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[PMID]:28079692
[Au] Autor:Galvis V; Tello A; Carreño NI; Berrospi RD; Niño CA; Leiva F
[Ad] Endereço:*Centro Oftalmológico Virgilio Galvis, Floridablanca, Colombia †Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Ophthalmology Department, Bucaramanga, Colombia ‡Fundación Oftalmológica de Santander (FOSCAL), Ophthalmology Department, Floridablanca, Colombia.
[Ti] Título:Keratoconus and Bowman Layer Transplantation.
[So] Source:Cornea;36(3):e8, 2017 03.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Lâmina Limitante Anterior
Ceratocone/cirurgia
[Mh] Termos MeSH secundário: Transplante de Córnea
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001142


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[PMID]:27590038
[Au] Autor:Qiu WY; Zheng LB; Pan F; Wang BB; Yao YF
[Ad] Endereço:Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China.
[Ti] Título:New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene.
[So] Source:BMC Ophthalmol;16(1):158, 2016 Sep 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman's layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for treatment in literatures. The study reported new histopathological and ultrastructural findings in RBCD caused by the Arg124Leu mutation of transforming growth factor induced (TGFBI) gene in a four-generation Chinese pedigree. METHODS: Subjects including eight patients and seven unaffected family members received slit-lamp biomicroscopy and photography. DNA was obtained from all subjects, and exons 4 and 11 to 14 of TGFBI gene were analyzed by polymerase chain reaction and the products were sequenced. Anterior segment optical coherence tomography (AS OCT) and in vivo confocal microscopy were conducted for ten eyes of five patients. Based on the results of AS OCT and in vivo confocal microscopy, deep anterior lamellar keratoplasty (DLKP) using cryopreserved donor cornea was applied for four eyes of four patients. Four lamellar dystrophic corneal buttons were studied by light and transmission electron microscopy, and TGFBI immunohistochemistry. RESULTS: Eight patients had typical clinical manifestations of RBCD presenting recurrent painful corneal erosion starting in their early first decades, along with age-dependent progressive geographic corneal opacities. TGFBI sequencing revealed a heterozygous mutation, Arg124Leu in all eight patients. Anterior segment optical coherence tomography and in vivo confocal microscopy showed the dystrophic deposits involved not only in subepithelial and superficial stroma, but also in mid- or posterior stroma in four examined advanced eyes. Light microscopy showed Bowman's layer was absent, replaced by abnormal deposits stain bright red with Masson's trichrome. In superficial cornea, the deposits stacked and produced three to five continuous bands parallel to the corneal collagen lamellae. In mid- to posterior stroma, numerous granular or dot- like aggregates were heavily scattered, and most of them presented around the nuclei of stromal keratocytes. Transmission electron microscopy revealed the multiple electron-dense rod-shaped deposits aggregated and formed a characteristic pattern of three to five continuous bands in superficial cornea, which were similar to those seen under light microscopy. In mid- to posterior stroma, clusters of rod-shaped bodies were scattered extracellular or intracellular of the stromal keratocytes between the stromal lamellae suggesting the close relationship between mutated proteins and keratocyte. CONCLUSIONS: The study offer evidences indicating DLKP is a viable treatment option for advanced RBCD to avoid recurrence, and the mutated TGFBIp in dystrophic corneas are of keratocytes origin.
[Mh] Termos MeSH primário: Distrofias Hereditárias da Córnea/genética
Distrofias Hereditárias da Córnea/patologia
Fator de Crescimento Transformador beta/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Grupo com Ancestrais do Continente Asiático
Lâmina Limitante Anterior/patologia
Lâmina Limitante Anterior/ultraestrutura
Criança
Pré-Escolar
Córnea/patologia
Córnea/ultraestrutura
Distrofias Hereditárias da Córnea/cirurgia
Ceratócitos da Córnea/patologia
Substância Própria/patologia
Substância Própria/ultraestrutura
Éxons
Proteínas da Matriz Extracelular/genética
Feminino
Seres Humanos
Imuno-Histoquímica
Ceratoplastia Penetrante
Masculino
Microscopia Confocal
Microscopia Eletrônica de Transmissão
Meia-Idade
Mutação
Linhagem
Reação em Cadeia da Polimerase
Tomografia de Coerência Óptica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Extracellular Matrix Proteins); 0 (Transforming Growth Factor beta)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-016-0325-y


