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[PMID]:29180190
[Au] Autor:Fang F; Zou W; Zhang Z; Zhang Q; Xie Y
[Ad] Endereço:Pharmacological Department, Fujian Medical University, Fuzhou, Fujian, China.
[Ti] Título:Patterns of sural nerve innervation of the sural artery with implication for reconstructive surgery.
[So] Source:J Surg Res;220:261-267, 2017 Dec.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most of the literature concerning the neurocutaneous flap is related to its anatomic investigation and clinical application, and the more in-depth physiological problem such as whether the cutaneous nerve contains sympathetic fibers that innervate its accompanying vessels has never been explored. MATERIALS AND METHODS: Dissection was first performed on three rabbits. In another 22 rabbits, two rabbits undergoing no surgery were used as the normal control group. In the remaining 20 rabbits, the 40 sides of hind limbs were divided into a nerve severance group, where the sural nerve was transected at its origin after creation of the proximally based sural neurocutaneous flap, and a nerve preservation group, in which the continuation of the sural nerve was preserved. The sural neurovascular bundles at four time points were harvested for immunohistochemical and Western blotting analyses of the expression of tyrosine hydroxylase (TH). An infrared thermal imager was used for measurement of the average flap temperature within the first 24 h. RESULTS: The sural neurovascular bundle entered the skin at 4.5 ± 1.2 cm above the lateral malleolus. The TH in the sural nerve and tunica adventitia of the sural artery showed a synchronized abated expression in the nerve severance group. The TH expression showed no decline in the nerve preservation group. The average flap temperature in the nerve severance group was higher than that in the nerve preservation group starting from 2 h after flap harvest (P = 0.05). CONCLUSIONS: The cutaneous nerve has meted out sympathetic fibers to the accompanying artery, regulating its vascular tone.
[Mh] Termos MeSH primário: Nervo Sural/anatomia & histologia
Retalhos Cirúrgicos/irrigação sanguínea
Retalhos Cirúrgicos/inervação
[Mh] Termos MeSH secundário: Animais
Artérias/inervação
Western Blotting
Imuno-Histoquímica
Coelhos
Retalhos Cirúrgicos/cirurgia
Temperatura Ambiente
Tirosina 3-Mono-Oxigenase/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:28710923
[Au] Autor:Kural MA; Karlsson P; Pugdahl K; Isak B; Fuglsang-Frederiksen A; Tankisi H
[Ad] Endereço:Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
[Ti] Título:Diagnostic utility of distal nerve conduction studies and sural near-nerve needle recording in polyneuropathy.
[So] Source:Clin Neurophysiol;128(9):1590-1595, 2017 Sep.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The electrodiagnosis of polyneuropathy (PNP) may benefit from examination using near-nerve needle technique (NNT) and from inclusion of distal nerves. This study compared the diagnostic utility of distal nerve conduction studies (NCS) and NNT recording. METHODS: Bilateral NNT and surface recording of the sural nerve and surface recording of the dorsal sural and medial plantar nerves were prospectively done in 91 patients with clinically suspected PNP. Distal NCS were additionally done in 37 healthy controls. Diagnostic reference standard was the final clinical diagnosis retrieved from the patients medical records after 1-4years. RESULTS: The clinical follow-up diagnosis confirmed PNP in 68 patients. Equally high sensitivities of the dorsal sural (72%), medial plantar (75%), and sural nerve with NNT recording (77%) were seen, while the sensitivity of conventional surface recording of the sural nerve was lower (60%). Sural NCS with both NNT and surface recording and dorsal sural NCS showed high specificities (85-95%) and positive predictive values (94-98%), while a lower specificity was seen for the medial plantar nerve (68%). CONCLUSION: NCS of distal nerves, especially the dorsal sural nerve, have high diagnostic power equalling sural NNT recording. SIGNIFICANCE: The electrodiagnostic evaluation of patients with suspected PNP benefits from NCS of distal nerves.
[Mh] Termos MeSH primário: Agulhas
Condução Nervosa/fisiologia
Polineuropatias/diagnóstico
Polineuropatias/fisiopatologia
Nervo Sural/fisiopatologia
Nervo Tibial/fisiopatologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adulto
Idoso
Eletrodiagnóstico/instrumentação
Eletrodiagnóstico/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28679600
[Au] Autor:Kollmer J; Sahm F; Hegenbart U; Purrucker JC; Kimmich C; Schönland SO; Hund E; Heiland S; Hayes JM; Kristen AV; Röcken C; Pham M; Bendszus M; Weiler M
[Ad] Endereço:From the Department of Neuroradiology (J.K., S.H., M.P., M.B.), Amyloidosis Center Heidelberg (J.K., U.H., J.C.P., C.K., S.O.S., E.H., A.V.K., M.W.), Department of Neuropathology (F.S.), Medical Department V (U.H., C.K., S.O.S.), Department of Neurology (J.C.P., E.H., M.W.), Division of Experimental
[Ti] Título:Sural nerve injury in familial amyloid polyneuropathy: MR neurography vs clinicopathologic tools.
[So] Source:Neurology;89(5):475-484, 2017 Aug 01.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To detect and quantify lesions of the small-caliber sural nerve (SN) in symptomatic and asymptomatic transthyretin familial amyloid polyneuropathy (TTR-FAP) by high-resolution magnetic resonance neurography (MRN) in correlation with electrophysiologic and histopathologic findings. METHODS: Twenty-five patients with TTR-FAP, 10 asymptomatic carriers of the mutated transthyretin gene (mut ), and 35 age- and sex-matched healthy controls were prospectively included in this cross-sectional case-control study. All participants underwent 3T MRN with high-structural resolution (fat-saturated, T2-weighted, and double-echo sequences). Total imaging time was ≈45 minutes per patient. Manual SN segmentation was performed from its origin at the sciatic nerve bifurcation to the lower leg with subsequent evaluation of quantitative microstructural and morphometric parameters. Additional time needed for postprocessing was ≈1.5 hours per participant. Detailed neurologic and electrophysiologic examinations were conducted in the TTR group. RESULTS: T2 signal and proton spin density (ρ) reliably differentiated between TTR-FAP (198.0 ± 13.3, 429.6 ± 15.25), mut carriers (137.0 ± 16.9, = 0.0009; 354.7 ± 21.64, = 0.0029), and healthy controls (90.0 ± 3.4, 258.2 ± 9.10; < 0.0001). Marked differences between mut carriers and controls were found for T2 signal ( = 0.0065) and ρ ( < 0.0001). T2 relaxation time was higher in patients with TTR-FAP only ( = 0.015 vs mut carriers, = 0.0432 vs controls). SN caliber was higher in patients with TTR-FAP vs controls and in mut carriers vs controls ( < 0.0001). Amyloid deposits were histopathologically detectable in 10 of 14 SN specimens. CONCLUSIONS: SN injury in TTR-FAP is detectable and quantifiable in vivo by MRN even in asymptomatic mut carriers. Differences in SN T2 signal between controls and asymptomatic mut carriers are derived mainly from an increase of ρ, which overcomes typical limitations of established diagnostic methods as a highly sensitive imaging biomarker for early detection of peripheral nerve lesions. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that MRN accurately identifies asymptomatic mut carriers.
[Mh] Termos MeSH primário: Neuropatias Amiloides Familiares/diagnóstico por imagem
Imagem por Ressonância Magnética
Nervo Sural/diagnóstico por imagem
Nervo Sural/lesões
[Mh] Termos MeSH secundário: Adulto
Idoso
Neuropatias Amiloides Familiares/genética
Neuropatias Amiloides Familiares/patologia
Estudos de Casos e Controles
Estudos Transversais
Avaliação da Deficiência
Diagnóstico Precoce
Feminino
Heterozigoto
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Meia-Idade
Condução Nervosa
Pré-Albumina/genética
Sintomas Prodrômicos
Estudos Prospectivos
Nervo Sural/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prealbumin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004178


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[PMID]:28640120
[Au] Autor:Özdemir G
[Ad] Endereço:Atatürk University Medical Faculty, Department of Neurology, Erzurum City, Turkey.
[Ti] Título:Working hand syndrome: A new definition of non-classified polyneuropathy condition.
[So] Source:Medicine (Baltimore);96(25):e7235, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this paper was to define an unexplained non-classified polyneuropathy condition as a new neurological disease. This new diagnosis of occupation related polyneuropathy has been named as "WORKING HAND SYNDROME (WHS)."This study collected and compared clinic and electrophysiological analyze data from healthy controls, WHS patients, carpal tunnel syndrome (CTS) patients and polyneuropathy patients. The WHS patients presented to the clinic with pain, numbness, tingling, and burning sensations in their hands that increased significantly during rest and nighttime. However, there was no weakness in the muscles, and the deep tendon reflexes were normal in this disease. The patients had all been working in physically demanding jobs requiring the use of their hands/arms for at least 1 year, but no vibrating tools were used by the patients. All of the cases were men. I supposed that overload caused by an action repeated chronically by the hand/arm may impair the sensory nerves in mentioned hand/arm. In patients with these complaints, for a definitive diagnosis, similar diseases must be excluded. Nonetheless, the specific electrophysiological finding that the sural nerves are normal on the lower sides, as well as the occurrence of sensory axonal polyneuropathy in the sensory nerves without a significant effect on velocity and latency in the work-ups of the upper extremity are enough to make a diagnosis.In conclusion, WHS has been defined as a polyneuropathy and occupational disease. Patients with WHS present with pain, numbness, tingling, and burning sensations in their hands that increases significantly during rest and nighttime. They also use their arms/hands for jobs that require heavy labor. The neurological examinations of patients with WHS are normal. Only the sensory nerves in the upper extremities are affected. This article is suggested to serve as a resource for patients, health care professionals, and members of the neurology community at large.
[Mh] Termos MeSH primário: Transtornos Traumáticos Cumulativos/classificação
Mãos
Doenças Profissionais/classificação
Doenças do Sistema Nervoso Periférico/classificação
Polineuropatias/classificação
[Mh] Termos MeSH secundário: Síndrome do Túnel Carpal/diagnóstico
Síndrome do Túnel Carpal/fisiopatologia
Transtornos Traumáticos Cumulativos/diagnóstico
Transtornos Traumáticos Cumulativos/fisiopatologia
Diagnóstico Diferencial
Eletromiografia
Mãos/fisiopatologia
Seres Humanos
Masculino
Nervo Mediano/fisiopatologia
Meia-Idade
Condução Nervosa
Doenças Profissionais/diagnóstico
Doenças Profissionais/fisiopatologia
Doenças do Sistema Nervoso Periférico/diagnóstico
Doenças do Sistema Nervoso Periférico/fisiopatologia
Polineuropatias/diagnóstico
Polineuropatias/fisiopatologia
Reflexo
Nervo Sural/fisiopatologia
Síndrome
Terminologia como Assunto
Nervo Ulnar/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007235


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[PMID]:28609352
[Au] Autor:O'Grady KM; Power HA; Olson JL; Morhart MJ; Harrop AR; Watt MJ; Chan KM
[Ad] Endereço:Edmonton and Calgary, Alberta, Canada From the Department of Occupational Therapy, Glenrose Rehabilitation Hospital; the Division of Plastic Surgery, the Department of Pediatrics, Faculty of Medicine, and the Division of Physical Medicine and Rehabilitation, University of Alberta; and the Division of Plastic Surgery, University of Calgary.
[Ti] Título:Comparing the Efficacy of Triple Nerve Transfers with Nerve Graft Reconstruction in Upper Trunk Obstetric Brachial Plexus Injury.
[So] Source:Plast Reconstr Surg;140(4):747-756, 2017 Oct.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Upper trunk obstetric brachial plexus injury can cause profound shoulder and elbow dysfunction. Although neuroma excision with interpositional sural nerve grafting is the current gold standard, distal nerve transfers have a number of potential advantages. The goal of this study was to compare the clinical outcomes and health care costs between nerve grafting and distal nerve transfers in children with upper trunk obstetric brachial plexus injury. METHODS: In this prospective cohort study, children who underwent triple nerve transfers were followed with the Active Movement Scale for 2 years. Their outcomes were compared to those of children who underwent nerve graft reconstruction. To assess health care use, a cost analysis was also performed. RESULTS: Twelve patients who underwent nerve grafting were compared to 14 patients who underwent triple nerve transfers. Both groups had similar baseline characteristics and showed improved shoulder and elbow function following surgery. However, the nerve transfer group displayed significantly greater improvement in shoulder external rotation and forearm supination 2 years after surgery (p < 0.05). The operative time and length of hospital stay were significantly lower (p < 0.05), and the overall cost was approximately 50 percent less in the nerve transfer group. CONCLUSION: Triple nerve transfer for upper trunk obstetric brachial plexus injury is a feasible option, with better functional shoulder external rotation and forearm supination, faster recovery, and lower cost compared with traditional nerve graft reconstruction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
[Mh] Termos MeSH primário: Traumatismos do Nascimento/cirurgia
Neuropatias do Plexo Braquial/cirurgia
Plexo Braquial/lesões
Transferência de Nervo/métodos
Procedimentos Cirúrgicos Reconstrutivos/métodos
Nervo Sural/transplante
Tronco/inervação
[Mh] Termos MeSH secundário: Plexo Braquial/cirurgia
Feminino
Seguimentos
Seres Humanos
Lactente
Masculino
Estudos Prospectivos
Recuperação de Função Fisiológica/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003668


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[PMID]:28550073
[Au] Autor:Schneider C; Wunderlich G; Bleistein J; Fink GR; Deckert M; Brunn A; Lehmann HC
[Ad] Endereço:Department of Neurology, University of Cologne, Köln, Germany.
[Ti] Título:Lymphocyte antigens targetable by monoclonal antibodies in non-systemic vasculitic neuropathy.
[So] Source:J Neurol Neurosurg Psychiatry;88(9):756-760, 2017 Sep.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To identify the most relevant antigens for monoclonal antibodies in lymphocytic infiltrates in non-systemic vasculitic neuropathy (NSVN). BACKGROUND: Current immunosuppressive treatment for NSVN is insufficient. Monoclonal antibodies might be a treatment option, but the expression profile for targetable antigens on lymphocytic infiltrates in NSVN is unknown. METHODS: Sural nerve biopsies from a cohort of patients with NSVN were immunohistochemically studied for the expression of potential candidate antigens in perivascular and intramural lymphocytic infiltrates and correlated with neurological and electrophysiological parameters. 20 patients with treatment naïve NSVN and 5 patients with idiopathic axonal neuropathy were included. RESULTS: The CD52, BAFF and CD49d antigens were expressed in epineurial, perivascular or intramural lymphocytes of all (20/20) patients. CD52 was most prominently expressed in 21.49% of all inflammatory infiltrates. BAFF and CD49d were detected in 11.25% and 10.99% of these lymphocytes, respectively. The CD20, CD25 and CD126 antigens were found less frequently and at low levels only (CD20: 10/20 patients, 5.84% of lymphocytes; CD25: 17/20 patients, 5.22% of lymphocytes; CD126: 3/20 patients, 0.15% of lymphocytes). CONCLUSION: This is the first study in NSVN that identifies antigens expressed by pathogenic lymphocytes, which are potential targets for future monoclonal antibody treatment. Our data suggest that NSVN is amenable to monoclonal antibodies and, moreover, that targeting CD52 may be particularly promising. Our results strongly warrant future clinical trials in NSVN with monoclonal antibodies.
[Mh] Termos MeSH primário: Anticorpos Monoclonais
Doenças do Sistema Nervoso Periférico/patologia
Nervo Sural/patologia
[Mh] Termos MeSH secundário: Idoso
Antígenos CD/análise
Antígenos de Neoplasias/análise
Fator Ativador de Células B/análise
Antígeno CD52
Glicoproteínas/análise
Seres Humanos
Inflamação/patologia
Integrina alfa4/análise
Meia-Idade
Estudos Retrospectivos
Vasculite/complicações
Vasculite/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antigens, CD); 0 (Antigens, Neoplasm); 0 (B-Cell Activating Factor); 0 (CD52 Antigen); 0 (CD52 protein, human); 0 (Glycoproteins); 0 (TNFSF13B protein, human); 143198-26-9 (Integrin alpha4)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170528
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2017-315878


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[PMID]:28521269
[Au] Autor:Hemmi S; Kurokawa K; Nagai T; Kushida R; Okamoto T; Murakami T; Sunada Y
[Ad] Endereço:Department of Neurology, Kawasaki Medical School, Kurashiki, Japan. Electronic address: shojihemmi@yahoo.co.jp.
[Ti] Título:A new technique for dorsal sural nerve conduction study with surface strip electrodes.
[So] Source:Clin Neurophysiol;128(7):1214-1219, 2017 Jul.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To obtain higher amplitude of dorsal sural sensory nerve action potentials (SNAPs), we used a new method for dorsal sural nerve conduction study with surface strip electrodes (SSEs). METHODS: Dorsal sural SNAPs were recorded orthodromically. The recording electrodes were placed behind the lateral malleolus. SSEs were attached to the laterodorsal aspect of the foot for stimulation of the dorsal sural nerve (DSN). We also used a conventional method with a standard bipolar stimulator and compared the findings. RESULTS: Dorsal sural SNAPs were recordable bilaterally from 49 healthy volunteers. Mean peak-to-peak amplitude for SNAPs was 12.9±6.3µV, and mean nerve conduction velocity was 44.8±5.5m/s. The mean amplitude of SNAPs obtained by our method was 118.6% higher than that of SNAPs obtained by the conventional method (12.9µVvs. 5.9µV; P<0.001). CONCLUSIONS: The highest amplitude of dorsal sural SNAPs was constantly obtained by SSEs since SNAPs arising from whole digital branches of the DSN could be elicited by placement of SSEs. SIGNIFICANCE: When the DSN supplies more cutaneous branches to the lateral half of the foot, SSEs gives higher amplitude of dorsal sural SNAPs than that of the standard innervation type.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Eletromiografia/métodos
Condução Nervosa/fisiologia
Nervo Sural/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Eletrodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE


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[PMID]:28501821
[Au] Autor:Horga A; Laurà M; Jaunmuktane Z; Jerath NU; Gonzalez MA; Polke JM; Poh R; Blake JC; Liu YT; Wiethoff S; Bettencourt C; Lunn MP; Manji H; Hanna MG; Houlden H; Brandner S; Züchner S; Shy M; Reilly MM
[Ad] Endereço:MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, UK.
[Ti] Título:Genetic and clinical characteristics of -related Charcot-Marie-Tooth disease.
[So] Source:J Neurol Neurosurg Psychiatry;88(7):575-585, 2017 Jul.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To analyse and describe the clinical and genetic spectrum of Charcot-Marie-Tooth disease (CMT) caused by mutations in the neurofilament light polypeptide gene ( ). METHODS: Combined analysis of newly identified patients with -related CMT and all previously reported cases from the literature. RESULTS: Five new unrelated patients with CMT carrying the mutations P8R and N98S and the novel variant L311P were identified. Combined data from these cases and 62 kindreds from the literature revealed four common mutations (P8R, P22S, N98S and E396K) and three mutational hotspots accounting for 37 (55%) and 50 (75%) kindreds, respectively. Eight patients had de novo mutations. Loss of large-myelinated fibres was a uniform feature in a total of 21 sural nerve biopsies and 'onion bulb' formations and/or thin myelin sheaths were observed in 14 (67%) of them. The neurophysiological phenotype was broad but most patients with E90K and N98S had upper limb motor conduction velocities <38 m/s. Age of onset was ≤3 years in 25 cases. Pyramidal tract signs were described in 13 patients and 7 patients were initially diagnosed with or tested for inherited ataxia. Patients with E90K and N98S frequently presented before age 3 years and developed hearing loss or other neurological features including ataxia and/or cerebellar atrophy on brain MRI. CONCLUSIONS: -related CMT is clinically and genetically heterogeneous. Based on this study, however, we propose mutational hotspots and relevant clinical-genetic associations that may be helpful in the evaluation of sequence variants and the differential diagnosis with other forms of CMT.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/genética
Doença de Charcot-Marie-Tooth/patologia
Mutação/genética
Proteínas de Neurofilamentos/genética
[Mh] Termos MeSH secundário: Axônios/patologia
Ataxia Cerebelar/genética
Ataxia Cerebelar/patologia
Genótipo
Seres Humanos
Linhagem
Fenótipo
Nervo Sural/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurofilament Proteins); 0 (neurofilament protein L)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2016-315077


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[PMID]:28434472
[Au] Autor:Alsubiheen A; Petrofsky J; Daher N; Lohman E; Balbas E; Lee H
[Ad] Endereço:Department of Physical Therapy, Loma Linda University, Loma Linda, CA, USA; Department of Physical Therapy, King Saud University, Riyadh, Saudi Arabia.
[Ti] Título:Tai Chi with mental imagery theory improves soleus H-reflex and nerve conduction velocity in patients with type 2 diabetes.
[So] Source:Complement Ther Med;31:59-64, 2017 Apr.
[Is] ISSN:1873-6963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Diabetes is a disease that leads to damage to the peripheral nerves which may eventually cause balance instability. The purpose of this study was to determine the effect of 8 weeks of Tai Chi (TC) training combined with mental imagery (MI) on soleus H-reflex and nerve conduction velocity (NCV) of the sural and superficial peroneal nerves in people with diabetes. DESIGNS: Quasi-experimental, one group pretest-posttest design. SETTING: Human Research Laboratory. INTERVENTIONS: A series of Yang style of Tai Chi classes with mental imagery, one hour, two sessions per week for 8 weeks was done. MAIN OUTCOME MEASURES: The Activities-specific Balance Confidence (ABC) Scale, Functional Reach Test (FRT), and One Leg Standing Test (OLS) were measured as functional data. Hoffman reflex (H-reflex), and sural and superficial peroneal NCV were measured as main outcomes. RESULTS: All functional outcomes measures were significantly improved after the intervention (p<0.01). In the H-reflex, there was a significant increase in amplitude (µV) after completing 8 weeks of TC exercise (p=0.02). In the sural nerve, the velocity (p=0.01), amplitude (p=0.01), and latency (p=0.01) were significantly improved between pre and post-test. In the superficial peroneal nerve, significant improvements were observed in (p=0.02) and latency (p=0.01), but not in amplitude (µV) (p>0.05). CONCLUSIONS: Combining TC intervention with MI theory showed an improvement in the H-reflex and NCV tests, which suggests improved balance and walking stability.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/terapia
Imagens (Psicoterapia)
Músculo Esquelético/inervação
Condução Nervosa/fisiologia
Tai Ji
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Músculo Esquelético/fisiologia
Nervo Fibular/fisiologia
Estudos Prospectivos
Nervo Sural/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28403726
[Au] Autor:Hoefnagels EM; Belkoff SM; Swierstra BA
[Ad] Endereço:a Department of Orthopedics , Sint Maartenskliniek , Nijmegen , the Netherlands.
[Ti] Título:Gastrocnemius recession: A cadaveric study of surgical safety and effectiveness.
[So] Source:Acta Orthop;88(4):411-415, 2017 Aug.
[Is] ISSN:1745-3682
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and purpose - Many methods of gastrocnemius lengthening have been described, with different surgical challenges, outcomes, and risks to the sural nerve. Our aims were (1) to locate the gastrocnemius muscular-tendinous junction in relation to the mid-length of the fibula (from here on designated the mid-fibula), (2) to compare the dorsiflexion achieved with dorsal recession or ventral recession, and (3) to determine the risk of injury to the sural nerve during gastrocnemius recession. Methods - In 10 pairs of fresh-frozen adult cadaveric lower extremities transected above the knee, we measured dorsiflexion, performed dorsal or ventral gastrocnemius recession at the mid-fibula, and then measured the increase in dorsiflexion and fasciotomy gap. We noted the course of the sural nerve and whether the gastrocnemius muscle provided it with enough muscular coverage to protect it during recession. Results - Dorsal and ventral recession produced statistically (p < 0.05) and clinically significant mean increases in dorsiflexion with extended knee from 12° to 19°, but they were not statistically significantly different from each other in this measure or in fasciotomy gap size. At the mid-fibula, the sural nerve coursed superficially between both heads of the gastrocnemius muscle in 14 of 20 specimens. Sufficient gastrocnemius muscle coverage to protect the sural nerve was provided by the medial head in 18 of 20 specimens and by the lateral head in only 5 of 20 specimens. Interpretation - A ventral gastrocnemius recession proximal to the mid-fibula level poses less risk to the sural nerve than a recession at the mid-fibula. This procedure provides adequate lengthening (1-3 cm) and increased dorsiflexion (compared with baseline), with less risk to the sural nerve than is incurred with recession at the mid-fibular reference line.
[Mh] Termos MeSH primário: Músculo Esquelético/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Seres Humanos
Meia-Idade
Músculo Esquelético/inervação
Nervo Sural/lesões
Tendões/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1080/17453674.2017.1314157



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