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  1 / 20427 MEDLINE  
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[PMID]:29237522
[Au] Autor:Yi LF; Wen HX; Qiu M; Cao XX
[Ad] Endereço:Department of Electrocardiogram, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China. 380947312@qq.com.
[Ti] Título:[An analysis of cardiac autonomic nerve function in girls with idiopathic central precocious puberty].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1239-1242, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the cardiac autonomic nerve function in girls with idiopathic central precocious puberty (ICPP). METHODS: A total of 66 girls with ICPP were enrolled, among whom 36 were obese and 30 were not obese. A total of 68 age-matched healthy girls (normal controls) and 51 girls with simple obesity were enrolled as controls. All the subjects underwent 24-hour ambulatory electrocardiography, and deceleration capacity of heart rate (DC), acceleration capacity of heart rate (AC), and heart rate variability (HRV), and body mass index (BMI) were compared between groups. RESULTS: Compared with the normal control group, the ICPP group had significantly lower DC, standard deviation of normal-to-normal R-R intervals (SDNN), standard deviation of the average normal-to-normal intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency power (HF) and significantly higher AC and BMI. The ICPP group had significantly lower RMSSD and BMI than the simple obesity group (P<0.05). Compared with the ICPP girls without obesity, those with obesity had significantly lower DC, RMSSD, and HF and significantly higher AC and BMI (P<0.05). CONCLUSIONS: Cardiac autonomic dysfunction is seen in girls with ICPP, especially those with obesity, mainly presenting with reduced vagal tone.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Coração/inervação
Puberdade Precoce/fisiopatologia
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Criança
Pré-Escolar
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Obesidade/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  2 / 20427 MEDLINE  
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[PMID]:29424499
[Au] Autor:Abrahamyan HT; Minasyan SM
[Ti] Título:[Corrective effect of aromatherapy on indices of heart rate variability in students under exam stress conditions].
[So] Source:Gig Sanit;95(6):563-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There were investigated changes in indices of the activity of regulatory mechanisms of heart rhythm in student under exam stress conditions and the possibility of their correction with aid of aromatherapy. The examination stress was established to be accompanied by pronounced shifts of integral and spectral indices of heart rhythm in students, indicating to the activation of the sympathetic circuit of Autonomic Nervous System in conditions of examination stress. A positive, relaxation impact of the essential oil of orange on the investigated indices was also recorded. The latter is expressed by weakly pronounced changes or lack of them in data of integral and spectral heart rate indices in students from the experimental group, that indicates to the stabilizing effect of used ethereal oil on the psycho-physiological state of students in conditions of exam stress
[Mh] Termos MeSH primário: Aromaterapia/métodos
Citrus sinensis
Frequência Cardíaca
Óleos Vegetais/farmacologia
Terapia de Relaxamento/métodos
Estresse Psicológico
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/efeitos dos fármacos
Sistema Nervoso Autônomo/fisiopatologia
Eletrocardiografia/métodos
Feminino
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Seres Humanos
Masculino
Ansiedade de Desempenho/diagnóstico
Ansiedade de Desempenho/fisiopatologia
Ansiedade de Desempenho/prevenção & controle
Estresse Psicológico/etiologia
Estresse Psicológico/fisiopatologia
Estresse Psicológico/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  3 / 20427 MEDLINE  
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[PMID]:29443663
[Au] Autor:Chen D; Ayala GE
[Ad] Endereço:From the Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway (D.C.); and the Department of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center, Houston (G.E.A.).
[Ti] Título:Innervating Prostate Cancer.