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[PMID]:27362885
[Au] Autor:Groeneveld-van Beek EA; Parker J; Lie JT; Bourgonje V; Ham L; van Dijk K; van der Wees J; Melles GR
[Ad] Endereço:*Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands;†Amnitrans Eyebank, Rotterdam, the Netherlands;‡UAB Callahan Eye Hospital, Birmingham, AL; and§Melles Cornea Clinic, Rotterdam, the Netherlands.
[Ti] Título:Donor Tissue Preparation for Bowman Layer Transplantation.
[So] Source:Cornea;35(12):1499-1502, 2016 Dec.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe and compare 2 preparation techniques for Bowman layer (BL) grafts for use in BL transplantation. METHODS: A retrospective evaluation of the 2 methods for preparing BL grafts was performed, that is, BL graft preparation from donor globes not eligible for penetrating keratoplasty or endothelial keratoplasty (technique I, n = 36) and BL graft preparation from previously excised corneoscleral buttons (technique II, n = 36) that could not be used for PK or had been denuded of Descemet membrane and endothelium for Descemet membrane endothelial keratoplasty graft preparation. BL graft preparation difficulties were recorded, and the preparation failure rate was examined and compared between the techniques. RESULTS: Overall, BL graft preparation was successful in 51 cases (51/72; 70.8%), of which 25 preparations were successful using technique I, and 26 using technique II, representing a success rate of 69.4% (25/36) and 72.2% (26/36) for techniques I and II, respectively. Reasons for discarding a BL graft were tearing of the BL tissue during the preparation (n = 19) and stroma attached to the graft (n = 2). CONCLUSIONS: Isolated BL grafts can be prepared from both whole donor globes and corneoscleral rims with equivalent success. Preparation from corneoscleral rims may offer the advantage that, from one donor cornea, the posterior layers can be used for Descemet membrane endothelial keratoplasty graft preparation and the anterior part for BL graft preparation.
[Mh] Termos MeSH primário: Lâmina Limitante Anterior
Bancos de Olhos/métodos
Doadores de Tecidos
Transplante de Tecidos
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000905


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[PMID]:27176595
[Au] Autor:Zhou WP; Zhu YF; Zhang B; Qiu WY; Yao YF
[Ad] Endereço:Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
[Ti] Título:The role of ultraviolet radiation in the pathogenesis of pterygia (Review).
[So] Source:Mol Med Rep;14(1):3-15, 2016 Jul.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Pterygium is a common ophthalmic disease affecting humans only. Extensive epidemiological data have demonstrated a causative effect of chronic ultraviolet (UV) radiation on pterygia. Progress has been made in determining the origin of pterygia, their nasal predilection and wing­shaped appearance, and the roles of UV radiation in the initiation and the development of pterygia. In the present review, the current understanding of the involvement of UV radiation in the pathogenesis of pterygia is summarized. This involvement includes the alteration of limbal stem cells and fibroblasts that contribute to the initiation of pterygia and the induction of various pro­inflammatory cytokines, growth factors and matrix metalloproteinases that promote the progression of pterygia. Further elucidation of the roles of UV radiation in the pathogenesis of pterygia may help to encourage individuals at risk of developing pterygia to take preventive measures and aid researchers in the development of novel targeted therapeutic agents to treat pterygia.
[Mh] Termos MeSH primário: Pterígio/etiologia
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Lâmina Limitante Anterior/metabolismo
Lâmina Limitante Anterior/patologia
Citocinas/genética
Citocinas/metabolismo
Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
Fibroblastos/efeitos da radiação
Regulação da Expressão Gênica/efeitos da radiação
Seres Humanos
Inflamação/etiologia
Inflamação/metabolismo
Inflamação/patologia
Peptídeos e Proteínas de Sinalização Intercelular/genética
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Metaloproteinases da Matriz/genética
Metaloproteinases da Matriz/metabolismo
Neovascularização Patológica/etiologia
Neovascularização Patológica/metabolismo
Neovascularização Patológica/patologia
Pterígio/patologia
Células Estromais/metabolismo
Células Estromais/efeitos da radiação
Inibidores Teciduais de Metaloproteinases/genética
Inibidores Teciduais de Metaloproteinases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Intercellular Signaling Peptides and Proteins); 0 (Tissue Inhibitor of Metalloproteinases); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5223


