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  1 / 2824 MEDLINE  
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[PMID]:28746726
[Au] Autor:Mackenzie SJ; Yi JL; Singla A; Russell TM; Osterhout DJ; Calancie B
[Ad] Endereço:Department of Neuroscience, Upstate Medical University, Syracuse, New York, USA.
[Ti] Título:Cauda equina repair in the rat: Part 3. Axonal regeneration across Schwann cell-Seeded collagen foam.
[So] Source:Muscle Nerve;57(1):E78-E84, 2018 Jan.
[Is] ISSN:1097-4598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Treatments for patients with cauda equina injury are limited. METHODS: In this study, we first used retrograde labeling to determine the relative contributions of cauda equina motor neurons to intrinsic and extrinsic rat tail muscles. Next, we transected cauda equina ventral roots and proceeded to bridge the proximal and distal stumps with either a type I collagen scaffold coated in laminin (CL) or a collagen-laminin scaffold that was also seeded with Schwann cells (CLSC). Regeneration was assessed by way of serial retrograde labeling. RESULTS: After accounting for the axonal contributions to intrinsic vs. extrinsic tail muscles, we noted a higher degree of double labeling in the CLSC group (58.0 ± 39.6%) as compared with the CL group (27.8 ± 16.0%; P = 0.02), but not the control group (33.5 ± 18.2%; P = 0.10). DISCUSSION: Our findings demonstrate the feasibility of using CLSCs in cauda equina injury repair. Muscle Nerve 57: E78-E84, 2018.
[Mh] Termos MeSH primário: Axônios/fisiologia
Cauda Equina/lesões
Colágeno Tipo I/farmacologia
Regeneração Nervosa/fisiologia
Células de Schwann/fisiologia
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Contagem de Células
Feminino
Laminina/farmacologia
Neurônios Motores
Músculo Esquelético/inervação
Músculo Esquelético/fisiologia
Ratos
Ratos Endogâmicos F344
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 0 (Laminin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/mus.25751


  2 / 2824 MEDLINE  
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[PMID]:28383409
[Au] Autor:Yan L; Liu Y; He B; Liu J; Luo Z; Hao D
[Ad] Endereço:aDepartment of Spinal Surgery bDepartment of Orthopaedics cDepartment of Anesthesiology, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi, China.
[Ti] Título:Clinical case-series report of traumatic cauda equina herniation: A pathological phenomena occurring with thoracolumbar and lumbar burst fractures.
[So] Source:Medicine (Baltimore);96(14):e6446, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Burst fractures in thoracolumbar and lumbar spine typically occur from severe trauma, which may result in cauda equina herniation (CEH). In this study, we attempted to document the incidence and evaluate the sequelae of CEH that were found during decompression and fusion surgery for patients with burst fractures. PATIENT CONCERNS: A total of 416 patients were enrolled in this study. DIAGNOSES: The patients had been operated on through an anterior or posterior approach for treatments of thoracolumbar and lumbar burst fractures at our department between June 1, 2008 and June 1, 2011. INTERVENTIONS: A retrospective analysis of hospital records and a review on radiographs were performed. Data regarding demographics, injury mechanism, radiographs, surgical procedures, outcomes and follow-ups were collected and analyzed. OUTCOMES: The CEH was observed in 49 patients (12%), including 40 males and 9 females with a mean age of 33.7 years old. The posterior approach group included 301 patients (215 males and 86 females), with 13% incident rate for CEH (40/301). The anterior approach group included 115 patients (80 males and 35 females), with 8% incident rate for CEH (9/115). Forty-four patients (90%) with CEH had neurological deficits; while other 5 patients (10%) were neurologically intact but entrapments of a significant proportion of their cauda equina rootlets in the dorsal lamina fracture were observed during operations. Both vertebrae burst fracture and lamina fracture were observed in 95% patients with posterior CEH (38 out of 40). LESSONS: Traumatic CEH were found in 12% of the patients with thoracolumbar and lumbar burst fractures that were treated by surgery. Patients with a lumbar burst fracture showing neurological deficits in combination with a laminar fracture have an increased risk of traumatic CEH.
[Mh] Termos MeSH primário: Cauda Equina/patologia
Vértebras Lombares/lesões
Doenças do Sistema Nervoso Periférico/etiologia
Fraturas da Coluna Vertebral/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças do Sistema Nervoso Periférico/patologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006446


  3 / 2824 MEDLINE  
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[PMID]:28347895
[Au] Autor:Liu Y; Yang R; Kong Q; Wang Y; Zhang B; Sun J; Yang Y; Zheng B; Yuan H; Shi J
[Ad] Endereço:Student Brigade, Second Military Medical University, Shanghai, China; Second Department of Spine Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
[Ti] Título:Metabolomic Changes in Rat Model of Cauda Equina Injury.
[So] Source:World Neurosurg;102:449-458, 2017 Jun.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To show the differences of metabolomic changes in a rat model of cauda equina injury (CEI) and find potent metabolic biomarkers of CEI. METHODS: A total of 28 Sprague-Dawley rats were used in this study. After the rats were given anesthesia and fixed in a prone position, a piece of silicone block was placed into the epidural space below the lamina. Behavior tests including the Basso, Beattie, and Bresnahan open field locomotor scale and an inclined plane test were conducted 1 day and 2 days after surgery. The cauda equina tissue was collected 12 hours, 1 day, and 2 days after surgery. Ultraperformance liquid chromatography coupled with quadruple time-of-flight mass spectrometry was used for a quantitative analysis of cauda equine metabolic changes in rats from different groups. The differences between the metabolic profiles of the rats in 4 groups were analyzed using partial least squares discriminant analysis. RESULTS: In behavior tests and histologic analyses given 2 days after surgery, the animals showed remarkable organ dysfunction and pathologic damage. Metabolic profiles showed remarkable differences between the control and model groups. Thirty-four potential CEI metabolite biomarkers were identified between the control group and different time-point model groups. These potential biomarkers appeared in 15 metabolic pathways. CONCLUSIONS: Our results may improve the cause of CEI and provide a basis for clinical diagnosis and locating biomarkers in the early stages of the pathologic process of CEI.
[Mh] Termos MeSH primário: Cauda Equina/patologia
Redes e Vias Metabólicas
Polirradiculopatia/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Modelos Animais de Doenças
Medo
Locomoção/fisiologia
Bainha de Mielina/patologia
Polirradiculopatia/fisiopatologia
Polirradiculopatia/psicologia
Análise de Componente Principal
Ratos
Ratos Sprague-Dawley
Índice de Gravidade de Doença
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


  4 / 2824 MEDLINE  
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[PMID]:28285756
[Au] Autor:Raftopoulos C; Koenig S; Joris V; Duprez T
[Ad] Endereço:Department of Neurosurgery, University Hospital St-Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium. Electronic address: christian.raftopoulos@uclouvain.be.
[Ti] Título:Partial cauda equina syndrome after an uneventful minimally invasive microdiscectomy in a patient with Crohn's disease.
[So] Source:Neurochirurgie;63(1):21-24, 2017 Mar.
[Is] ISSN:1773-0619
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Cauda equina syndrome is a serious condition resulting from dysfunction of the lumbosacral nerve roots and characterized by impairment of bladder, bowel, sexual and lower limb functions. We report the case of a 48-year-old woman who had Crohn's disease for more than twenty years. The patient was undergoing immunotherapy with infliximab and developed a partial cauda equina syndrome after an uneventful minimally invasive microdiscectomy (L -S ) that completely cured her sciatica. A postoperative magnetic resonance imaging examination showed root clumping but no compressive lesion. We discuss a possible relationship between the cauda equina syndrome and the patient's active Crohn's disease, treatment and surgery.
[Mh] Termos MeSH primário: Cauda Equina/cirurgia
Doença de Crohn/cirurgia
Vértebras Lombares/cirurgia
Polirradiculopatia/cirurgia
Ciática/cirurgia
[Mh] Termos MeSH secundário: Cauda Equina/patologia
Doença de Crohn/complicações
Doença de Crohn/diagnóstico
Discotomia/métodos
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos
Polirradiculopatia/diagnóstico
Ciática/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  5 / 2824 MEDLINE  
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[PMID]:28133986
[Au] Autor:Wajima D; Nakagawa I; Park HS; Haku T; Wada T; Kichikawa K; Nakase H
[Ad] Endereço:1 Department of Neurosurgery, Nara Medical University, Japan.
[Ti] Título:A case of filum terminale arterial venous fistula needed a long arterial access for trans-arterial shunt obliteration.
[So] Source:Interv Neuroradiol;23(2):221-227, 2017 Apr.
[Is] ISSN:2385-2011
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 78-year-old man was referred to our institution with a predominantly progressive numbness of both legs, and bladder dysfunction with urinary retention. He was diagnosed as the symptomatic arteriovenous fistula of the filum terminale (AVFFT). A trans-arterial embolization (TAE) of the arteriovenous shunt was planned for his symptomatic AVFFT. The long distance between the origin of the radiculo meningeal artery (Th8) and the site of the fistula (S1) resulted in the first TAE having a feeder occlusion. The length of accessible feeder in the first TAE was the longest (about 40 cm) as the past reports of the endovascular therapy. However, complete shunt occlusion was accomplished at a second session two weeks after the initial TAE because a more accessible feeder was developed by the initial feeder occlusion.
[Mh] Termos MeSH primário: Fístula Arteriovenosa/terapia
Cauda Equina
Embolização Terapêutica/métodos
[Mh] Termos MeSH secundário: Idoso
Angiografia
Fístula Arteriovenosa/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1177/1591019916687716


  6 / 2824 MEDLINE  
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[PMID]:28109509
[Au] Autor:Chau AM; Xu LL; Gragnaniello C
[Ad] Endereço:Department of Neurosurgery, Canberra Hospital, Canberra, Australian Capital Territory, Australia. Electronic address: amtchau@gmail.com.
[Ti] Título:In Reply to the Letter to the Editor "Cauda Equina Syndrome: The Importance of Including Small Studies in a Meta-Analysis".
[So] Source:World Neurosurg;97:731, 2017 01.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cauda Equina
Polirradiculopatia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


  7 / 2824 MEDLINE  
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[PMID]:28109508
[Au] Autor:DeLong WB; Polissar NL; Neradilek MB; Laam LA
[Ad] Endereço:Department of Neurosurgery, University of California, San Francisco, San Francisco, California, USA. Electronic address: wbdelongmd@gmail.com.
[Ti] Título:Cauda Equina Syndrome: The Importance of Including Small Studies in a Meta-Analysis: Comment on "Timing of Surgical Intervention in Cauda Equina Syndrome: A Systematic Critical Review".
[So] Source:World Neurosurg;97:728-730, 2017 01.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cauda Equina
Polirradiculopatia/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


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[PMID]:28088216
[Au] Autor:Candanedo-Gonzalez F; Ortiz-Arce CS; Rosales-Perez S; Remirez-Castellanos AL; Cordova-Uscanga C; Gamboa-Dominguez A
[Ad] Endereço:Department of Pathology, Hospital de Oncologia, Centro Medico Nacional Siglo XXI, IMSS, Av Cuauhtemoc #330, Col: Doctores CP, 06720, Mexico City, Mexico. fernando.candanedog@incmnsz.mx.
[Ti] Título:Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation.
[So] Source:Diagn Pathol;12(1):7, 2017 Jan 14.
[Is] ISSN:1746-1596
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior. CASE PRESENTATION: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion. Therefore the tumor was considered unresectable and only incisional biopsy was obtained, establishing the tentative diagnosis of a poorly differentiated neoplasia. A second evaluation of the case revealed the presence of numerous non-cohesive pleomorphic giant cells with intranuclear inclusions and broad eosinophilic cytoplasm, alternating with intermediate size cells with round, hyperchromatic nuclei and forming a perivascular pseudo-rosettes pattern. The ependymal phenotype was supported by light microscopy and corroborated by immunohistochemistry analysis. The patient was subsequently treated with radiotherapy 54Gy. She is alive after a 27-month follow-up, with residual disease, difficulty ambulating and pain. CONCLUSIONS: GCE of filum terminale may have an atypical clinical and radiological presentation, albeit with invasive characteristics and anaplasia on histologic analysis. However, its biological behavior is indolent and associated to longer survival. Due to the presence of giant cells, the differential diagnosis of other primary neoplasias at that site were considered, including paraganglioma, malignant peripheral nerve sheath tumors as well as metastatic malignant melanoma, adrenal carcinoma, thyroid gland carcinoma and urothelial carcinoma, that may all harbor giant cells.
[Mh] Termos MeSH primário: Cauda Equina/patologia
Ependimoma/patologia
Tumores de Células Gigantes/patologia
Neoplasias do Sistema Nervoso Periférico/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Imuno-Histoquímica
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[St] Status:MEDLINE
[do] DOI:10.1186/s13000-016-0595-y


  9 / 2824 MEDLINE  
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[PMID]:28040529
[Au] Autor:Khan NR; VanLandingham M; O'Brien T; Boop FA; Arnautovic K
[Ad] Endereço:Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
[Ti] Título:Primary Seeding of Myxopapillary Ependymoma: Different Disease in Adult Population? Case Report and Review of Literature.
[So] Source:World Neurosurg;99:812.e21-812.e26, 2017 Mar.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myxopapillary ependymoma (MPE) is a slow-growing tumor, occurring most often in adults. It originates from the filum terminale in the area of the conus medullaris and cauda equina and is considered a benign lesion. Despite this classification, however, recurrence after both partial and gross total resection is well known. In the pediatric population, primary MPE seeding and generally more aggressive clinical course is well documented and treated through gross total resection, if possible, followed by irradiation. In adults, however, primary MPE seeding is rarely seen. There are few prior reports describing primary metastases into multiple spinal locations in an adult before resection of an MPE. The reason for this difference among pediatric and adult MPE remains unclear. We present the case of a 32-year-old man with primary seeding of an MPE into multiple lumbosacral areas. The patient underwent gross total resection of the lesions and had an uneventful postoperative course. Primary seeding could be a sign of aggressive behavior in this tumor. Complete craniospinal magnetic resonance imaging studies should be done before and after surgery in patients who present with a multifocal primary MPE. Furthermore, patients with a history of primary tumor seeding of MPE should be thoroughly evaluated radiologically. Unlike in pediatric populations, the need for postoperative irradiation in adults is less clear and further studies-particularly genetic ones-are warranted.
[Mh] Termos MeSH primário: Cauda Equina/cirurgia
Ependimoma/cirurgia
Inoculação de Neoplasia
Neoplasias Primárias Múltiplas/cirurgia
Neoplasias da Medula Espinal/cirurgia
[Mh] Termos MeSH secundário: Adulto
Cauda Equina/diagnóstico por imagem
Ependimoma/diagnóstico por imagem
Seres Humanos
Laminectomia
Vértebras Lombares/cirurgia
Imagem por Ressonância Magnética
Masculino
Neoplasias Primárias Múltiplas/diagnóstico por imagem
Neoplasias da Medula Espinal/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


  10 / 2824 MEDLINE  
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[PMID]:27884878
[Au] Autor:Hong T; Park JE; Ling F; terBrugge KG; Tymianski M; Zhang HQ; Krings T
[Ad] Endereço:From the Department of Neurosurgery (T.H., F.L., H.Q.Z.), Xuanwu Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Comparison of 3 Different Types of Spinal Arteriovenous Shunts below the Conus in Clinical Presentation, Radiologic Findings, and Outcomes.
[So] Source:AJNR Am J Neuroradiol;38(2):403-409, 2017 Feb.
[Is] ISSN:1936-959X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Spinal arteriovenous shunts below the conus constitute 3 types of lesions, which have previously been mainly described in case reports, given their rarity, and are sometimes misdiagnosed. The purpose of this study was to describe the features of each type and compare these types as to epidemiologic features, clinical and radiologic presentations, treatment, and outcomes in a consecutive series of 48 cases. MATERIALS AND METHODS: The prospectively collected data bases of 2 referral centers for spinal vascular lesions were retrospectively reviewed. Spinal arteriovenous shunts below the conus were defined as all dural and intradural shunts below the conus medullaris. Clinical features, radiologic findings, treatment results, and clinical outcomes were assessed. RESULTS: There were filum terminale arteriovenous fistulas in 11 patients (22.9%), radicular arteriovenous shunts in 7 patients (14.6%), and spinal dural arteriovenous fistulas in 30 patients (62.5%). Radicular arteriovenous shunts presented at a younger age ( = .017) and with a higher incidence of back pain symptoms ( = .037). A tethered spinal cord was found in 54.5% of patients with filum terminale arteriovenous fistulas and 23.3% of patients with spinal dural arteriovenous fistulas. After treatment, the angiographic complete obliteration rate was 89.4% and spinal function was improved significantly ( < .001). CONCLUSIONS: Three groups of spinal arteriovenous shunts below the conus can be differentiated according to clinical and radiologic features. Filum terminale arteriovenous fistulas are frequently associated with dysraphic malformations, which may suggest a particular embryologic origin.
[Mh] Termos MeSH primário: Derivação Arteriovenosa Cirúrgica/métodos
Coluna Vertebral/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Fístula Arteriovenosa/diagnóstico por imagem
Fístula Arteriovenosa/cirurgia
Dor nas Costas/diagnóstico por imagem
Dor nas Costas/cirurgia
Cauda Equina/diagnóstico por imagem
Cauda Equina/cirurgia
Criança
Pré-Escolar
Caramujo Conus
Diagnóstico Diferencial
Dura-Máter/diagnóstico por imagem
Dura-Máter/cirurgia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Defeitos do Tubo Neural/diagnóstico por imagem
Defeitos do Tubo Neural/cirurgia
Estudos Retrospectivos
Coluna Vertebral/diagnóstico por imagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.3174/ajnr.A5001



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