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[PMID]:28456809
[Au] Autor:Pearce JMS
[Ad] Endereço:Emeritus Consultant Neurologist, Department of Neurology, Hull Royal Infirmary, Hull, UK.
[Ti] Título:Samuel Thomas Soemmerring (1755-1830): The Naming of Cranial Nerves.
[So] Source:Eur Neurol;77(5-6):303-306, 2017.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Samuel Thomas Soemmerring was a Prussian polymathic doctor with remarkable achievements in anatomy, draftsmanship and inventions. His naming of 12 pairs of cranial nerves in his graduation thesis is of particular importance. He also gave original descriptions of the macula, sensory pathways and of the substantia nigra. His non-medical contributions were diverse and included criticism of the guillotine, invention of a telegraphic system, and discoveries in palaeontology.
[Mh] Termos MeSH primário: Nervos Cranianos
Neuroanatomia/história
[Mh] Termos MeSH secundário: História do Século XVIII
História do Século XIX
Seres Humanos
Masculino
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Soemmerring ST
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1159/000475812


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[PMID]:28457000
[Au] Autor:O'gorman CM; Weikamp JG; Baria M; Van Den Engel-Hoek L; Kassardjian C; Van Alfen N; Boon AJ
[Ad] Endereço:Department of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA.
[Ti] Título:Detecting fasciculations in cranial nerve innervated muscles with ultrasound in amyotrophic lateral sclerosis.
[So] Source:Muscle Nerve;56(6):1072-1076, 2017 Dec.
[Is] ISSN:1097-4598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cranial muscle fasciculations may be difficult to detect in amyotrophic lateral sclerosis (ALS). Ultrasound (US) detection of fasciculations in these muscles may have clinical utility. METHODS: Patients with suspected ALS were prospectively enrolled. Nerve conduction studies, needle electromyography (EMG), and US examination of cranial muscles were performed. Controls were examined by US only. Fasciculations were counted and scored for each muscle after 10 or 30 seconds. RESULTS: There were 84 patients with ALS. Fasciculations were most frequently found in the genioglossus muscle. Overall, detection rates by US and EMG were similar, but US was more likely to detect frequent fasciculations. Fasciculations were rare in controls, seen in 7 of 1,090 (0.6%) muscles. No control had > 5 fasciculations in any muscle. DISCUSSION: Fasciculations were frequently detected in cranial muscles of patients with ALS. US was found to be a sensitive method, and was not impaired by factors such as anxiety and the inability of the patient to relax. Muscle Nerve 56: 1072-1076, 2017.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/diagnóstico por imagem
Nervos Cranianos/diagnóstico por imagem
Fasciculação/diagnóstico por imagem
Músculo Esquelético/diagnóstico por imagem
Músculo Esquelético/inervação
[Mh] Termos MeSH secundário: Idoso
Esclerose Amiotrófica Lateral/fisiopatologia
Nervos Cranianos/fisiopatologia
Eletromiografia/métodos
Fasciculação/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Músculo Esquelético/fisiopatologia
Condução Nervosa/fisiologia
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1002/mus.25676


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[PMID]:28423034
[Au] Autor:Linedale R; Schmidt C; King BT; Ganko AG; Simpson F; Panizza BJ; Leggatt GR
[Ad] Endereço:The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia.
[Ti] Título:Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.
[So] Source:PLoS One;12(4):e0175755, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.
[Mh] Termos MeSH primário: Antígeno CTLA-4/genética
Carcinoma de Células Escamosas/genética
Neoplasias de Cabeça e Pescoço/genética
Receptor Celular 2 do Vírus da Hepatite A/genética
Recidiva Local de Neoplasia/genética
Receptor de Morte Celular Programada 1/genética
Neoplasias Cutâneas/genética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antígeno B7-H1/genética
Antígeno B7-H1/imunologia
Linfócitos T CD8-Positivos/imunologia
Linfócitos T CD8-Positivos/patologia
Antígeno CTLA-4/imunologia
Carcinoma de Células Escamosas/imunologia
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/cirurgia
Estudos de Coortes
Nervos Cranianos/imunologia
Nervos Cranianos/patologia
Nervos Cranianos/cirurgia
Feminino
Citometria de Fluxo
Regulação Neoplásica da Expressão Gênica
Neoplasias de Cabeça e Pescoço/imunologia
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/cirurgia
Receptor Celular 2 do Vírus da Hepatite A/imunologia
Seres Humanos
Células Matadoras Naturais/imunologia
Células Matadoras Naturais/patologia
Masculino
Meia-Idade
Recidiva Local de Neoplasia/imunologia
Recidiva Local de Neoplasia/patologia
Recidiva Local de Neoplasia/cirurgia
Receptor de Morte Celular Programada 1/imunologia
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (CTLA-4 Antigen); 0 (HAVCR2 protein, human); 0 (Hepatitis A Virus Cellular Receptor 2); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175755


