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  1 / 8516 MEDLINE  
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[PMID]:28453791
[Au] Autor:Beel S; Moisse M; Damme M; De Muynck L; Robberecht W; Van Den Bosch L; Saftig P; Van Damme P
[Ad] Endereço:Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium.
[Ti] Título:Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
[So] Source:Hum Mol Genet;26(15):2850-2863, 2017 08 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We previously showed that GRN is neurotrophic in vitro. Here, we used an in vivo axonal outgrowth system and observed a delayed recovery in GRN-/- mice after facial nerve injury. This deficit was rescued by reintroduction of human GRN and relied on its C-terminus and on neuronal GRN production. Transcriptome analysis of the facial motor nucleus post injury identified cathepsin D (CTSD) as the most upregulated gene. In aged GRN-/- cortices, CTSD was also upregulated, but the relative CTSD activity was reduced and improved upon exogenous GRN addition. Moreover, GRN and its C-terminal granulin domain granulinE (GrnE) both stimulated the proteolytic activity of CTSD in vitro. Pull-down experiments confirmed a direct interaction between GRN and CTSD. This interaction was also observed with GrnE and stabilized the CTSD enzyme at different temperatures. Investigating the importance of this interaction for axonal regeneration in vivo we found that, although individually tolerated, a combined reduction of GRN and CTSD synergistically reduced axonal outgrowth. Our data links the neurotrophic effect of GRN and GrnE with a lysosomal chaperone function on CTSD to maintain its proteolytic capacity.
[Mh] Termos MeSH primário: Catepsina D/metabolismo
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
[Mh] Termos MeSH secundário: Animais
Catepsina D/genética
Nervo Facial/metabolismo
Demência Frontotemporal/genética
Haploinsuficiência
Seres Humanos
Peptídeos e Proteínas de Sinalização Intercelular/genética
Camundongos
Camundongos Transgênicos
Chaperonas Moleculares/genética
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (GRN protein, human); 0 (Grn protein, mouse); 0 (Intercellular Signaling Peptides and Proteins); 0 (Molecular Chaperones); 134710-81-9 (granulin precursor protein); EC 3.4.23.5 (Cathepsin D)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx162


  2 / 8516 MEDLINE  
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[PMID]:29184204
[Au] Autor:Winder AT; Echagarruga C; Zhang Q; Drew PJ
[Ad] Endereço:Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA.
[Ti] Título:Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
[So] Source:Nat Neurosci;20(12):1761-1769, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
[Mh] Termos MeSH primário: Hemodinâmica/fisiologia
Descanso/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Volume Sanguíneo
Circulação Cerebrovascular/fisiologia
Nervo Facial/fisiologia
Imagem por Ressonância Magnética
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Movimento/fisiologia
Fenômenos Fisiológicos do Sistema Nervoso
Estimulação Luminosa
Córtex Somatossensorial/irrigação sanguínea
Vibrissas/inervação
Vibrissas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0007-y


  3 / 8516 MEDLINE  
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[PMID]:28847113
[Au] Autor:Zhang Y; Yu X
[Ad] Endereço:Department of Neurosurgery, PLA General Hospital, Beijing, China.
[Ti] Título:In Reply to "Predicting Shape, Location, and Course of Facial Nerve in Relation to Large Vestibular Schwannoma on Diffusion Tensor Imaging with Intraoperative Correlation: Important Surgical Adjunct".
[So] Source:World Neurosurg;105:1003, 2017 09.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Nervo Facial
Neuroma Acústico/cirurgia
[Mh] Termos MeSH secundário: Nervo Coclear
Imagem de Tensor de Difusão
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  4 / 8516 MEDLINE  
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[PMID]:28847112
[Au] Autor:Satyarthee GD
[Ad] Endereço:Department of Neurosurgery, Neurosciences Center, AIIMS New Delhi, New Delhi, India. Electronic address: drguruduttaaiims@gmail.com.
[Ti] Título:Predicting Shape, Location, and Course of Facial Nerve in Relation to Large Vestibular Schwannoma on Diffusion Tensor Imaging with Intraoperative Correlation: Important Surgical Adjunct.
