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[PMID]:28471103
[Au] Autor:Yeo JH; Moon NJ; Lee JK
[Ad] Endereço:Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.
[Ti] Título:Measurement of Angle Kappa Using Ultrasound Biomicroscopy and Corneal Topography.
[So] Source:Korean J Ophthalmol;31(3):257-262, 2017 Jun.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To introduce a new convenient and accurate method to measure the angle kappa using ultrasound biomicroscopy (UBM) and corneal topography. METHODS: Data from 42 eyes (13 males and 29 females) were analyzed in this study. The angle kappa was measured using Orbscan II and calculated with UBM and corneal topography. The angle kappa of the dominant eye was compared with measurements by Orbscan II. RESULTS: The mean patient age was 36.4 ± 13.8 years. The average angle kappa measured by Orbscan II was 3.98° ± 1.12°, while the average angle kappa calculated with UBM and corneal topography was 3.19° ± 1.15°. The difference in angle kappa measured by the two methods was statistically significant (p < 0.001). The two methods showed good reliability (intraclass correlation coefficient, 0.671; p < 0.001). Bland-Altman plots were used to demonstrate the agreement between the two methods. CONCLUSIONS: We designed a new method using UBM and corneal topography to calculate the angle kappa. This method is convenient to use and allows for measurement of the angle kappa without an expensive device.
[Mh] Termos MeSH primário: Córnea/diagnóstico por imagem
Topografia da Córnea/métodos
Microscopia Acústica/métodos
[Mh] Termos MeSH secundário: Adulto
Câmara Anterior/anatomia & histologia
Feminino
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0021


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[PMID]:29374460
[Au] Autor:Xu Z; Hua Y; Qiu W; Li G; Wu Q
[Ad] Endereço:Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, NO. 600, Yishan Road, Xuhui District, Shanghai, 200233, China.
[Ti] Título:Precision and agreement of higher order aberrations measured with ray tracing and Hartmann-Shack aberrometers.
[So] Source:BMC Ophthalmol;18(1):18, 2018 Jan 27.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To assess the precision and agreement of measurements of higher order aberrations (HOAs) obtained with a ray tracing aberrometer (iTrace) and a Hartmann-Shack aberrometer (Topcon KR-1 W). METHODS: Prospective evaluation of the diagnostic test. Data from the right eyes of 92 normal subjects obtained using the two devices were included in this study. Two observers performed 3 consecutive scans to determine the intraobserver repeatability and interobserver reproducibility. About one week later, one observer performed an additional 3 consecutive scans to obtain the intersession reproducibility. The within-subject standard deviation (Sw), test-retest repeatability (TRT) and intraclass correlation coefficient (ICC) were used to assess the precision, while Bland-Altman plots were performed to assess the agreement. RESULTS: For intraobserver repeatability of the ocular, corneal and internal HOAs, Topcon KR-1 W showed a 2.77Sw of 0.079 µm or less and ICCs of 0.761 or more; and iTrace showed a 2.77Sw of 0.105 µm or less and ICCs of 0.805 or more. The ICCs of the internal HOAs of interobserver reproducibility were less than 0.75 except for spherical aberration (SA) (0.862), and interobserver reproducibility of the counterpart showed similar but lower results. For the ocular, corneal and internal HOA measurements, statistically significant differences existed between the Topcon KR-1 W and iTrace (all P < 0.05). No significant differences were observed in the ocular SA and internal coma. CONCLUSIONS: The ray tracing and Hartmann-Shack method aberrometers provided excellent repeatability but less reliable reproducibility in the measurement of HOAs (except for SA). The two aberrometers should not be interchangeable in clinical application because of the significant differences in HOA measurements between them.
[Mh] Termos MeSH primário: Aberrometria/instrumentação
Córnea/diagnóstico por imagem
Aberrações de Frente de Onda da Córnea/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Desenho de Equipamento
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Curva ROC
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0683-8


