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  1 / 15122 MEDLINE  
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[PMID]:28463416
[Au] Autor:Kaja S; Payne AJ; Naumchuk Y; Koulen P
[Ad] Endereço:Departments of Ophthalmology and Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.
[Ti] Título:Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes.
[So] Source:Curr Protoc Toxicol;72:2.26.1-2.26.10, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drug discovery heavily relies on cell viability studies to assess the potential toxicity of drug candidates. L-Lactate dehydrogenase (LDH) is a cytoplasmic enzyme that catalyzes the concomitant interconversions of pyruvate to L-lactate and NADH to NAD during glycolysis, and the reverse reactions during the Cori cycle. In response to cellular damage, induced by endogenous cellular mechanisms or as a result of exogenously applied insults, LDH is released from the cytoplasm into the extracellular environment. Its stability in cell culture medium makes it a well-suited correlate for the presence of damage and toxicity in tissues and cells. We herein present protocols for a reproducible and validated LDH assay optimized for several cell types. In contrast to commercially available LDH assays, often associated with proprietary formulations and high cost, our protocols provide ample opportunities for experiment-specific optimization with low variability and cost. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Astrócitos/enzimologia
Sobrevivência Celular
L-Lactato Desidrogenase/análise
Toxicologia/métodos
[Mh] Termos MeSH secundário: Animais
Técnicas de Cultura de Células
Linhagem Celular
Linhagem Celular Tumoral
Meios de Cultura/química
Citoplasma/enzimologia
Espaço Extracelular/enzimologia
Glicólise
Seres Humanos
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Nervo Óptico/citologia
Nervo Óptico/efeitos dos fármacos
Cultura Primária de Células
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Neuroprotective Agents); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.21


  2 / 15122 MEDLINE  
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[PMID]:29384857
[Au] Autor:Kurysheva NI; Shlapak VN; Ryabova TY
[Ad] Endereço:Ophthalmological Department of the Federal Medical and Biological Agency of the Russian Federation.
[Ti] Título:Heart rate variability in normal tension glaucoma: A case-control study.
[So] Source:Medicine (Baltimore);97(5):e9744, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary vascular dysregulation (PVD) is believed to be a main cause of local vasospasm and impaired autoregulation as a possible contributing factor in the pathogenesis of normal tension glaucoma (NTG). Subjects with PVD respond stronger to psychological stress. Autonomic dysfunction is another reason of instable ocular blood flow and may be studied by means of assessment of heart rate variability (HRV) especially during a hand-cold provocation test (CPT).To compare the shift of HRV parameters in NTG and healthy subjects after a cold provocation test and to assess the relation between structural damage, circulatory parameters and autonomic dysfunction in NTG.HRV was studied using CPT in 78 NTG patients and 60 health control matches. The ocular blood flow was measured using color Doppler imaging (CDI). The 24 hours blood pressure (BP) monitoring was carried out. The cardiovascular fitness assessment was made to all patients before and after CPT. Mean group difference of HRV parameters was compared between NTG and healthy subjects using the Euclidean metric. The mean ocular perfusion pressure (MOPP) was measured. Optic nerve head and retinal nerve fiber layer (RNFL) were evaluated using spectral-domain optic coherence tomography (SD-OCT). The relation between HRV, CDI, and SD-OCT-parameters was assessed.In contrast to healthy subjects, a predominance of the sympathetic activity after the CPT was revealed in the NTG group. The end diastolic velocity (EDV) in central retinal artery (CRA) and short posterior ciliary artery (SPCA) was significantly reduced in NTG compared to healthy eyes. In NTG, the main HRV parameter characterizing the total effect of autonomic blood circulation regulation (SDNN) correlated with MOPP (0.75, P = .035), SPCA EDV (0.93, P < .001), and CRA EDV (0.9, P < .001). The average daily diastolic BP correlated with RNFL (0.67, P = .009).The NTG patients have the disturbance of the autonomic nervous system, which increases in response to stress provocation and is related to ocular blood flow and structural damage.
[Mh] Termos MeSH primário: Frequência Cardíaca
Glaucoma de Baixa Tensão/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Determinação da Pressão Arterial
Estudos de Casos e Controles
Temperatura Baixa
Olho/diagnóstico por imagem
Olho/fisiopatologia
Determinação da Frequência Cardíaca
Seres Humanos
Glaucoma de Baixa Tensão/diagnóstico por imagem
Meia-Idade
Nervo Óptico/diagnóstico por imagem
Fluxo Sanguíneo Regional
Tomografia de Coerência Óptica
Ultrassonografia Doppler em Cores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009744


  3 / 15122 MEDLINE  
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[PMID]:29420144
[Au] Autor:Gilbert AL; Chwalisz B; Mallery R
[Ad] Endereço:a Department of Neuro-Ophthalmology , Massachusetts Eye & Ear, Harvard Medical School , Boston , MA , USA.
[Ti] Título:Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension.
[So] Source:Semin Ophthalmol;33(1):36-41, 2018.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are a number of surgical options for treatment of idiopathic intracranial hypertension (IIH) when it is refractory to medical treatment and weight loss. Optic nerve sheath fenestration (ONSF) is one of these options. Use of this procedure varies among centers due to experience with the procedure and concern for associated complications that can result in severe loss of vision. This review summarizes the literature concerning post-surgical complications of ONSF for IIH.
[Mh] Termos MeSH primário: Cegueira
Descompressão Cirúrgica/efeitos adversos
Procedimentos Neurocirúrgicos/efeitos adversos
Traumatismos do Nervo Óptico/etiologia
Nervo Óptico/cirurgia
Papiledema/cirurgia
Pseudotumor Cerebral/complicações
[Mh] Termos MeSH secundário: Cegueira/epidemiologia
Cegueira/etiologia
Cegueira/fisiopatologia
Seres Humanos
Nervo Óptico/patologia
Traumatismos do Nervo Óptico/diagnóstico
Traumatismos do Nervo Óptico/fisiopatologia
Papiledema/diagnóstico
Papiledema/etiologia
Complicações Pós-Operatórias
Pseudotumor Cerebral/fisiopatologia
Pseudotumor Cerebral/cirurgia
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353810


  4 / 15122 MEDLINE  
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[PMID]:29342153
[Au] Autor:Yapp M; Rennie G; Hennessy MP; Kalloniatis M; Zangerl B
[Ad] Endereço:Centre for Eye Health, UNSW Australia, Sydney, New South Wales, Australia.
[Ti] Título:The impact of optic nerve and related characteristics on disc area measurements derived from different imaging techniques.
[So] Source:PLoS One;13(1):e0190273, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Optic nerve head (ONH) assessment and its interpretation in healthy patients and those with glaucoma remains a pivotal topic specifically considering rapid advancements in imaging technologies. We undertook a large-scale, mixed cohort, comparative study to assess the correlation of optic disc measurements between different imaging modalities and investigated the impact of patient and disc associated parameters. METHODS: ONH sizes were obtained from one randomly selected eye of each of 209 patients using stereophotography, confocal scanning laser ophthalmoscopy and two different optical coherence tomographers (OCT). Patient related data, glaucoma status and optic disc variables, specifically oblique insertion, torsion, presence of beta PPA and spherical equivalent were recorded. Measurements between imaging modalities were analysed using Pearson correlation, linear regression analysis and Blend-Altman plots. Individual variables were compared applying multivariate regression analysis, ANOVA and chi square statistics was used to determine correlations between patient and clinical characteristics. RESULTS: Absolute measurements significantly differed between imaging modalities generally producing smaller measurements for OCT derived measurements of Bruch's membrane opening (BMO). Pairwise correlations between imaging modalities were between 0.83 and 0.93 for discs without myopia, oblique insertion, or beta PPA. These features impacted on measurements for individual modalities and consequently contributed to inconsistencies and variability. CONCLUSION: In comparison to planimetry, OCT derived BMO measurements are more variable in the presence of oblique insertion, beta PPA or magnification errors due to myopia. Impact of these factors, however, differs between instruments and needs to be considered to accurately interpret optic disc features in particular within the context of glaucoma diagnosis.
[Mh] Termos MeSH primário: Disco Óptico/diagnóstico por imagem
Nervo Óptico/diagnóstico por imagem
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190273


