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[PMID]:29366748
[Au] Autor:Teixeira RB; Zimmer A; de Castro AL; Carraro CC; Casali KR; Dias IGM; Godoy AEG; Litvin IE; Belló-Klein A; da Rosa Araujo AS
[Ad] Endereço:Laboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Título:Exercise training versus T3 and T4 hormones treatment: The differential benefits of thyroid hormones on the parasympathetic drive of infarcted rats.
[So] Source:Life Sci;196:93-101, 2018 Mar 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: This study aimed to investigate whether beneficial effects of thyroid hormones are comparable to those provided by the aerobic exercise training, to verify its applicability as a therapeutic alternative to reverse the pathological cardiac remodeling post-infarction. MATERIALS AND METHODS: Male rats were divided into SHAM-operated (SHAM), myocardial infarction (MI), MI subjected to exercise training (MIE), and MI who received T3 and T4 treatment (MIH) (n = 8/group). MI, MIE and MIH groups underwent an infarction surgery while SHAM was SHAM-operated. One-week post-surgery, MIE and MIH groups started the exercise training protocol (moderate intensity on treadmill), or the T3 (1.2 µg/100 g/day) and T4 (4.8 µg/100 g/day) hormones treatment by gavage, respectively, meanwhile SHAM and MI had no intervention for 9 weeks. The groups were accompanied until 74 days after surgery, when all animals were anesthetized, left ventricle echocardiography and femoral catheterization were performed, followed by euthanasia and left ventricle collection for morphological, oxidative stress, and intracellular kinases expression analysis. KEY FINDINGS: Thyroid hormones treatment was more effective in cardiac dilation and infarction area reduction, while exercise training provided more protection against fibrosis. Thyroid hormones treatment increased the lipoperoxidation and decreased GSHPx activity as compared to MI group, increased the t-Akt2 expression as compared to SHAM group, and increased the vascular parasympathetic drive. SIGNIFICANCE: Thyroid hormones treatment provided differential benefits on the LV function and autonomic modulation as compared to the exercise training. Nevertheless, the redox unbalance induced by thyroid hormones highlights the importance of more studies targeting the ideal duration of this treatment.
[Mh] Termos MeSH primário: Terapia por Exercício
Infarto do Miocárdio/tratamento farmacológico
Infarto do Miocárdio/terapia
Sistema Nervoso Parassimpático/efeitos dos fármacos
Condicionamento Físico Animal
Tiroxina/uso terapêutico
Tri-Iodotironina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Ecocardiografia
Fibrose
Hipertrofia Ventricular Esquerda/diagnóstico por imagem
Hipertrofia Ventricular Esquerda/etiologia
Hipertrofia Ventricular Esquerda/patologia
Masculino
Infarto do Miocárdio/diagnóstico por imagem
Estresse Oxidativo/efeitos dos fármacos
Sistema Nervoso Parassimpático/fisiopatologia
Proteínas Proto-Oncogênicas c-akt/biossíntese
Proteínas Proto-Oncogênicas c-akt/genética
Ratos
Ratos Wistar
Sistema Nervoso Simpático/efeitos dos fármacos
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
06LU7C9H1V (Triiodothyronine); EC 2.7.11.1 (Akt2 protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 8264 MEDLINE  
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[PMID]:29254326
[Au] Autor:Rosato E; Gigante A; Liberatori M; Gasperini ML; Barbano B; Amoroso A; Tubani L; Laviano A
[Ad] Endereço:Department of Clinical Medicine, Scleroderma Unit, Sapienza University of Rome, Italy.
[Ti] Título:Altered diurnal cardiac sympathovagal balance correlates with nutritional status indexes in systemic sclerosis patients.
[So] Source:J Biol Regul Homeost Agents;31(4):1133-1138, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Autonomic nervous system is involved in body weight regulation. Gastrointestinal manifestations of systemic sclerosis (SSc) can influence patients’ nutritional status and facilitate the development of protein–energy malnutrition. The aim of the study is to assess the nutritional status of SSc patients and to explore its possible correlation with autonomic dysfunction using heart rate variability (HRV). We enrolled 19 SSc subjects and 19 healthy subjects as controls. Body mass index (BMI) and body surface area (BSA) were collected and recorded in all patients. HRV was measured and the domains of low frequencies (LF, index of the sympathetic modulation) and high frequencies (HF, index of the parasympathetic modulation) were recorded. As assessed by the LF/HF RATIO, sympathovagal balance is altered in SSc patients because of increased sympathetic modulation and reduced parasympathetic activity. BMI positively correlates with LF (r=0.57; p less than 0.01) and LF/HF RATIO during daytime (r= 0.46; p less than 0.05). Similarly, BSA positively correlates with LF (r= 0.51; p less than 0.05), LF day time (r= 0.53; p less than 0.05) and LF/HF RATIO night time (r=-0.51; p less than 0.05). In SSc patients the autonomic dysfunction is characterized by increased sympathetic modulation. We observed a correlation between autonomic dysfunction and nutritional status in SSc patients.