[So] Source:World Neurosurg;105:1002, 2017 09.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Nervo Facial
Neuroma Acústico/cirurgia
[Mh] Termos MeSH secundário: Nervo Coclear
Imagem de Tensor de Difusão
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  5 / 8516 MEDLINE  
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[PMID]:28684285
[Au] Autor:van Veen MM; Dijkstra PU; Werker PMN
[Ad] Endereço:University of Groningen, University Medical Centre Groningen, Department of Plastic Surgery, Groningen, The Netherlands. Electronic address: m.m.van.veen@umcg.nl.
[Ti] Título:A higher quality of life with cross-face-nerve-grafting as an adjunct to a hypoglossal-facial nerve jump graft in facial palsy treatment.
[So] Source:J Plast Reconstr Aesthet Surg;70(11):1666-1674, 2017 Nov.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nerve reconstructions are the preferred technique for short-standing facial paralysis, most commonly using the contralateral facial nerve or ipsilateral hypoglossal nerve. The hypoglossal nerve provides a strong motor signal, whereas the signal of a cross-face nerve graft is weaker but spontaneous. Spontaneity in facial expression is believed to be important for psychological wellbeing. Therefore, a combination of the two procedures incorporates the best of both: a strong motor signal and a spontaneous smile. This study aimed to objectify this expected benefit. Of the 20 patients who received a hypoglossal-facial nerve anastomosis from 1995 to 2015 in our institutions, 12 patients were included in this study, 5 with and 7 without a cross-face nerve graft. The outcomes were compared using photographs, disease-specific quality of life (Facial Clinimetric Evaluation (FaCE) scale), a self-reported synkinesis scale (Synkinesis Assessment Questionnaire) and the presence of a spontaneous smile. Significant differences were found in preoperative excursion of the affected side of the mouth and the change in excursion. Median Total FaCE scores were considerably larger (18.3 points) for patients who underwent the combined procedure. A spontaneous smile was observed both with (n = 2) and without (n = 1) a cross-face nerve graft. The addition of a cross-face nerve graft to a hypoglossal-facial nerve anastomosis resulted in a positive trend in disease-specific quality of life. This benefit could also be present with the combination of a cross-face nerve graft with another nerve transfer such as a masseteric-facial nerve anastomosis.
[Mh] Termos MeSH primário: Nervo Facial/cirurgia
Paralisia Facial/cirurgia
Nervo Hipoglosso/transplante
Músculo Esquelético/transplante
Transferência de Nervo/métodos
Qualidade de Vida
Ritidoplastia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Expressão Facial
Paralisia Facial/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Masculino
Microcirurgia/métodos
Meia-Idade
Estudos Retrospectivos
Sorriso
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  6 / 8516 MEDLINE  
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[PMID]:28682547
[Au] Autor:Lei W; Wenjie Z; Libo S; Hangyu Z; Shuangjiang W; Jingang X
[Ad] Endereço:Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou 646000, China.
[Ti] Título:[Application of modified coronal approach in treatment of craniomaxillofacial fractures].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;35(2):167-170, 2017 Apr 01.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: This study aimed to investigate clinical efficacy of a modified coronal approach in treatment of craniomaxillofacial fractures. METHODS: Thirty-seven cases of craniomaxillofacial fractures underwent open reduction and rigid internal fixation through modified coronal approach. Clinical follow-up visits were conducted to evaluate facial nerve functional status, temporal shape, appearance restoration, and reduction of fracture and surgical area scars. RESULTS: During follow-up period of 6-36 months, appearance and function of all 37 patients recovered well without facial nerve injury and temporal depression deformity. All cases presented hidden scars, except for one case with hypertrophic scar. CONCLUSIONS: Applying modified coronal approach to craniomaxillofacial surgery effectively reduces incidence of temporal depression and facial nerve injury compared with traditional approach. The modified coronal approach produced more subtle scars compared with traditional approach and should be applied to treatment of craniomaxillofacial fractures.
[Mh] Termos MeSH primário: Fraturas Mandibulares/cirurgia
[Mh] Termos MeSH secundário: Nervo Facial
Fixação Interna de Fraturas
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.7518/hxkq.2017.02.011


  7 / 8516 MEDLINE  
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[PMID]:28617736
[Au] Autor:Chen G; Wang W; Wang W; Ding W; Yang X
[Ad] Endereço:Shanghai, People's Republic of China From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
[Ti] Título:Symmetry Restoration at Rest after Masseter-to-Facial Nerve Transfer: Is It as Efficient as Smile Reanimation?
