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Pesquisa : A08.800.050.050 [Categoria DeCS]
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[PMID]:28667178
[Au] Autor:Donadio V; Incensi A; Rizzo G; Capellari S; Pantieri R; Stanzani Maserati M; Devigili G; Eleopra R; Defazio G; Montini F; Baruzzi A; Liguori R
[Ad] Endereço:From the IRCCS Institute of Neurological Sciences (V.D., A.I., G.R., S.C., R.P., M.S.M., F.M., A.B., R.L.); Department of Biomedical and Neuromotor Sciences (G.R., S.C., R.L.), University of Bologna; Neurological Unit (G. Devigili, R.E.), Department of Neurosciences, "Santa Maria della Misericordia"
[Ti] Título:A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.
[So] Source:Neurology;89(4):318-326, 2017 Jul 25.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate whether (1) phosphorylated α-synuclein (p-syn) deposits in skin nerves could be useful in differentiating dementia with Lewy bodies (DLB) from different forms of dementia and (2) small fiber neuropathy (SFN) is associated with DLB. METHODS: We studied 18 well-characterized patients with DLB (11 with autonomic dysfunction), 23 patients with nonsynucleinopathy dementia (NSD; 13 with young-onset Alzheimer disease dementia, 6 frontotemporal dementia, and 4 vascular dementia), and 25 healthy controls. All participants underwent skin biopsies from proximal (i.e., cervical) and distal (i.e., thigh and distal leg) sites to study small nerve fibers and deposits of p-syn, considered the pathologic form of α-synuclein. RESULTS: No p-syn was detected in any skin sample in patients with NSD and controls but was found in all patients with DLB. SFN was found in patients with DLB and the autonomic denervation of skin was more severe in patients with autonomic dysfunctions. CONCLUSIONS: (1) In autonomic skin nerves, p-syn is a sensitive biomarker for DLB diagnosis, helping to differentiate DLB from other forms of dementia, although this needs to be confirmed in a larger, more representative sample; and (2) skin autonomic neuropathy is part of the DLB pathology and may contribute to autonomic symptoms. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that p-syn in skin nerve fibers on skin biopsy accurately distinguishes DLB from other forms of dementia.
[Mh] Termos MeSH primário: Doença por Corpos de Lewy/diagnóstico
Doença por Corpos de Lewy/metabolismo
Pele/inervação
Pele/metabolismo
alfa-Sinucleína/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/diagnóstico
Doença de Alzheimer/metabolismo
Doença de Alzheimer/patologia
Vias Autônomas/metabolismo
Vias Autônomas/patologia
Biomarcadores/metabolismo
Demência Vascular/diagnóstico
Demência Vascular/metabolismo
Demência Vascular/patologia
Diagnóstico Diferencial
Feminino
Demência Frontotemporal/diagnóstico
Demência Frontotemporal/metabolismo
Demência Frontotemporal/patologia
Seres Humanos
Perna (Membro)/inervação
Perna (Membro)/patologia
Doença por Corpos de Lewy/patologia
Masculino
Microscopia Confocal
Meia-Idade
Fosforilação
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (SNCA protein, human); 0 (alpha-Synuclein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004146


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[PMID]:28534336
[Au] Autor:Shi H; Tian Y; Dai F; Xiao L; Ke Z; Tong W
[Ti] Título:[Establishment of pelvic nerve denervation modal in mice].
[So] Source:Zhonghua Wei Chang Wai Ke Za Zhi;20(5):560-565, 2017 May 25.