[So] Source:N Engl J Med;378(7):675-677, 2018 02 15.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neurônios Adrenérgicos/efeitos dos fármacos
Antagonistas Adrenérgicos beta/farmacologia
Carcinogênese
Neoplasias da Próstata/prevenção & controle
[Mh] Termos MeSH secundário: Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/fisiopatologia
Neurônios Adrenérgicos/fisiologia
Antagonistas Adrenérgicos beta/uso terapêutico
Animais
Sistema Nervoso Autônomo/efeitos dos fármacos
Sistema Nervoso Autônomo/fisiologia
Modelos Animais de Doenças
Masculino
Camundongos
Neovascularização Patológica
Neoplasias da Próstata/irrigação sanguínea
Neoplasias da Próstata/fisiopatologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcibr1714003


  4 / 20427 MEDLINE  
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[PMID]:29097329
[Au] Autor:Solianik R; Sujeta A
[Ad] Endereço:Institute of Sports Science and Innovations, Lithuanian Sports University, Sporto str. 6, Kaunas, Lithuania. Electronic address: rima.solianik@lsu.lt.
[Ti] Título:Two-day fasting evokes stress, but does not affect mood, brain activity, cognitive, psychomotor, and motor performance in overweight women.
[So] Source:Behav Brain Res;338:166-172, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The physiological, cognitive state, and motor behavior changes that occur during acute fasting are not completely understood. Thus, the aim of this study was to estimate the effect of 2-day total fasting on evoked stress, mood, brain activity, and cognitive, psychomotor, and motor function in overweight women. Eleven overweight women (body mass index above 25kg/m ) aged 20-30 years were tested under two conditions allocated randomly: 2-day zero-calorie diet with water provided ad libitum and 2-day usual diet. One week before the experiment, aerobic fitness was evaluated. Subjective stress ratings in relation to the diet, autonomic function, prefrontal cortex activity, cognitive performance, psychomotor coordination, and grip strength were evaluated before and after each diet. The study demonstrated that fasting decreased log-transformed high-frequency (HF) power, without affecting heart rate. The relative maximum oxygen uptake was negatively correlated with subjective stress rating and changes in log-transformed HF. Fasting did not affect mood, brain activity, and cognitive, motor, and psychomotor performance. Thus, 2-day total fasting evoked moderate stress with a shift of the autonomic nervous system balance toward sympathetic activity in overweight women. Better aerobic endurance is likely to facilitate the capacity for dealing with acute fasting. Regardless of the evoked stress, cognitive state and motor behavior remained intact.
[Mh] Termos MeSH primário: Afeto/fisiologia
Encéfalo/fisiopatologia
Cognição/fisiologia
Jejum/psicologia
Sobrepeso/fisiopatologia
Desempenho Psicomotor/fisiologia
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/fisiopatologia
Índice de Massa Corporal
Jejum/fisiologia
Feminino
Seres Humanos
Testes Neuropsicológicos
Sobrepeso/psicologia
Consumo de Oxigênio/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


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[PMID]:29338020
[Au] Autor:Moretta T; Buodo G
[Ad] Endereço:Department of General Psychology, University of Padova, Padova, Italy.
[Ti] Título:Autonomic stress reactivity and craving in individuals with problematic Internet use.
[So] Source:PLoS One;13(1):e0190951, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The link between autonomic stress reactivity and subjective urge/craving has been less systematically examined in behavioral addictions (i.e. problematic Internet use) than in substance use disorders. The present study investigated whether problematic Internet users (PU) show enhanced autonomic stress reactivity than non-PU, indexed by lower Heart Rate Variability (HRV) and higher Skin Conductance Level (SCL) reactivity during the Trier Social Stress Test (TSST), whether greater reactivity is related to stronger Internet craving, and whether problematic Internet usage is associated with some dysfunctional psychological features. Based on their Internet Addiction Test scores, participants were divided into PU (N = 24) and non-PU (N = 21). Their heart rate and skin conductance were continuously recorded during baseline, social stressors, and recovery. Craving for Internet usage were collected using a Likert scale before and after the TSST. The SDNN, an overall measure of HRV, was significantly lower in PU than non-PU during baseline, but not during and after stressful task. Furthermore, only among PU a significant negative correlation emerged between SDNN during recovery and craving ratings after the test. No group differences emerged for SCL. Lastly, PU endorsed more mood, obsessive-compulsive, and alcohol-related problems. Our findings suggest that problems in controlling one's use of the Internet may be related to reduced autonomic balance at rest. Moreover, our results provide new insights into the characterization of craving in PIU, indicating the existence of a relationship between craving for Internet usage and reduced autonomic flexibility.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Comportamento Aditivo/fisiopatologia
Fissura/fisiologia
Internet
[Mh] Termos MeSH secundário: Adulto
Afeto
Feminino
Resposta Galvânica da Pele
Frequência Cardíaca
Seres Humanos
Masculino
Modelos Neurológicos
Modelos Psicológicos
Estresse Fisiológico
Estresse Psicológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190951


  6 / 20427 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:27776149
[Au] Autor:Flueck JL; Schaufelberger F; Lienert M; Schäfer Olstad D; Wilhelm M; Perret C
[Ad] Endereço:Institute of Sports Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
[Ti] Título:Acute Effects of Caffeine on Heart Rate Variability, Blood Pressure and Tidal Volume in Paraplegic and Tetraplegic Compared to Able-Bodied Individuals: A Randomized, Blinded Trial.
