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  1 / 3178 MEDLINE  
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[PMID]:28464931
[Au] Autor:Wulf MA; Senatore A; Aguzzi A
[Ad] Endereço:Institute of Neuropathology, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.
[Ti] Título:The biological function of the cellular prion protein: an update.
[So] Source:BMC Biol;15(1):34, 2017 05 02.
[Is] ISSN:1741-7007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The misfolding of the cellular prion protein (PrP ) causes fatal neurodegenerative diseases. Yet PrP is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrP in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrP , but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiological roles of PrP in the central and peripheral nervous systems and highlight the need for their critical reassessment using new, rigorously controlled animal models.
[Mh] Termos MeSH primário: Sistema Nervoso Central/patologia
Sistema Nervoso Periférico/patologia
Doenças Priônicas/metabolismo
Proteínas Priônicas/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Camundongos
Doenças Priônicas/etiologia
Proteínas Priônicas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Prion Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12915-017-0375-5


  2 / 3178 MEDLINE  
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[PMID]:29198722
[Au] Autor:Palmer EE; Kumar R; Gordon CT; Shaw M; Hubert L; Carroll R; Rio M; Murray L; Leffler M; Dudding-Byth T; Oufadem M; Lalani SR; Lewis AM; Xia F; Tam A; Webster R; Brammah S; Filippini F; Pollard J; Spies J; Minoche AE; Cowley MJ; Risen S; Powell-Hamilton NN; Tusi JE; Immken L; Nagakura H; Bole-Feysot C; Nitschké P; Garrigue A; de Saint Basile G; Kivuva E; Scott RH; Rendon A; Munnich A; Newman W; Kerr B; Besmond C; Rosenfeld JA; Amiel J; Field M; Gecz J; DDD Study
[Ad] Endereço:Genetics of Learning Disability Service, Hunter Genetics, Waratah, NSW 2298, Australia; School of Women and Children's Health, University of New South Wales, Randwick, NSW 2031, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
[Ti] Título:A Recurrent De Novo Nonsense Variant in ZSWIM6 Results in Severe Intellectual Disability without Frontonasal or Limb Malformations.
[So] Source:Am J Hum Genet;101(6):995-1005, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A recurrent de novo missense variant within the C-terminal Sin3-like domain of ZSWIM6 was previously reported to cause acromelic frontonasal dysostosis (AFND), an autosomal-dominant severe frontonasal and limb malformation syndrome, associated with neurocognitive and motor delay, via a proposed gain-of-function effect. We present detailed phenotypic information on seven unrelated individuals with a recurrent de novo nonsense variant (c.2737C>T [p.Arg913Ter]) in the penultimate exon of ZSWIM6 who have severe-profound intellectual disability and additional central and peripheral nervous system symptoms but an absence of frontonasal or limb malformations. We show that the c.2737C>T variant does not trigger nonsense-mediated decay of the ZSWIM6 mRNA in affected individual-derived cells. This finding supports the existence of a truncated ZSWIM6 protein lacking the Sin3-like domain, which could have a dominant-negative effect. This study builds support for a key role for ZSWIM6 in neuronal development and function, in addition to its putative roles in limb and craniofacial development, and provides a striking example of different variants in the same gene leading to distinct phenotypes.
[Mh] Termos MeSH primário: Proteínas de Ligação a DNA/genética
Deficiência Intelectual/genética
Transtornos Neurocognitivos/genética
[Mh] Termos MeSH secundário: Sistema Nervoso Central/anormalidades
Sistema Nervoso Central/embriologia
Códon sem Sentido/genética
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Deformidades Congênitas dos Membros/genética
Disostose Mandibulofacial/genética
Sistema Nervoso Periférico/anormalidades
Sistema Nervoso Periférico/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (DNA-Binding Proteins); 0 (ZSWIM6 protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  3 / 3178 MEDLINE  
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[PMID]:28458358
[Au] Autor:Sasaki T; Nishimura Y; Ikegaya Y
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, The University of Tokyo.
[Ti] Título:Simultaneous Recordings of Central and Peripheral Bioelectrical Signals in a Freely Moving Rodent.