[Is] ISSN:1671-0274
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To establishment and verify pelvic nerve denervation (PND) model in mice. METHODS: (1) Establishment of models. Seventy-two healthy male SPE class C57 mice with age of 7 weeks and body weight of (25±1) g were chosen. These 72 mice were randomly divided into PND group containing 36 mice and sham operation group containing 36 mice. Referring to the establishment method of PND rats, after anesthesia, a laparotomy was performed on the mouse with an abdominal median incision. Under the dissection microscope, the pelvic nerves behind and after each sides of the prostate gland were bluntly separated with cotton swabs and cut with a dissecting scissor. After the operation, the urination of mice was assisted twice every day. For the mice of sham operation group, the pelvic nerves were only exposed without cutting. (2) Detection of models. Colonic transit test was performed in 18 mice chosen randomly from each group to detect the colonic transit ratio (colored colon by methylene blue/ whole colon) and visceral sensitivity tests was performed in the rest mice to observe and record the changes of electromyogram. RESULTS: Three mice died of colonic transit test in each group. Uroschesis occurred in all the mice of PND group and needed bladder massage to assist the urination. Colonic transit test showed that the colonic transit ratios of sham operation group at postoperative day (POD) 1, 3 and 7 were (0.4950±0.3858)%, (0.6386±0.1293)% and (0.6470±0.1088)% without significant difference (F=0.3647, P=0.058), while in PND group, the colonic transit ratio at POD 7 [(0.6044±0.1768) %] was obviously higher than that both at POD 3[(0.3876±0.1364)%, P=0.022] and POD 1[(0.2542±0.0371)%, P=0.001], indicating a recovery trend of colonic transit function (F=9.143, P=0.004). Compared with the sham operation group, the colonic transit function in PND group decreased significantly at POD 1 and POD 3(both P<0.05), and at POD 7, there was no significant difference between two groups. Visceral sensitivity test showed that the visceral sensitivity of sham operation group at POD 1, 3 and 7 was 24.2808±9.5566, 33.6725±7.9548 and 43.9086±12.1875 with significant difference (F=5.722, P=0.014). The visceral sensitivity of PND group at POD 1, 3 and 7 was 11.7609±2.1049, 21.8415±8.1527 and 26.2310±4.2235 with significant difference as well (F=11.154, P=0.001). The visceral sensitivity at POD 3 and POD 7 was obviously higher than that at POD 1 (P=0.006, P<0.001), and there was no significant difference between POD 3 and POD 7 (P=0.183). Compared with sham operation group, the visceral sensitivity of PND group decreased significantly at POD 1, 3 and 7(all P<0.05). CONCLUSIONS: Denervation of pelvic nerves can obviously decrease the colonic transit function and the visceral sensitivity of mice, but these changes can recover over time, which suggests that the establishment of PND model in mice is successful.
[Mh] Termos MeSH primário: Vias Autônomas/cirurgia
Colo/inervação
Denervação/métodos
Modelos Animais de Doenças
Tecido Nervoso/cirurgia
Pelve/inervação
[Mh] Termos MeSH secundário: Dor Abdominal/fisiopatologia
Animais
Vias Autônomas/crescimento & desenvolvimento
Vias Autônomas/fisiopatologia
Colo/fisiopatologia
Trânsito Gastrointestinal/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Tecido Nervoso/crescimento & desenvolvimento
Tecido Nervoso/fisiopatologia
Dor Pós-Operatória/fisiopatologia
Pelve/fisiopatologia
Pelve/cirurgia
Próstata/inervação
Recuperação de Função Fisiológica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28245283
[Au] Autor:Hwang M; Lim B; Song JS; Yu HT; Ryu AJ; Lee YS; Joung B; Shim EB; Pak HN
[Ad] Endereço:Division of Cardiology, Yonsei University Health System, Seoul, Republic of Korea.
[Ti] Título:Ganglionated plexi stimulation induces pulmonary vein triggers and promotes atrial arrhythmogenecity: In silico modeling study.
[So] Source:PLoS One;12(2):e0172931, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The role of the autonomic nervous system (ANS) on atrial fibrillation (AF) is difficult to demonstrate in the intact human left atrium (LA) due to technical limitations of the current electrophysiological mapping technique. We examined the effects of the ANS on the initiation and maintenance of AF by employing a realistic in silico human left atrium (LA) model integrated with a model of ganglionated plexi (GPs). METHODS: We incorporated the morphology of the GP and parasympathetic nerves in a three-dimensional (3D) realistic LA model. For the model of ionic currents, we used a human atrial model. GPs were stimulated by increasing the IK[ACh], and sympathetic nerve stimulation was conducted through a homogeneous increase in the ICa-L. ANS-induced wave-dynamics changes were evaluated in a model that integrated a patient's LA geometry, and we repeated simulation studies using LA geometries from 10 different patients. RESULTS: The two-dimensional model of pulmonary vein (PV) cells exhibited late phase 3 early afterdepolarization-like activity under 0.05µM acetylcholine (ACh) stimulation. In the 3D simulation model, PV tachycardia was induced, which degenerated to AF via GP (0.05µM ACh) and sympathetic (7.0×ICa-L) stimulations. Under sustained AF, local reentries were observed at the LA-PV junction. We also observed that GP stimulation reduced the complex fractionated atrial electrogram (CFAE)-cycle length (CL, p<0.01) and the life span of phase singularities (p<0.01). GP stimulation also increased the overlap area of the GP and CFAE areas (CFAE-CL≤120ms, p<0.01). When 3 patterns of virtual ablations were applied to the 3D AF models, circumferential PV isolation including the GP was the most effective in terminating AF. CONCLUSION: Cardiac ANS stimulations demonstrated triggered activity, automaticity, and local reentries at the LA-PV junction, as well as co-localized GP and CFAE areas in the 3D in silico GP model of the LA.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Gânglios Autônomos/fisiopatologia
Átrios do Coração/fisiopatologia
Taquicardia/metabolismo
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Adulto
Idoso
Fibrilação Atrial/fisiopatologia
Vias Autônomas/efeitos dos fármacos
Eletrofisiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Modelos Teóricos
Taquicardia/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172931


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[PMID]:28173996
[Au] Autor:Sabetghadam A; Korim WS; Verberne AJ
[Ad] Endereço:Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
[Ti] Título:Perifornical hypothalamic pathway to the adrenal gland: Role for glutamatergic transmission in the glucose counter-regulatory response.
[So] Source:Auton Neurosci;203:67-73, 2017 Mar.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Adrenaline is an important counter-regulatory hormone that helps restore glucose homeostasis during hypoglycaemia. However, the neurocircuitry that connects the brain glucose sensors and the adrenal sympathetic outflow to the chromaffin cells is poorly understood. We used electrical microstimulation of the perifornical hypothalamus (PeH) and the rostral ventrolateral medulla (RVLM) combined with adrenal sympathetic nerve activity (ASNA) recording to examine the relationship between the RVLM, the PeH and ASNA. In urethane-anaesthetised male Sprague-Dawley rats, intermittent single pulse electrical stimulation of the rostroventrolateral medulla (RVLM) elicited an evoked ASNA response that consisted of early (60±3ms) and late peaks (135±4ms) of preganglionic and postganglionic activity. In contrast, RVLM stimulation evoked responses in lumbar sympathetic nerve activity that were almost entirely postganglionic. PeH stimulation also produced an evoked excitatory response consisting of both preganglionic and postganglionic excitatory peaks in ASNA. Both peaks in ASNA following RVLM stimulation were reduced by intrathecal kynurenic acid (KYN) injection. In addition, the ASNA response to systemic neuroglucoprivation induced by 2-deoxy-d-glucose was abolished by bilateral microinjection of KYN into the RVLM. This suggests that a glutamatergic pathway from the perifornical hypothalamus (PeH) relays in the RVLM to activate the adrenal SPN and so modulate ASNA. The main findings of this study are that (i) adrenal premotor neurons in the RVLM may be, at least in part, glutamatergic and (ii) that the input to these neurons that is activated during neuroglucoprivation is also glutamatergic.