[So] Source:Plast Reconstr Surg;140(4):793-801, 2017 Oct.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Masseter-to-facial nerve transfer is a highly efficient technique for reanimating paralyzed muscle and has been reported to restore facial symmetry at rest. However, no systematic studies have been performed, and the effects of preoperative droop of the oral commissure on postoperative symmetry at rest have rarely been reported. METHODS: The authors retrospectively analyzed 35 patients with masseteric-to-facial nerve anastomosis and assessed the quality and quantity of the dynamic recovery and the oral commissure symmetry at rest. The dynamic and static effects were then compared. RESULTS: All of the patients' Terzis scores were increased postoperatively, and over half of the patients presented restored symmetric smiles (Terzis scores of 4 or 5). The postoperative symmetry scale of the oral commissure at rest improved in 18 of 35 patients. Both the mean postoperative altitude difference of oral commissure excursion and the postoperative altitude difference of bilateral oral commissure position were decreased compared with preoperative values. The preoperative symmetry had a significant effect on the postoperative altitude difference of the bilateral oral commissure position. The effects of the dynamic and static symmetry improvements were transformed to a comparable factor α. The dynamic α was significantly greater than the static α. CONCLUSIONS: Masseter-to-facial nerve transfer is a reliable technique for smile reanimation. However, it has only a limited effect on the improvement of symmetry at rest. Assessing the preoperative symmetry of the oral commissure at rest can be used to predict postoperative outcomes, and patients with severe droop of the oral commissure (symmetry scale grade III or IV) should receive static suspension.
[Mh] Termos MeSH primário: Nervo Facial/transplante
Paralisia Facial/cirurgia
Músculo Masseter/inervação
Transferência de Nervo/métodos
Recuperação de Função Fisiológica
Ritidoplastia/métodos
Sorriso/fisiologia
[Mh] Termos MeSH secundário: Adulto
Expressão Facial
Paralisia Facial/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Masculino
Microcirurgia/métodos
Meia-Idade
Descanso
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003698


  8 / 8516 MEDLINE  
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[PMID]:28576712
[Au] Autor:Tayebi Meybodi A; Lawton MT; Yousef S; Sánchez JJG; Benet A
[Ad] Endereço:Department of Neurological Surgery, University of California, San Francisco, California, USA; Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA.
[Ti] Título:Preserving the Facial Nerve During Orbitozygomatic Craniotomy: Surgical Anatomy Assessment and Stepwise Illustration.
[So] Source:World Neurosurg;105:359-368, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Surgical safety and efficiency during an orbitozygomatic (OZ) osteotomy rely on thorough knowledge of the surgical anatomy of the facial nerve. Although the anatomy of the facial nerve and its relation to the pterional craniotomy are described, a thorough assessment of facial nerve preservation techniques during the OZ approach and its variations is lacking. We assessed the surgical anatomy of the facial nerve related to the OZ approach and provided a thorough stepwise description on how to preserve it. METHODS: The OZ approach was performed bilaterally in 15 cadaveric heads. The interfascial and subfascial techniques were performed to study their nuances in preserving the facial nerve. We compared the 2 techniques and provided a thorough description on how to preserve the facial nerve during each step of the OZ approach. RESULTS: At the zygomatic arch, the facial nerve was found between the galea and the superficial temporal fascia. A cut in the fascia at the posterior end of the zygomatic arch did not cross any facial nerve branches. The subfascial technique was simpler, more efficient, and provided more structural protection of the facial nerve branches than the interfascial technique. CONCLUSIONS: The frontal division of the facial nerve is related directly to dissection over the zygomatic bone and may be injured during fascial dissection or osteotomies. Both interfascial and subfascial techniques are feasible to use during the OZ craniotomy and provide ample exposure of the OZ unit. Regarding the preservation of the facial nerve branches, we favor the subfascial method.
[Mh] Termos MeSH primário: Craniotomia/métodos
Nervo Facial/cirurgia
Cabeça/cirurgia
Osteotomia/métodos
Zigoma/cirurgia
[Mh] Termos MeSH secundário: Cadáver
Feminino
Cabeça/anatomia & histologia
Seres Humanos
Masculino
Zigoma/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


  9 / 8516 MEDLINE  
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[PMID]:28434953
[Au] Autor:Nagata Y; Watanabe T; Nagatani T; Takeuchi K; Chu J; Wakabayashi T
[Ad] Endereço:Department of Neurosurgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Aichi, Japan. Electronic address: you1ngta@gmail.com.
[Ti] Título:The Multiscope Technique for Microvascular Decompression.
[So] Source:World Neurosurg;103:310-314, 2017 Jul.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Endoscopic surgery has rapidly become widespread in neurosurgery in recent years. Endoscopy can offer close and panoramic surgical views with fine illumination, even in the deep intracranial area. However, it also has the following serious drawback: an intracranial blind area between the field lens of the endoscope and the site of the dural opening. This blind area cannot be viewed on the endoscopic monitor, and several surgical complications, including accidental intracranial neurovascular structural injury, can occur in this area. In this article, we report a new multiscope surgical technique that can compensate for this serious disadvantage of endoscopic surgery. METHODS: In the multiscope technique, endoscopic and exoscopic systems are used simultaneously with 2 monitors. Microvascular decompression (MVD) is performed fully endoscopically using an exoscope that compensates for the intracranial blind area of the endoscopic view. Two high-definition monitors for the endoscope and exoscope are placed side-by-side in front of the primary surgeon. RESULTS: Two patients with hemifacial spasm were treated by endoscopic MVD with the multiscope technique. In these procedures, fine surgical views were obtained by both the endoscope and exoscope. Two monitors were placed side-by-side in front of the surgeon; as a result, the physician could easily view them simultaneously during the operation. No surgery-related complications occurred. CONCLUSIONS: The multiscope technique can facilitate the performance of safer neuroendoscopic surgery than conventional endoscopic surgery. This technique can also be adopted in other skull base surgeries, in which the importance of endoscopy is growing.
[Mh] Termos MeSH primário: Doenças do Nervo Facial/cirurgia
Nervo Facial/cirurgia
Espasmo Hemifacial/cirurgia
Cirurgia de Descompressão Microvascular/métodos
Neuroendoscopia/métodos
[Mh] Termos MeSH secundário: Doenças do Nervo Facial/complicações
Feminino
Espasmo Hemifacial/etiologia
Seres Humanos
Masculino
Cirurgia de Descompressão Microvascular/instrumentação
Meia-Idade
Neuroendoscopia/instrumentação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  10 / 8516 MEDLINE  
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[PMID]:28415058
[Au] Autor:Nishi K; Murai S; Itami H; Otsuka S; Kusaka N; Nishiura T; Kimura N; Ogihara K
[Ad] Endereço:Department of Neurosurgery, National Hospital Organization Iwakuni Clinical Center.
[Ti] Título:[A Case of Arteriovenous Malformation of the Parotid Gland Associated with Cowden Disease].
[So] Source:No Shinkei Geka;45(4):333-338, 2017 Apr.
[Is] ISSN:0301-2603
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a rare case of arteriovenous malformation(AVM)of the parotid gland associated with Cowden disease successfully treated with preoperative embolization followed by surgical removal. A 39-year-old man with a history of Cowden disease presented with a pulsating and growing mass on his left lower jaw. Contrast-enhanced computed tomography(CT)and angiography revealed a high-flow AVM in the deep lobe of the left parotid gland. After intravascular embolization of the feeding arteries, surgery was performed using the NIM-response®3.0, facial nerve monitoring system. The AVM was almost completely removed and the facial nerves were morphologically preserved. Interestingly, the intraoperative findings revealed that the enlarged vasa nervorum of the facial nerve also fed the AVM. Although left facial nerve palsy appeared after the surgery, the nerve function gradually improved over one year. No recurrence of the AVM has been observed for one year.
[Mh] Termos MeSH primário: Nervo Facial/cirurgia
Síndrome do Hamartoma Múltiplo/cirurgia
Malformações Arteriovenosas Intracranianas/cirurgia
Recidiva Local de Neoplasia/cirurgia
Glândula Parótida/cirurgia
[Mh] Termos MeSH secundário: Adulto
Angiografia Cerebral/métodos
Síndrome do Hamartoma Múltiplo/diagnóstico
Seres Humanos
Masculino
Recidiva Local de Neoplasia/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.11477/mf.1436203505



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