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[PMID]:27124782
[Au] Autor:Luceri S; Parker J; Dapena I; Baydoun L; Oellerich S; van Dijk K; Melles GR
[Ad] Endereço:*Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands; †Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands; and ‡Amnitrans EyeBank, Rotterdam, the Netherlands.
[Ti] Título:Corneal Densitometry and Higher Order Aberrations After Bowman Layer Transplantation: 1-Year Results.
[So] Source:Cornea;35(7):959-66, 2016 Jul.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate corneal densitometry and higher order aberrations (HOAs) up to 1 year after Bowman layer (BL) transplantation. METHODS: This was a retrospective study carried out at a tertiary referral center. Fifteen eyes of 14 patients who underwent BL transplantation for advanced keratoconus and had at least 1 year of follow-up were examined before BL transplantation and postoperatively at 1 day, 1 week, and 1, 3, 6, and 12 months. Corrected distance visual acuity (CDVA) with spectacles and contact lenses, anterior and posterior HOAs, and corneal densitometry were analyzed. RESULTS: One year after surgery, average logarithm of the minimum angle of resolution of spectacle-CDVA changed from 1.35 (±0.46) preoperatively to 0.96 (±0.32, P < 0.001), whereas average logarithm of the minimum angle of resolution of CDVA with contact lens remained stable after surgery (P = 0.126). Anterior and posterior HOA root mean square decreased from 3.08 ± 0.59 to 2.67 ± 0.71 µm and 7.32 ± 2.20 to 6.30 ± 2.18 µm, respectively (P < 0.05). Spherical aberration ((Equation is included in full-text article.)) improved on both anterior and posterior corneal surfaces (P < 0.001). After 1 year, corneal backscattering values showed an increase as compared with preoperative values mostly involving the central and posterior layers of the cornea, with a peak 1 month after surgery (P < 0.005 in zones 2-6 and 6-10 mm). No correlation between HOAs or corneal backscatter and CDVA was found. CONCLUSIONS: Corneal HOAs, especially spherical aberration, decreased for both anterior and posterior corneal surfaces after BL transplantation, whereas corneal backscattering increased, mostly in the central and posterior layers, where the graft has been placed. Changes in HOAs and corneal backscattering did not correlate with CDVA.
[Mh] Termos MeSH primário: Lâmina Limitante Anterior/cirurgia
Córnea/fisiopatologia
Transplante de Córnea
Aberrações de Frente de Onda da Córnea/fisiopatologia
Ceratocone/cirurgia
[Mh] Termos MeSH secundário: Aberrometria
Adolescente
Adulto
Idoso
Densitometria
Feminino
Seres Humanos
Ceratocone/fisiopatologia
Luz
Masculino
Meia-Idade
Estudos Retrospectivos
Espalhamento de Radiação
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000860


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[PMID]:26890669
[Au] Autor:Shetty R; Deshpande K; Deshmukh R; Jayadev C; Shroff R
[Ad] Endereço:Cornea and Refractive Surgery Department, Narayana Nethralaya, Bangalore, Karnataka, India.
[Ti] Título:Bowman Break and Subbasal Nerve Plexus Changes in a Patient With Dry Eye Presenting With Chronic Ocular Pain and Vitamin D Deficiency.
[So] Source:Cornea;35(5):688-91, 2016 May.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report the case of a 40-year-old patient with persistent bilateral ocular pain and discomfort for 2 years in whom conventional management of dry eye had failed. Detailed ocular examination, meibography, and tear film evaluation were suggestive of bilateral meibomian gland dysfunction and evaporative dry eye. Topical medication failed to alleviate the patient's symptoms. To identify the cause of pain, imaging was performed with in vivo confocal microscopy and anterior segment spectral domain optical coherence tomography. Systemic evaluation revealed severe vitamin D deficiency with a value of 5.86 ng/mL. METHODS: Case report. RESULTS: In vivo confocal microscopy showed abnormal subbasal nerve plexus morphology, increased dendritic cell density, and enlarged terminal nerve sprouts. A breach in the Bowman layer was detected in both eyes on spectral domain optical coherence tomography. Conventional management having failed, LipiFlow treatment (TearScience, Morrisville, NC) was performed and topical therapy with cyclosporine 0.05%, steroids, and lubricating eye drops was initiated with incomplete symptomatic relief. However, with parenteral therapy for vitamin D deficiency, there was a dramatic improvement in the patient's symptoms. CONCLUSIONS: Inflammation aggravated by vitamin D deficiency results in an altered epithelial profile, Bowman layer damage, recruitment of dendritic cells, and altered subbasal nerve plexus features in patients with chronic dry eye disease. These can serve as potential imaging markers for studying the underlying mechanisms in patients with dry eye disease with persisting symptoms despite aggressive conventional treatment.
[Mh] Termos MeSH primário: Lâmina Limitante Anterior/patologia
Córnea/inervação
Doenças dos Nervos Cranianos/diagnóstico
Síndromes do Olho Seco/diagnóstico
Dor Ocular/diagnóstico
Nervo Oftálmico/patologia
Deficiência de Vitamina D/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Doenças dos Nervos Cranianos/tratamento farmacológico
Células Dendríticas/patologia
Síndromes do Olho Seco/tratamento farmacológico
Dor Ocular/tratamento farmacológico
Seres Humanos
Injeções Intramusculares
Masculino
Microscopia Confocal
Fibras Nervosas/patologia
Tomografia de Coerência Óptica
Vitamina D/administração & dosagem
Deficiência de Vitamina D/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000785


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[PMID]:26812711
[Au] Autor:López de la Fuente C; Sánchez-Cano A; Segura F; Hospital EO; Pinilla I
[Ti] Título:Evaluation of Total Corneal Thickness and Corneal Layers With Spectral-Domain Optical Coherence Tomography.
[So] Source:J Refract Surg;32(1):27-32, 2016 Jan.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate total corneal thickness and corneal layers in healthy young adults using spectral-domain optical coherence tomography and to describe its repeatability and reproducibility. METHODS: Eighty-six eyes from 86 healthy volunteers were prospectively and consecutively enrolled. Manual measurements of central corneal thickness (CCT) and central thickness of epithelium, Bowman's layer, stroma, and the Descemet-endothelium complex were performed using Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). To assess the reliability of the repeated measurements, intraclass correlation coefficients and coefficients of variation were used. RESULTS: Mean CCT, epithelium, Bowman's layer, stroma, and Descemet-endothelium values were 555.50 ± 29.64, 54.60 ± 4.25, 16.70 ± 1.73, 467.51 ± 28.91, and 16.74 ± 1.66 µm, respectively. The intraclass correlation coefficients ranged from 0.746 (Bowman's layer) to 0.999 (CCT and stroma) and from 0.483 (Bowman's layer) to 0.995 (CCT) and 0.998 (stroma) for intraobserver repeatability and interobserver reproducibility, respectively. The measurements showed coefficients of variation lower than 11% in all cases. CONCLUSIONS: This study establishes a normal database for corneal thickness and all its layers in healthy young adults with spectral-domain optical coherence tomography. This device exhibited a high degree of intraobserver repeatability and interobserver reproducibility for all regions except Bowman's layer.
[Mh] Termos MeSH primário: Córnea/anatomia & histologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adulto
Lâmina Limitante Anterior/anatomia & histologia
Substância Própria/anatomia & histologia
Lâmina Limitante Posterior/anatomia & histologia
Epitélio Posterior/anatomia & histologia
Epitélio Anterior/anatomia & histologia
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Variações Dependentes do Observador
Tamanho do Órgão
Estudos Prospectivos
Valores de Referência
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160127
[Lr] Data última revisão:
160127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20151207-03


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[PMID]:26084010
[Au] Autor:Zhang H; He S; Liu S; Xie Y; Chen G; Zhang J; Sun S; Liang D; Wang L
[Ad] Endereço:a Henan Eye Institute, Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University , Zhengzhou , People's Republic of China and.
[Ti] Título:Measurement of In Vivo Three-Dimensional Corneal Cell Density and Size Using Two-Photon Imaging in C57BL/6 Mice.
[So] Source:Curr Eye Res;41(4):448-55, 2016 04.
[Is] ISSN:1460-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To measure the cell size and cell density in five layers of the central cornea in the widely used inbred C57BL/6 mouse strain using in vivo three-dimensional (3D) two-photon (2PH) imaging. METHODS: Corneas were scanned using a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain and Hoechst 33342. Good quality 3D images were selected for the cell density and cell size analysis. Cell density was determined by counting the cell nuclei in a predefined cube of 3D images. Cell size measurements, including cell surface area, cell volume, nuclear surface area and nuclear volume, were automatically quantified using the Imaris software. The cell and nuclear surface-area-to-volume ratio (S:V ratio) and the cell nuclear-cytoplasmic ratio (N:C ratio) were calculated. RESULTS: The highest cell density was observed in the basal epithelium and the lowest in the posterior stroma. The highest cell surface area was found in the anterior stroma, and the highest cell volume was observed in the superficial epithelium. The lowest cell surface area and cell volume were both found in the basal epithelium. The highest S:V ratio was observed in the basal epithelium and the lowest in the superficial epithelium. The highest cell nuclear surface area and volume were both observed in the superficial epithelium and the lowest in the basal epithelium. The highest cell nuclear S:V ratio was observed in the basal epithelium and the lowest in the superficial epithelium. The highest N:C ratio was found in the basal epithelial cells and the lowest in the posterior keratocytes. CONCLUSIONS: We are the first to quantify the cell density and size parameters, including cell surface area and volume, cell nuclear surface area and volume, and the S:V ratio, in the five layers of the central cornea. These data provide important cell morphology features for the study of corneal physiology, pathology and disease in mice, particularly in C57BL/6 mice.
[Mh] Termos MeSH primário: Córnea/citologia
Imagem Tridimensional
Microscopia Confocal/métodos
[Mh] Termos MeSH secundário: Animais
Lâmina Limitante Anterior/citologia
Contagem de Células
Tamanho Celular
Substância Própria/citologia
Epitélio Posterior/citologia
Epitélio Anterior/citologia
Camundongos
Camundongos Endogâmicos C57BL
Modelos Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150618
[St] Status:MEDLINE
[do] DOI:10.3109/02713683.2015.1031253