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[PMID]:29334923
[Au] Autor:Park K; Shin J; Lee J
[Ad] Endereço:Department of Ophthalmology, Pusan National University School of Medicine, #179 Gudeok-ro, Seo-gu, Busan, 602-739, South Korea.
[Ti] Título:Relationship between corneal biomechanical properties and structural biomarkers in patients with normal-tension glaucoma: a retrospective study.
[So] Source:BMC Ophthalmol;18(1):7, 2018 Jan 15.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS: All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonometric (GAT) data, axial length, and the spherical equivalent (SE), were also measured. Confocal scanning laser ophthalmoscopy was performed with the aid of a Heidelberg retina tomograph (HRT III). We sought correlations between HRT parameters and different variables including CCT, CH, and the CRF. Multiple linear regression analysis was performed to identify significant associations between corneal biomechanical properties and optic nerve head parameters. RESULTS: We enrolled 95 eyes of 95 NTG patients and 93 eyes of 93 normal subjects. CH and the CRF were significantly lower in more advanced glaucomatous eyes (P = 0.001, P = 0.008, respectively). The rim area, rim volume, linear cup-to-disc ratio (LCDR), and mean retinal nerve fiber layer (RNFL) thickness were significantly worse in more advanced glaucomatous eyes (P < 0.001, P < 0.001, P < 0.001, and P = 0.001). CH was directly associated with rim area, rim volume, and mean RNFL thickness (P = 0.012, P = 0.028, and P = 0.043) and inversely associated with LCDR (P = 0.015), after adjusting for age, axial length, CCT, disc area, GAT data, and SE. However, in normal subjects, there were no significant associations between corneal biomechanical properties and HRT parameters. CONCLUSIONS: A lower CH is significantly associated with a smaller rim area and volume, a thinner RNFL, and a larger LCDR, independent of disc size, corneal thickness, intraocular pressure, and age.
[Mh] Termos MeSH primário: Córnea/fisiopatologia
Pressão Intraocular/fisiologia
Glaucoma de Baixa Tensão/fisiopatologia
Oftalmoscopia/métodos
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Córnea/patologia
Estudos Transversais
Feminino
Seguimentos
Seres Humanos
Glaucoma de Baixa Tensão/diagnóstico
Masculino
Meia-Idade
Estudos Retrospectivos
Tonometria Ocular
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0673-x


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[PMID]:29390284
[Au] Autor:He Y; Li J; Zhu J; Jie Y; Wang N; Wang J
[Ad] Endereço:Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory.
[Ti] Título:The improvement of dry eye after cataract surgery by intraoperative using ophthalmic viscosurgical devices on the surface of cornea: The results of a consort-compliant randomized controlled trial.
[So] Source:Medicine (Baltimore);96(50):e8940, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUD: This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery. METHODS: A total of 149 eyes (149 patients) diagnosed with age-related cataract, age 69.19 ±â€Š9.74 years, were enrolled in this prospective, parallel-design, continuous, randomised controlled study. Patients were randomly assigned to receive HPMC 2% (study group) or balanced salt solution (control group) during the surgery to moisturize the cornea surface. The Ocular Surface Disease Index, Schirmer test without topical anesthetics, tear break-up time, and corneal fluorescein staining were assessed preoperatively, 1 day, 1 week, and 1 month after the surgery, respectively. RESULTS: The Schirmer test value of male patients in the study group at 1 week postoperation was higher than that of male patients in the control group (P = .019). For patients diagnosed with dry eye before the surgery, Schirmer test value in the male patients in the study group at 1 month after surgery was higher than that in the male patients in the control group (P = .037). Furthermore, for the cluster of preoperative dry eye patients whose surgical time was longer than median, corneal fluorescein staining of the patients in the study group was superior to that of the patients in the control group (P = .032). CONCLUSION: Intraoperative use of HPMC 2% on the cornea surface could improve clinical outcomes of tear film and ocular surface health to some degree, especially in the patients diagnosed with dry eye before the surgery, male patients, and patients whose surgical time was relatively longer.
[Mh] Termos MeSH primário: Extração de Catarata/métodos
Síndromes do Olho Seco/prevenção & controle
Derivados da Hipromelose/uso terapêutico
Soluções Oftálmicas/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Córnea
Síndromes do Olho Seco/etiologia
Feminino
Seres Humanos
Cuidados Intraoperatórios
Masculino
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 3NXW29V3WO (Hypromellose Derivatives)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008940


