has no close homolog in vertebrates. There is little information about insect-specific Rab proteins. RabX4 was expressed in Escherichia coli and subsequently purified. Antibodies against Bombyx mori RabX4 were produced in rabbits for western immunoblotting and immunohistochemistry. Western blotting of neural tissues revealed a single band, at approximately 26 kD. RabX4-like immunohistochemical reactivity was restricted to neurons of the pars intercerebralis and dorsolateral protocerebrum in the brain. Further immunohistochemical analysis revealed that RabX4 colocalized with Rab6 and bombyxin in the corpus allatum, a neuronal organ that secretes neuropeptides synthesized in the brain into the hemolymph. RabX4 expression in the frontal ganglion, part of the insect stomatogastric nervous system that is found in most insect orders, was restricted to two neurons on the outer region and did not colocalize with allatotropin or Rab6. Furthermore, RNA interference of RabX4 decreased bombyxin expression levels in the brain. These findings suggest that RabX4 is involved in the neurosecretion of a secretory organ in Bombyx mori.
[Mh] Termos MeSH primário: Bombyx/metabolismo
Corpora Allata/metabolismo
Proteínas de Insetos/metabolismo
Proteínas rab de Ligação ao GTP/metabolismo
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Gânglios dos Invertebrados/metabolismo
Hormônios de Inseto/metabolismo
Neurônios/metabolismo
Neurônios/secreção
Neuropeptídeos/metabolismo
Neuropeptídeos/secreção
Interferência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Insect Proteins); 0 (Neuropeptides); 110098-88-9 (bombyxins); 75831-28-6 (allatotropin); EC 3.6.5.2 (rab GTP-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21404


  2 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28623149
[Au] Autor:Beani L; Marchini D; Cappa F; Petrocelli I; Gottardo M; Manfredini F; Giusti F; Dallai R
[Ad] Endereço:Dipartimento di Biologia, Università di Firenze, Via Madonna del piano 6, 50019 Sesto Fiorentino (Firenze), Italy. Electronic address: laura.beani@unifi.it.
[Ti] Título:Subtle effect of Xenos vesparum (Xenidae, Strepsiptera) on the reproductive apparatus of its male host: Parasite or parasitoid?
[So] Source:J Insect Physiol;101:22-30, 2017 Aug.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Parasitic castration is an adaptive strategy where parasites usurp the hosts' reproductive physiology to complete their life cycle. The alterations in the host traits vary in their magnitude, from subtle changes in the host morpho-physiology and behaviour to the production of complex aberrant phenotypes, which often depend on the host gender. The strepsipteran macroparasite Xenos vesparum induces dramatic behavioural and physiological changes in its female host, the paper wasp Polistes dominula, while its effect on the male phenotype is largely unknown. In this study we investigated how a single X. vesparum parasite influences the functional morphology of P. dominula male reproductive apparatus. We performed morphometry and ultrastructure characterization of corpora allata, testes, seminal vesicles and accessory glands in parasitized and unparasitized males, and also in young and old males to control for the effect of age on the natural deterioration of these organs. Our results show that age significantly affects the development of male reproductive apparatus. A low parasite load - one parasite per host is the common prevalence in the field - has only a marginal impact on the reproductive morphology of P. dominula males, affecting quantitatively but not qualitatively the protein content of male accessory glands. Thus, in male P. dominula wasps, X. vesparum appears to behave as a true "parasite", in clear opposition to the role of "parasitoid" that it takes in female hosts where castration causes the reproductive death.
[Mh] Termos MeSH primário: Corpora Allata/parasitologia
Interações Hospedeiro-Parasita
Insetos/fisiologia
Vespas/parasitologia
[Mh] Termos MeSH secundário: Animais
Corpora Allata/anatomia & histologia
Corpora Allata/ultraestrutura
Genitália Masculina/anatomia & histologia
Genitália Masculina/parasitologia
Genitália Masculina/ultraestrutura
Masculino
Microscopia Eletrônica de Transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE


  3 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28254268
[Au] Autor:Ibrahim E; Hejníková M; Shaik HA; Dolezel D; Kodrík D
[Ad] Endereço:Institute of Entomology, Biology Centre, CAS, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic; Faculty of Agriculture, University of Cairo, Giza, Egypt.
[Ti] Título:Adipokinetic hormone activities in insect body infected by entomopathogenic nematode.
[So] Source:J Insect Physiol;98:347-355, 2017 Apr.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of adipokinetic hormone (AKH) in the firebug Pyrrhocoris apterus adults infected by the entomopathogenic nematode (EPN) Steinernema carpocapsae was examined in this study. It was found that co-application of EPN and AKH enhanced firebug mortality about 2.5 times within 24h (from 20 to 51% in EPN vs. EPN+AKH treatments), and resulted in metabolism intensification, as carbon dioxide production in firebugs increased about 2.1 and 1.6times compared to control- and EPN-treated insects, respectively. Accordingly, firebugs with reduced expression of AKH receptors showed a significantly lower mortality (by 1.6 to 2.9-folds), and lower general metabolism after EPN+AKH treatments. In addition, EPN application increased Akh gene expression in the corpora cardiaca (1.6times), AKH level in the corpora cardiaca (1.3times) and haemolymph (1.7times), and lipid and carbohydrate amounts in the haemolymph. Thus, the outcomes of the present study demonstrate involvement of AKH into the anti-stress reaction elicited by the nematobacterial infection. The exact mechanism by which AKH acts is unknown, but results suggested that the increase of metabolism and nutrient amounts in haemolymph might play a role.
[Mh] Termos MeSH primário: Heterópteros/metabolismo
Heterópteros/parasitologia
Hormônios de Inseto/metabolismo
Oligopeptídeos/metabolismo
Ácido Pirrolidonocarboxílico/análogos & derivados
Rabditídios/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpora Allata/metabolismo
Hemolinfa/metabolismo
Masculino
Especificidade de Órgãos
Ácido Pirrolidonocarboxílico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Hormones); 0 (Oligopeptides); 0 (adipokinetic hormone); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  4 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28158248
[Au] Autor:Martínez-Rincón RO; Rivera-Pérez C; Diambra L; Noriega FG
[Ad] Endereço:Centro de Investigaciones Biológicas del Noroeste (CIBNOR), CONACYT, La Paz, Baja California Sur, México.
[Ti] Título:Modeling the flux of metabolites in the juvenile hormone biosynthesis pathway using generalized additive models and ordinary differential equations.
[So] Source:PLoS One;12(2):e0171516, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Juvenile hormone (JH) regulates development and reproductive maturation in insects. The corpora allata (CA) from female adult mosquitoes synthesize fluctuating levels of JH, which have been linked to the ovarian development and are influenced by nutritional signals. The rate of JH biosynthesis is controlled by the rate of flux of isoprenoids in the pathway, which is the outcome of a complex interplay of changes in precursor pools and enzyme levels. A comprehensive study of the changes in enzymatic activities and precursor pool sizes have been previously reported for the mosquito Aedes aegypti JH biosynthesis pathway. In the present studies, we used two different quantitative approaches to describe and predict how changes in the individual metabolic reactions in the pathway affect JH synthesis. First, we constructed generalized additive models (GAMs) that described the association between changes in specific metabolite concentrations with changes in enzymatic activities and substrate concentrations. Changes in substrate concentrations explained 50% or more of the model deviances in 7 of the 13 metabolic steps analyzed. Addition of information on enzymatic activities almost always improved the fitness of GAMs built solely based on substrate concentrations. GAMs were validated using experimental data that were not included when the model was built. In addition, a system of ordinary differential equations (ODE) was developed to describe the instantaneous changes in metabolites as a function of the levels of enzymatic catalytic activities. The results demonstrated the ability of the models to predict changes in the flux of metabolites in the JH pathway, and can be used in the future to design and validate experimental manipulations of JH synthesis.
[Mh] Termos MeSH primário: Aedes/metabolismo
Hormônios Juvenis/biossíntese
Redes e Vias Metabólicas
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Corpora Allata/metabolismo
Feminino
Matemática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Juvenile Hormones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171516


  5 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27815096
[Au] Autor:Dong YQ; Wang ZY; Jing TZ
[Ad] Endereço:School of Forestry, Northeast Forestry University, Harbin, China.
[Ti] Título:Functional characterization of ASTC (allatostatin C) and ASTCC (allatostatin double C) in Clostera anastomosis (Lepidoptera: Notodontidae).
[So] Source:Gene;598:1-8, 2017 Jan 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:ASTC (allatostatin C) and ASTCC (allatostatin double C) are two neuropeptide genes that encode allatostatin C-like peptides. Whether these peptides inhibit or have other effects on juvenile hormone (JH) synthesis in the corpora allata remains in question. The juvenile hormone acid O-methyltransferase (JHAMT), a key gene in the JH biosynthesis pathway, was selected to study the effects of ASTC and ASTCC on juvenile hormones. In this study, we first characterized the expression patterns and correlations between ASTC and ASTCC in Clostera anastomosis under natural conditions, and then the functions of these two genes were investigated by RNAi. The results showed the expression of JHAMT was strongly positive correlated with ASTC and ASTCC in the heads of larvae after ASTC and ASTCC were knocked down simultaneously, while negative correlations were found in the heads of female adults. These results suggest that both ASTC and ASTCC may stimulate JH biosynthesis in larvae while inhibit in female adults of C. anastomosis. And after either ASTC or ASTCC was knocked down alone, the correlation between the two genes were positive, indicating ASTC and ASTCC may function dependently in female heads. In addition, simultaneous suppression of ASTC and ASTCC increased the mortalities of larvae and pupae.
[Mh] Termos MeSH primário: Proteínas de Insetos/genética
Proteínas de Insetos/metabolismo
Mariposas/genética
Mariposas/metabolismo
Neuropeptídeos/genética
Neuropeptídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Corpora Allata/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Técnicas de Silenciamento de Genes
Genes de Insetos
Hormônios Juvenis/biossíntese
Larva/metabolismo
Mariposas/crescimento & desenvolvimento
Neuropeptídeos/antagonistas & inibidores
Pupa/metabolismo
Interferência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Proteins); 0 (Juvenile Hormones); 0 (Neuropeptides); 110119-33-0 (allatostatin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


  6 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27717114
[Au] Autor:Wu X; Wang M; Huang J; Zhang L; Zhang Z; Ling Y; Yang X; Tobe SS
[Ad] Endereço:Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, China.
[Ti] Título:A potential insect growth regulator for cockroach control: design, synthesis and bioactivity of N-terminal-modified allatostatin analogues.
[So] Source:Pest Manag Sci;73(3):500-505, 2017 Mar.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The FGLa-allatostatins (ASTs) are a family of neuropeptides that can inhibit juvenile hormone biosynthesis by the corpora allata (CA) in vitro, and therefore they are regarded as insect growth regulator (IGR) candidates for pest control. In our previous studies, an AST mimic, H17, was found to have a significant effect on JH biosynthesis by cockroach CA, both in vitro and in vivo. To discover new potential mimics and explore the substituent effect on the inhibition of JH biosynthesis, 30 analogues, modified with various substituents on the benzene ring at the N-terminus of lead compound H17, were designed and synthesised. Their bioactivity in inhibiting JH biosynthesis by the CA of Diploptera punctata and the potency of M9, M10 and M11 in activation of Dippu-AstR were evaluated. RESULTS: All the analogues showed an effect on JH biosynthesis by CA in vitro. M9, M10 and M11 can activate the Dippu-AstR, albeit with much lower potency than that of AST 1. M11 also exhibited improved in vitro activity (IC 6.98 nm) in comparison with the lead compound H17 (IC 29.5 nm). In particular, M11 displayed good in vivo activity in inhibiting JH biosynthesis and basal oocyte growth. CONCLUSION: The structure-activity relationship studies suggest that different positions of substituents on the benzene ring of the cinnamic acid can lead to different activities. The para-substitution on the benzene ring plays an important role in inhibiting JH biosynthesis in vitro. Moreover, M11 is considered to be a potential IGR for cockroach control. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Baratas/efeitos dos fármacos
Hormônios Juvenis/farmacologia
Neuropeptídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Corpora Allata/efeitos dos fármacos
Corpora Allata/metabolismo
Feminino
Inseticidas/síntese química
Inseticidas/farmacologia
Hormônios Juvenis/síntese química
Neuropeptídeos/síntese química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Juvenile Hormones); 0 (Neuropeptides); 110119-33-0 (allatostatin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4444