[So] Source:Biol Pharm Bull;40(5):711-715, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Understanding physiological interactions between the central and peripheral nervous systems requires an experimental strategy to simultaneously monitor activity patterns of the brain and peripheral organs. In this study, we developed a novel method to record extracellular field potential signals from a wide range of brain regions together with electrocardiograms, electromyograms, and breathing signals from a freely moving rodent. This method collects all recorded signals into a single device mounted on an animal's head, allowing the reduction of experimental costs and the simplification of data processing. The methodological concept is applicable to a number of biological research issues of how the brain-body association is altered in response to various environmental changes, emotional challenges, and acute and chronic dysfunction of internal organs.
[Mh] Termos MeSH primário: Sistema Nervoso Central/fisiologia
Eletrofisiologia/métodos
Sistema Nervoso Periférico/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Eletrocardiografia
Eletrodos Implantados
Eletromiografia
Fenômenos Eletrofisiológicos
Eletrofisiologia/instrumentação
Emoções
Espaço Extracelular/fisiologia
Masculino
Ratos
Ratos Wistar
Respiração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b17-00070


  4 / 3178 MEDLINE  
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[PMID]:29020118
[Au] Autor:Marmiroli P; Riva B; Pozzi E; Ballarini E; Lim D; Chiorazzi A; Meregalli C; Distasi C; Renn CL; Semperboni S; Morosi L; Ruffinatti FA; Zucchetti M; Dorsey SG; Cavaletti G; Genazzani A; Carozzi VA
[Ad] Endereço:Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
[Ti] Título:Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights.
[So] Source:PLoS One;12(10):e0186250, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic severe sensory peripheral neuropathy. However, despite similar co-morbidities, cancer stage, demographics and treatment schedule, patients develop oxaliplatin-induced peripheral neurotoxicity with remarkably different severity. This suggests individual genetic variability, which might be used to glean the mechanistic insights into oxaliplatin neurotoxicity. We characterized the susceptibility of different mice strains to oxaliplatin neurotoxicity investigating the phenotypic features of neuropathy and gene expression profiles in dorsal root ganglia of six genetically different mice strains (Balb-c, C57BL6, DBA/2J, AJ, FVB and CD1) exposed to the same oxaliplatin schedule. Differential gene expression in dorsal root ganglia from each mice strain were assayed using a genome-wide expression analysis and selected genes were validated by RT-PCR analysis. The demonstration of consistent differences in the phenotypic response to oxaliplatin across different strains is interesting to allow the selection of the appropriate strain based on the pre-defined read-out parameters. Further investigation of the correlation between gene expression changes and oxaliplatin-induced neurotoxicity phenotype in each strain will be useful to deeper investigate the molecular mechanisms of oxaliplatin neurotoxicity.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Síndromes Neurotóxicas/genética
Síndromes Neurotóxicas/patologia
Compostos Organoplatínicos/efeitos adversos
Sistema Nervoso Periférico/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Biópsia
Doença Crônica
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/patologia
Regulação da Expressão Gênica/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos
Bainha de Mielina/metabolismo
Condução Nervosa/efeitos dos fármacos
Neuralgia/complicações
Neuralgia/genética
Neuralgia/patologia
Neurônios/metabolismo
Neurônios/patologia
Síndromes Neurotóxicas/complicações
Síndromes Neurotóxicas/fisiopatologia
Medição da Dor
Sistema Nervoso Periférico/fisiopatologia
Reação em Cadeia da Polimerase em Tempo Real
Nervo Isquiático/patologia
Nervo Isquiático/fisiopatologia
Pele/patologia
Corno Dorsal da Medula Espinal/efeitos dos fármacos
Corno Dorsal da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186250


  5 / 3178 MEDLINE  
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[PMID]:28716325
[Au] Autor:Barboglio Romo PG; Gupta P
[Ad] Endereço:Female Pelvic Medicine and Reconstructive Surgery, Department of Urology, University of Michigan, 1500 East Medical Center Drive, 3875 Taubman Center, Ann Arbor, MI 48109-5330, USA.