[Mh] Termos MeSH primário: Ritmo Circadiano
Estado Nutricional
Sistema Nervoso Parassimpático/fisiopatologia
Escleroderma Sistêmico/fisiopatologia
Sistema Nervoso Simpático/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea
Índice de Massa Corporal
Peso Corporal
Estudos de Casos e Controles
Feminino
Frequência Cardíaca
Seres Humanos
Masculino
Meia-Idade
Escleroderma Sistêmico/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29320537
[Au] Autor:Garabedian C; Clermont-Hama Y; Sharma D; Aubry E; Butruille L; Deruelle P; Storme L; De Jonckheere J; Houfflin-Debarge V
[Ad] Endereço:Univ. Lille, EA 4489 -Perinatal Environment and Health, Lille, France.
[Ti] Título:Correlation of a new index reflecting the fluctuation of parasympathetic tone and fetal acidosis in an experimental study in a sheep model.
[So] Source:PLoS One;13(1):e0190463, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The autonomic nervous system plays a leading role in the control of fetal homeostasis. Fetal heart rate variability (HRV) analysis is a reflection of its activity. We developed a new index (the Fetal Stress Index, FSI) reflecting parasympathetic tone. The objective of this study was to evaluate this index as a predictor of fetal acid-base status. This was an experimental study on chronically instrumented fetal lambs (n = 11, surgery at 128 +/- 2 days gestational age, term = 145 days). The model was based on 75% occlusion of the umbilical cord for a maximum of 120 minutes or until an arterial pH ≤ 7.20 was reached. Hemodynamic, gasometric and FSI parameters were recorded throughout the experimentation. We studied the FSI during the 10 minutes prior to pH samplings and compared values for pH>7.20 and pH≤ 7.20. In order to analyze the FSI evolution during the 10 minutes periods, we analyzed the minimum, maximum and mean values of the FSI (respectively FSImin, FSImax and FSImean) over the periods. 11 experimentations were performed. During occlusion, the heart rate dropped with an increase in blood pressure (respectively 160(155-182) vs 106(101-120) bpm and 42(41-45) vs 58(55-62) mmHg after occlusion). The FSImin was 38.6 (35.2-43.3) in the group pH>7.20 and was higher in the group pH less than 7.20 (46.5 (43.3-52.0), p = 0.012). The correlation of FSImin was significant for arterial pH (coefficient of -0.671; p = 0.004) and for base excess (coefficient of -0.632; p = 0.009). The correlations were not significant for the other parameters. In conclusion, our new index seems well correlated with the fetal acid-base status. Other studies must be carried out in a situation close to the physiology of labor by sequential occlusion of the cord.
[Mh] Termos MeSH primário: Acidose/fisiopatologia
Doenças Fetais/fisiopatologia
Sistema Nervoso Parassimpático/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190463


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[PMID]:29049251
[Au] Autor:Kao MC; Tzeng IS; Chan HL
[Ad] Endereço:aDepartment of Anesthesiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City bSchool of Medicine, Tzu Chi University, Hualien cDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City dDepartment of Electrical Engineering, Chang Gung University, Taoyuan eNeuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan.
[Ti] Título:Esmolol pretreatment attenuates heart rate increase and parasympathetic inhibition during rapid increases in desflurane concentration: A preliminary randomized study.
[So] Source:Medicine (Baltimore);96(42):e8340, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rapid increases in desflurane concentration can transiently increase the heart rate (HR). Esmolol possesses a high ß1-adrenoceptor selectivity and a short duration of action. This preliminary study aimed at investigating the effects of esmolol on the HR and autonomic modulation during a desflurane-induced HR increase. METHODS: American Society of Anesthesiologists physical status I female subjects, aged 20 to 50 years, who were undergoing minor breast surgery were randomly assigned to 2 groups. Rapid increases in desflurane concentration were commenced after induction of anesthesia. Each subject received either i.v. saline (control group) or esmolol 0.5 mg/kg (esmolol group) before desflurane inhalation. Using time-frequency spectral analysis of HR variability, the HR indices were studied at baseline, postinduction, posttreatment, as well as at minimal alveolar concentrations of desflurane reaching 1.0, 1.3, and 1.5. The low frequency (LF) power is influenced by both the sympathetic and parasympathetic activity, whereas the high frequency (HF) power reflects the parasympathetic activity. The LF/HF ratio is thought to reflect either sympathovagal balance or sympathetic modulation. RESULTS: Electrocardiograms for data analysis were obtained from 8 subjects in each group. Rapid increases in desflurane concentration after induction caused a HR increase. Both the corresponding LF and HF powers were low and the LF/HF ratio remained unchanged. This indicates that the desflurane-induced HR increase may be attributed to parasympathetic inhibition and may be independent of sympathetic activation. Esmolol pretreatment effectively attenuated desflurane-induced HR increase. Moreover, subjects receiving esmolol pretreatment had increased LF and HF powers, but did not have changes in their LF/HF ratios, as compared to those without esmolol. CONCLUSION: Esmolol pretreatment attenuates HR increase and parasympathetic inhibition during rapid increases in desflurane concentration.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/efeitos adversos
Frequência Cardíaca/efeitos dos fármacos
Isoflurano/análogos & derivados
Sistema Nervoso Parassimpático/efeitos dos fármacos
Propanolaminas/farmacologia
[Mh] Termos MeSH secundário: Adulto
Eletrocardiografia
Feminino
Seres Humanos
Isoflurano/efeitos adversos
Meia-Idade
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Propanolamines); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane); MDY902UXSR (esmolol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008340


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[PMID]:28726661
[Au] Autor:Kuleshov A
[Ad] Endereço:National Pirogov Memorial Medical University, Ukraine.
[Ti] Título:[HEART RATE VARIABILITY IN CHILDREN WITH FALSE CHORDS IN THE LEFT CARDIAC VENTRICULAR].
[So] Source:Georgian Med News;(267):84-88, 2017 Jun.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:rus
[Ab] Resumo:We examined 64 children with false tendons in the left cardiac ventricular. The research included evaluation of time and frequency domain parameters of the heart rhythm with cardiointervalography. The parameter changes were noted. Thus, sympathetic vegetative system (VS) part prevalence was present in boys and characterized by decreasing of SDNN when compared with control data (85,4±5,8 и 158,2 ±25,6, Ñ€<0,05). rMSSD and PNN50%, which are responsible for parasympathetic VS part have the tendency to increasing in girls. Nevertheless, frequency domain analysis showed an increasing of the total spectrum power (TP) in both subgroups with statistically significant result (4734,2±319,4 and 3520±381 - boys, Ñ€<0,05 when compared with control; 4961,7±413,7 and 3520±381, Ñ€<0,05 - girls, respectively). That was proved by other parameters. VLF were also increased when compared with control group (4188,4±413,1 and 1717±154, Ñ€<0,05 - boys; 3050,5±468,1 and 1433±811 - girls, Ñ€<0,05, respectively), which characterizes sympathetic VS part prevalence in both subgroups. Other frequency domain parameters statistically were not changed but they had tendency as to increasing as to decreasing. All previously noted shows the sympathicotonia in children with FT. These children should be under observation of pediatricians and child cardiologists.
[Mh] Termos MeSH primário: Frequência Cardíaca
Ventrículos do Coração/inervação
Tendões/anormalidades
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Feminino
Ventrículos do Coração/anormalidades
Seres Humanos
Masculino
Sistema Nervoso Parassimpático/fisiopatologia
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


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[PMID]:28708930
[Au] Autor:Adams SC; DeLorey DS; Davenport MH; Stickland MK; Fairey AS; North S; Szczotka A; Courneya KS
[Ad] Endereço:Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Effects of high-intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial.
