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  1 / 2910 MEDLINE  
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[PMID]:28738358
[Au] Autor:Sommer JU; Hörmann K
[Ti] Título:Innovative Surgery for Obstructive Sleep Apnea: Nerve Stimulator.
[So] Source:Adv Otorhinolaryngol;80:116-124, 2017.
[Is] ISSN:1662-2847
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Obstructive sleep apnea (OSA) as a multifactorial disease is treated with continuous positive airway pressure (CPAP) as the gold standard. Yet, if patients suffer from CPAP incompliance, traditional OSA surgery only targets morphological changes of the upper airway while neglecting functional issues. With the advent of upper airway stimulation, and in particular hypoglossal nerve stimulation as a treatment option, a highly effective, clinically proven and functional therapy with good evidence is available. This article gives a comprehensive overview of current and upcoming hypoglossal nerve stimulation systems (Inspire, ImThera, and Nyxoah), the specific advantages of this approach, the selection criteria and screening process, relevant clinical data, and a description of the different implantation procedures. Upper airway stimulation and hypoglossal nerve stimulation appears to be a long-term, low-morbidity treatment for moderate-to-severe OSA patients suffering from CPAP incompliance.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica/métodos
Nervo Hipoglosso
Apneia Obstrutiva do Sono/terapia
[Mh] Termos MeSH secundário: Pressão Positiva Contínua nas Vias Aéreas
Seres Humanos
Apneia Obstrutiva do Sono/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1159/000470880


  2 / 2910 MEDLINE  
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[PMID]:28684285
[Au] Autor:van Veen MM; Dijkstra PU; Werker PMN
[Ad] Endereço:University of Groningen, University Medical Centre Groningen, Department of Plastic Surgery, Groningen, The Netherlands. Electronic address: m.m.van.veen@umcg.nl.
[Ti] Título:A higher quality of life with cross-face-nerve-grafting as an adjunct to a hypoglossal-facial nerve jump graft in facial palsy treatment.
[So] Source:J Plast Reconstr Aesthet Surg;70(11):1666-1674, 2017 Nov.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nerve reconstructions are the preferred technique for short-standing facial paralysis, most commonly using the contralateral facial nerve or ipsilateral hypoglossal nerve. The hypoglossal nerve provides a strong motor signal, whereas the signal of a cross-face nerve graft is weaker but spontaneous. Spontaneity in facial expression is believed to be important for psychological wellbeing. Therefore, a combination of the two procedures incorporates the best of both: a strong motor signal and a spontaneous smile. This study aimed to objectify this expected benefit. Of the 20 patients who received a hypoglossal-facial nerve anastomosis from 1995 to 2015 in our institutions, 12 patients were included in this study, 5 with and 7 without a cross-face nerve graft. The outcomes were compared using photographs, disease-specific quality of life (Facial Clinimetric Evaluation (FaCE) scale), a self-reported synkinesis scale (Synkinesis Assessment Questionnaire) and the presence of a spontaneous smile. Significant differences were found in preoperative excursion of the affected side of the mouth and the change in excursion. Median Total FaCE scores were considerably larger (18.3 points) for patients who underwent the combined procedure. A spontaneous smile was observed both with (n = 2) and without (n = 1) a cross-face nerve graft. The addition of a cross-face nerve graft to a hypoglossal-facial nerve anastomosis resulted in a positive trend in disease-specific quality of life. This benefit could also be present with the combination of a cross-face nerve graft with another nerve transfer such as a masseteric-facial nerve anastomosis.
[Mh] Termos MeSH primário: Nervo Facial/cirurgia
Paralisia Facial/cirurgia
Nervo Hipoglosso/transplante
Músculo Esquelético/transplante
Transferência de Nervo/métodos
Qualidade de Vida
Ritidoplastia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Expressão Facial
Paralisia Facial/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Masculino
Microcirurgia/métodos
Meia-Idade
Estudos Retrospectivos
Sorriso
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  3 / 2910 MEDLINE  
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[PMID]:28676575
[Au] Autor:Skyberg R; Sun C; Hill DL
[Ad] Endereço:Department of Psychology, University of Virginia, Charlottesville, Virginia 22904-4400.
[Ti] Título:Maintenance of Mouse Gustatory Terminal Field Organization Is Disrupted following Selective Removal of Peripheral Sodium Salt Taste Activity at Adulthood.
[So] Source:J Neurosci;37(32):7619-7630, 2017 Aug 09.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural activity plays a critical role in the development of central circuits in sensory systems. However, the maintenance of these circuits at adulthood is usually not dependent on sensory-elicited neural activity. Recent work in the mouse gustatory system showed that selectively deleting the primary transduction channel for sodium taste, the epithelial sodium channel (ENaC), throughout development dramatically impacted the organization of the central terminal fields of three nerves that carry taste information to the nucleus of the solitary tract. More specifically, deleting ENaCs during development prevented the normal maturation of the fields. The present study was designed to extend these findings by testing the hypothesis that the loss of sodium taste activity impacts the maintenance of the normal adult terminal field organization in male and female mice. To do this, we used an inducible Cre-dependent genetic recombination strategy to delete ENaC function after terminal field maturation occurred. We found that removal of sodium taste neural activity at adulthood resulted in significant reorganization of mature gustatory afferent terminal fields in the nucleus of the solitary tract. Specifically, the chorda tympani and greater superficial petrosal nerve terminal fields were 1.4× and 1.6× larger than age-matched controls, respectively. By contrast, the glossopharyngeal nerve, which is not highly sensitive to sodium taste stimulation, did not undergo terminal field reorganization. These surprising results suggest that gustatory nerve terminal fields remain plastic well into adulthood, which likely impacts central coding of taste information and taste-related behaviors with altered taste experience. Neural activity plays a major role in the development of sensory circuits in the mammalian brain. However, the importance of sensory-driven activity in maintaining these circuits at adulthood, especially in subcortical structures, appears to be much less. Here, we tested whether the loss of sodium taste activity in adult mice impacts the maintenance of how taste nerves project to the first central relay. We found that specific loss of sodium-elicited taste activity at adulthood produced dramatic and selective reorganization of terminal fields in the brainstem. This demonstrates, for the first time, that taste-elicited activity is necessary for the normal maintenance of central gustatory circuits at adulthood and highlights a level of plasticity not seen in other sensory system subcortical circuits.
[Mh] Termos MeSH primário: Bulbo/fisiologia
Sódio na Dieta/administração & dosagem
Papilas Gustativas/fisiologia
Percepção Gustatória/fisiologia
Paladar/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Feminino
Nervo Glossofaríngeo/efeitos dos fármacos
Nervo Glossofaríngeo/fisiologia
Nervo Hipoglosso/efeitos dos fármacos
Nervo Hipoglosso/fisiologia
Masculino
Bulbo/efeitos dos fármacos
Camundongos
Camundongos Knockout
Camundongos Transgênicos
Terminações Pré-Sinápticas/efeitos dos fármacos
Terminações Pré-Sinápticas/fisiologia
Papilas Gustativas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium, Dietary)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3838-16.2017


  4 / 2910 MEDLINE  
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[PMID]:28527784
[Au] Autor:Andrzejewski K; Budzinska K; Kaczynska K
[Ad] Endereço:Laboratory of Respiration Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. Electronic address: kandrzejewski@imdik.pan.pl.
[Ti] Título:Phrenic and hypoglossal nerve activity during respiratory response to hypoxia in 6-OHDA unilateral model of Parkinson's disease.
[So] Source:Life Sci;180:143-150, 2017 Jul 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Parkinson's disease (PD) patients apart from motor dysfunctions exhibit respiratory disturbances. Their mechanism is still unknown and requires investigation. Our research was designed to examine the activity of phrenic (PHR) and hypoglossal (HG) nerves activity during a hypoxic respiratory response in the 6-hydroxydopamine (6-OHDA) model of PD. MAIN METHODS: Male adult Wistar rats were injected unilaterally with 6-OHDA (20µg) or the vehicle into the right medial forebrain bundle (MFB). Two weeks after the surgery the activity of the phrenic and hypoglossal nerve was registered in anesthetized, vagotomized, paralyzed, and mechanically ventilated rats under normoxic and hypoxic conditions. Lesion effectiveness was confirmed by the cylinder test, performed before the MFB injection and 14days after, before the respiratory experiment. KEY FINDINGS: 6-OHDA lesioned animals showed a significant increase in normoxic inspiratory time. Expiratory time and total time of the respiratory cycle were prolonged in PD rats after hypoxia. The amplitude of the PHR activity and its minute activity were increased in comparison to the sham group at recovery time and during 30s of hypoxia. The amplitude of the HG activity was increased in response to hypoxia in 6-OHDA lesioned animals. The degeneration of dopaminergic neurons decreased the pre-inspiratory/inspiratory ratio of the hypoglossal burst amplitude during and after hypoxia. SIGNIFICANCE: Unilateral MFB lesion changed the activity of the phrenic and hypoglossal nerves. The altered pre-inspiratory hypoglossal nerve activity indicates modifications to the central mechanisms controlling the activity of the HG nerve and may explain respiratory disorders seen in PD, i.e. apnea.
[Mh] Termos MeSH primário: Nervo Hipoglosso/metabolismo
Hipóxia/metabolismo
Transtornos Parkinsonianos/fisiopatologia
Nervo Frênico/metabolismo
Respiração
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Masculino
Oxidopamina/toxicidade
Ratos
Ratos Wistar
Transtornos Respiratórios/etiologia
Transtornos Respiratórios/fisiopatologia
Respiração Artificial
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8HW4YBZ748 (Oxidopamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


  5 / 2910 MEDLINE  
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[PMID]:28194999
[Au] Autor:Gillespie MB; Soose RJ; Woodson BT; Strohl KP; Maurer JT; de Vries N; Steward DL; Baskin JZ; Badr MS; Lin HS; Padhya TA; Mickelson S; Anderson WM; Vanderveken OM; Strollo PJ; STAR Trial Investigators
[Ad] Endereço:1 University of Tennessee, Memphis, Tennessee, USA.
[Ti] Título:Upper Airway Stimulation for Obstructive Sleep Apnea: Patient-Reported Outcomes after 48 Months of Follow-up.
[So] Source:Otolaryngol Head Neck Surg;156(4):765-771, 2017 Apr.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To assess patient-based outcomes of participants in a large cohort study-the STAR trial (Stimulation Therapy for Apnea Reduction)-48 months after implantation with an upper airway stimulation system for moderate to severe obstructive sleep apnea. Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical setting. Subjects Participants (n = 91) at 48 months from a cohort of 126 implanted participants. Methods A total of 126 participants received an implanted upper airway stimulation system in a prospective phase III trial. Patient-reported outcomes at 48 months, including Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), and snoring level, were compared with preimplantation baseline. Results A total of 91 subjects completed the 48-month visit. Daytime sleepiness as measured by ESS was significantly reduced ( P = .01), and sleep-related quality of life as measured by FOSQ significantly improved ( P = .01) when compared with baseline. Soft to no snoring was reported by 85% of bed partners. Two patients required additional surgery without complication for lead malfunction. Conclusion Upper airway stimulation maintained a sustained benefit on patient-reported outcomes (ESS, FOSQ, snoring) at 48 months in select patients with moderate to severe obstructive sleep apnea.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica
Apneia Obstrutiva do Sono/terapia
[Mh] Termos MeSH secundário: Distúrbios do Sono por Sonolência Excessiva/terapia
Seguimentos
Seres Humanos
Nervo Hipoglosso
Neuroestimuladores Implantáveis
Masculino
Meia-Idade
Medidas de Resultados Relatados pelo Paciente
Estudos Prospectivos
Qualidade de Vida
Autorrelato
Ronco/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817691491


  6 / 2910 MEDLINE  
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[PMID]:28148643
[Au] Autor:Cholanian M; Wealing J; Levine RB; Fregosi RF
[Ad] Endereço:Department of Physiology, The University of Arizona, Tucson, Arizona.
[Ti] Título:Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat.
[So] Source:J Neurophysiol;117(4):1544-1552, 2017 Apr 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We previously showed that nicotine exposure in utero and after birth via breast milk [developmental nicotine exposure (DNE)] is associated with many changes in the structure and function of hypoglossal motoneurons (XIIMNs), including a reduction in the size of the dendritic arbor and an increase in cell excitability. Interestingly, the elevated excitability was associated with a reduction in the expression of glutamate receptors on the cell body. Together, these observations are consistent with a homeostatic compensation aimed at restoring cell excitability. Compensation for increased cell excitability could also occur by changing potassium conductance, which plays a critical role in regulating resting potential, spike threshold, and repetitive spiking behavior. Here we test the hypothesis that the previously observed increase in the excitability of XIIMNs from DNE animals is associated with an increase in whole cell potassium currents. Potassium currents were measured in XIIMNs in brain stem slices derived from DNE and control rat pups ranging in age from 0 to 4 days by whole cell patch-clamp electrophysiology. All currents were measured after blockade of action potential-dependent synaptic transmission with tetrodotoxin. Compared with control cells, XIIMNs from DNE animals showed significantly larger transient and sustained potassium currents, but this was observed only under conditions of increased cell and network excitability, which we evoked by raising extracellular potassium from 3 to 9 mM. These observations suggest that the larger potassium currents in nicotine-exposed neurons are an important homeostatic compensation that prevents "runaway" excitability under stressful conditions, when neurons are receiving elevated excitatory synaptic input. Developmental nicotine exposure is associated with increased cell excitability, which is often accompanied by compensatory changes aimed at normalizing excitability. Here we show that whole cell potassium currents are also increased in hypoglossal motoneurons from nicotine-exposed neonatal rats under conditions of increased cell and network excitability. This is consistent with a compensatory response aimed at preventing instability under conditions in which excitatory synaptic input is high and is compatible with the concept of homeostatic plasticity.
[Mh] Termos MeSH primário: Potenciais de Ação/efeitos dos fármacos
Tronco Encefálico
Neurônios Motores/efeitos dos fármacos
Nicotina/farmacologia
Agonistas Nicotínicos/farmacologia
Potássio/metabolismo
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Animais Recém-Nascidos
Tronco Encefálico/efeitos dos fármacos
Tronco Encefálico/crescimento & desenvolvimento
Tronco Encefálico/metabolismo
Cloreto de Cádmio/farmacologia
Feminino
Nervo Hipoglosso/citologia
Nervo Hipoglosso/fisiologia
Masculino
Neurônios Motores/fisiologia
Técnicas de Patch-Clamp
Potássio/farmacologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Ratos
Ratos Sprague-Dawley
Bloqueadores dos Canais de Sódio/farmacologia
Transmissão Sináptica/efeitos dos fármacos
Tetrodotoxina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nicotinic Agonists); 0 (Sodium Channel Blockers); 4368-28-9 (Tetrodotoxin); 6M3C89ZY6R (Nicotine); J6K4F9V3BA (Cadmium Chloride); RWP5GA015D (Potassium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00774.2016


  7 / 2910 MEDLINE  
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[PMID]:28126502
[Au] Autor:Gagnadoux F; Jouvenot M; Meslier N; Priou P; Trzepizur W
[Ad] Endereço:CHU, département de pneumologie, 4, rue Larrey, 49033 Angers cedex 9, France; Université Bretagne-Loire, Inserm U1063, Angers, France. Electronic address: frgagnadoux@chu-angers.fr.
[Ti] Título:[Therapeutic alternatives to continuous positive airway pressure for obstructive sleep apnea-hypopnea syndrome].
[Ti] Título:Modalités thérapeutiques du syndrome d'apnées-hypopnées obstructives du sommeil de l'adulte en dehors de la pression positive continue..
[So] Source:Presse Med;46(4):432-437, 2017 Apr.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Oral appliance therapy (OAT) is the main therapeutic alternative to continuous positive airway pressure (CPAP). OAT has been recommended as an appropriate first-line treatment option for moderate obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients without severe cardiovascular comorbidity. The lower efficacy of OAT in reducing sleep-disordered breathing could be offset by a higher compliance relative to CPAP, resulting in similar health outcomes in terms of sleepiness, neurobehavioral functioning, quality of life and blood pressure. Electrical stimulation of the hypoglossal nerve is a promising treatment approach for moderate to severe OSAHS. Avoiding the supine position during sleep and reducing the overnight rostral fluid shift from the legs to the neck can also achieve a partial improvement of sleep-disordered breathing. There are currently no medications to treat OSAHS effectively. At least fifty percent of OSAHS patients are affected by central obesity and related metabolic disorders. To date, there is no evidence that treating OSAHS may improve comorbid metabolic disorders. Weight-loss intervention is a central component of the strategies used to improve the cardiovascular risk-factor profile in patients with OSAHS and obesity.
[Mh] Termos MeSH primário: Apneia Obstrutiva do Sono/terapia
[Mh] Termos MeSH secundário: Terapia por Estimulação Elétrica
Seres Humanos
Nervo Hipoglosso
Avanço Mandibular
Obesidade Abdominal/complicações
Obesidade Abdominal/terapia
Placas Oclusais
Apneia Obstrutiva do Sono/etiologia
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


  8 / 2910 MEDLINE  
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[PMID]:28110076
[Au] Autor:Takagi S; Kono Y; Nagase M; Mochio S; Kato F
[Ad] Endereço:Department of Neurology, The Jikei University School of Medicine, Japan; Department of Neuroscience, The Jikei University School of Medicine, Japan.
[Ti] Título:Facilitation of distinct inhibitory synaptic inputs by chemical anoxia in neurons in the oculomotor, facial and hypoglossal motor nuclei of the rat.
[So] Source:Exp Neurol;290:95-105, 2017 Apr.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the brainstem and spinal cord. Clinical studies have indicated that there is a distinct region-dependent difference in the vulnerability of motor neurons. For example, the motor neurons in the facial and hypoglossal nuclei are more susceptible to neuronal death than those in the oculomotor nucleus. To understand the mechanism underlying the differential susceptibility to cell death of the neurons in different motor nuclei, we compared the effects of chemical anoxia on the membrane currents and postsynaptic currents in different motor nuclei. The membrane currents were recorded from neurons in the oculomotor, facial and hypoglossal nuclei in brain slices of juvenile Wistar rats by using whole-cell recording in the presence of tetrodotoxin that prevents action potential-dependent synaptic transmission. NaCN consistently induced an inward current and a significant increase in the frequency of spontaneous synaptic inputs in neurons from these three nuclei. However, this increase in the synaptic input frequency was abolished by strychnine, a glycine receptor antagonist, but not by picrotoxin in neurons from the hypoglossal and facial nuclei, whereas that in neurons from the oculomotor nucleus was abolished by picrotoxin, but not by strychnine. Blocking ionotropic glutamate receptors did not significantly affect the NaCN-induced release facilitation in any of the three motor nuclei. These results suggest that anoxia selectively facilitates glycine release in the hypoglossal and facial nuclei and GABA release in the oculomotor nucleus. The region-dependent differences in the neurotransmitters involved in the anoxia-triggered release facilitation might provide a basis for the selective vulnerability of motor neurons in the neurodegeneration associated with ALS.
[Mh] Termos MeSH primário: Nervo Facial/patologia
Nervo Hipoglosso/patologia
Hipóxia/induzido quimicamente
Hipóxia/patologia
Neurônios/patologia
Nervo Oculomotor/patologia
Sinapses/patologia
[Mh] Termos MeSH secundário: Esclerose Amiotrófica Lateral/patologia
Animais
Morte Celular/efeitos dos fármacos
Modelos Animais de Doenças
Técnicas de Patch-Clamp
Ratos
Ratos Wistar
Cianeto de Sódio
Transmissão Sináptica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
O5DDB9Z95G (Sodium Cyanide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


  9 / 2910 MEDLINE  
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[PMID]:28109859
[Au] Autor:Iwanaga J; Fisahn C; Alonso F; DiLorenzo D; Grunert P; Kline MT; Watanabe K; Oskouian RJ; Spinner RJ; Tubbs RS
[Ad] Endereço:Seattle Science Foundation, Seattle, Washington, USA; Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan. Electronic address: joei@seattlesciencefoundation.org.
[Ti] Título:Microsurgical Anatomy of the Hypoglossal and C1 Nerves: Description of a Previously Undescribed Branch to the Atlanto-Occipital Joint.
[So] Source:World Neurosurg;100:590-593, 2017 Apr.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Distal branches of the C1 nerve that travel with the hypoglossal nerve have been well investigated but relationships of C1 and the hypoglossal nerve near the skull base have not been described in detail. Therefore, the aim of this study was to investigate these small branches of the hypoglossal and first cervical nerves by anatomic dissection. METHODS: Twelve sides from 6 cadaveric specimens were used in this study. To elucidate the relationship among the hypoglossal, vagus, and first and cervical nerve, the mandible was removed and these nerves were dissected under the surgical microscope. RESULTS: A small branch was found to always arise from the dorsal aspect of the hypoglossal nerve at the level of the transverse process of the atlas and joined small branches from the first and second cervical nerves. The hypoglossal and C1 nerves formed a nerve plexus, which gave rise to branches to the rectus capitis anterior and rectus capitis lateralis muscles and the atlanto-occipital joint. CONCLUSIONS: Improved knowledge of such articular branches might aid in the diagnosis and treatment of patients with pain derived from the atlanto-occipital joint. We believe this to be the first description of a branch of the hypoglossal nerve being involved in the innervation of this joint.
[Mh] Termos MeSH primário: Articulação Atlantoccipital/anatomia & histologia
Articulação Atlantoccipital/inervação
Medula Cervical/anatomia & histologia
Nervo Hipoglosso/anatomia & histologia
Microcirurgia/métodos
Nervos Espinhais/anatomia & histologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Pontos de Referência Anatômicos/anatomia & histologia
Cadáver
Dissecação/métodos
Feminino
Seres Humanos
Nervo Hipoglosso/cirurgia
Masculino
Nervos Espinhais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


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[PMID]:28105667
[Au] Autor:Heiser C; Edenharter G; Bas M; Wirth M; Hofauer B
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Technical University of Munich, Munich, Germany.
[Ti] Título:Palatoglossus coupling in selective upper airway stimulation.
[So] Source:Laryngoscope;127(10):E378-E383, 2017 Oct.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: Selective upper airway stimulation (sUAS) of the hypoglossal nerve is a useful therapy to treat patients with obstructive sleep apnea. Is it known that multiple obstructions can be solved by this stimulation technique, even at the retropalatal region. The aim of this study was to verify the palatoglossus coupling at the soft palate during stimulation. STUDY DESIGN: Single-center, prospective clinical trail. METHODS: Twenty patients who received an sUAS implant from April 2015 to April 2016 were included. A drug-induced sedated endoscopy (DISE) was performed before surgery. Six to 12 months after activation of the system, patients' tongue motions were recorded, an awake transnasal endoscopy was performed with stimulation turned on, and a DISE with stimulation off and on was done. RESULTS: Patients with a bilateral protrusion of the tongue base showed a significantly increased opening at the retropalatal level compared to ipsilateral protrusions. Furthermore, patients with a clear activation of the geniohyoid muscle showed a better reduction in apnea-hypopnea index. CONCLUSIONS: A bilateral protrusion of the tongue base during sUAS seems to be accompanied with a better opening of the soft palate. This effect can be explained by the palatoglossal coupling, due to its linkage of the muscles within the soft palate to those of the lateral tongue body. LEVEL OF EVIDENCE: 4 Laryngoscope, 127:E378-E383, 2017.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica/métodos
Acoplamento Excitação-Contração
Músculos Palatinos/fisiopatologia
Apneia Obstrutiva do Sono/cirurgia
[Mh] Termos MeSH secundário: Idoso
Terapia por Estimulação Elétrica/instrumentação
Seres Humanos
Nervo Hipoglosso/fisiopatologia
Masculino
Meia-Idade
Cirurgia Endoscópica por Orifício Natural/métodos
Nariz/cirurgia
Músculos Palatinos/inervação
Palato Mole/inervação
Palato Mole/fisiopatologia
Estudos Prospectivos
Implante de Prótese/métodos
Apneia Obstrutiva do Sono/fisiopatologia
Língua/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26487



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