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[PMID]:28362892
[Au] Autor:Zamora C; Castillo M
[Ti] Título:Sellar and Parasellar Imaging.
[So] Source:Neurosurgery;80(1):17-38, 2017 Jan 01.
[Is] ISSN:1524-4040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The skull base is a complex anatomical region that harbors many important neurovascular structures in a relatively confined space. The pathology that can develop at this site is varied, and many disease processes may present with similar clinical and neuroimaging findings. While computed tomography maintains a role in the evaluation of many entities and can, for instance, delineate osseous erosion with great detail and characterize calcified tumor matrices, magnetic resonance imaging (MRI) is the mainstay in the neuroimaging assessment of most pathology occurring at the skull base. Various MRI sequences have proven to be robust tools for tissue characterization and can provide information on the presence of lipids, paramagnetic and diamagnetic elements, and tumor cellularity, among others. In addition, currently available MRI techniques are able to generate high spatial resolution images that allow visualization of cranial nerves and their involvement by adjacent pathology. The information obtained from such examinations may aid in the distinction of these disease processes and in the accurate delineation of their extent prior to biopsy or treatment planning.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Neuroimagem
Sela Túrcica/diagnóstico por imagem
Base do Crânio/diagnóstico por imagem
[Mh] Termos MeSH secundário: Nervos Cranianos
Seres Humanos
Imagem por Ressonância Magnética
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1093/neuros/nyw013


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[PMID]:28243811
[Au] Autor:Horiuchi T; Nagm A; Hasegawa T; Hongo K
[Ad] Endereço:Department of Neurosurgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Japan. tetuyosi@shinshu-u.ac.jp.
[Ti] Título:Transjugular tubercle-preaccessory approach for ventrocaudally located PICA aneurysm.
[So] Source:Acta Neurochir (Wien);159(4):641-644, 2017 Apr.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Posterior inferior cerebellar artery (PICA) aneurysms are often located in the ventral craniocervical junction. Such deep-seated aneurysms are usually treated with coil embolization. However, recurred and/or very small PICA aneurysms are hardly treated with an endovascular approach. METHOD: We present a modification of the transcondylar fossa approach with intradural and extradural removal of the jugular tubercle. An adequate preaccessory surgical corridor was created with this novel technique. CONCLUSION: The ventocaudal PICA aneurysm was clipped through the outside of the spinal accessory nerve without surgical manipulation of other lower cranial nerves. This approach is worthwhile to avoid dysphagia.
[Mh] Termos MeSH primário: Cerebelo/irrigação sanguínea
Aneurisma Intracraniano/cirurgia
Microcirurgia/métodos
Procedimentos Neurocirúrgicos/métodos
[Mh] Termos MeSH secundário: Artérias/cirurgia
Cerebelo/cirurgia
Nervos Cranianos/cirurgia
Feminino
Seres Humanos
Masculino
Microcirurgia/efeitos adversos
Meia-Idade
Procedimentos Neurocirúrgicos/efeitos adversos
Complicações Pós-Operatórias/prevenção & controle
Instrumentos Cirúrgicos/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-017-3126-z


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[PMID]:28214652
[Au] Autor:Posa A; Emmer A; Kornhuber ME
[Ad] Endereço:Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. Electronic address: andreas.posa@medizin.uni-halle.de.
[Ti] Título:Unilateral oculomotor palsy in Charcot-Marie-Tooth disease 1A (CMT 1A).
[So] Source:Clin Neurol Neurosurg;155:20-21, 2017 Apr.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Charcot-Marie-Tooth disease (CMT) type 1A is the most common form of CMT 1 and one of the autosomal dominant demyelinating hereditary motor and sensory neuropathies (HMSN). Cranial nerves may be frequently subclinically affected in CMT disease. However manifest clinical signs of cranial nerve involvement are rare. METHODS: This case comprise neurological, ophthalmological, internal medicine and ear-nose-throat investigation, motor and sensory nerve conduction velocity, auditory evoked potentials and orbicularis-oculi reflex measurements, lumbar puncture and blood examination, inclusive molecular genetic testing, as well as electrocardiogram and cranial imaging such as computer tomography and magnetic resonance imaging RESULTS: The present case shows a Charcot-Marie-Tooth (CMT) 1A patient with complete unilateral oculomotor palsy in combination with predominant ipsilateral subclinical trigeminal demyelination. A combined of third and fifth cranial nerves as in our patient has not been reported yet. CONCLUSIONS: This case shows cranial nerve involvement as an unusual leading symptom of CMT 1A. It may remind us that hereditary neuropathies have to be taken into consideration in patients with slowly progressing unilateral or asymmetric cranial neuropathies.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/fisiopatologia
Nervos Cranianos/fisiopatologia
Neuropatia Hereditária Motora e Sensorial/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Doença de Charcot-Marie-Tooth/diagnóstico
Doença de Charcot-Marie-Tooth/genética
Doenças Desmielinizantes/complicações
Doenças Desmielinizantes/diagnóstico
Doenças Desmielinizantes/fisiopatologia
Neuropatia Hereditária Motora e Sensorial/diagnóstico
Seres Humanos
Masculino
Fenótipo
Reflexo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE


  7 / 3079 MEDLINE  
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[PMID]:28209311
[Au] Autor:Malhotra A; Zhang M; Wu X; Jindal S; Durand D; Makhani N
[Ad] Endereço:Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar St, New Haven, CT 06520-8042, United States. Electronic address: ajay.malhotra@yale.edu.
[Ti] Título:MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature.
[So] Source:J Clin Neurosci;39:63-67, 2017 May.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS. CASE SERIES: We retrospectively reviewed brain imaging findings in 17 pediatric patients with of Guillain-Barré syndrome (GBS) meeting Brighton criteria who had brain MRIs performed during their acute illness. Cranial nerve enhancement was seen in 6/17 patients and optic nerve/chiasm enhancement was seen in 3 patients. CONCLUSION: Cranial nerve enhancement and optic pathway in particular, can be seen in patients with MFS. Imaging findings do not always correlate with clinical manifestations of cranial nerve involvement.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética
Síndrome de Miller Fisher/diagnóstico por imagem
Quiasma Óptico/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Tronco Encefálico/diagnóstico por imagem
Criança
Pré-Escolar
Nervos Cranianos/diagnóstico por imagem
Feminino
Síndrome de Guillain-Barré/diagnóstico por imagem
Síndrome de Guillain-Barré/terapia
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Síndrome de Miller Fisher/terapia
Neuroimagem/métodos
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28118941
[Au] Autor:Karamanakos PN; Panteli ES
[Ad] Endereço:Department of Neurosurgery, Olympion General Hospital and Rehabilitation Center, Volou and Milihou, 26443 Patras, Greece. Electronic address: pkaramanakos@olympion-sa.gr.
[Ti] Título:Comment on: Sensory-motor axonal polyneuropathy involving cranial nerves: An uncommon manifestation of disulfiram toxicity (Santos et al., Clin Neurol Neurosurg, 152:12-15, 2016).
[So] Source:Clin Neurol Neurosurg;154:109, 2017 03.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Dissulfiram
Doenças do Sistema Nervoso Periférico
[Mh] Termos MeSH secundário: Nervos Cranianos
Seres Humanos
Polineuropatias
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
TR3MLJ1UAI (Disulfiram)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:28011040
[Au] Autor:Kemp A
[Ad] Endereço:Griffith School of Environment and the School of Biomolecular and Physical Sciences, Griffith University, 170 Kessels Road, Nathan, Brisbane, Queensland 4111, Australia. Electronic address: a.kemp@griffith.edu.au.
[Ti] Título:Cranial nerves in the Australian lungfish, Neoceratodus forsteri, and in fossil relatives (Osteichthyes: Dipnoi).
[So] Source:Tissue Cell;49(1):45-55, 2017 Feb.
[Is] ISSN:1532-3072
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Three systems, two sensory and one protective, are present in the skin of the living Australian lungfish, Neoceratodus forsteri, and in fossil lungfish, and the arrangement and innervation of the sense organs is peculiar to lungfish. Peripheral branches of nerves that innervate the sense organs are slender and unprotected, and form before any skeletal structures appear. When the olfactory capsule develops, it traps some of the anterior branches of cranial nerve V, which emerged from the chondrocranium from the lateral sphenotic foramen. Cranial nerve I innervates the olfactory organ enclosed within the olfactory capsule and cranial nerve II innervates the eye. Cranial nerve V innervates the sense organs of the snout and upper lip, and, in conjunction with nerve IX and X, the sense organs of the posterior and lateral head. Cranial nerve VII is primarily a motor nerve, and a single branch innervates sense organs in the mandible. There are no connections between nerves V and VII, although both emerge from the brain close to each other. The third associated system consists of lymphatic vessels covered by an extracellular matrix of collagen, mineralised as tubules in fossils. Innervation of the sensory organs is separate from the lymphatic system and from the tubule system of fossil lungfish.
[Mh] Termos MeSH primário: Nervos Cranianos/anatomia & histologia
Peixes/anatomia & histologia
Fósseis/anatomia & histologia
Órgãos dos Sentidos/inervação
[Mh] Termos MeSH secundário: Animais
Austrália
Cabeça/anatomia & histologia
Cabeça/inervação
Vasos Linfáticos/anatomia & histologia
Órgãos dos Sentidos/anatomia & histologia
Pele/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


