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[PMID]:29370308
[Au] Autor:Zhang M; Zhou Q; Luo Y; Nguyen T; Rosenblatt MI; Guaiquil VH
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, Illinois, United States of America.
[Ti] Título:Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development.
[So] Source:PLoS One;13(1):e0191962, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury. Nerves can regenerate after injury but do not recover their original density and patterning. Sema3A is a well known axon guidance and growth cone repellent protein during development, however its role in adult cornea nerve regeneration remains undetermined. Here we investigated the neuro-regenerative potential of Sema3A on adult peripheral nervous system neurons such as those that innervate the cornea. First, we examined the gene expression profile of the Semaphorin class 3 family members and found that all are expressed in the cornea. However, upon cornea injury there is a fast increase in Sema3A expression. We then corroborated that Sema3A totally abolished the growth promoting effect of nerve growth factor (NGF) on embryonic neurons and observed signs of growth cone collapse and axonal retraction after 30 min of Sema3A addition. However, in adult isolated trigeminal ganglia or dorsal root ganglia neurons, Sema3A did not inhibited the NGF-induced neuronal growth. Furthermore, adult neurons treated with Sema3A alone produced similar neuronal growth to cells treated with NGF and the length of the neurites and branching was comparable between both treatments. These effects were replicated in vivo, where thy1-YFP neurofluorescent mice subjected to cornea epithelium debridement and receiving intrastromal pellet implantation containing Sema3A showed increased corneal nerve regeneration than those receiving pellets with vehicle. In adult PNS neurons, Sema3A is a potent inducer of neuronal growth in vitro and cornea nerve regeneration in vivo. Our data indicates a functional switch for the role of Sema3A in PNS neurons where the well-described repulsive role during development changes to a growth promoting effect during adulthood. The high expression of Sema3A in the normal and injured adult corneas could be related to its role as a growth factor.
[Mh] Termos MeSH primário: Regeneração Nervosa/efeitos dos fármacos
Semaforina-3A/farmacologia
[Mh] Termos MeSH secundário: Animais
Epitélio Anterior/efeitos dos fármacos
Epitélio Anterior/lesões
Epitélio Anterior/metabolismo
Gânglios Espinais/citologia
Gânglios Espinais/efeitos dos fármacos
Cones de Crescimento/efeitos dos fármacos
Camundongos
Nervo Trigêmeo/citologia
Nervo Trigêmeo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Semaphorin-3A)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191962


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[PMID]:29381959
[Au] Autor:Wu PC; Tien PT; Li YH; Chen RY; Cho DY
[Ad] Endereço:Division of Rheumatology and Immunology, Department of Internal Medicine, China Medical University Hospital.
[Ti] Título:IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.
[So] Source:Medicine (Baltimore);96(47):e8709, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system. PATIENT CONCERNS: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. She also reported a painless right submandibular mass that had been present for 1 year. Her best-corrected visual acuity (BCVA) was 2.0 LogMAR, with an almost total visual field defect in the right eye. DIAGNOSES: Magnetic resonance imaging (MRI) revealed lobulated parasellar tumors with perineural spreading along branches of the trigeminal nerves causing right optic nerve compression. A craniotomy with tumor removal and submandibular gland biopsy was performed. Histopathological analysis of the tumor revealed stromal fibrosis with atypical lymphoid infiltrations. Histopathological and immunohistochemical analysis of the submandibular gland confirmed the diagnosis of IgG4-RD. INTERVENTIONS: The patient was administered 500mg/d of pulse methylprednisolone for 3 days, 500mg of intravenous rituximab every 2 weeks (for a total of 2 doses), and 500mg of intravenous pulse cyclophosphamide every month (for a total of 3 doses). OUTCOMES: Two months after the initiation of immunosuppressive therapy, the patient's BCVA returned to 0.1 LogMAR with visual field defect recovery. The follow-up MRI showed the almost complete disappearance of the previously contrast-enhanced lesions. LESSONS: Herein, we report a rare case of IgG4-RD presenting as a parasellar tumor and present a review of the related literature. Based on the case report, we propose that aggressive therapy with glucocorticoid, rituximab, and cyclophosphamide may potentially be useful for treating such cases.
[Mh] Termos MeSH primário: Imunoglobulina G/imunologia
Doenças do Nervo Óptico/imunologia
Pseudotumor Cerebral/imunologia
Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Metilprednisolona/uso terapêutico
Doenças do Nervo Óptico/tratamento farmacológico
Doenças do Nervo Óptico/cirurgia
Pseudotumor Cerebral/tratamento farmacológico
Pseudotumor Cerebral/cirurgia
Rituximab/uso terapêutico
Glândula Submandibular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008709


  3 / 7933 MEDLINE  
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[PMID]:29055360
[Au] Autor:Dieckmann G; Goyal S; Hamrah P
[Ad] Endereço:Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts; Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
[Ti] Título:Neuropathic Corneal Pain: Approaches for Management.
[So] Source:Ophthalmology;124(11S):S34-S47, 2017 Nov.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients with NCP are scarce. The objectives of this review are to provide guidelines for diagnosis and treatment of patients with NCP and to summarize current evidence-based literature in this area. We performed a systematic literature search of all relevant publications between 1966 and 2017. Treatment recommendations are, in part, based on methodologically sound randomized controlled trials (RCTs), demonstrating superiority to placebo or relevant control treatments, and on the consistency of evidence, degree of efficacy, and safety. In addition, the recommendations include our own extensive experience in the management of these patients over the past decade. A comprehensive algorithm, based on clinical evaluation and complementary tests, is presented for diagnosis and subcategorization of patients with NCP. Recommended first-line topical treatments include neuroregenerative and anti-inflammatory agents, and first-line systemic pharmacotherapy includes tricyclic antidepressants and an anticonvulsant. Second-line oral treatments recommended include an opioid-antagonist and opiate analgesics. Complementary and alternative treatments, such as cardiovascular exercise, acupuncture, omega-3 fatty acid supplementation, and gluten-free diet, may have additional benefits, as do potential noninvasive and invasive procedures in recalcitrant cases. Medication selection should be tailored on an individual basis, considering side effects, comorbidities, and levels of peripheral and centralized pain. Nevertheless, there is an urgent need for long-term studies and RCTs assessing the efficacy of treatments for NCP.
[Mh] Termos MeSH primário: Doenças da Córnea/terapia
Dor Ocular/terapia
Neuralgia/terapia
[Mh] Termos MeSH secundário: Córnea/inervação
Doenças da Córnea/diagnóstico
Dor Ocular/diagnóstico
Seres Humanos
Neuralgia/diagnóstico
Nervo Trigêmeo/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171023
[St] Status:MEDLINE


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[PMID]:28975309
[Au] Autor:Gascho J
[Ad] Endereço:Division of Cardiology, Penn State University College of Medicine, Hershey, Pennsylvania.
[Ti] Título:The Lower Seven-Eighths.
[So] Source:JAMA;318(11):1005-1006, 2017 Sep 19.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dor/psicologia
Relações Médico-Paciente
Nervo Trigêmeo/cirurgia
Neuralgia do Trigêmeo/psicologia
[Mh] Termos MeSH secundário: Tomada de Decisões
Seres Humanos
Cirurgia de Descompressão Microvascular
Neuralgia do Trigêmeo/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.7751


  5 / 7933 MEDLINE  
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[PMID]:28957441
[Au] Autor:Nguyen MQ; Wu Y; Bonilla LS; von Buchholtz LJ; Ryba NJP
[Ad] Endereço:Taste and Smell Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing.
[So] Source:PLoS One;12(9):e0185543, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The trigeminal ganglion contains somatosensory neurons that detect a range of thermal, mechanical and chemical cues and innervate unique sensory compartments in the head and neck including the eyes, nose, mouth, meninges and vibrissae. We used single-cell sequencing and in situ hybridization to examine the cellular diversity of the trigeminal ganglion in mice, defining thirteen clusters of neurons. We show that clusters are well conserved in dorsal root ganglia suggesting they represent distinct functional classes of somatosensory neurons and not specialization associated with their sensory targets. Notably, functionally important genes (e.g. the mechanosensory channel Piezo2 and the capsaicin gated ion channel Trpv1) segregate into multiple clusters and often are expressed in subsets of cells within a cluster. Therefore, the 13 genetically-defined classes are likely to be physiologically heterogeneous rather than highly parallel (i.e., redundant) lines of sensory input. Our analysis harnesses the power of single-cell sequencing to provide a unique platform for in silico expression profiling that complements other approaches linking gene-expression with function and exposes unexpected diversity in the somatosensory system.
[Mh] Termos MeSH primário: Ensaios de Triagem em Larga Escala
Neurônios/citologia
Análise de Célula Única
Nervo Trigêmeo/citologia
[Mh] Termos MeSH secundário: Animais
Capsaicina/farmacologia
Gânglios Espinais/citologia
Ativação do Canal Iônico/efeitos dos fármacos
Camundongos
Canais de Cátion TRPV/efeitos dos fármacos
Canais de Cátion TRPV/fisiologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TRPV Cation Channels); 0 (TRPV1 protein, mouse); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185543


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[PMID]:28910445
[Au] Autor:Di G; Qi X; Zhao X; Zhang S; Danielson P; Zhou Q
[Ad] Endereço:Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
[Ti] Título:Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4695-4702, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To explore the neurotrophic factor expression in corneal epithelium and evaluate their effects on the trigeminal ganglion (TG) neurite outgrowth and corneal nerve regeneration in mice. Methods: The expression of neurotrophic factors was compared among the intact, regenerating, and regenerated mouse corneal epithelium. Mouse primary TG neurons were treated with the conditioned medium of mouse corneal epithelial cells. Nerve growth factor (NGF) neutralizing antibody and glial cell-derived neurotrophic factor (GDNF) neutralizing antibody were used to evaluate their roles in mouse corneal nerve regeneration and TG neurite outgrowth. The promoting effects of NGF and GDNF for the corneal nerve regeneration were further evaluated in the diabetic mice. Results: The expression of NGF and GDNF showed significant up-regulation in regenerating corneal epithelium and return to the preinjury levels in the regenerated epithelium, which was consistent with the progress of corneal subbasal nerve regeneration. The conditioned medium of corneal epithelial cells promoted the TG neurite outgrowth with extended branching and elongation. Furthermore, the blockage of either NGF or GDNF significantly impaired the promotion of the neurite outgrowth by the conditioned medium or the corneal nerve regeneration in normal mice. Moreover, the expression of NGF and GDNF was attenuated in the diabetic regenerating corneal epithelium as compared to that in normal mice, while exogenous NGF or GDNF supplement promoted the corneal epithelial and nerve regeneration in diabetic mice. Conclusions: Corneal epithelium expresses multiple neurotrophic factors, among which NGF and GDNF may play an important role in the corneal nerve regeneration.
[Mh] Termos MeSH primário: Córnea/inervação
Diabetes Mellitus Experimental/metabolismo
Epitélio Anterior/metabolismo
Fator Neurotrófico Derivado de Linhagem de Célula Glial/metabolismo
Fator de Crescimento Neural/metabolismo
Regeneração Nervosa/fisiologia
Nervo Trigêmeo/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Diabetes Mellitus Experimental/genética
Ensaio de Imunoadsorção Enzimática
Técnica Indireta de Fluorescência para Anticorpo
Fator Neurotrófico Derivado de Linhagem de Célula Glial/genética
Camundongos
Camundongos Endogâmicos C57BL
Fator de Crescimento Neural/genética
Neuritos/fisiologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gdnf protein, mouse); 0 (Glial Cell Line-Derived Neurotrophic Factor); 9061-61-4 (Nerve Growth Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21372


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[PMID]:28903153
[Au] Autor:Chucair-Elliott AJ; Gurung HR; Carr MM; Carr DJJ
[Ad] Endereço:Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
[Ti] Título:Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4670-4682, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Herpes simplex virus type-1 (HSV-1) is a leading cause of neurotrophic keratitis, characterized by decreased or absent corneal sensation due to damage to the sensory corneal innervation. We previously reported the elicited immune response to infection contributes to the mechanism of corneal nerve regression/damage during acute HSV-1 infection. Our aim is to further establish the involvement of infiltrated macrophages in the mechanism of nerve loss upon infection. Methods: Macrophage Fas-Induced Apoptosis (MAFIA) transgenic C57BL/6 mice were systemically treated with AP20187 dimerizer or vehicle (VEH), and their corneas, lymph nodes, and blood were assessed for CD45+CD11b+GFP+ cell depletion by flow cytometry (FC). Mice were ocularly infected with HSV-1 or left uninfected. At 2, 4, and/or 6 days post infection (PI), corneas were assessed for sensitivity and harvested for FC, nerve structure by immunohistochemistry, viral content by plaque assay, soluble factor content by suspension array, and activation of signaling pathways by Western blot analysis. C57BL6 mice were used to compare to the MAFIA mouse model. Results: MAFIA mice treated with AP20187 had efficient depletion of CD45+CD11b+GFP+ cells in the tissues analyzed. The reduction of CD45+CD11b+GFP+ cells recruited to the infected corneas of AP20187-treated mice correlated with preservation of corneal nerve structure and function, decreased protein concentration of inflammatory cytokines, and decreased STAT3 activation despite no changes in viral content in the cornea compared to VEH-treated animals. Conclusions: Our results suggest infiltrated macrophages are early effectors in the nerve regression following HSV-1 infection. We propose the neurodegeneration mechanism involves macrophages, local up-regulation of IL-6, and activation of STAT3.
[Mh] Termos MeSH primário: Córnea/inervação
Herpesvirus Humano 1/crescimento & desenvolvimento
Ceratite Herpética/imunologia
Macrófagos/fisiologia
Degeneração Neural/imunologia
Receptor de Fator Estimulador de Colônias de Macrófagos/metabolismo
Doenças do Nervo Trigêmeo/imunologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Modelos Animais de Doenças
Citometria de Fluxo
Imuno-Histoquímica
Interleucina-6/metabolismo
Ceratite Herpética/patologia
Ceratite Herpética/virologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Degeneração Neural/patologia
Degeneração Neural/virologia
Fator de Transcrição STAT3/metabolismo
Tacrolimo/análogos & derivados
Tacrolimo/farmacologia
Nervo Trigêmeo/metabolismo
Doenças do Nervo Trigêmeo/patologia
Doenças do Nervo Trigêmeo/virologia
Ensaio de Placa Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AP20187); 0 (Interleukin-6); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, mouse); 0 (interleukin-6, mouse); EC 2.7.10.1 (Receptor, Macrophage Colony-Stimulating Factor); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22159


  8 / 7933 MEDLINE  
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[PMID]:28888821
[Au] Autor:Kumata K; Yui J; Zhang Y; Kurihara Y; Ogawa M; Mori W; Fujinaga M; Zhang MR
[Ad] Endereço:Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
[Ti] Título:[ C]BCTC: Radiosynthesis and in vivo binding to transient receptor potential vanilloid subfamily member 1 (TRPV1) receptor in the mouse trigeminal nerve.
[So] Source:Bioorg Med Chem Lett;27(19):4521-4524, 2017 10 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to synthesize a new positron emission tomography radiotracer, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-[ C]carboxamide ([ C]BCTC, [ C]1), and assess its in vivo binding to the transient receptor potential vanilloid subfamily member 1 (TRPV1) receptor in mice. [ C]BCTC was synthesized by reacting the hydrochloride of 4-tertiarybutylaniline (2·HCl) with [ C]phosgene ([ C]COCl ) to give isocyanate [ C]4, followed by reaction with 4-(3-chloropyridin-2-yl)tetrahydropyrazine (3). [ C]BCTC was obtained at a 16-20% radiochemical yield, based on the cyclotron-produced [ C]CO (decay-corrected to the end of bombardment), with >98% radiochemical purity and 65-110GBq/µmol specific activity at the end of synthesis. An ex vivo biodistribution study in mice confirmed the specific binding of [ C]BCTC to TRPV1 in the trigeminal nerve, which is a tissue with high TRPV1 expression.
[Mh] Termos MeSH primário: Pirazinas/farmacocinética
Piridinas/farmacocinética
Canais de Cátion TRPV/química
Nervo Trigêmeo/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação/efeitos dos fármacos
Isótopos de Carbono
Relação Dose-Resposta a Droga
Camundongos
Camundongos Endogâmicos
Estrutura Molecular
Tomografia por Emissão de Pósitrons
Pirazinas/síntese química
Pirazinas/química
Piridinas/síntese química
Piridinas/química
Traçadores Radioativos
Relação Estrutura-Atividade
Canais de Cátion TRPV/biossíntese
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide); 0 (Pyrazines); 0 (Pyridines); 0 (Radioactive Tracers); 0 (TRPV Cation Channels); 0 (TRPV1 receptor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


  9 / 7933 MEDLINE  
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[PMID]:28877282
[Au] Autor:Won SY; Kim HK; Kim ME; Kim KS
[Ad] Endereço:Department of Oral Medicine, Dankook University College of Dentistry, Cheonan, South Korea.
[Ti] Título:Two-point discrimination values vary depending on test site, sex and test modality in the orofacial region: a preliminary study.
[So] Source:J Appl Oral Sci;25(4):427-435, 2017 Jul-Aug.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aims of the present study were to determine the normal values of TPD in the six trigeminal sites (the forehead, cheek, mentum, upper lip, lower lip, and the tongue tip) and to investigate the effect of the site, sex, and test modality on the TPD perception. Material and Methods: Forty healthy volunteers consisting of age-matched men (20) and women (20) with a mean age of 27.1 years were recruited. One examiner performed the TPD test using a simple hand-operated device, i.e., by drawing compass with a blunt or sharp-pointed tip. The static TPD with a blunt-pointed tip (STPDB), moving TPD with a blunt-pointed tip (MTPDB), and static TPD with a sharp-pointed tip (STPDS) were measured. The predictors were the site, sex, and test modality, and the outcome variable was the TPD value. Three-way ANOVA was used for statistics. Results: The analysis showed a significant effect of the site, sex and test modality on the TPD values. Significant differences between the test sites were observed with the descending order from the forehead and cheek>mentum>upper lip and lower lip>tongue tip and index finger. Women showed lower TPD values than those of men. The STPDS measurements were consistently lower than those of the STPDB and MTPDB. Conclusions: The normal values of TPD in this study suggest that the cheek and forehead were less sensitive than other regions evaluated and women were more sensitive than men. The STPDS was the most sensitive test modality.
[Mh] Termos MeSH primário: Face/inervação
Boca/inervação
Exame Neurológico/métodos
Sensação/fisiologia
Nervo Trigêmeo/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Pontos de Referência Anatômicos/fisiologia
Feminino
Seres Humanos
Masculino
Padrões de Referência
Valores de Referência
Fatores Sexuais
Fenômenos Fisiológicos da Pele
Estatísticas não Paramétricas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28727882
[Au] Autor:Petropoulos IN; Kamran S; Li Y; Khan A; Ponirakis G; Akhtar N; Deleu D; Shuaib A; Malik RA
[Ad] Endereço:Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
[Ti] Título:Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in Multiple Sclerosis.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3677-3681, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate whether corneal confocal microscopy (CCM) detects axonal degeneration and whether this is associated with retinal nerve fiber degeneration and clinical disability in patients with multiple sclerosis (MS). Methods: Twenty-five patients with MS and 25 healthy control subjects underwent CCM, optical coherence tomography (OCT), and assessment of neurological disability using the expanded disability status scale (EDSS) and MS severity score (MSSS). Results: In patients with MS compared with controls, there was a significant reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and length (CNFL). There was no significant difference in CCM parameters between patients with optic neuritis (MS-ON) and without (MS-NON), or between relapsing-remitting (RRMS) and secondary-progressive MS (SPMS). There was significant thinning of the retinal nerve fiber layer (RNFL) in the global, temporal, temporal superior, and temporal inferior quadrants, with no difference between MS-ON and MS-NON. Patients with SPMS compared with RRMS had a significantly lower global, temporal superior, temporal inferior, nasal, and nasal superior RNFL. The EDSS and MSSS correlated significantly with CNBD, nasal, nasal superior, and nasal inferior RNFL and with CNBD and nasal inferior RNFL, respectively. Conclusions: CCM and OCT detect significant corneal and retinal nerve degeneration which relates to the severity of neurological deficits in patients with mild MS.
[Mh] Termos MeSH primário: Axônios/patologia
Córnea/inervação
Esclerose Múltipla/diagnóstico por imagem
Degeneração Neural/diagnóstico por imagem
Neurite Óptica/diagnóstico por imagem
Doenças do Nervo Trigêmeo/diagnóstico por imagem
Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Microscopia Confocal
Esclerose Múltipla/patologia
Degeneração Neural/patologia
Neurite Óptica/patologia
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica
Doenças do Nervo Trigêmeo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22050



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