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[PMID]:29311455
[Au] Autor:Nakagawa H; Matsumaru Y; Nose S; Sasaki H; Kitahara T
[Ad] Endereço:Department of Pharmacy, Nagasaki University Hospital.
[Ti] Título:[Evaluation of the Safety of 2.0% Ganciclovir Eye Drops for Hospital Preparation].
[So] Source:Yakugaku Zasshi;138(1):107-110, 2018.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The concentration of ganciclovir eye drops for hospital preparation was changed from 0.5% to 2.0% at the Nagasaki University Hospital from March 2015. We investigated the incidence of side effects in 12 patients using 2.0% ganciclovir eye drops and evaluated the cytotoxicity of 2.0% ganciclovir eye drops using cultured rabbit corneal cells in vitro. As a side effect of 2.0% ganciclovir eye drops, three patients exhibited an early feeling of transient stimulation. The 2.0% ganciclovir eye drops did not demonstrate cell cytotoxicity for cultured corneal cells after 5 min, but did after 10 min. These findings suggested that the 2.0% ganciclovir eye drops can be used without corneal epithelium disorder in clinical settings.
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Ganciclovir/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Córnea/citologia
Córnea/efeitos dos fármacos
Testes Imunológicos de Citotoxicidade
Relação Dose-Resposta a Droga
Ganciclovir/toxicidade
Hospitais Universitários
Seres Humanos
Incidência
Japão/epidemiologia
Soluções Oftálmicas
Coelhos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ophthalmic Solutions); P9G3CKZ4P5 (Ganciclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00015


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[PMID]:29422750
[Au] Autor:Bussières N; Ababneh OH; Abu Ameerh MA; Al Bdour MD
[Ad] Endereço:Department of Vision Rehabilitation, Faculty of Applied Medical Sciences, German Jordanian University, Amman, Jordan.
[Ti] Título:Keratoconus Asymmetry between Both Eyes Based on Corneal Tomography.
[So] Source:Middle East Afr J Ophthalmol;24(4):171-176, 2017 Oct-Dec.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To characterize the asymmetry between both eyes in patients with keratoconus based on corneal tomography. MATERIALS AND METHODS: All patients with keratoconus who presented to the eye clinic at Jordan University Hospital between January 2008 and November 2011 were included in the study. Using computerized corneal tomography, the keratometric values and indices of both eyes of participants with keratoconus and normal controls were compared. For both eyes to be considered symmetrical, the difference between the mean curvature power (Km), flat curvature power (K1), or steep curvature power (K2) in both eyes was equal to or <2.5 diopters, and the difference between the thinnest corneal points was equal to or <25.0 µm between both eyes. RESULTS: Ninety-eight patients with keratoconus and 49 normal participants were evaluated. The mean age of the participants was 26.3 ± 6.6 years. The results showed two populations of patients with keratoconus: one with asymmetrical corneas who were more affected by the disease and another with symmetrical corneas. As the disease severity increased, the differences between the two eyes increased for patients with the asymmetrical form, while both corneas of patients with the symmetrical form were similar. CONCLUSIONS: Corneal tomography identified two forms of keratoconus: symmetrical and asymmetrical. The latter tended to be more severe and occurred in a younger age group. Questions remain about whether the two keratoconic forms are specific to the Middle Eastern population and whether there are ethnic or demographic forms of the disease.
[Mh] Termos MeSH primário: Córnea/patologia
Ceratocone/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Topografia da Córnea
Feminino
Seres Humanos
Masculino
Meia-Idade
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_311_16


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[PMID]:29227515
[Au] Autor:Carriazo C; Cosentino MJ
[Ti] Título:A Novel Corneal Remodeling Technique for the Management of Keratoconus.
[So] Source:J Refract Surg;33(12):854-856, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe a novel technique to reshape the ectatic cornea by means of crescent keratectomy performed with an excimer laser using a mask. METHODS: A crescent-shaped perforation at the base of the mask allowed the laser ablation to be directed only to the intended region, shielding the remaining cornea. This technique was performed in 3 eyes of 3 patients with keratoconus grade 2 to 3. Arcs of 180° and 360° had been performed depending on the severity of the keratoconus. The edges of the crescent were closed by 10-0 nylon interrupted sutures. RESULTS: At 1 year postoperatively, all cases showed improvement in visual acuity, keratometry, and corneal topography. The treatment also reduced optical aberrations and shortened the anterior chamber depth. CONCLUSIONS: Although the preliminary results are promising, there is a need to standardize a nomogram of this technique for treating keratoconus. [J Refract Surg. 2017;33(12):854-856.].
[Mh] Termos MeSH primário: Córnea/fisiologia
Cirurgia da Córnea a Laser/métodos
Ceratocone/cirurgia
Lasers de Excimer/uso terapêutico
Fenômenos Fisiológicos Oculares
[Mh] Termos MeSH secundário: Adulto
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/fisiopatologia
Masculino
Refração Ocular/fisiologia
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20171004-05


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[PMID]:29227513
[Au] Autor:Vinciguerra R; Romano V; Arbabi EM; Brunner M; Willoughby CE; Batterbury M; Kaye SB
[Ti] Título:In Vivo Early Corneal Biomechanical Changes After Corneal Cross-linking in Patients With Progressive Keratoconus.
[So] Source:J Refract Surg;33(12):840-846, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report early corneal biomechanical changes after corneal cross-linking (CXL) in patients with keratoconus. METHODS: Thirty-four eyes of 34 patients undergoing CXL for progressive keratoconus were included in this prospective clinical study. Dynamic corneal response (DCR) parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed at baseline (day of CXL) and after 1 month of follow-up; conversely, corneal tomography with the Pentacam (OCULUS Optikgeräte GmbH) was assessed at baseline and at 1, 3, and 6 months after CXL. RESULTS: At the last follow-up visit (123.7 ± 69.6 days), all morphological parameters including steepest point (Kmax) and thinnest corneal thickness (ThCT) indicated stabilization of keratoconus (P > .05). Comparative analyses showed a rise of corneal stiffness demonstrated by a significant increase of Stiffness Parameter A1 (SP-A1) and Highest Concavity (SP-HC) and a significant decrease of Inverse Concave Radius (1/R) and Deformation Amplitude Ratio (DA Ratio) (P < .05). There was a significant correlation between the preoperative keratoconus characteristics (Kmax, Belin/Ambrósio final D value [BAD-D], and ThCT) and the DCR parameters (P < .05). Kmax and BAD-D showed a significant positive correlation with DA Ratio, Deflection Amplitude (DefA), and 1/R and a significant negative correlation with SPA1 and SP-HC. ThCT showed a significant positive correlation with SP-A1 and SP-HC and a significant negative correlation with DA Ratio, DefA, and 1/R. CONCLUSIONS: This study suggests that the new DCR parameters of the Corvis ST are able to detect early changes in biomechanics following CXL and those that are measurable before corneal shape modifications take place. Based on these results, the authors suggest the use of these metrics to assess the early efficacy of cross-linking. [J Refract Surg. 2017;33(12):840-846.].
[Mh] Termos MeSH primário: Córnea/fisiologia
Reagentes para Ligações Cruzadas
Elasticidade/fisiologia
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Colágeno/metabolismo
Substância Própria/metabolismo
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/metabolismo
Ceratocone/fisiopatologia
Masculino
Estudos Prospectivos
Raios Ultravioleta
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170922-02


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[PMID]:29227512
[Au] Autor:Anumanthan G; Sharma A; Waggoner M; Hamm CW; Gupta S; Hesemann NP; Mohan RR
[Ti] Título:Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo.
[So] Source:J Refract Surg;33(12):834-839, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo. METHODS: Corneal haze in rabbits was produced with -9.00 diopter PRK. A single application of SAHA (25 µM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence. RESULTS: Single topical adjunct use of SAHA (25 µM) or MMC (0.02%) after PRK attenuated more than 95% corneal haze and myofibroblast formation (P < .001). SAHA did not reduce keratocyte density, cause keratocyte apoptosis, or increase immune cell infiltration compared to MMC (P < .01 or .001). Furthermore, SAHA dosing did not compromise corneal endothelial phenotype, density, or function in rabbit eyes, whereas MMC application did (P < .01 or .001). CONCLUSIONS: SAHA and MMC significantly decreased corneal haze after PRK in rabbits in vivo. SAHA exhibited significantly reduced short- and long-term damage to the corneal endothelium compared to MMC in rabbits. SAHA is an effective and potentially safer alternative to MMC for the prevention of corneal haze after PRK. Clinical trials are warranted. [J Refract Surg. 2017;33(12):834-839.].
[Mh] Termos MeSH primário: Alquilantes/uso terapêutico
Opacidade da Córnea/prevenção & controle
Modelos Animais de Doenças
Inibidores de Histona Desacetilases/uso terapêutico
Ácidos Hidroxâmicos/uso terapêutico
Mitomicina/uso terapêutico
Ceratectomia Fotorrefrativa/efeitos adversos
[Mh] Termos MeSH secundário: Alquilantes/efeitos adversos
Animais
Apoptose
Córnea/cirurgia
Opacidade da Córnea/etiologia
Técnica Indireta de Fluorescência para Anticorpo
Inibidores de Histona Desacetilases/efeitos adversos
Ácidos Hidroxâmicos/efeitos adversos
Marcação In Situ das Extremidades Cortadas
Mitomicina/efeitos adversos
Coelhos
Lâmpada de Fenda
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkylating Agents); 0 (Histone Deacetylase Inhibitors); 0 (Hydroxamic Acids); 50SG953SK6 (Mitomycin); 58IFB293JI (vorinostat)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170921-02


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[PMID]:29227510
[Au] Autor:Lin DTC; Holland SP; Verma S; Hogden J; Arba-Mosquera S
[Ti] Título:Postoperative Corneal Asphericity in Low, Moderate, and High Myopic Eyes After Transepithelial PRK Using a New Pulse Allocation.
[So] Source:J Refract Surg;33(12):820-826, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the postoperative asphericity in low, moderate, and high myopic eyes after combined transepithelial photorefractive keratectomy and SmartSurf treatment (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany). METHODS: In this retrospective case series, the outcomes of myopic SmartSurf were evaluated at 3 months postoperatively in 106 eyes and divided into low (less than -4.125 diopters [D]), moderate (-4.125 to -6.25 D), and high (more than -6.25 D) myopia groups. In all cases, standard examinations and preoperative and postoperative corneal topography (SCHWIND Sirius) were performed. The analysis comprised evaluating the change in asphericity versus planned correction, comparing expected and achieved postoperative asphericity for all eyes, and comparison of the three groups in terms of the preoperative and postoperatively expected and achieved asphericity. RESULTS At 3 months postoperatively, the low myopia group (n = 33) improved average negative asphericity (Q = -0.04 ± 0.17 preoperative vs -0.19 ± 0.20 postoperative, P < .05). The moderate myopia group (n = 35) maintained or slightly improved average negative asphericity (Q = -0.07 ± 0.14 preoperative vs -0.05 ± 0.24 postoperative, P = .35). For the high myopia group (n = 38), the eyes became more oblate compared to the preoperative status (Q = -0.09 ± 0.15 preoperative vs 0.62 ± 0.70 postoperative, P < .05). In terms of asphericity, the difference between the three groups was not statistically significant preoperatively (P > .10), but showed significant differences postoperatively (P < .007). The cohort's average preoperative corrected distance visual acuity was 0.01 ± 0.04 logMAR (range: 0.0 to 0.18 logMAR) and uncorrected distance visual acuity was 0.03 ± 0.08 logMAR (range: -0.12 to 0.40 logMAR) 3 months postoperatively. CONCLUSIONS: SmartSurf maintained or slightly improved preoperative corneal asphericity for low to moderate myopic corrections (up to -6.00 D). This may provide advantages in the quality of vision and the onset of presbyopic symptoms after laser refractive surgery in myopic patients. [J Refract Surg. 2017;33(12):820-826.].
[Mh] Termos MeSH primário: Córnea/fisiopatologia
Lasers de Excimer/uso terapêutico
Miopia/cirurgia
Ceratectomia Fotorrefrativa/métodos
[Mh] Termos MeSH secundário: Adulto
Topografia da Córnea
Feminino
Seres Humanos
Masculino
Meia-Idade
Miopia/classificação
Miopia/fisiopatologia
Período Pós-Operatório
Refração Ocular/fisiologia
Estudos Retrospectivos
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170920-02



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