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[PMID]:29298506
[Au] Autor:Malafronte G
[Ad] Endereço:1 S.G. Moscati Hospital Company of National Importance, Avellino, Italy.
[Ti] Título:A New Reversal Steps Stapedotomy.
[So] Source:Ann Otol Rhinol Laryngol;127(3):167-170, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate whether removal of the stapes head and not the entire stapes superstructure prevents footplate complications. STUDY DESIGN: Prospective study. PATIENTS: One hundred and forty-five patients with otosclerosis were included. Patients were divided into 2 groups as follows: Individuals in group 1 (n = 75) underwent removal of the entire stapes superstructure; individuals in group 2 (n = 70) underwent removal of the stapes head only. These 2 groups were further subdivided into 2 subgroups based on the type of otosclerosis. Group 1a included 55 cases of marginal otosclerosis, while group 1b included 15 diffusive and 5 biscuit otosclerosis cases. Group 2a included 51 marginal otosclerosis cases, while group 2b included 14 diffuse and 5 biscuit otosclerosis cases. Estimations were made regarding statistical correlation between type of reversal steps stapedotomy, otosclerosis type, incidence of footplate complications, and hearing results. RESULTS: There were 9 footplate complications in group 1b and no complications in group 2b. This difference was significant. Air-bone gap closure to within 10 dB was achieved in 65% of cases in group 1b and 94.7% in group 2b. This difference was significant. CONCLUSION: The new stapedotomy prevented footplate complications and improved hearing results in diffuse and biscuit otosclerosis.
[Mh] Termos MeSH primário: Otosclerose
Complicações Pós-Operatórias
Cirurgia do Estribo
Estribo/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Perda Auditiva Condutiva/diagnóstico
Perda Auditiva Condutiva/etiologia
Perda Auditiva Condutiva/cirurgia
Testes Auditivos/métodos
Seres Humanos
Itália
Masculino
Meia-Idade
Otosclerose/diagnóstico
Otosclerose/cirurgia
Avaliação de Processos e Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/prevenção & controle
Cirurgia do Estribo/efeitos adversos
Cirurgia do Estribo/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417751156


  2 / 1163 MEDLINE  
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[PMID]:28558458
[Au] Autor:Yang Y; Chen M; Hao JS; Liu W; Zhang J
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
[Ti] Título:[Clinical characteristics in children with cleft palate associated with middle ear cholesteatoma].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(5):377-380, 2017 May 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To summarize the characteristics of children diagnosed as cleft palate associated with middle ear cholesteatoma. There were five middle ear cholesteatoma cases who had previously received cleft palate repairment surgery. All of the patients were followed up for 17 to 47 months. Median follow-up time was 31 months. There were three males and two females with three to eleven years old , and the average of age was seven years and ten months. The time of cleft palate repairment surgery was from six months to four years, and the average age was one year and nine months. No history of grommet insertion. Three cases were unilateral choleateatoma (right ear in two cases and left ear in one case, of which two cases of contralateral ear with secretory otitis media) and two cases were bilateral choleateatoma. Five cases(seven ears) received surgeries. Radical mastoidectomy + canal wall down tympanoplasty were performed in three ears, in which we found stapes disappeared. Radical mastoidectomy + canal wall up tympanoplasty were performed in four ears, in which we found intact foot plate, with recurrence occurred in one case nine months after the first surgery. No recurrence occurred after the second canal wall down tympanoplasty. The postoperative average hearing thresholds of air conduction were improved in different degrees. There may be a relationship between cleft palate associated with middle ear cholesteatoma and no grommet insertion history. The incidence of bilateral cases is relatively high, and otitis media with effusion may occur because of poor Eustachian tube function in the unilateral cases. Choice of surgical methods should be decided basing on combination of decreasing the recrudescence and improving the hearing.