[Mh] Termos MeSH primário: Glândulas Suprarrenais/metabolismo
Vias Autônomas/metabolismo
Glucose/metabolismo
Ácido Glutâmico/metabolismo
Hipotálamo/metabolismo
Sistema Nervoso Simpático/metabolismo
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/efeitos dos fármacos
Glândulas Suprarrenais/inervação
Anestésicos Intravenosos/farmacologia
Animais
Vias Autônomas/efeitos dos fármacos
Estimulação Elétrica
Antagonistas de Aminoácidos Excitatórios/farmacologia
Hipotálamo/efeitos dos fármacos
Ácido Cinurênico/administração & dosagem
Ácido Cinurênico/metabolismo
Vértebras Lombares
Ratos Sprague-Dawley
Receptores de Glutamato/metabolismo
Sistema Nervoso Simpático/efeitos dos fármacos
Transmissão Sináptica/efeitos dos fármacos
Transmissão Sináptica/fisiologia
Uretana/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Excitatory Amino Acid Antagonists); 0 (Receptors, Glutamate); 3IN71E75Z5 (Urethane); 3KX376GY7L (Glutamic Acid); H030S2S85J (Kynurenic Acid); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


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[PMID]:28106665
[Au] Autor:Tsioufis C; Dimitriadis K; Kasiakogias A; Kalos T; Liatakis I; Koutra E; Nikolopoulou L; Kordalis A; Ella RO; Lau EO; Grassi G; Papademetriou V; Tousoulis D
[Ad] Endereço:aFirst Cardiology Clinic, National and Kapodistrian University of Athens, Hippocration Hospital, Athens, Greece bSt. Jude Medical, Inc., Irvine, California, USA cClinica Medica, University Milano-Biococca dIRCCS Multimedica, Sesto San Giovanni, Milano, Italy eVeterans Affairs and Georgetown University Medical Centers, Washington, District of Columbia, USA.
[Ti] Título:Effects of multielectrode renal denervation on elevated sympathetic nerve activity and insulin resistance in metabolic syndrome.
[So] Source:J Hypertens;35(5):1100-1108, 2017 May.
[Is] ISSN:1473-5598
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to investigate the effects of renal denervation (RDN) on sympathetic nerve activity and insulin resistance in patients with metabolic syndrome. METHODS: Seventeen patients fulfilled at least four of five criteria for metabolic syndrome and under stable use of at least two antihypertensive drugs were randomized in 3 : 1 ratio to RDN (n = 13, 12 men, age: 58 ±â€Š7 years) and control groups (n = 4, three men, age: 60 ±â€Š5 years) and followed up for 3 months. Muscle sympathetic nerve activity (MSNA) at rest and during standard 75 g oral glucose tolerance test (OGTT) was assessed. RESULTS: In the RDN group, office and average 24-h blood pressures reduced by 16 ±â€Š21/10 ±â€Š11 mmHg (P = 0.01/0.007) and 14 ±â€Š16/5 ±â€Š8 mmHg (P = 0.008/0.03) respectively; waist circumference reduced by 3.1 ±â€Š3.6 cm (P = 0.008); and resting MSNA reduced from 55 ±â€Š9 bursts per minute to 46 ±â€Š8 bursts per minute (P = 0.0008) at month 3 post-RDN. During OGTT, although blunted MSNA responses were noted at baseline throughout the 120-min test, improved MSNA responses with burst frequency increased to 52 ±â€Š8 bursts per minute (P < 0.001 vs. the resting MSNA, n = 13) at 30 min and to 54 ±â€Š8 bursts per minute (P = 0.004 vs. the resting MSNA, n = 10) at 120 min and were observed at month 3 post-RDN. No such improvements were observed in the controls. No significant change was observed in the HOMA-IR in both groups at month 3. CONCLUSION: In this pilot study of patients with metabolic syndrome and associated hypertension, RDN reduced elevated sympathetic nerve activity and restored the normal neural response to oral glucose loading.
[Mh] Termos MeSH primário: Denervação
Hipertensão/tratamento farmacológico
Resistência à Insulina
Síndrome Metabólica/fisiopatologia
Síndrome Metabólica/cirurgia
Sistema Nervoso Simpático/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Anti-Hipertensivos/uso terapêutico
Vias Autônomas/fisiopatologia
Pressão Sanguínea
Feminino
Teste de Tolerância a Glucose
Seres Humanos
Hipertensão/fisiopatologia
Rim/inervação
Masculino
Microeletrodos
Meia-Idade
Músculo Esquelético/inervação
Nervo Fibular/fisiopatologia
Projetos Piloto
Estudos Prospectivos
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antihypertensive Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1097/HJH.0000000000001262


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[PMID]:28091409
[Au] Autor:Zhao HY; Zhang SD; Zhang K; Wang X; Zhao QY; Zhang SJ; Dai ZX; Qian YS; Zhang YJ; Wei HT; Tang YH; Huang CX
[Ad] Endereço:Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060; Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060; Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China.
[Ti] Título:Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity.
[So] Source:Chin Med J (Engl);130(2):171-178, 2017 01 20.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. METHODS: Eighteen mongrel dogs were randomly divided into control group (n = 6), pacing group (n = 6), and pacing + SSYX group (n = 6). The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing + SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration. RESULTS: Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing + SSYX group (low-frequency [LF] component: 20.85 ± 3.14 vs. 15.3 ± 1.89 ms 2 , P = 0.004; LF component/high-frequency component: 1.34 ± 0.33 vs. 0.77 ± 0.15, P < 0.001). The atrial effective refractory period (AERP) was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing + SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing + SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing. CONCLUSIONS: SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.
[Mh] Termos MeSH primário: Fibrilação Atrial/tratamento farmacológico
Fibrilação Atrial/metabolismo
Medicamentos de Ervas Chinesas/uso terapêutico
[Mh] Termos MeSH secundário: Acetilcolina/sangue
Animais
Vias Autônomas/efeitos dos fármacos
Western Blotting
Cães
Eletrofisiologia
Ensaio de Imunoadsorção Enzimática
Frequência Cardíaca/efeitos dos fármacos
Imuno-Histoquímica
Interleucina-6/sangue
Modelos Animais
Fator de Necrose Tumoral alfa/sangue
Receptor Nicotínico de Acetilcolina alfa7/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); 0 (alpha7 Nicotinic Acetylcholine Receptor); 0 (shensongyangxin); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.197997


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[PMID]:27932203
[Au] Autor:Zhang HQ; Zhang Y; Liu L; Li JL; Lu YC; Yu YY; Li H; Zhang T; Chan YS; Zhang FX; Li YQ
[Ad] Endereço:Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, People's Republic of China; Department of Orthopedics, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China.
[Ti] Título:Neural connection supporting endogenous 5-hydroxytryptamine influence on autonomic activity in medial prefrontal cortex.
[So] Source:Auton Neurosci;203:25-32, 2017 Mar.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities. The present study investigated the physical relationship between 5-HT fibers and the autonomic-related mPFC neurons by examining and quantitatively characterizing the 5-HT contacts upon retrogradely labeled mPFC-DVC projection neurons in pre- and infra-limbic cortices (PrL/IL) with light and electron microscopies combined with immunocytochemistry for 5-HT and presynaptic vesicle marker synaptophysin (Syn). 5-HT varicosities were observed, under confocal microscope, to form close appositions to or, at ultrastructural level, to form asymmetric axodendritic synapses and direct contacts upon the target neurons. About 16% of the entire 5-HTergic varicosities in lamina V of PrL/IL coexpressed Syn and about 24% of the peri-somatic 5-HTergic swellings demonstrated Syn-immunoreactivity (ir), suggesting a low frequency of putative synapses estimated at optical level. Ultrastructurally, examination of thirty-seven serially cut thin 5-HT boutons closely apposed to the labeled dendritic profiles demonstrated that only three contacts presented with identifiable asymmetric, synaptic membrane specializations. These data provide the first and direct morphological evidence supporting that endogenous 5-HT may be released mainly via direct contacts bearing no identifiable synaptic specializations as well as synapses, targeting autonomic-related mPFC neurons for autonomic regulation.
[Mh] Termos MeSH primário: Vias Autônomas/metabolismo
Tronco Encefálico/metabolismo
Neurônios/metabolismo
Córtex Pré-Frontal/metabolismo
Serotonina/metabolismo
[Mh] Termos MeSH secundário: Animais
Vias Autônomas/citologia
Tronco Encefálico/citologia
Imuno-Histoquímica
Masculino
Microscopia de Fluorescência
Microscopia Imunoeletrônica
Técnicas de Rastreamento Neuroanatômico
Neurônios/citologia
Córtex Pré-Frontal/citologia
Ratos Sprague-Dawley
Sinaptofisina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Synaptophysin); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


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[PMID]:27930438
[Au] Autor:Redón P; Grassi G; Redon J; Álvarez-Pitti J; Lurbe E
[Ad] Endereço:aPediatric Department, Consorcio Hospital General, University of Valencia, Valencia bCIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Madrid, Spain cDipartimento di Scienze della Salute, Clinica Medica, Universitá Milano-Bicocca dIRCCS Multimedica, Sesto San Giovanni, Milano, Italy eINCLIVA Research Institute fHypertension Clinic, Department of Internal Medicine, Hospital Clínico de Valencia, University of Valencia, Valencia, Spain.
[Ti] Título:Sympathetic neural activity, metabolic parameters and cardiorespiratory fitness in obese youths.
[So] Source:J Hypertens;35(3):571-577, 2017 Mar.
[Is] ISSN:1473-5598
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The main objective of this cross-sectional study is to assess the cardiac autonomic neural activity in the presence of abnormally increased body weight in youths and its relationship to metabolic risk factors and cardiorespiratory fitness (CRF). METHODS: Sixty-four overweight and obese patients, aged 9-17 years, of both sexes, stratified according to the international BMI cut-off, were enrolled. Continuous ECG was recorded during 15 min in resting conditions, and the heart rate variability (HRV) was measured in the time domain, frequency domain and for nonlinear dynamics. In addition, cardiometabolic risk factors and CRF in effort conditions were assessed. RESULTS: Among the overweight and obese youths, no significant differences were observed regarding metabolic parameters and heart rate, although CRF was the lowest in the severely obese youths. Likewise, no significant differences were observed in HRV, independent of how it was assessed. A positive and significant relationship, independent of the degree of obesity, pubertal stage and breathing rate under resting conditions, has been observed among sympathovagal balance, insulin and the homeostatic model assessment index. Furthermore, CRF assessed by volume oxygen peak was associated with insulin levels (r = -0.273; P < 0.05), the SD of the NN interval series (r = 0.268, P < 0.05) and the long-term variation using the Poincaré plot (PS1: r = 0.275, P < 0.05; PS2: r = 0.273, P < 0.05). CONCLUSION: The key findings of the present study were the presence of a link among fasting insulin, HRV and CRF independent of the degree of obesity, indicating the heterogeneity of obese children and adolescents.
[Mh] Termos MeSH primário: Aptidão Cardiorrespiratória
Frequência Cardíaca
Obesidade/fisiopatologia
Sistema Nervoso Simpático/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Vias Autônomas/fisiopatologia
Criança
Estudos Transversais
Eletrocardiografia
Feminino
Coração/inervação
Seres Humanos
Insulina/sangue
Resistência à Insulina
Masculino
Sobrepeso/fisiopatologia
Consumo de Oxigênio
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.1097/HJH.0000000000001200


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[PMID]:27484205
[Au] Autor:Bessede T; Sooriakumaran P; Takenaka A; Tewari A
[Ad] Endereço:Department of Urology, Icahn School of Medicine at Mount Sinai, New York City, NY, 10029, USA. thomas.bessede@gmail.com.
[Ti] Título:Neural supply of the male urethral sphincter: comprehensive anatomical review and implications for continence recovery after radical prostatectomy.
[So] Source:World J Urol;35(4):549-565, 2017 Apr.
[Is] ISSN:1433-8726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To review the anatomical facts of urethral sphincter (US) innervation discovered over the last three decades and to determine the implications for continence recovery after radical prostatectomy (RP). METHODS: Using the PubMed database, we searched for peer-reviewed articles in English between January 1985 and September 2015, with the following terms: 'urethral sphincter,' 'urethral rhabdosphincter,' 'urinary continence and nerve supply' and 'neuroanatomy and nerve sparing.' The anatomical methodology, number of bodies examined, data, figures, relevant facts and text were analyzed. RESULTS: Seventeen articles on 254 anatomical subjects were reviewed. Coexisting pathways were described in every article. Dissection, histology, simulation or electron microscopy evidence supported arguments for somatic and autonomic pathways. From the most to the least substantiated, somatic sphincteric fibers were described extra- or intrapelvic as: direct from the distal pudendal nerve (PuN), recurrent from the dorsal nerve of the penis, from the proximal PuN with an intrapelvic course, extrapudendal somatic fibers dispersed among autonomic pelvic fibers. From the pelvic plexus, or from the neurovascular bundles, autonomic fibers to the US have been described in 13 of the reviewed articles, with at least each of the available anatomical methods. CONCLUSION: Because continence depends on a number of factors, it is challenging to delineate the specific impact of periprostatic nerve sparing on continence, but the anatomical data suggest that RP surgeons should steer toward the preservation and protection of these nerves whenever possible.
[Mh] Termos MeSH primário: Vias Autônomas/anatomia & histologia
Plexo Hipogástrico/anatomia & histologia
Próstata/anatomia & histologia
Prostatectomia/métodos
Neoplasias da Próstata/cirurgia
Nervo Pudendo/anatomia & histologia
Uretra/inervação
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Tratamentos com Preservação do Órgão
Complicações Pós-Operatórias
Recuperação de Função Fisiológica
Incontinência Urinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1007/s00345-016-1901-8


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[PMID]:28268900
[Au] Autor:Burns J; Yee-Hsee Hsieh; Mueller A; Chevallier J; Sriram TS; Lewis SJ; Chew D; Achyuta A; Fiering J
[Ti] Título:High density penetrating electrode arrays for autonomic nerves.
[So] Source:Conf Proc IEEE Eng Med Biol Soc;2016:2802-2805, 2016 08.
[Is] ISSN:1557-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electrode arrays for recording and stimulation in the central nervous system have enabled numerous advances in basic science and therapeutic strategies. In particular, micro-fabricated arrays with precision size and spacing offer the benefit of accessing single neurons and permit mapping of neuronal function. Similar advances are envisioned toward understanding the autonomic nervous system and developing therapies based on its modulation, but appropriate electrode arrays are lacking. Here, we present for the first time, a multi-channel electrode array suitable for penetration of peripheral nerves having diameters as small as 0.1mm, and demonstrate performance in vivo. These arrays have the potential to access multiple discrete nerve fibers in small nerves. We fabricated and characterized five-channel arrays and obtained preliminary recordings of activity when penetrating rat carotid sinus nerve. The electrodes were constructed using hybrid microfabrication processes. The individual electrode shafts are as small as 0.01mm in diameter and at its tip each has a defined site that is addressable via a standard electronic connector. In addition to acute in vivo results, we evaluate the device by electrochemical impedance spectroscopy. Having established the fabrication method, our next steps are to incorporate the arrays into an implantable configuration for chronic studies, and here we further describe concepts for such a device.
[Mh] Termos MeSH primário: Vias Autônomas/fisiologia
Microtecnologia/instrumentação
[Mh] Termos MeSH secundário: Animais
Vias Autônomas/citologia
Seio Carotídeo/inervação
Espectroscopia Dielétrica
Masculino
Microeletrodos
Fibras Nervosas/fisiologia
Neurônios/citologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1109/EMBC.2016.7591312



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