[So] Source:PLoS One;11(10):e0165034, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caffeine increases sympathetic nerve activity in healthy individuals. Such modulation of nervous system activity can be tracked by assessing the heart rate variability. This study aimed to investigate the influence of caffeine on time- and frequency-domain heart rate variability parameters, blood pressure and tidal volume in paraplegic and tetraplegic compared to able-bodied participants. Heart rate variability was measured in supine and sitting position pre and post ingestion of either placebo or 6 mg caffeine in 12 able-bodied, 9 paraplegic and 7 tetraplegic participants in a placebo-controlled, randomized and double-blind study design. Metronomic breathing was applied (0.25 Hz) and tidal volume was recorded during heart rate variability assessment. Blood pressure, plasma caffeine and epinephrine concentrations were analyzed pre and post ingestion. Most parameters of heart rate variability did not significantly change post caffeine ingestion compared to placebo. Tidal volume significantly increased post caffeine ingestion in able-bodied (p = 0.021) and paraplegic (p = 0.036) but not in tetraplegic participants (p = 0.34). Systolic and diastolic blood pressure increased significantly post caffeine in able-bodied (systolic: p = 0.003; diastolic: p = 0.021) and tetraplegic (systolic: p = 0.043; diastolic: p = 0.042) but not in paraplegic participants (systolic: p = 0.09; diastolic: p = 0.33). Plasma caffeine concentrations were significantly increased post caffeine ingestion in all three groups of participants (p<0.05). Plasma epinephrine concentrations increased significantly in able-bodied (p = 0.002) and paraplegic (p = 0.032) but not in tetraplegic participants (p = 0.63). The influence of caffeine on the autonomic nervous system seems to depend on the level of lesion and the extent of the impairment. Therefore, tetraplegic participants may be less influenced by caffeine ingestion. TRIAL REGISTRATION: ClinicalTrials.gov NCT02083328.
[Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos
Cafeína/efeitos adversos
Frequência Cardíaca/efeitos dos fármacos
Paraplegia/fisiopatologia
Quadriplegia/fisiopatologia
Respiração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/efeitos dos fármacos
Determinação da Pressão Arterial
Cafeína/sangue
Método Duplo-Cego
Epinefrina/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Paraplegia/metabolismo
Quadriplegia/metabolismo
Volume de Ventilação Pulmonar/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3G6A5W338E (Caffeine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0165034


  7 / 20427 MEDLINE  
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[PMID]:27773678
[Au] Autor:Pyne JM; Constans JI; Wiederhold MD; Gibson DP; Kimbrell T; Kramer TL; Pitcock JA; Han X; Williams DK; Chartrand D; Gevirtz RN; Spira J; Wiederhold BK; McCraty R; McCune TR
[Ad] Endereço:Center for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Division of Heal
[Ti] Título:Heart rate variability: Pre-deployment predictor of post-deployment PTSD symptoms.
[So] Source:Biol Psychol;121(Pt A):91-98, 2016 12.
[Is] ISSN:1873-6246
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Heart rate variability is a physiological measure associated with autonomic nervous system activity. This study hypothesized that lower pre-deployment HRV would be associated with higher post-deployment post-traumatic stress disorder (PTSD) symptoms. Three-hundred-forty-three Army National Guard soldiers enrolled in the Warriors Achieving Resilience (WAR) study were analyzed. The primary outcome was PTSD symptom severity using the PTSD Checklist - Military version (PCL) measured at baseline, 3- and 12-month post-deployment. Heart rate variability predictor variables included: high frequency power (HF) and standard deviation of the normal cardiac inter-beat interval (SDNN). Generalized linear mixed models revealed that the pre-deployment PCL*ln(HF) interaction term was significant (p<0.0001). Pre-deployment SDNN was not a significant predictor of post-deployment PCL. Covariates included age, pre-deployment PCL, race/ethnicity, marital status, tobacco use, childhood abuse, pre-deployment traumatic brain injury, and previous combat zone deployment. Pre-deployment heart rate variability predicts post-deployment PTSD symptoms in the context of higher pre-deployment PCL scores.
[Mh] Termos MeSH primário: Distúrbios de Guerra/psicologia
Frequência Cardíaca/fisiologia
Militares/psicologia
Transtornos de Estresse Pós-Traumáticos/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/fisiopatologia
Distúrbios de Guerra/complicações
Feminino
Seres Humanos
Guerra do Iraque 2003-2011
Modelos Lineares
Estudos Longitudinais
Masculino
Valor Preditivo dos Testes
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  8 / 20427 MEDLINE  
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[PMID]:29173409
[Au] Autor:Huang WA; Boyle NG; Vaseghi M
[Ad] Endereço:UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, 100 MP, Suite 660, Los Angeles, CA 90095, USA.
[Ti] Título:Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.
[So] Source:Card Electrophysiol Clin;9(4):665-679, 2017 Dec.
[Is] ISSN:1877-9190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural remodeling in the autonomic nervous system contributes to sudden cardiac death. The fabric of cardiac excitability and propagation is controlled by autonomic innervation. Heart disease predisposes to malignant ventricular arrhythmias by causing neural remodeling at the level of the myocardium, the intrinsic cardiac ganglia, extracardiac intrathoracic sympathetic ganglia, extrathoracic ganglia, spinal cord, and the brainstem, as well as the higher centers and the cortex. Therapeutic strategies at each of these levels aim to restore the balance between the sympathetic and parasympathetic branches. Understanding this complex neural network will provide important therapeutic insights into the treatment of sudden cardiac death.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo
Morte Súbita Cardíaca
Coração/inervação
[Mh] Termos MeSH secundário: Seres Humanos
Taquicardia Ventricular
Fibrilação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  9 / 20427 MEDLINE  
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[PMID]:29283233
[Au] Autor:Tsirkin VI; Nozdrachev AD; Sizova EN; Polezhaeva TV; Khlybova SV
[Ti] Título:Endogenous Sensitizer of Beta-Adrenergic Receptors (ESBAR) as a Component of Humoral Links Element of Autonomic Nervous System and Its Analogs (Review).
[So] Source:Usp Fiziol Nauk;47(4):18-42, 2016 Oct-Dec.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Kirov State Medical Academy, Kirov The results of the 20-years studies of the presence in blood serum and other body fluids of endogenous modulators of adrenergic and M-cholinergic impact a A COMPONENT of humoral element of autonomic nervous system. The article is devoted to the endogenous sensitizer of beta-adrenergic receptor (ESBAR) - water-soluble low molecular weight substances, analogues of which are histidine, tryptophan, tyrosine, mildronat and preduktal. It is shown, that separate dilutions of human serum and animal (as a source of ESBAR) and ESBAR - analogues ways to enhance the effectiveness of activation of beta-adrenoceptors (AR) of smooth muscle (uterus, coronary and renal arteries, trachea, stomach), myocardium and erythrocytes and platelets (respectively influenced of histidine and tryptophan). It is reported? that content of ESBAR in human serum (according to the titers of its dilution) depends on the sex and the presence of somatic diseases, and at women are also on the stage of reproduction and obstetric complications It is discussed hossible mechanisms of ESBAR action, its physiological role, including as a component of beta-adrenoreceptor myometrium inhibitory mechanism, as well as the prospect of the use of analogues ESBAR, including for the prevention of preterm labor, and for the treatment of bronchial asthma, coronary heart disease, hypertension and heart failure.
[Mh] Termos MeSH primário: Agonistas Adrenérgicos/uso terapêutico
Sistema Nervoso Autônomo/efeitos dos fármacos
Agonistas Colinérgicos/uso terapêutico
Insuficiência Cardíaca/prevenção & controle
Músculo Liso/efeitos dos fármacos
Trabalho de Parto Prematuro/prevenção & controle
[Mh] Termos MeSH secundário: Agonistas Adrenérgicos/sangue
Asma/tratamento farmacológico
Asma/metabolismo
Asma/fisiopatologia
Sistema Nervoso Autônomo/metabolismo
Sistema Nervoso Autônomo/fisiopatologia
Agonistas Colinérgicos/sangue
Doença das Coronárias/tratamento farmacológico
Doença das Coronárias/metabolismo
Doença das Coronárias/fisiopatologia
Feminino
Insuficiência Cardíaca/metabolismo
Insuficiência Cardíaca/fisiopatologia
Histidina/sangue
Histidina/uso terapêutico
Seres Humanos
Hipertensão/tratamento farmacológico
Hipertensão/metabolismo
Hipertensão/fisiopatologia
Metilidrazinas/uso terapêutico
Músculo Liso/metabolismo
Músculo Liso/fisiopatologia
Trabalho de Parto Prematuro/metabolismo
Trabalho de Parto Prematuro/fisiopatologia
Gravidez
Triptofano/sangue
Triptofano/uso terapêutico
Tirosina/sangue
Tirosina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic Agonists); 0 (Cholinergic Agonists); 0 (Methylhydrazines); 42HK56048U (Tyrosine); 4QD397987E (Histidine); 73H7UDN6EC (3-(2,2,2-trimethylhydrazine)propionate); 8DUH1N11BX (Tryptophan)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


  10 / 20427 MEDLINE  
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[PMID]:29238017
[Au] Autor:Nakane S; Mukaino A; Ando Y
[Ad] Endereço:Department of Neurology, Graduate School of Medical Sciences, Kumamoto University.
[Ti] Título:[The interface between the immune system and autonomic nervous system].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(5):352-360, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  The nervous system and the immune system are two major systems in human body. Although it was revealed these two systems correlated, the control of immune cell dynamics by the nervous system has come to draw a lot of attention at the present time. Recent advances in basic and preclinical science reveal that reflex neural circuits inhibit the production of cytokines and inflammation in several animal models. One well-characterized cytokine-inhibiting mechanism, termed the "inflammatory reflex", is dependent upon vagus nerve stimulation that inhibits cytokine production and attenuates the inflammation. And the mechanism for controlling lymphocyte trafficking becomes clear, and molecular basis of immune regulation by the nervous system was reported. On the other hand, the nervous system is protected from the invasion of harmful agents by the barrier. However, there are neuroimmunological disorders, which is associated with autoimmunity, tumor immunity, and infection immunity. Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to widespread autonomic manifestations, in which autoantibodies to ganglionic nicotinic acetylcholine receptors play a central role. Previously, we elucidated the prevalence of extra-autonomic manifestations in patients with AAG. It is necessary to establish the new systems for the detection of autoantibodies to other subunits of acetylcholine receptor.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/imunologia
Sistema Imunitário/imunologia
Inflamação/imunologia
[Mh] Termos MeSH secundário: Animais
Autoanticorpos/imunologia
Autoimunidade/imunologia
Citocinas/imunologia
Citocinas/metabolismo
Gânglios Autônomos/imunologia
Seres Humanos
Neuroimunomodulação/imunologia
Receptores Colinérgicos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Cytokines); 0 (Receptors, Cholinergic)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.352



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