  7 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27570150
[Au] Autor:Hejnikova M; Paroulek M; Hodkova M
[Ad] Endereço:Faculty of Sciences, University of South Bohemia, 37005 Ceske Budejovice, Czech Republic.
[Ti] Título:Decrease in Methoprene tolerant and Taiman expression reduces juvenile hormone effects and enhances the levels of juvenile hormone circulating in males of the linden bug Pyrrhocoris apterus.
[So] Source:J Insect Physiol;93-94:72-80, 2016 Oct - Nov.
[Is] ISSN:1879-1611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Juvenile hormone (JH) produced by the corpus allatum (CA) stimulates vitellogenesis and reduces the synthesis of hexamerin proteins in adult females of Pyrrhocoris apterus. At present it is unknown whether the signaling pathway involving the JH receptor gene Methoprene tolerant (Met) and its binding partner Taiman (Tai), regulates the synthesis of accessory gland proteins (ACPs) and hexamerin proteins or effects male survival. Knockdown of genes by injecting Met dsRNA or Tai dsRNA, reduced the amount of ACPs whilst enhancing the amount of hexamerin mRNA in the fat body and the release of hexamerin proteins into haemolymph, as occurs after the ablation of CA. Lifespan was enhanced by injecting Met but not Tai dsRNA. Diapause associated with the natural absence of JH had a stronger effect on all these parameters than the ablation of CA or the knockdown of genes. This indicates there is an additional regulating agent. Both Met and Tai dsRNA induced a several fold increase in JH (JH III skiped bisepoxide) but a concurrent loss of Met or Tai disabled its function. This supports the view that the Met/Tai complex functions as a JH receptor in the regulation of ACPs and hexamerins.
[Mh] Termos MeSH primário: Corpora Allata/fisiologia
Heterópteros/fisiologia
Hormônios Juvenis/genética
Transdução de Sinais
[Mh] Termos MeSH secundário: Animais
Corpora Allata/cirurgia
Técnicas de Silenciamento de Genes
Hemolinfa/química
Heterópteros/genética
Hormônios Juvenis/sangue
Hormônios Juvenis/metabolismo
Masculino
Interferência de RNA
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Juvenile Hormones)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE


  8 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27477941
[Au] Autor:Xie Y; Wang M; Zhang L; Wu X; Yang X; Tobe SS
[Ad] Endereço:Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
[Ti] Título:Synthesis and biological activity of FGLamide allatostatin analogs with Phe(3) residue modifications.
[So] Source:J Pept Sci;22(9):600-6, 2016 Sep.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A FGLamide allatostatin neuropeptide mimic (H17) is a potential insect growth regulator which inhibits the production of juvenile hormone by the corpora allata. To find more evidence to reveal the structure-activity relationships of the Phe(3) residue in the C-terminal conserved pentapeptide and search for novel analogs with high activity, a series of Phe(3) residue-modified analogs were designed and synthesized using H17 as the lead compound. Bioassay using juvenile hormone (JH) production by corpora allata of the cockroach Diploptera punctata indicated that analogs 4, 11, and 13 showed strong ability to inhibit JH production in vitro, with IC50 of 38.5, 22.5, and 26 nM, respectively. As well, the activity of analog 2 (IC50 : 89.5 nM) proved roughly equivalent to that of H17. Based on the primary structure-activity relationships of Phe(3) residue, we suggest that for analogs containing six-membered aromatic rings, removing the methylene group of Phe(3) or an o-halogen or p-halogen-substituted benzene ring could increase the ability to inhibit biosynthesis of JH. This study will be useful for the design of new allatostatin analogs for insect management. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Corpora Allata/efeitos dos fármacos
Antagonistas de Hormônios/síntese química
Proteínas de Insetos/antagonistas & inibidores
Hormônios Juvenis/antagonistas & inibidores
Neuropeptídeos/síntese química
Peptidomiméticos/síntese química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Baratas/efeitos dos fármacos
Baratas/genética
Baratas/metabolismo
Corpora Allata/metabolismo
Relação Dose-Resposta a Droga
Feminino
Regulação da Expressão Gênica
Antagonistas de Hormônios/farmacologia
Proteínas de Insetos/biossíntese
Proteínas de Insetos/genética
Hormônios Juvenis/biossíntese
Hormônios Juvenis/genética
Masculino
Neuropeptídeos/farmacologia
Peptidomiméticos/farmacologia
Fenilalanina/química
Fenilalanina/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormone Antagonists); 0 (Insect Proteins); 0 (Juvenile Hormones); 0 (Neuropeptides); 0 (Peptidomimetics); 110119-33-0 (allatostatin); 47E5O17Y3R (Phenylalanine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2906


  9 / 391 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27063193
[Au] Autor:Sánchez-Higueras C; Hombría JC
[Ad] Endereço:CABD, CSIC/JA/U. Pablo de Olavide, Carretera de Utrera Km1, Sevilla, Spain.
[Ti] Título:Precise long-range migration results from short-range stepwise migration during ring gland organogenesis.
[So] Source:Dev Biol;414(1):45-57, 2016 06 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many organs are specified far from the location they occupy when functional, having to migrate long distances through the heterogeneous and dynamic environment of the early embryo. We study the formation of the main Drosophila endocrine organ, the ring gland, as a new model to investigate in vivo the genetic regulation of collective cell migration. The ring gland results from the fusion of three independent gland primordia that migrate from the head towards the anterior aorta as the embryo is experiencing major morphogenetic movements. To complete their long-range migration, the glands extend filopodia moving sequentially towards a nearby intermediate target and from there to more distal ones. Thus, the apparent long-range migration is composed of several short-range migratory steps that facilitate reaching the final destination. We find that the target tissues react to the gland's proximity by sending filopodia towards it. Our finding of a succession of independent migration stages is consistent with the stepwise evolution of ring gland assembly and fits with the observed gland locations found in extant crustaceans, basal insects and flies.
[Mh] Termos MeSH primário: Corpora Allata/embriologia
Drosophila melanogaster/embriologia
Glândulas Endócrinas/embriologia
Organogênese/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Aorta/embriologia
Movimento Celular
Corpora Allata/secreção
Proteínas de Drosophila/deficiência
Drosophila melanogaster/citologia
Glândulas Endócrinas/anormalidades
Genes Reporter
Proteínas de Homeodomínio
Hormônios de Inseto/secreção
Terapia a Laser
Proteínas Luminescentes/análise
Microscopia Confocal
Microscopia de Fluorescência
Pseudópodes/fisiologia
Fatores de Tempo
Imagem com Lapso de Tempo
Fatores de Transcrição/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Homeodomain Proteins); 0 (Insect Hormones); 0 (Luminescent Proteins); 0 (Transcription Factors); 0 (trh protein, Drosophila); 0 (unplugged protein, Drosophila)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE


  10 / 391 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27003411
[Au] Autor:Wijesekera TP; Saurabh S; Dauwalder B
[Ad] Endereço:Department of Biology and Biochemistry, University of Houston, Houston, TX, United States of America.
[Ti] Título:Juvenile Hormone Is Required in Adult Males for Drosophila Courtship.
[So] Source:PLoS One;11(3):e0151912, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Juvenile Hormone (JH) has a prominent role in the regulation of insect development. Much less is known about its roles in adults, although functions in reproductive maturation have been described. In adult females, JH has been shown to regulate egg maturation and mating. To examine a role for JH in male reproductive behavior we created males with reduced levels of Juvenile Hormone Acid O-Methyl Transferase (JHAMT) and tested them for courtship. JHAMT regulates the last step of JH biosynthesis in the Corpora Allata (CA), the organ of JH synthesis. Males with reduced levels of JHAMT showed a reduction in courtship that could be rescued by application of Methoprene, a JH analog, shortly before the courtship assays were performed. In agreement with this, reducing JHAMT conditionally in mature flies led to courtship defects that were rescuable by Methoprene. The same result was also observed when the CA were conditionally ablated by the expression of a cellular toxin. Our findings demonstrate that JH plays an important physiological role in the regulation of male mating behavior.
[Mh] Termos MeSH primário: Drosophila/metabolismo
Drosophila/fisiologia
Hormônios Juvenis/metabolismo
Comportamento Sexual Animal/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpora Allata/efeitos dos fármacos
Corpora Allata/metabolismo
Corpora Allata/fisiologia
Corte
Drosophila/efeitos dos fármacos
Larva/efeitos dos fármacos
Larva/metabolismo
Larva/fisiologia
Masculino
Metoprene/farmacologia
Reprodução/efeitos dos fármacos
Reprodução/fisiologia
Comportamento Sexual Animal/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Juvenile Hormones); 8B830OJ2UX (Methoprene)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160326
[Lr] Data última revisão:
160326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0151912



página 1 de 40 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde