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  1 / 3355 MEDLINE  
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[PMID]:28719825
[Au] Autor:Chang CM; Young YH; Jaw FS; Wang CT; Cheng PW
[Ad] Endereço:Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.
[Ti] Título:Degeneration of the vestibular nerve in unilateral Meniere's disease evaluated by galvanic vestibular-evoked myogenic potentials.
[So] Source:Clin Neurophysiol;128(9):1617-1624, 2017 Sep.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The staging system of Meniere's disease utilizes audiograms to probe cochlear dysfunction. We explored the addition of galvanic vestibular-evoked myogenic potentials (VEMP) to further explore vestibular function. METHODS: Seventy patients with unilateral Meniere's disease were enrolled in this study. Within 2weeks of diagnosis, all subjects underwent pure tone audiometry, cervical and ocular VEMP, and caloric test. The prevalence of abnormal tests and the VEMP characteristic parameters such as latencies and amplitudes were analyzed. RESULTS: In affected ears, the abnormal rate of acoustic cVEMPs, galvanic cVEMPs, vibratory oVEMPs and galvanic oVEMPs was 37%, 17%, 20%, and 9%, respectively. No significant differences existed in VEMP latencies and amplitudes between affected ears and unaffected ears. CONCLUSIONS: The impairment of otolithic organs was found to be more than that of vestibular afferents. The deterioration of the saccule was more than that of the utricle, whereas retrolabyrinthine degeneration of sacculo-collic reflex and vestibulo-ocular reflex was similar. SIGNIFICANCE: This study is the first to use an electrophysiological test to evaluate the retrolabyrinthine function of patients with unilateral Meniere's disease.
[Mh] Termos MeSH primário: Resposta Galvânica da Pele/fisiologia
Doença de Meniere/fisiopatologia
Degeneração Neural/fisiopatologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
Nervo Vestibular/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Audiometria/métodos
Eletromiografia/métodos
Feminino
Seres Humanos
Masculino
Doença de Meniere/diagnóstico
Meia-Idade
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  2 / 3355 MEDLINE  
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[PMID]:28446678
[Au] Autor:Himmelein S; Lindemann A; Sinicina I; Horn AKE; Brandt T; Strupp M; Hüfner K
[Ad] Endereço:Department of Neurology, University Hospital, Munich, Germany susanne.himmelein@med.uni-muenchen.de.
[Ti] Título:Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis.
[So] Source:J Virol;91(14), 2017 Jul 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). Especially uncertain is why the superior vestibular nerve (SVN) is more frequently affected than the inferior vestibular nerve (IVN), which is partially or totally spared. To address this question, we developed an improved method for preparing human vestibular ganglia (VG) and nerve. Subsequently, macro- and microanatomical as well as PCR studies were performed on 38 human ganglia from 38 individuals. The SVN was 2.4 mm longer than the IVN, and in 65% of the cases, the IVN ran in two separate bony canals, which was not the case for the SVN. Anastomoses between the facial and cochlear nerves were more common for the SVN (14/38 and 9/38, respectively) than for the IVN (7/38 and 2/38, respectively). Using reverse transcription-quantitative PCR (RT-qPCR), we found only a few latently herpes simplex virus 1 (HSV-1)-infected VG (18.4%). In cases of two separate neuronal fields, infected neurons were located in the superior part only. In summary, these PCR and micro- and macroanatomical studies provide possible explanations for the high frequency of SVN infection in vestibular neuritis. Vestibular neuritis is known to affect the superior part of the vestibular nerve more frequently than the inferior part. The reason for this clinical phenomenon remains unclear. Anatomical differences may play a role, or if latent HSV-1 infection is assumed, the etiology may be due to the different distribution of the infection. To shed further light on this subject, we conducted different macro- and microanatomical studies. We also assessed the presence of HSV-1 in VG and in different sections of the VG. Our findings add new information on the macro- and microanatomy of the VG as well as the pathophysiology of vestibular neuritis. We also show that latent HSV-1 infection of VG neurons is less frequent than previously reported.
[Mh] Termos MeSH primário: Gânglios/virologia
Herpesvirus Humano 1/fisiologia
Nervo Vestibular/virologia
Neuronite Vestibular/patologia
Neuronite Vestibular/virologia
Latência Viral
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Seres Humanos
Meia-Idade
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  3 / 3355 MEDLINE  
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[PMID]:28436631
[Au] Autor:Guan Q; Zhang L; Hong W; Yang Y; Chen Z; Zhang D; Hu X
[Ad] Endereço:Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China; Department of Neurology, Ningbo Second Hospital, Ningbo 315001, China.
[Ti] Título:[Video head impulse test for evaluation of vestibular function in patients with vestibular neuritis and benign paroxysmal positional vertigo].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;46(1):52-58, 2017 Jan 25.
[Is] ISSN:1008-9292
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To assess the clinical application of video head impulse test (vHIT) for vestibular function in vestibular neuritis (VN) and benign paroxysmal positional vertigo (BPPV) patients. Thirty-three patients with VN and 43 patients with BPPV were enrolled from Sir Run Run Shaw Hospital and Ningbo Second Hospital from March 15 to September 10, 2015; and 50 healthy controls were also enrolled in the study. vHIT was used to quantitatively test the vestibulo-ocular reflex (VOR) gains of a pair of horizontal semicircular canals. VOR gains two pairs of vertical semicircular canals, and the corresponding asymmetrical value of three VOR gains. The saccades information was also recorded. Compared with the healthy control group and BPPV patients, the affected horizontal and vertical VOR gains were declined and the corresponding asymmetries were increased in VN patients (all <0.01). BPPV group also showed higher vertical VOR gain asymmetries compared with the healthy control group (all <0.01), but no significant difference was observed in VOR gains and horizontal VOR gain asymmetry (all >0.05). The sensibility of vHIT in diagnosis of VN was 87.9%. Among 33 VN patients, 22 were diagnosed with superior vestibular nerve dysfunction, 7 were found with inferior vestibular nerve dysfunction and 3 were with both dysfunction; and 1 case was not distinguished. Video head impulse test can quantitatively evaluate the vestibular dysfunction of VN and can help early diagnosis of VN, which may be widely used in clinic.
[Mh] Termos MeSH primário: Vertigem Posicional Paroxística Benigna/diagnóstico
Reflexo Vestíbulo-Ocular/fisiologia
Doenças Vestibulares/classificação
Doenças Vestibulares/diagnóstico
Nervo Vestibular/patologia
Neuronite Vestibular/classificação
Neuronite Vestibular/diagnóstico
[Mh] Termos MeSH secundário: Teste do Impulso da Cabeça
Seres Humanos
Movimentos Sacádicos/fisiologia
Canais Semicirculares/inervação
Canais Semicirculares/fisiopatologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  4 / 3355 MEDLINE  
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[PMID]:28265687
[Au] Autor:Kim N; Choi MA; Koo H; Park BR; Han SW; Cheong C; Kim MS
[Ad] Endereço:Department of Physiology, Wonkwang University School of Medicine and Brain Science Institute at Wonkwang University, Iksan, 570-749, Korea.
[Ti] Título:Activation of the thalamic parafascicular nucleus by electrical stimulation of the peripheral vestibular nerve in rats.
[So] Source:Exp Brain Res;235(5):1617-1625, 2017 May.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The parafascicular nucleus (PFN) of the thalamus is a primary structure in the feedback circuit of the basal ganglia-thalamo-cortical system, as well as in the neural circuit of the vestibulo-thalamo-striatal pathway. We investigated the characteristics of the functional connectivity between the peripheral vestibular system and the PFN in rats. A single electrical stimulation was applied to the horizontal semicircular canal nerve in the peripheral vestibular end-organs. This resulted in polysynaptic local field potentials (LFPs) in the PFN, which were composed of long-lasting multiple waves. The LFPs were prominently seen contralateral to the stimulation site. The PFN LFPs were suppressed by transient chemical de-afferentation of peripheral vestibular activity using a 5% lidocaine injection into the middle ear. The spontaneous firing rate of the single units increased after electrical stimulation to the horizontal canal nerve in a frequency-dependent manner. The induction of cFos protein was more prominent in the contralateral PFN than in the ipsilateral PFN following horizontal semicircular canal nerve stimulation. The functional vestibulo-parafascicular connection is a neural substrate for the transmission of vestibular sensory information to the basal ganglia.
[Mh] Termos MeSH primário: Vias Aferentes/fisiologia
Estimulação Elétrica
Núcleos Intralaminares do Tálamo/fisiologia
Neurônios/fisiologia
Nervo Vestibular/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Análise de Variância
Animais
Biofísica
Lateralidade Funcional
Núcleos Intralaminares do Tálamo/citologia
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos
Ratos Sprague-Dawley
Potenciais Sinápticos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-fos)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1007/s00221-016-4864-5


  5 / 3355 MEDLINE  
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[PMID]:28244847
[Au] Autor:Abou-Elew MH; Hosni NA; Obaid EA; Ewida AH
[Ad] Endereço:Audio-Vestibular Unit,ORL Department,Otorhinolaryngology Department,Faculty of Medicine,Cairo University,Cairo,Egypt.
[Ti] Título:The N3 potential and the efferent cochlear pathway in profound sensorineural hearing loss.
[So] Source:J Laryngol Otol;131(4):334-340, 2017 Apr.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to evaluate the presence of the N3 potential (acoustically evoked short latency negative response) in profound sensorineural hearing loss, its association with the cervical vestibular evoked myogenic potential and the relationship between both potentials and loss of auditory function. METHODS: Otological examinations of 66 ears from 50 patients aged from 4 to 36 years were performed, and the vestibular evoked myogenic potential and auditory brainstem response were measured. RESULTS: The N3 potential was recorded in 36 out of 66 ears (55 per cent) and a vestibular evoked myogenic potential was recorded in 34 (52 per cent). The N3 potential was recorded in 23 out of 34 ears (68 per cent) with a vestibular evoked myogenic potential response and absent in 19 out of 32 ears (59 per cent) without a vestibular evoked myogenic potential response. The presence of an N3 potential was significantly associated with a vestibular evoked myogenic potential response (p = 0.028), but there was no significant difference in the latency or amplitude of the N3 potential in either the presence or absence of a vestibular evoked myogenic potential. CONCLUSION: The presence of an N3 potential in profound sensorineural hearing loss with good or poor vestibular function can be explained by the contribution of the efferent cochlear pathway through olivocochlear fibres that join the inferior vestibular nerve. This theory is supported by its early latency and reversed polarity, which is masked in normal hearing by auditory brainstem response waves.
[Mh] Termos MeSH primário: Cóclea/inervação
Potenciais Evocados/fisiologia
Perda Auditiva Neurossensorial/fisiopatologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
Nervo Vestibular/fisiopatologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Adolescente
Adulto
Audiometria de Resposta Evocada
Criança
Pré-Escolar
Cóclea/fisiopatologia
Estudos Transversais
Vias Eferentes/fisiologia
Feminino
Seres Humanos
Masculino
Tempo de Reação
Testes de Função Vestibular
Vestíbulo do Labirinto/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000317


  6 / 3355 MEDLINE  
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[PMID]:28125514
[Au] Autor:Gluth MB; Nelson EG
[Ad] Endereço:Bloom Otopathology Lab, Section of Otolaryngology-Head and Neck Surgery, University of Chicago Medicine & Biological Sciences, Chicago, Illinois.
[Ti] Título:Age-Related Change in Vestibular Ganglion Cell Populations in Individuals With Presbycusis and Normal Hearing.
[So] Source:Otol Neurotol;38(4):540-546, 2017 Apr.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HYPOTHESIS: We sought to establish that the decline of vestibular ganglion cell counts uniquely correlates with spiral ganglion cell counts, cochlear hair cell counts, and hearing phenotype in individuals with presbycusis. BACKGROUND: The relationship between aging in the vestibular system and aging in the cochlea is a topic of ongoing investigation. Histopathologic age-related changes the vestibular system may mirror what is seen in the cochlea, but correlations with hearing phenotype and the impact of presbycusis are not well understood. METHODS: Vestibular ganglion cells, spiral ganglion cells, and cochlear hair cells were counted in specimens from individuals with presbycusis and normal hearing. These were taken from within a large collection of processed human temporal bones. Correlations between histopathology and hearing phenotype were investigated. RESULTS: Vestibular ganglion cell counts were positively correlated with spiral ganglion cell counts and cochlear hair cell counts and were negatively correlated with hearing phenotype. There was no statistical evidence on linear regression to suggest that the relationship between age and cell populations differed significantly according to whether presbycusis was present or not. Superior vestibular ganglion cells were more negatively correlated with age than inferior ganglion cells. No difference in vestibular ganglion cells was noted based on sex. CONCLUSION: Vestibular ganglion cell counts progressively deteriorate with age, and this loss correlates closely with changes in the cochlea, as well as hearing phenotype. However, these correlations do not appear to be unique in individuals with presbycusis as compared with those with normal hearing.
[Mh] Termos MeSH primário: Envelhecimento/patologia
Presbiacusia/patologia
Nervo Vestibular/patologia
[Mh] Termos MeSH secundário: Idoso
Contagem de Células
Cóclea/patologia
Feminino
Células Ciliadas Auditivas/patologia
Audição
Seres Humanos
Masculino
Gânglio Espiral da Cóclea/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001325


  7 / 3355 MEDLINE  
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[PMID]:27885877
[Au] Autor:Kang WS; Kim SA; Yang CJ; Nam SH; Chung JW
[Ad] Endereço:a Department of Otorhinolaryngology-Head & Neck Surgery , Asan Medical Center, University of Ulsan College of Medicine , Seoul , South Korea.
[Ti] Título:Surgical outcomes of middle fossa approach in intracanalicular vestibular schwannoma.
[So] Source:Acta Otolaryngol;137(4):352-355, 2017 Apr.
[Is] ISSN:1651-2251
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONCLUSION: Middle fossa approach (MFA) shows a hearing preservation rate of 86% and facial nerve function was preserved with HB grade I or II in 93%. MFA is a good treatment option for intra-canalicular vestibular schwannomas when surgical excision is needed. BACKGROUND: Surgical outcomes of vestibular schwannoma have progressively improved with the advancement of microsurgical instruments. MFA is known to have better chances to preserve hearing, while it has limited access to the posterior fossa, limitation of tumor size, and higher risk of post-operative facial nerve weakness. OBJECTIVES: To investigate surgical outcomes and clinical efficiency of MFA in vestibular schwannoma. METHODS: A retrospective study was done in 14 patients who underwent MFA for vestibular schwannoma in Asan Medical Center. RESULTS: The median age at diagnosis was 46.3 years. At initial presentation, 57% of the patients had vertigo, 43% hearing disturbance, and 64% tinnitus. The mean tumor size was 9.7 mm. The tumors were completely resected in 86% of the patients. Hearing was post-operatively preserved in 12 patients and two patients lost their hearing following surgery. Facial nerve function post-operatively remained unchanged in 12 patients (86%).
[Mh] Termos MeSH primário: Neuroma Acústico/cirurgia
[Mh] Termos MeSH secundário: Adulto
Nervo Facial/fisiologia
Feminino
Audição
Seres Humanos
Masculino
Meia-Idade
Neuroma Acústico/patologia
Procedimentos Cirúrgicos Otorrinolaringológicos
Estudos Retrospectivos
Nervo Vestibular/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1080/00016489.2016.1255992


  8 / 3355 MEDLINE  
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[PMID]:27867121
[Au] Autor:van den Berge MJ; van Dijk JM; Free RH; Stienstra J; van Dijk P; van der Laan BF
[Ad] Endereço:Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, Groningen, The Netherlands. Ele
[Ti] Título:Effect of Direct Stimulation of the Cochleovestibular Nerve on Tinnitus: A Long-Term Follow-Up Study.
[So] Source:World Neurosurg;98:571-577, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Tinnitus is a common entity that may lead to severe impairment in quality of life. An adequate treatment modality for severe tinnitus is currently lacking. Neurostimulation of the auditory tract may serve as a promising adjunct in tinnitus treatment. The aim is to investigate the effect of direct stimulation on the cochleovestibular nerve for intractable tinnitus. METHODS: This study was conducted at the University Medical Center Groningen, The Netherlands. We studied 10 patients with severe, unilateral, intractable tinnitus, who were implanted with a cuff electrode around the cochleovestibular nerve between 2001 and 2013. All patients had preoperative ipsilateral hearing loss. Tinnitus Handicap Inventory (THI) scores and audiometric values were collected. Treatment success was determined based on the self-assessment of satisfactory usage by each patient. RESULTS: The mean preoperative tinnitus duration was 8.0 ± 5.9 years. The preoperative THI score was 71 ± 18 points. During mean follow-up of 49 months, the mean THI reduction was 24 ± 26 points (P = 0.02). Treatment was regarded successful in 6 patients (60%). In these patients, tinnitus did not disappear, but transformed into a more bearable sound. In 4 patients, transient complications occurred, and 1 patient experienced permanent vertigo postoperatively. Furthermore, hearing deterioration was a result of implantation in 86% of the patients. CONCLUSIONS: Direct neurostimulation resulted in treatment success in a small majority of the patients, with a significant decrease in THI score. However, because of a high risk of additional hearing damage, this technique seems not viable for patients with moderate hearing loss.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica/métodos
Zumbido/terapia
[Mh] Termos MeSH secundário: Idoso
Nervo Coclear
Terapia por Estimulação Elétrica/instrumentação
Feminino
Seguimentos
Seres Humanos
Neuroestimuladores Implantáveis
Masculino
Meia-Idade
Desenho de Prótese
Resultado do Tratamento
Nervo Vestibular
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


  9 / 3355 MEDLINE  
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[PMID]:27812817
[Au] Autor:Canzi P; Manfrin M; Perotti M; Aprile F; Quaglieri S; Rebecchi E; Locatelli G; Benazzo M
[Ad] Endereço:Department of Otorhinolaryngology, University of Pavia, IRCCS Policlinico "S. Matteo" Foundation, Viale Camillo Golgi, 19, 27100, Pavia, Italy. pietro.canzi@unipv.it.
[Ti] Título:Translabyrinthine vestibular neurectomy and simultaneous cochlear implant for Ménière's disease.
[So] Source:Acta Neurochir (Wien);159(1):123-130, 2017 Jan.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surgical management of Ménière's disease (MD) is recommended in case of medical and intratympanic treatment failures. Translabyrinthine vestibular nerve section has been considered the gold standard for denervation procedures in order to control vertigo attacks, although at the cost of sacrificing residual hearing. To the best of our knowledge, no work has been published with regard to a group of patients submitted to translabyrinthine vestibular neurectomy and simultaneous cochlear implant for MD. The aim of the present study was to assess the effectiveness of translabyrinthine vestibular nerve section and simultaneous cochlear implant in a prospective study. METHODS: All adult patients (over 18 years of age) with a diagnosis of intractable unilateral definite MD and useless residual hearing function were enrolled after medical and intratympanic treatment failures. Pre- and postoperative otoneurological evaluation concerned: frequency of vertigo attacks, head impulse test and caloric testing, pure tone average and speech perception audiometry in quiet conditions, tinnitus handicap inventory test, functional level scale and rate of vertigo control, dizziness handicap inventory test, and MD patient-oriented severity index. At least 6 months of follow-up were needed to be enrolled in the study. RESULTS: Four patients were included in the study. Translabyrinthine vestibular nerve section and simultaneous cochlear implant seemed to considerably improve the disabling effects of MD, achieving a good control of vestibular symptoms (mean pre/postoperative vertigo attacks per month: 16.5/0), resolving hearing loss (mean pre/postoperative pure tone average in the affected ear: 86.2/32.5 dB), improving the tinnitus (mean pre/postoperative tinnitus handicap inventory test: 77.2/6), and finally increasing the overall quality-of-life parameters. CONCLUSIONS: In our preliminary report, translabyrinthine vestibular nerve section and simultaneous cochlear implant showed encouraging results in order to definitively control both vestibular and cochlear symptoms during the same therapeutic procedure.
[Mh] Termos MeSH primário: Implantes Cocleares
Denervação/métodos
Doença de Meniere/terapia
Nervo Vestibular/cirurgia
[Mh] Termos MeSH secundário: Adulto
Implante Coclear
Feminino
Seres Humanos
Masculino
Doença de Meniere/cirurgia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-016-2996-9


  10 / 3355 MEDLINE  
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[PMID]:27108289
[Au] Autor:Hong K; Shim HM; Goh M; Jang SY; Lee S; Kim KS
[Ad] Endereço:Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
[Ti] Título:Direct perturbation of neural integrator by bilateral galvanic vestibular stimulation.
[So] Source:Med Biol Eng Comput;55(2):207-212, 2017 Feb.
[Is] ISSN:1741-0444
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caloric vestibular stimulation (CVS) and galvanic vestibular stimulation (GVS) act primarily on the peripheral vestibular system. Although the electrical current applied during GVS is thought to flow through peripheral vestibular organs, some current may spread into areas within the central nervous system, particularly when the bilateral galvanic vestibular stimulation (bGVS) method is used. According to Alexander's law, the magnitude of nystagmus increases with eccentric gaze movement, due to the function of the neural integrator (NI); thus, if the information for vestibular stimulation corresponds to Alexander's law, the peripheral vestibular organ is stimulated. Therefore, it would appear that if CVS results comply with Alexander's law, and bGVS results do not, the sites stimulated by bGVS are not perfectly located in the peripheral vestibular area. In our experiments on normal human subjects, the magnitude of nystagmus under CVS increased with rising gaze eccentricity in the direction that the magnitude of the nystagmus increases, and this change was found to follow Alexander's law. However, in the case of nystagmus under bGVS, results did not follow Alexander's law. In addition, study of the influences of bGVS at different current intensities on nystagmus magnitude showed that bGVS at 5 mA distorted nystagmus magnitude more than at 3 mA, which suggests bGVS acts not only on the peripheral vestibular nerves, but also on some areas of the central nervous system, particularly the NI. According to our experiments, bGVS directly affects neural integrator function.
[Mh] Termos MeSH primário: Estimulação Elétrica/métodos
Nistagmo Fisiológico/fisiologia
Reflexo Vestíbulo-Ocular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Nervo Vestibular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160425
[St] Status:MEDLINE
[do] DOI:10.1007/s11517-016-1502-0



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