[Mh] Termos MeSH primário: Colesteatoma da Orelha Média/complicações
Fissura Palatina/complicações
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Fissura Palatina/cirurgia
Feminino
Seres Humanos
Masculino
Processo Mastoide/cirurgia
Ventilação da Orelha Média
Otite Média/etiologia
Otite Média com Derrame/complicações
Recidiva
Estribo
Resultado do Tratamento
Timpanoplastia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.05.011


  3 / 1163 MEDLINE  
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[PMID]:28244845
[Au] Autor:Britze A; Møller ML; Ovesen T
[Ad] Endereço:Department of Otorhinolaryngology - Head and Neck Surgery,Aarhus Universitetshospital,Denmark.
[Ti] Título:Incidence, 10-year recidivism rate and prognostic factors for cholesteatoma.
[So] Source:J Laryngol Otol;131(4):319-328, 2017 Apr.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Cholesteatoma patients have a high risk of recurrence with complications, and knowledge exchange is a prerequisite for improving treatment. This study aimed to apply appropriate statistics to provide meaningful and transferable results from cholesteatoma surgery, to highlight independent prognostic factors, and to assess the incidence rate. METHODS: Incidence rates were assessed for the district of Aarhus, Denmark. From 147 patients operated on mainly with canal wall up mastoidectomies for debuting cholesteatomas, 10-year Kaplan-Meier recidivism rates were calculated and independent prognostic factors for the recidivism were identified by Cox multivariate regression analyses. RESULTS: Incidence rate was 6.8 per 100 000 per year. The 10-year cumulative recidivism rate was 0.44 (95 per cent confidence interval, 0.37-0.53). Independent prognostic factors for the recidivism were: age below 15 years (hazard ratio = 2.2; p > z = 0.002), cholesteatoma localised to the mastoid (hazard ratio = 1.7; p > z = 0.04), stapes erosion (hazard ratio = 1.9; p > z = 0.02) and incus erosion (hazard ratio = 1.9; p > z = 0.04). CONCLUSION: The recidivism rate is influenced by several factors that are important to observe, both in the clinic and when comparing results from surgery.
[Mh] Termos MeSH primário: Colesteatoma/epidemiologia
Colesteatoma/patologia
Otopatias/epidemiologia
Otopatias/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Dinamarca/epidemiologia
Feminino
Seres Humanos
Incidência
Bigorna/patologia
Estimativa de Kaplan-Meier
Masculino
Processo Mastoide/patologia
Prognóstico
Modelos de Riscos Proporcionais
Recidiva
Análise de Regressão
Estudos Retrospectivos
Estribo/patologia
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000299


  4 / 1163 MEDLINE  
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[PMID]:28189837
[Au] Autor:Greene NT; Jenkins HA; Tollin DJ; Easter JR
[Ad] Endereço:Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, USA; Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: nathaniel.greene@ucdenver.edu.
[Ti] Título:Stapes displacement and intracochlear pressure in response to very high level, low frequency sounds.
[So] Source:Hear Res;348:16-30, 2017 May.
[Is] ISSN:1878-5891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The stapes is held in the oval window by the stapedial annular ligament (SAL), which restricts total peak-to-peak displacement of the stapes. Previous studies have suggested that for moderate (<130 dB SPL) sound levels intracochlear pressure (P ), measured at the base of the cochlea far from the basilar membrane, increases directly proportionally with stapes displacement (D ), thus a current model of impulse noise exposure (the Auditory Hazard Assessment Algorithm for Humans, or AHAAH) predicts that peak P will vary linearly with D up to some saturation point. However, no direct tests of D , or of the relationship with P during such motion, have been performed during acoustic stimulation of the human ear. In order to examine the relationship between D and P to very high level sounds, measurements of D and P were made in cadaveric human temporal bones. Specimens were prepared by mastoidectomy and extended facial recess to expose the ossicular chain. Measurements of P were made in scala vestibuli (P ) and scala tympani (P ), along with the SPL in the external auditory canal (P ), concurrently with laser Doppler vibrometry (LDV) measurements of stapes velocity (V ). Stimuli were moderate (∼100 dB SPL) to very high level (up to ∼170 dB SPL), low frequency tones (20-2560 Hz). Both D and P increased proportionally with sound pressure level in the ear canal up to approximately ∼150 dB SPL, above which both D and P showed a distinct deviation from proportionality with P . Both D and P approached saturation: D at a value exceeding 150 µm, which is substantially higher than has been reported for small mammals, while P showed substantial frequency dependence in the saturation point. The relationship between P and D remained constant, and cochlear input impedance did not vary across the levels tested, consistent with prior measurements at lower sound levels. These results suggest that P sound pressure holds constant relationship with D , described by the cochlear input impedance, at these, but perhaps not higher, stimulation levels. Additionally, these results indicate that the AHAAH model, which was developed using results from small animals, underestimates the sound pressure levels in the cochlea in response to high level sound stimulation, and must be revised.
[Mh] Termos MeSH primário: Cóclea/fisiologia
Audição/fisiologia
Rampa do Tímpano/fisiologia
Rampa do Vestíbulo/fisiologia
Estribo/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Acústica
Cadáver
Ossículos da Orelha/fisiologia
Orelha Média/fisiologia
Impedância Elétrica
Seres Humanos
Lasers
Prótese Ossicular
Pressão
Modelos de Riscos Proporcionais
Janela da Cóclea/fisiologia
Som
Estribo/anatomia & histologia
Osso Temporal/anatomia & histologia
Osso Temporal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


  5 / 1163 MEDLINE  
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[PMID]:28169396
[Au] Autor:Tang L; Wu X; Zhang H; Lu S; Wu M; Shen C; Chen X; Wang Y; Wang W; Shen Y; Gu M; Ding X; Jin X; Fei J; Wang Z
[Ad] Endereço:State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, P.R. China.
[Ti] Título:A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.
[So] Source:Hum Mol Genet;26(7):1280-1293, 2017 Apr 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human multiple synostoses syndrome (SYNS) is an autosomal dominant disorder characterized by multiple joint fusions. We previously identified a point mutation (S99N) in FGF9 that causes human SYNS3. However, the physiological function of FGF9 during joint development and comprehensive molecular portraits of SYNS3 remain elusive. Here, we report that mice harboring the S99N mutation in Fgf9 develop the curly tail phenotype and partially or fully fused caudal vertebrae and limb joints, which mimic the major phenotypes of SYNS3 patients. Further study reveals that the S99N mutation in Fgf9 disrupts joint interzone formation by affecting the chondrogenic differentiation of mesenchymal cells at the early stage of joint development. Consistently, the limb bud micromass culture (LBMMC) assay shows that Fgf9 inhibits mesenchymal cell differentiation into chondrocytes by downregulating the expression of Sox6 and Sox9. However, the mutant protein does not exhibit the same inhibitory effect. We also show that Fgf9 is required for normal expression of Gdf5 in the prospective elbow and knee joints through its activation of Gdf5 promoter activity. Signal transduction assays indicate that the S99N mutation diminishes FGF signaling in developmental limb joints. Finally, we demonstrate that the conformational change in FGF9 resulting from the S99N mutation disrupts FGF9/FGFR/heparin interaction, which impedes FGF signaling in developmental joints. Taken together, we conclude that the S99N mutation in Fgf9 causes SYNS3 via the disturbance of joint interzone formation. These results further implicate the crucial role of Fgf9 during embryonic joint development.
[Mh] Termos MeSH primário: Ossos do Carpo/anormalidades
Diferenciação Celular/genética
Fator 9 de Crescimento de Fibroblastos/genética
Deformidades Congênitas do Pé/genética
Deformidades Congênitas da Mão/genética
Estribo/anormalidades
Sinostose/genética
Ossos do Tarso/anormalidades
[Mh] Termos MeSH secundário: Animais
Ossos do Carpo/fisiopatologia
Condrogênese/genética
Fator 9 de Crescimento de Fibroblastos/biossíntese
Fator 9 de Crescimento de Fibroblastos/química
Deformidades Congênitas do Pé/fisiopatologia
Regulação da Expressão Gênica no Desenvolvimento
Fator 5 de Diferenciação de Crescimento/genética
Deformidades Congênitas da Mão/fisiopatologia
Seres Humanos
Articulações/crescimento & desenvolvimento
Articulações/patologia
Camundongos
Mutação Puntual
Conformação Proteica
Fatores de Transcrição SOX9/genética
Fatores de Transcrição SOXD/genética
Transdução de Sinais
Estribo/fisiopatologia
Sinostose/fisiopatologia
Ossos do Tarso/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FGF9 protein, human); 0 (Fgf9 protein, mouse); 0 (Fibroblast Growth Factor 9); 0 (Gdf5 protein, mouse); 0 (Growth Differentiation Factor 5); 0 (SOX9 Transcription Factor); 0 (SOXD Transcription Factors); 0 (Sox6 protein, mouse); 0 (Sox9 protein, mouse)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx029


  6 / 1163 MEDLINE  
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[PMID]:28151457
[Au] Autor:Alzhrani F; Mokhatrish MM; Al-Momani MO; Alshehri H; Hagr A; Garadat SN
[Ti] Título:Effectiveness of stapedotomy in improving hearing sensitivity for 53 otosclerotic patients: retrospective review.
[So] Source:Ann Saudi Med;37(1):49-55, 2017 Jan-Feb.
[Is] ISSN:0975-4466
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Otosclerosis is a common cause of progressive hearing impairment that causes fixation of the stapes. Surgical intervention is the preferred treatment approach to ameliorate the conductive hearing loss associated with stapedial otosclerosis. However, given that it is a difficult and delicate procedure, the surgery may fail for a number of reasons. Therefore, it is very important to evaluate the success rate of the surgical approach used in each regional center. OBJECTIVE: To examine the effectiveness of stapedotomy in improving hearing sensitivity for otosclerotic patients at King Abdul Aziz University Hospital in Riyadh. DESIGN: Retrospective chart review with an analysis of pre- and postoperative surgical treatment. SETTING: Tertiary referral otolaryngology clinic. PATIENTS AND METHODS: All cases who underwent stapedotomy between 1997 and 2009 were retrospectively reviewed. Preoperative and postoperative audiometric assessments were conducted using conventional pure tone audiometry. Differences were analyzed by two-way repeated measures ANOVA. MAIN OUTCOME MEASURE(S): Pre- and postoperative pure tone thresholds for air and bone conduction. RESULT: Fifty-three patients underwent stapedotomy. Stapedotomy yielded significant improvements in mean (SD) postoperative air-conduction thresholds of about 18.7 (11.7) dB (P < .0001) and mean (SD) post.operative bone-conduction thresholds of about 2 (7.2) dB (P < .05). Additionally, a significant correlation was found between improvement in air-conduction thresholds and the size of preoperatve air-bone gap (P < .01) About 70%of patients achieved an air-bone gap of 20 dB or better. None of the cases examined in this study exhibited sensorineural hearing loss or adverse complications following stapedotomy. CONCLUSIONS: Stapedotomy is a safe and effective treatment option for patients with otosclerosis. Given that the majority of participants in this study exhibited mixed hearing loss preoperatively, the results further suggest that stapedotomy can also be effective in improving thresholds for these patients. LIMITATIONS: The sample size was relatively small.
[Mh] Termos MeSH primário: Perda Auditiva Condutiva/cirurgia
Otosclerose/cirurgia
Cirurgia do Estribo/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Audiometria de Tons Puros
Condução Óssea
Feminino
Audição
Perda Auditiva Condutiva/etiologia
Perda Auditiva Condutiva/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Otosclerose/complicações
Otosclerose/fisiopatologia
Período Pós-Operatório
Estudos Retrospectivos
Estribo/fisiopatologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.5144/0256-4947.2017.49


  7 / 1163 MEDLINE  
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[PMID]:28122097
[Au] Autor:Ginat DT
[Ad] Endereço:Department of Radiology, University of Chicago, Chicago, IL, USA.
[Ti] Título:Anomalous stapes in Down syndrome.
[So] Source:Ear Nose Throat J;96(1):15-19, 2017 Jan.
[Is] ISSN:1942-7522
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anormalidades Craniofaciais/complicações
Síndrome de Down/complicações
Perda Auditiva Condutiva/etiologia
Estribo/anormalidades
[Mh] Termos MeSH secundário: Audiometria
Criança
Anormalidades Craniofaciais/diagnóstico por imagem
Feminino
Perda Auditiva Condutiva/fisiopatologia
Seres Humanos
Teste do Limiar de Recepção da Fala
Estribo/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:28079680
[Au] Autor:Dong W; Tian Y; Gao X; Jung TT
[Ad] Endereço:*Research Service, VA Loma Linda Healthcare System †Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Health, Loma Linda, California ‡Department of Otolaryngology, The First Affiliated Hospital, China Medical University, Shenyang, P. R. China.
[Ti] Título:Middle-Ear Sound Transmission Under Normal, Damaged, Repaired, and Reconstructed Conditions.
[So] Source:Otol Neurotol;38(4):577-584, 2017 Apr.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HYPOTHESIS: We hypothesize that current clinical treatment strategies for the disarticulated or eroded incus have the effect of combining the incus and stapes of the human middle ear (ME) into one rigid structure, which, while capable of adequately transmitting lower-frequency sounds, fails for higher frequencies. BACKGROUND: ME damage causes conductive hearing loss (CHL) and while great progress has been made in repairing or reconstructing damaged MEs, the outcomes are often far from ideal. METHODS: Temporal bones (TBs) from human cadavers, a laser Doppler vibrometer (LDV), and a fiber-optic based micro-pressure sensor were used to characterize ME transmission under various ME conditions: normal; with a disarticulated incus; repaired using medical glue; or reconstructed using a partial ossicular replacement prosthesis (PORP). RESULTS: Repairing the disarticulated incus using medical glue, or replacing the incus using a commercial PORP, provided similar restoration of ME function including almost perfect function at frequencies below 4 kHz, but with more than a 20-dB loss at higher frequencies. Associated phase responses under these conditions sometimes varied and seemed dependent on the degree of coupling of the PORP to the remaining ME structure. A new ME-prosthesis design may be required to allow the stapes to move in three-dimensional (3-D) space to correct this deficiency at higher frequencies. CONCLUSIONS: Fixation of the incus to the stapes or ossicular reconstruction using a PORP limited the efficiency of sound transmission at high frequencies.
[Mh] Termos MeSH primário: Orelha Média/fisiologia
Perda Auditiva Condutiva/fisiopatologia
Bigorna/fisiologia
Prótese Ossicular
[Mh] Termos MeSH secundário: Cadáver
Orelha Média/cirurgia
Seres Humanos
Bigorna/cirurgia
Som
Estribo/fisiologia
Osso Temporal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001330


  9 / 1163 MEDLINE  
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[PMID]:27999999
[Au] Autor:Hess-Erga J; Engelen BLHJ; Vassbotn FS
[Ad] Endereço:Department of Otorhinolaryngology and Head and Neck Surgery, Haukeland University Hospital, 5021, Bergen, Norway. jeanette.hess-erga@helse-bergen.no.
[Ti] Título:Cartilage island on stapes: autologous PORP in the hypoventilated middle ear.
[So] Source:Eur Arch Otorhinolaryngol;274(4):1859-1864, 2017 Apr.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The most common technique in sound restoration of the middle ear is prosthetic surgery. Hypoventilation of the middle ear may cause adhesive otitis or atelectasis resulting in a higher risk of prosthetic extrusion rate and recurrence of the underlying cholesteatoma. We report long-term results using an island of tragal cartilage as an autologous PORP in selected patients with poor middle ear ventilation. Retrospective chart reviews were performed for procedures involving 52 patients between year 2000 and 2009. All patients that underwent surgery using tragal cartilage interposed between the suprastructure of the stapes and the tympanic membrane were included in this study. Audiological parameters using four frequencies, 0.5, 1, 2 and 3 kHz, according to AAO-HNS guidelines, were assessed pre-and postoperatively. The hearing results on different PTA frequencies were also investigated. We report long-term follow-up of patients with hypoventilated middle ear with a success rate of 71% (ABG <20%). With regards to the ABG, the low frequency component (5 and 1 kHz) showed a significantly (p < 0.05) larger improvement of mean values after surgery as compared to the high-frequency component (2 and 3 kHz). Cartilage island PORP on stapes is a stable and efficient method for selected patients with chronic middle ear disease.
[Mh] Termos MeSH primário: Cartilagem/transplante
Colesteatoma/cirurgia
Prótese Ossicular
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Audiometria
Autoenxertos
Criança
Orelha Média/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Substituição Ossicular/métodos
Estudos Retrospectivos
Estribo
Membrana Timpânica/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4429-z


  10 / 1163 MEDLINE  
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[PMID]:27560038
[Au] Autor:Lee JM; Jung J; Moon IS; Kim SH; Choi JY
[Ad] Endereço:Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Benefits of active middle ear implants in mixed hearing loss: Stapes versus round window.
[So] Source:Laryngoscope;127(6):1435-1441, 2017 Jun.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: We compared the audiologic benefits of active middle ear implants with those of passive middle ear implants with hearing aids in mixed hearing loss, and also compared the outcomes of stapes vibroplasty with those of round window vibroplasty. STUDY DESIGN: Retrospective chart review. METHODS: Thirty-four patients with mixed hearing loss due to chronic otitis media were treated with a middle ear implant. Of these, 15 were treated with a passive middle ear implant (conventional ossiculoplasty with a partial ossicular replacement prosthesis), nine with an active middle ear implant coupling to the stapes, and 10 with an active middle ear implant coupling to the round window. Patients underwent pure-tone/free-field audiograms and speech discrimination tests before surgery and 6 months after surgery, and the results of these tests were compared. RESULTS: The active middle ear implant resulted in better outcomes than the passive middle ear implant with hearing aids at mid to high frequencies (P < .05). Patients who received either a stapes vibroplasty or a round window vibroplasty showed comparable hearing gain except at 8,000 Hz (48.9 dB vs. 31.0 dB, P < .05). Patients who received a stapes vibroplasty showed an improvement even in bone conduction at 1,000 Hz and 2,000 Hz (both P < .05). CONCLUSIONS: Active middle ear implantation could be a better option than treatment with passive middle ear implants with hearing aids for achieving rehabilitation in patients with mixed hearing loss. Vibroplasty via either oval window or round window stimulation shares similar good results. LEVEL OF EVIDENCE: 4 Laryngoscope, 127:1435-1441, 2017.
[Mh] Termos MeSH primário: Correção de Deficiência Auditiva/métodos
Perda Auditiva Condutiva-Neurossensorial Mista/reabilitação
Prótese Ossicular
Janela da Cóclea/cirurgia
Cirurgia do Estribo/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Audiometria de Tons Puros
Feminino
Auxiliares de Audição
Perda Auditiva Condutiva-Neurossensorial Mista/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Janela da Cóclea/fisiopatologia
Testes de Discriminação da Fala
Estribo/fisiopatologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26244



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