  10 / 3079 MEDLINE  
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[PMID]:27989971
[Au] Autor:Shkarubo AN; Chernov IV; Ogurtsova AA; Moshchev DA; Lubnin AJ; Andreev DN; Koval KV
[Ad] Endereço:Department of Neurooncology, N. N. Burdenko Institute of Neurosurgery, Moscow, Russian Federation. Electronic address: AShkarubo@nsi.ru.
[Ti] Título:Neurophysiological Identification of Cranial Nerves During Endoscopic Endonasal Surgery of Skull Base Tumors: Pilot Study Technical Report.
[So] Source:World Neurosurg;98:230-238, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Intraoperative identification of cranial nerves is crucial for safe surgery of skull base tumors. Currently, only a small number of published papers describe the technique of trigger electromyography (t-EMG) in endoscopic endonasal removal of such tumors. OBJECTIVE: To assess the effectiveness of t-EMG in preventing intraoperative cranial nerve damage in endoscopic endonasal surgery of skull base tumors. MATERIALS AND METHODS: Nine patients were operated on using the endoscopic endonasal approach within a 1-year period. The tumors included large skull base chordomas and trigeminal neurinomas localized in the cavernous sinus. During the surgical process, cranial nerve identification was carried out using monopolar and bipolar t-EMG methods. Assessment of cranial nerve functional activity was conducted both before and after tumor removal. RESULTS: We mapped 17 nerves in 9 patients. Third, fifth, and sixth cranial nerves were identified intraoperatively. There were no cases of postoperative functional impairment of the mapped cranial nerves. In one case we were unable to get an intraoperative response from the fourth cranial nerve and observed its postoperative transient plegia (the function was normal before surgery). CONCLUSION: t-EMG allows surgeons to control the safety of cranial nerves both during and after skull base tumor removal.
[Mh] Termos MeSH primário: Nervos Cranianos/fisiologia
Nervos Cranianos/cirurgia
Monitorização Neurofisiológica Intraoperatória/métodos
Cavidade Nasal/cirurgia
Neuroendoscopia/métodos
Neoplasias da Base do Crânio/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Nervos Cranianos/diagnóstico por imagem
Eletromiografia/métodos
Feminino
Seres Humanos
Meia-Idade
Cavidade Nasal/diagnóstico por imagem
Cavidade Nasal/inervação
Projetos Piloto
Relatório de Pesquisa
Neoplasias da Base do Crânio/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE



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