[So] Source:Cancer;123(20):4057-4065, 2017 Oct 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Testicular cancer survivors (TCS) have an increased risk of treatment-related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high-intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a population-based sample of TCS. METHODS: This phase 2 trial (ClinicalTrials.gov identifier NCT02459132) randomly assigned 63 TCS to usual care (UC) or 12 weeks of supervised HIIT (ie, alternating periods of vigorous-intensity and light-intensity aerobic exercise). The primary outcome was peak aerobic fitness (VO ) assessed via a treadmill-based maximal cardiorespiratory exercise test. Secondary endpoints included CVD risk (eg, Framingham Risk Score), arterial health, parasympathetic nervous system function, and blood-based biomarkers. RESULTS: Postintervention VO data were obtained for 61 participants (97%). HIIT participants attended 99% of the exercise sessions and achieved 98% of the target exercise intensity. Analysis of covariance demonstrated that HIIT was superior to UC for improving VO (adjusted between-group mean difference, 3.7 mL O /kg/min; 95% confidence interval, 2.4-5.1 [P<.001]) and multiple secondary outcomes including CVD risk (P = .011), arterial thickness (P<.001), arterial stiffness (P<.001), postexercise parasympathetic reactivation (P = .001), inflammation (P = .045), and low-density lipoprotein (P = .014). Overall, HIIT reduced the prevalence of modifiable CVD risk factors by 20% compared with UC. CONCLUSIONS: This randomized trial provides the first evidence that HIIT improves cardiorespiratory fitness, multiple pathways of CVD risk, and surrogate markers of mortality in TCS. These findings have important implications for the management of TCS. Further research concerning the long-term effects of HIIT on CVD morbidity and mortality in TCS is warranted. Cancer 2017;123:4057-65. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Treinamento Intervalado de Alta Intensidade/métodos
Sobreviventes
Neoplasias Testiculares/reabilitação
[Mh] Termos MeSH secundário: Adulto
Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/fisiopatologia
Doenças das Artérias Carótidas/epidemiologia
Comorbidade
Teste de Esforço
Terapia por Exercício
Seres Humanos
Hipogonadismo/epidemiologia
Inflamação
Lipoproteínas LDL/metabolismo
Masculino
Síndrome Metabólica/epidemiologia
Meia-Idade
Obesidade/epidemiologia
Consumo de Oxigênio
Sistema Nervoso Parassimpático/fisiopatologia
Aptidão Física
Pré-Hipertensão/epidemiologia
Neoplasias Testiculares/epidemiologia
Rigidez Vascular/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Lipoproteins, LDL)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30859


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[PMID]:28701323
[Au] Autor:Becker BK; Feagans AC; Chen D; Kasztan M; Jin C; Speed JS; Pollock JS; Pollock DM
[Ad] Endereço:Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:Renal denervation attenuates hypertension but not salt sensitivity in ET receptor-deficient rats.
[So] Source:Am J Physiol Regul Integr Comp Physiol;313(4):R425-R437, 2017 Oct 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertension is a prevalent pathology that increases risk for numerous cardiovascular diseases. Because the etiology of hypertension varies across patients, specific and effective therapeutic approaches are needed. The role of renal sympathetic nerves is established in numerous forms of hypertension, but their contribution to salt sensitivity and interaction with factors such as endothelin-1 are poorly understood. Rats deficient of functional ET receptors (ET -def) on all tissues except sympathetic nerves are hypertensive and exhibit salt-sensitive increases in blood pressure. We hypothesized that renal sympathetic nerves contribute to hypertension and salt sensitivity in ET -def rats. The hypothesis was tested through bilateral renal sympathetic nerve denervation and measuring blood pressure during normal salt (0.49% NaCl) and high-salt (4.0% NaCl) diets. Denervation reduced mean arterial pressure in ET -def rats compared with sham-operated controls by 12 ± 3 (SE) mmHg; however, denervation did not affect the increase in blood pressure after 2 wk of high-salt diet (+19 ± 3 vs. +16 ± 3 mmHg relative to normal salt diet; denervated vs. sham, respectively). Denervation reduced cardiac sympathetic-to-parasympathetic tone [low frequency-high frequency (LF/HF)] during normal salt diet and vasomotor LF/HF tone during high-salt diet in ET -def rats. We conclude that the renal sympathetic nerves contribute to the hypertension but not to salt sensitivity of ET -def rats.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Denervação
Hipertensão/genética
Hipertensão/cirurgia
Rim/inervação
Receptor de Endotelina B/genética
Cloreto de Sódio na Dieta/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Barorreflexo/efeitos dos fármacos
Barorreflexo/fisiologia
Pressão Sanguínea/efeitos dos fármacos
Hipertensão/fisiopatologia
Rim/fisiopatologia
Rim/cirurgia
Sistema Nervoso Parassimpático/fisiopatologia
Ratos
Ratos Transgênicos
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Endothelin B); 0 (Sodium Chloride, Dietary)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00174.2017


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[PMID]:28700617
[Au] Autor:Garabedian C; Champion C; Servan-Schreiber E; Butruille L; Aubry E; Sharma D; Logier R; Deruelle P; Storme L; Houfflin-Debarge V; De Jonckheere J
[Ad] Endereço:Univ. Lille, EA 4489 - Perinatal Environment and Health, Lille, France.
[Ti] Título:A new analysis of heart rate variability in the assessment of fetal parasympathetic activity: An experimental study in a fetal sheep model.
[So] Source:PLoS One;12(7):e0180653, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Analysis of heart rate variability (HRV) is a recognized tool in the assessment of autonomic nervous system (ANS) activity. Indeed, both time and spectral analysis techniques enable us to obtain indexes that are related to the way the ANS regulates the heart rate. However, these techniques are limited in terms of the lack of thresholds of the numerical indexes, which is primarily due to high inter-subject variability. We proposed a new fetal HRV analysis method related to the parasympathetic activity of the ANS. The aim of this study was to evaluate the performance of our method compared to commonly used HRV analysis, with regard to i) the ability to detect changes in ANS activity and ii) inter-subject variability. This study was performed in seven sheep fetuses. In order to evaluate the sensitivity and specificity of our index in evaluating parasympathetic activity, we directly administered 2.5 mg intravenous atropine, to inhibit parasympathetic tone, and 5 mg propranolol to block sympathetic activity. Our index, as well as time analysis (root mean square of the successive differences; RMSSD) and spectral analysis (high frequency (HF) and low frequency (LF) spectral components obtained via fast Fourier transform), were measured before and after injection. Inter-subject variability was estimated by the coefficient of variance (%CV). In order to evaluate the ability of HRV parameters to detect fetal parasympathetic decrease, we also estimated the effect size for each HRV parameter before and after injections. As expected, our index, the HF spectral component, and the RMSSD were reduced after the atropine injection. Moreover, our index presented a higher effect size. The %CV was far lower for our index than for RMSSD, HF, and LF. Although LF decreased after propranolol administration, fetal stress index, RMSSD, and HF were not significantly different, confirming the fact that those indexes are specific to the parasympathetic nervous system. In conclusion, our method appeared to be effective in detecting parasympathetic inhibition. Moreover, inter-subject variability was much lower, and effect size higher, with our method compared to other HRV analysis methods.
[Mh] Termos MeSH primário: Feto/fisiologia
Frequência Cardíaca/fisiologia
Sistema Nervoso Parassimpático/fisiologia
[Mh] Termos MeSH secundário: Administração Intravenosa
Animais
Atropina/administração & dosagem
Atropina/farmacologia
Gasometria
Feminino
Feto/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Modelos Animais
Sistema Nervoso Parassimpático/efeitos dos fármacos
Propranolol/administração & dosagem
Propranolol/farmacologia
Ovinos
Estresse Fisiológico/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7C0697DR9I (Atropine); 9Y8NXQ24VQ (Propranolol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180653


  9 / 8264 MEDLINE  
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[PMID]:28637453
[Au] Autor:Hu X; Yuan M; Yin Y; Wang Y; Li Y; Zhang N; Sun X; Yu Z; Xu B
[Ad] Endereço:Key Laboratory of Integrated Acupuncture and Drugs Constructed, Nanjing University of Chinese Medicine, Ministry of Education, Nanjing, 210023, China.
[Ti] Título:Electroacupuncture at LI11 promotes jejunal motility via the parasympathetic pathway.
[So] Source:BMC Complement Altern Med;17(1):329, 2017 Jun 21.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gastrointestinal motility disorder has been demonstrated to be regulated by acupuncture treatment. The mechanisms underlying the effects of acupuncture stimulation of abdominal and lower limb acupoints on gastrointestinal motility have been thoroughly studied; however, the physiology underlying the effects of acupuncture on the forelimbs to mediate gastrointestinal motility requires further exploration. The aim of this study was to determine whether electroacupuncture (EA) at LI11 promotes jejunal motility, whether the parasympathetic pathway participates in this effect, and if so, which somatic afferent nerve fibres are involved. METHODS: A manometric balloon was used to observe jejunal motility. The effects and mechanisms of EA at LI11 were explored in male Sprague-Dawley rats with or without drug administration (propranolol, clenbuterol, acetylcholine, and atropine) and with or without vagotomy. Three types of male mice (ß ß receptor-knockout [ß ß ] mice, M M receptor-knockout [M M ] mice and wild-type [WT] mice) were also studied by using different EA intensities (1, 2, 4, 6, and 8 mA). A total of 72 rats and 56 mice were included in the study. RESULTS: EA at LI11 increased the contractile amplitude of jejunal motility in the majority of both rats and mice. However, EA at LI11 did not enhance jejunal motility in rats administered atropine, rats that underwent vagotomy, and M M mice (at all intensities). In WT mice, EA at LI11 significantly increased jejunal motility at all intensities except 1 mA, and a plateau was reached at intensities greater than 4 mA. CONCLUSION: Our results suggest that EA at LI11 promotes jejunal motility primarily by exciting the parasympathetic pathway, and that Aδ-fibres and C-fibres may play important roles in the process.
[Mh] Termos MeSH primário: Eletroacupuntura
Gastroenteropatias/terapia
Jejuno/fisiopatologia
Sistema Nervoso Parassimpático/fisiopatologia
[Mh] Termos MeSH secundário: Pontos de Acupuntura
Terapia por Acupuntura
Animais
Gastroenteropatias/fisiopatologia
Motilidade Gastrointestinal
Seres Humanos
Masculino
Camundongos Knockout
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1826-9


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[PMID]:28587876
[Au] Autor:Scarduzio M; Zimmerman CN; Jaunarajs KL; Wang Q; Standaert DG; McMahon LL
[Ad] Endereço:Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
[Ti] Título:Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia.
[So] Source:Exp Neurol;295:162-175, 2017 Sep.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Balance between cholinergic and dopaminergic signaling is central to striatal control of movement and cognition. In dystonia, a common disorder of movement, anticholinergic therapy is often beneficial. This observation suggests there is a pathological increase in cholinergic tone, yet direct confirmation is lacking. In DYT1, an early-onset genetic form of dystonia caused by a mutation in the protein torsinA (TorA), the suspected heightened cholinergic tone is commonly attributed to faulty dopamine D2 receptor (D2R) signaling where D2R agonists cause excitation of striatal cholinergic interneurons (ChIs), rather than the normal inhibition of firing observed in wild-type animals, an effect known as "paradoxical excitation". Here, we provide for the first time direct measurement of elevated striatal extracellular acetylcholine (ACh) in a knock-in mouse model of human DYT1 dystonia (TorA mice), confirming a striatal hypercholinergic state. We hypothesized that this elevated extracellular ACh might cause chronic over-activation of muscarinic acetylcholine receptors (mAChRs) and disrupt normal D2R function due to their shared coupling to G -proteins. We tested this concept in vitro first using a broad-spectrum mAChR antagonist, and then using a M2/M4 mAChR selective antagonist to specifically target mAChRs expressed by ChIs. Remarkably, we found that mAChR inhibition reverses the D2R-mediated paradoxical excitation of ChIs recorded in slices from TorA mice to a typical inhibitory response. Furthermore, we recapitulated the paradoxical D2R excitation of ChIs in striatal slices from wild-type mice within minutes by simply increasing cholinergic tone through pharmacological inhibition of acetylcholinesterase (AChE) or by prolonged agonist activation of mAChRs. Collectively, these results show that enhanced mAChR tone itself is sufficient to rapidly reverse the polarity of D2R regulation of ChI excitability, correcting the previous notion that the D2R mediated paradoxical ChI excitation causes the hypercholinergic state in dystonia. Further, using a combination of genetic and pharmacological approaches, we found evidence that this switch in D2R polarity results from a change in coupling from the preferred G pathway to non-canonical ß-arrestin signaling. These results highlight the need to fully understand how the mutation in TorA leads to pathologically heightened extracellular ACh. Furthermore the discovery of this novel ACh-dopamine interaction and the participation of ß-arrestin in regulation of cholinergic interneurons is likely important for other basal ganglia disorders characterized by perturbation of ACh-dopamine balance, including Parkinson and Huntington diseases, l-DOPA-induced dyskinesia and schizophrenia.
[Mh] Termos MeSH primário: Distonia/genética
Distonia/fisiopatologia
Interneurônios
Chaperonas Moleculares/genética
Neostriado/fisiopatologia
Sistema Nervoso Parassimpático/fisiopatologia
Receptores de Dopamina D2/metabolismo
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Inibidores da Colinesterase/farmacologia
Técnicas de Introdução de Genes
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Chaperonas Moleculares/metabolismo
Neostriado/metabolismo
Sistema Nervoso Parassimpático/citologia
Receptores Muscarínicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (DRD2 protein, mouse); 0 (Molecular Chaperones); 0 (Receptors, Dopamine D2); 0 (Receptors, Muscarinic); 0 (TOR1A protein, human); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE



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