  5 / 15122 MEDLINE  
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[PMID]:28457789
[Au] Autor:Cameron JR; Megaw RD; Tatham AJ; McGrory S; MacGillivray TJ; Doubal FN; Wardlaw JM; Trucco E; Chandran S; Dhillon B
[Ad] Endereço:Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. Electronic address:
[Ti] Título:Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.
[So] Source:Prog Retin Eye Res;59:131-157, 2017 Jul.
[Is] ISSN:1873-1635
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:No biological system or structure is likely to be perfectly symmetrical, or have identical right and left forms. This review explores the evidence for eye and visual pathway asymmetry, in health and in disease, and attempts to provide guidance for those studying the structure and function of the visual system, where recognition of symmetry or asymmetry may be essential. The principal question with regards to asymmetry is not 'are the eyes the same?', for some degree of asymmetry is pervasive, but 'when are they importantly different?'. Knowing if right and left eyes are 'importantly different' could have significant consequences for deciding whether right or left eyes are included in an analysis or for examining the association between a phenotype and ocular parameter. The presence of significant asymmetry would also have important implications for the design of normative databases of retinal and optic nerve metrics. In this review, we highlight not only the universal presence of asymmetry, but provide evidence that some elements of the visual system are inherently more asymmetric than others, pointing to the need for improved normative data to explain sources of asymmetry and their impact on determining associations with genetic, environmental or health-related factors and ultimately in clinical practice.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Disco Óptico/patologia
Nervo Óptico/patologia
Doenças Retinianas/diagnóstico
Células Ganglionares da Retina/patologia
Vasos Retinianos/patologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 15122 MEDLINE  
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[PMID]:27777775
[Au] Autor:Wilson MA; Guld K; Galetta S; Walsh RD; Kharlip J; Tamhankar M; McGettigan S; Schuchter LM; Fecher LA
[Ad] Endereço:Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA USA ; Present address: Division of Hematology and Medical Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY USA.
[Ti] Título:Acute visual loss after ipilimumab treatment for metastatic melanoma.
[So] Source:J Immunother Cancer;4:66, 2016.
[Is] ISSN:2051-1426
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ipilimumab, a humanized CLTA-4 antibody is a standard therapy in the treatment of advanced melanoma. While ipilimumab provides an overall survival benefit to patients, it can be associated with immune related adverse events (IrAEs). CASE PRESENTATION: Here we describe a patient treated with ipilimumab who experienced known IrAEs, including hypophysitis, as well as a profound vision loss due to optic neuritis. There are rare reports of optic neuritis occurring as an adverse event associated with ipilimumab treatment. Furthermore, the patient experienced multiple complications from high dose steroids used to manage his IrAEs. CONCLUSIONS: This case highlights the need for recognition of atypical immune mediated processes associated with newer checkpoint inhibitor therapies including ipilimumab.
[Mh] Termos MeSH primário: Antineoplásicos Imunológicos/efeitos adversos
Ipilimumab/efeitos adversos
Melanoma/complicações
Transtornos da Visão/diagnóstico
Transtornos da Visão/etiologia
[Mh] Termos MeSH secundário: Doença Aguda
Antineoplásicos Imunológicos/uso terapêutico
Biomarcadores
Encéfalo/patologia
Antígeno CTLA-4/antagonistas & inibidores
Angiofluoresceinografia
Seres Humanos
Ipilimumab/uso terapêutico
Imagem por Ressonância Magnética
Masculino
Melanoma/tratamento farmacológico
Melanoma/patologia
Meia-Idade
Terapia de Alvo Molecular/efeitos adversos
Metástase Neoplásica
Nervo Óptico/patologia
Testes Visuais
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Immunological); 0 (Biomarkers); 0 (CTLA-4 Antigen); 0 (Ipilimumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 15122 MEDLINE  
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[PMID]:28465303
[Au] Autor:Solebo AL; Teoh L; Rahi J
[Ad] Endereço:Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, Institute of Child Health, University College London, London, UK.
[Ti] Título:Epidemiology of blindness in children.
[So] Source:Arch Dis Child;102(9):853-857, 2017 09.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An estimated 14 million of the world's children are blind. A blind child is more likely to live in socioeconomic deprivation, to be more frequently hospitalised during childhood and to die in childhood than a child not living with blindness. This update of a previous review on childhood visual impairment focuses on emerging therapies for children with severe visual disability (severe visual impairment and blindness or SVI/BL).For children in higher income countries, cerebral visual impairment and optic nerve anomalies remain the most common causes of SVI/BL, while retinopathy of prematurity (ROP) and cataract are now the most common avoidable causes. The constellation of causes of childhood blindness in lower income settings is shifting from infective and nutritional corneal opacities and congenital anomalies to more resemble the patterns seen in higher income settings. Improvements in maternal and neonatal health and investment in and maintenance of national ophthalmic care infrastructure are the key to reducing the burden of avoidable blindness. New therapeutic targets are emerging for childhood visual disorders, although the safety and efficacy of novel therapies for diseases such as ROP or retinal dystrophies are not yet clear. Population-based epidemiological research, particularly on cerebral visual impairment and optic nerve hypoplasia, is needed in order to improve understanding of risk factors and to inform and support the development of novel therapies for disorders currently considered 'untreatable'.
[Mh] Termos MeSH primário: Cegueira/epidemiologia
[Mh] Termos MeSH secundário: Cegueira/diagnóstico
Cegueira/etiologia
Catarata/complicações
Catarata/epidemiologia
Criança
Opacidade da Córnea/complicações
Opacidade da Córnea/epidemiologia
Oftalmopatias Hereditárias/complicações
Oftalmopatias Hereditárias/epidemiologia
Saúde Global/estatística & dados numéricos
Seres Humanos
Renda/estatística & dados numéricos
Recém-Nascido
Nervo Óptico/anormalidades
Prevalência
Doenças Retinianas/complicações
Doenças Retinianas/epidemiologia
Retinopatia da Prematuridade/complicações
Retinopatia da Prematuridade/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2016-310532


  8 / 15122 MEDLINE  
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[PMID]:28459737
[Au] Autor:Mercuri MA; White H; Oliveira C
[Ad] Endereço:Departments of Neurology (MAM, HW) and Ophthalmology (CO), Weill Cornell Medical College, New York, New York.
[Ti] Título:Vision Loss and Symmetric Basal Ganglia Lesions in Leber Hereditary Optic Neuropathy.
[So] Source:J Neuroophthalmol;37(4):411-413, 2017 12.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 30-year-old woman with progressive vision loss was found to have asymptomatic, bilateral, and symmetric basal ganglia lesions on MRI and was later diagnosed with Leber hereditary optic neuropathy (LHON). The rare occurrence of basal ganglia changes on MRI in patients with LHON is discussed.
[Mh] Termos MeSH primário: Gânglios da Base/patologia
Cegueira/etiologia
Atrofia Óptica Hereditária de Leber/complicações
Acuidade Visual
[Mh] Termos MeSH secundário: Adulto
Cegueira/diagnóstico
Cegueira/fisiopatologia
Progressão da Doença
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Atrofia Óptica Hereditária de Leber/diagnóstico
Atrofia Óptica Hereditária de Leber/fisiopatologia
Quiasma Óptico/patologia
Nervo Óptico/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000524


  9 / 15122 MEDLINE  
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[PMID]:28459736
[Au] Autor:Hoch MJ; Bruno MT; Shepherd TM
[Ad] Endereço:Department of Radiology and Imaging Sciences (MJH), Emory University, Atlanta, Georgia; Department of Radiology, Section of Neuroradiology (MTB, TMS), New York University Langone Medical Center, New York, New York; and Center for Advanced Imaging Innovation and Research (CAI2R) (TMS), New York, New York.
[Ti] Título:Advanced MRI of the Optic Nerve.
[So] Source:J Neuroophthalmol;37(2):187-196, 2017 06.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clinical orbital MRI protocols are routinely used to study the optic nerves and exclude compressive lesions, infarctions, or inflammation. However, the small caliber and divergent oblique orientations of the optic nerves make it challenging to characterize them well with conventional MRI, especially since adjacent air-filled bony structures distort the MRI signal and motion is a problem even in cooperative, healthy volunteers. EVIDENCE ACQUISITION: Over the past 3 years we have experimented with multiple novel MRI approaches and sequences to better characterize the optic nerves. The perfect MRI protocol would be quantitative and sensitive to subtle optic nerve pathologic changes, provide high spatial resolution, be rapidly acquired, and resistant to motion degradation. RESULTS: This review provides an update of recent MRI sequence innovations for the optic nerves being currently translated into clinical practice. Methods discussed include rapid MRI with compressed sensing or simultaneous multislice approaches, postprocessing techniques for quantitative T2 mapping or track density imaging, and multiple MRI sequences for measuring diffusion in the optic nerves. CONCLUSIONS: Recently-developed orbit-specific MRI coils, quantitative sequences, and rapid acquisition techniques can improve our future ability to study optic nerve pathologies noninvasively. As advanced MRI becomes more proficient at characterizing the optic nerves, its role in the clinical management of patients should increase.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética/métodos
Nervo Óptico/patologia
Neurite Óptica/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000511


  10 / 15122 MEDLINE  
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[PMID]:28452990
[Au] Autor:Pircher A; Montali M; Berberat J; Remonda L; Killer HE
[Ad] Endereço:Department of Ophthalmology, Cantonal Hospital Aarau, Aarau, Switzerland.
[Ti] Título:Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma.
[So] Source:Eye (Lond);31(9):1365-1372, 2017 Sep.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PurposeTo investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).Patients and methodsRetrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed t-test and the non-parametric Spearman's correlation test.ResultsThe mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance (t-test: P<0.000). The mean CSF-p in NTG was 11.6±3.7 mm Hg. There was no statistical significant correlation between ONSD and CSF-p (Spearman's correlation coefficient ρ=0.06, P=0.72).ConclusionsThis study demonstrates enlarged ONSDs and normal lumbar CSF-p in 38 Caucasian NTG patients. As enlarged ONSDs generally are associated with increased intracranial CSF-p, these results can be explained by a disturbed communication of CSF-p between the intracranial and intraorbital subarachnoid spaces.
[Mh] Termos MeSH primário: Pressão do Líquido Cefalorraquidiano/fisiologia
Glaucoma de Baixa Tensão/fisiopatologia
Bainha de Mielina/patologia
Nervo Óptico/patologia
[Mh] Termos MeSH secundário: Idoso
Grupo com Ancestrais do Continente Europeu
Feminino
Seres Humanos
Pressão Intraocular/fisiologia
Masculino
Nervo Óptico/diagnóstico por imagem
Estudos Retrospectivos
Punção Espinal
Espaço Subaracnóideo
Tomografia Computadorizada por Raios X
Tonometria Ocular
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2017.70



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde