[PMID]: | 28807901 |
[Au] Autor: | Furutera T; Takechi M; Kitazawa T; Takei J; Yamada T; Vu Hoang T; Rijli FM; Kurihara H; Kuratani S; Iseki S |
[Ad] Endereço: | Section of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. |
[Ti] Título: | Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick. |
[So] Source: | Development;144(18):3315-3324, 2017 09 15. |
[Is] ISSN: | 1477-9129 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | We have proposed that independent origins of the tympanic membrane (TM), consisting of the external auditory meatus (EAM) and first pharyngeal pouch, are linked with distinctive middle ear structures in terms of dorsal-ventral patterning of the pharyngeal arches during amniote evolution. However, previous studies have suggested that the first pharyngeal arch (PA1) is crucial for TM formation in both mouse and chick. In this study, we compare TM formation along the anterior-posterior axis in these animals using expression as a marker of the second pharyngeal arch (PA2). In chick, the EAM begins to invaginate at the surface ectoderm of PA2, not at the first pharyngeal cleft, and the entire TM forms in PA2. Chick-quail chimera that have lost PA2 and duplicated PA1 suggest that TM formation is achieved by developmental interaction between a portion of the EAM and the columella auris in PA2, and that PA1 also contributes to formation of the remaining part of the EAM. By contrast, in mouse, TM formation is highly associated with an interdependent relationship between the EAM and tympanic ring in PA1. |
[Mh] Termos MeSH primário: |
Região Branquial/embriologia Membrana Timpânica/embriologia
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[Mh] Termos MeSH secundário: |
Animais Região Branquial/metabolismo Embrião de Galinha Galinhas Meato Acústico Externo/embriologia Orelha Média/embriologia Embrião de Mamíferos/metabolismo Proteínas de Fluorescência Verde/metabolismo Proteínas de Homeodomínio/metabolismo Camundongos Camundongos Knockout Modelos Biológicos Fenótipo Codorniz/embriologia Membrana Timpânica/metabolismo
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Homeodomain Proteins); 0 (Hoxa2 protein, mouse); 0 (enhanced green fluorescent protein); 147336-22-9 (Green Fluorescent Proteins) |
[Em] Mês de entrada: | 1710 |
[Cu] Atualização por classe: | 171126 |
[Lr] Data última revisão:
| 171126 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170816 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1242/dev.149765 |
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