[Ti] Título:Peripheral and Sacral Neuromodulation in the Treatment of Neurogenic Lower Urinary Tract Dysfunction.
[So] Source:Urol Clin North Am;44(3):453-461, 2017 Aug.
[Is] ISSN:1558-318X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sacral and peripheral neuromodulation are minimally invasive surgical procedures that are third-line therapy options for the treatment of patients with idiopathic overactive bladder syndrome. There has been interest in their efficacy in the management of neurogenic lower urinary tract dysfunction (NLUTD). Contemporary data suggest promising outcomes for urinary and bowel symptoms in carefully selected patients with spinal cord injury and/or multiple sclerosis. This article reviews the current literature regarding urinary and bowel outcomes in patients with NLUTD and also discusses contemporary studies that suggest that treatment during particular stages of neurologic injury may prevent long-term urinary sequelae.
[Mh] Termos MeSH primário: Neuroestimuladores Implantáveis
Sintomas do Trato Urinário Inferior/cirurgia
Bexiga Urinaria Neurogênica/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Sintomas do Trato Urinário Inferior/etiologia
Plexo Lombossacral
Esclerose Múltipla/complicações
Procedimentos Neurocirúrgicos
Sistema Nervoso Periférico
Traumatismos da Medula Espinal/complicações
Bexiga Urinaria Neurogênica/etiologia
Procedimentos Cirúrgicos Urológicos/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  6 / 3178 MEDLINE  
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[PMID]:28700706
[Au] Autor:Freundt-Revilla J; Kegler K; Baumgärtner W; Tipold A
[Ad] Endereço:Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover Foundation, Hannover, Germany.
[Ti] Título:Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system.
[So] Source:PLoS One;12(7):e0181064, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and peripheral nervous systems (PNS) in mammalians and is involved in neuromodulatory functions. Since endocannabinoids were shown to be elevated in cerebrospinal fluid of epileptic dogs, knowledge about the species specific CB receptor expression in the nervous system is required. Therefore, we assessed the spatial distribution of CB1 receptors in the normal canine CNS and PNS. Immunohistochemistry of several regions of the brain, spinal cord and peripheral nerves from a healthy four-week-old puppy, three six-month-old dogs, and one ten-year-old dog revealed strong dot-like immunoreactivity in the neuropil of the cerebral cortex, Cornu Ammonis (CA) and dentate gyrus of the hippocampus, midbrain, cerebellum, medulla oblongata and grey matter of the spinal cord. Dense CB1 expression was found in fibres of the globus pallidus and substantia nigra surrounding immunonegative neurons. Astrocytes were constantly positive in all examined regions. CB1 labelled neurons and satellite cells of the dorsal root ganglia, and myelinating Schwann cells in the PNS. These results demonstrate for the first time the spatial distribution of CB1 receptors in the healthy canine CNS and PNS. These results can be used as a basis for further studies aiming to elucidate the physiological consequences of this particular anatomical and cellular distribution.
[Mh] Termos MeSH primário: Sistema Nervoso Periférico/metabolismo
Receptor CB1 de Canabinoide/metabolismo
[Mh] Termos MeSH secundário: Animais
Moduladores de Receptores de Canabinoides/metabolismo
Cerebelo/metabolismo
Córtex Cerebral/metabolismo
Giro Denteado/metabolismo
Cães
Feminino
Gânglios Espinais/metabolismo
Hipocampo/metabolismo
Imuno-Histoquímica
Masculino
Bulbo/metabolismo
Mesencéfalo/metabolismo
Bulbo Olfatório/metabolismo
Nervos Periféricos/metabolismo
Receptor CB1 de Canabinoide/genética
Medula Espinal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cannabinoid Receptor Modulators); 0 (Receptor, Cannabinoid, CB1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181064


  7 / 3178 MEDLINE  
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[PMID]:28671695
[Au] Autor:Chan KY; Jang MJ; Yoo BB; Greenbaum A; Ravi N; Wu WL; Sánchez-Guardado L; Lois C; Mazmanian SK; Deverman BE; Gradinaru V
[Ad] Endereço:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
[Ti] Título:Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.
[So] Source:Nat Neurosci;20(8):1172-1179, 2017 Aug.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer. Nevertheless, AAVs that provide efficient transduction across specific organs or cell populations are needed. Here, we describe AAV-PHP.eB and AAV-PHP.S, capsids that efficiently transduce the central and peripheral nervous systems, respectively. In the adult mouse, intravenous administration of 1 × 10 vector genomes (vg) of AAV-PHP.eB transduced 69% of cortical and 55% of striatal neurons, while 1 × 10 vg of AAV-PHP.S transduced 82% of dorsal root ganglion neurons, as well as cardiac and enteric neurons. The efficiency of these vectors facilitates robust cotransduction and stochastic, multicolor labeling for individual cell morphology studies. To support such efforts, we provide methods for labeling a tunable fraction of cells without compromising color diversity. Furthermore, when used with cell-type-specific promoters and enhancers, these AAVs enable efficient and targetable genetic modification of cells throughout the nervous system of transgenic and non-transgenic animals.
[Mh] Termos MeSH primário: Dependovirus/genética
Técnicas de Transferência de Genes
Vetores Genéticos/genética
Neurônios/metabolismo
Sistema Nervoso Periférico/metabolismo
[Mh] Termos MeSH secundário: Animais
Gânglios Espinais/metabolismo
Terapia Genética/métodos
Camundongos Transgênicos
Transdução Genética/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4593


  8 / 3178 MEDLINE  
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[PMID]:28663436
[Au] Autor:Peng T; Chanthaphavong RS; Sun S; Trigilio JA; Phasouk K; Jin L; Layton ED; Li AZ; Correnti CE; De van der Schueren W; Vazquez J; O'Day DR; Glass IA; Knipe DM; Wald A; Corey L; Zhu J
[Ad] Endereço:Department of Laboratory Medicine, University of Washington, Seattle, WA tpeng@uw.edu.
[Ti] Título:Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.
[So] Source:J Exp Med;214(8):2315-2329, 2017 Aug 07.
[Is] ISSN:1540-9538
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite frequent herpes simplex virus (HSV) reactivation, peripheral nerve destruction and sensory anesthesia are rare. We discovered that skin biopsies obtained during asymptomatic human HSV-2 reactivation exhibit a higher density of nerve fibers relative to biopsies during virological and clinical quiescence. We evaluated the effects of HSV infection on keratinocytes, the initial target of HSV replication, to better understand this observation. Keratinocytes produced IL-17c during HSV-2 reactivation, and IL-17RE, an IL-17c-specific receptor, was expressed on nerve fibers in human skin and sensory neurons in dorsal root ganglia. In ex vivo experiments, exogenous human IL-17c provided directional guidance and promoted neurite growth and branching in microfluidic devices. Exogenous murine IL-17c pretreatment reduced apoptosis in HSV-2-infected primary neurons. These results suggest that IL-17c is a neurotrophic cytokine that protects peripheral nerve systems during HSV reactivation. This mechanism could explain the lack of nerve damage from recurrent HSV infection and may provide insight to understanding and treating sensory peripheral neuropathies.
[Mh] Termos MeSH primário: Herpes Genital/fisiopatologia
Herpesvirus Humano 2/fisiologia
Interleucina-17/fisiologia
Queratinócitos/metabolismo
Sistema Nervoso Periférico/virologia
[Mh] Termos MeSH secundário: Animais
Herpes Genital/virologia
Seres Humanos
Queratinócitos/virologia
Neuritos/fisiologia
Neuroblastoma/fisiopatologia
Sistema Nervoso Periférico/fisiopatologia
Ativação Viral/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-17)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1084/jem.20160581


  9 / 3178 MEDLINE  
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[PMID]:28640089
[Au] Autor:Wang SI; Kwon TY; Hwang HP; Kim JR
[Ad] Endereço:aDepartment of Orthopedics Surgery, Chonbuk National University Medical School, Research Institute for Endocrine Sciences and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital bDepartment of Surgery, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
[Ti] Título:Functional outcomes of Gartland III supracondylar humerus fractures with early neurovascular complications in children: A retrospective observational study.
[So] Source:Medicine (Baltimore);96(25):e7148, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This was a retrospective observational study. The aim of this study was to evaluate functional outcomes in children treated for Gartland III supracondylar humerus (SCH) fracture with neurovascular (NV) injuries using validated outcome measures. A secondary goal was to determine whether clinical parameters such as age at injury, sex, weight, fracture site, and/or direction of displacement could predict NV injury at the time of fracture or long-term functional outcomes in these patients.One hundred fifty-four patients of Gartland III SCH fractures between March 2004 and May 2013 were studied retrospectively. The patients were divided into 2 groups according to the presence of NV injury. Medical records and radiographs were reviewed to assess several parameters, including age, sex, weight, treatment intervention, the extremity involved, direction of fracture displacement, and NV injury. Functional outcome was assessed on final follow-up using the Pediatric Outcomes Data Collection Instrument (PODCI) and Quick Disabilities of the Arm, Shoulder, and Hand (Quick DASH) outcome measures. Statistical analysis was used to determine the relationship between NV injury and functional outcomes.There were 33 cases with Gartland III SCH fracture associated with NV injuries (10 cases of vascular compromise, 14 cases of neural injury, and 9 cases involving both vascular compromise and neural injury). There were significant differences between the 2 groups in age (P  =  .048), weight (P  =  .009), and direction of displacement (P  =  .004). Vascular compromise and median nerve injury were most common in fractures with posterolateral displacement, and radial nerve injuries were common in fractures with posteromedial displacement. The mean global function score in the PODCI was 91.4 points, and the mean Quick DASH score was 11.7 points, with excellent functional outcomes. No differences in outcomes were identified based upon age, fracture site, sex, weight, direction of displacement, or operative technique in NV injury patients (P > .05).The majority of patients with Gartland III SCH fractures associated with NV injuries returned to a high functioning level after treatment of their injuries. NV injury does not appear to influence functional outcomes. Good functional results can be expected regardless of age, fracture site, sex, weight, direction of displacement, and operative technique.
[Mh] Termos MeSH primário: Fraturas do Úmero/complicações
Fraturas do Úmero/cirurgia
Sistema Nervoso Periférico/lesões
Sistema Nervoso Periférico/cirurgia
Lesões do Sistema Vascular/complicações
Lesões do Sistema Vascular/cirurgia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Avaliação da Deficiência
Feminino
Seguimentos
Seres Humanos
Úmero/lesões
Úmero/cirurgia
Lactente
Modelos Lineares
Masculino
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007148


  10 / 3178 MEDLINE  
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[PMID]:28636859
[Au] Autor:David WS; Bowley MP; Mehan WA; Shin JH; Gerstner ER; DeWitt JC
[Ad] Endereço:From the Departments of Neurology (W.S.D., M.P.B., E.R.G.), Radiology (W.A.M.), Neurosurgery (J.H.S.), and Pathology (J.C.D.), Massachusetts General Hospital, and the Departments of Neurology (W.S.D., M.P.B., E.R.G.), Radiology (W.A.M.), Neurosurgery (J.H.S.), and Pathology (J.C.D.), Harvard Medical
[Ti] Título:Case 19-2017 - A 53-Year-Old Woman with Leg Numbness and Weakness.
[So] Source:N Engl J Med;376(25):2471-2481, 2017 Jun 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Linfoma Difuso de Grandes Células B/patologia
Raízes Nervosas Espinhais/patologia
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Líquido Cefalorraquidiano/química
Líquido Cefalorraquidiano/citologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Hipestesia/etiologia
Vértebras Lombares/diagnóstico por imagem
Linfoma Difuso de Grandes Células B/complicações
Linfoma Difuso de Grandes Células B/diagnóstico por imagem
Imagem por Ressonância Magnética
Meia-Idade
Debilidade Muscular/etiologia
Sistema Nervoso Periférico/anatomia & histologia
Sistema Nervoso Periférico/fisiologia
Sarcoidose/diagnóstico
Tuberculose/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1701762



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