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[PMID]:25941959
[Au] Autor:Shetty R; Nagaraja H; Pahuja NK; Jayaram T; Vohra V; Jayadev C
[Ad] Endereço:a Narayana Nethralaya Eye Hospital , Bangalore , India.
[Ti] Título:Safety and Efficacy of Epi-Bowman Keratectomy in Photorefractive Keratectomy and Corneal Collagen Cross-Linking: A Pilot Study.
[So] Source:Curr Eye Res;41(5):623-9, 2016 May.
[Is] ISSN:1460-2202
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study is to compare the efficacy and safety of Epi-Bowman Keratectomy (EBK) using Epi-clear™ epikeratome with a mechanical scraper for corneal epithelium debridement during photorefractive keratectomy (PRK) and corneal collagen cross-linking (CXL). METHODOLOGY: Sixty eyes of 30 patients undergoing PRK and 44 eyes of 44 patients undergoing CXL were included in this study. In the PRK group, one eye of each patient underwent EBK and the other eye epithelial debridement with a mechanical scraper. In the CXL group, 22 eyes of 22 patients underwent EBK and the other 22 eyes with a mechanical scraping to remove the epithelium. Intra-operative spectral domain optical coherence tomography (SD OCT; Bioptigen Inc, Durham, NC) was performed to evaluate the integrity of Bowman's membrane following epithelial removal. The time taken for epithelial removal, post-operative pain score using the Wong-Baker's pain scale, time for epithelial healing, and the epithelial profile using the Optovue (Optovue Inc. Fremont, CA) during the healing was observed and analyzed between the two groups and subgroups. RESULTS: Intra-operative SD OCT showed a smooth and undamaged Bowman's membrane when EBK was performed. Post-operative pain was significantly less (p < 0.01 in the PRK group and p < 0.001 in the CXL group) with faster epithelial healing (p < 0.001 in the PRK group and p < 0.0001 in the CXL group) in the EBK subgroup as compared with the mechanical scraper subgroup. Epithelial profiling during the healing phase showed an edematous epithelium in the initial 2 weeks in the mechanical scraper subgroup while the EBK subgroup showed minimal epithelial edema lasting up to a week with regularized and smooth corneal epithelium healing. CONCLUSION: Epi-Bowman Keratectomy appears to be an effective and safe method of corneal epithelial debridement with negligible damage to Bowman's membrane and the surrounding epithelium leading to early healing thereby reducing the post-operative pain and complications.
[Mh] Termos MeSH primário: Colágeno/farmacologia
Doenças da Córnea/terapia
Reagentes para Ligações Cruzadas/farmacologia
Lasers de Excimer/uso terapêutico
Ceratectomia Fotorrefrativa/métodos
Refração Ocular/fisiologia
Acuidade Visual
[Mh] Termos MeSH secundário: Lâmina Limitante Anterior/cirurgia
Córnea/patologia
Córnea/cirurgia
Doenças da Córnea/diagnóstico
Paquimetria Corneana
Feminino
Seguimentos
Seres Humanos
Masculino
Projetos Piloto
Estudos Prospectivos
Tomografia de Coerência Óptica
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 9007-34-5 (Collagen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150506
[St] Status:MEDLINE
[do] DOI:10.3109/02713683.2015.1045082


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[PMID]:26592674
[Au] Autor:Raven ML; Rodriquez ME; Nehls SM
[Ad] Endereço:University of Wisconsin - Madison, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin.
[Ti] Título:Changes in the Corneal Architecture Following Corneal Hydrops.
[So] Source:Ophthalmology;122(12):2456, 2015 Dec.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Lâmina Limitante Anterior/patologia
Edema da Córnea/diagnóstico
Lâmina Limitante Posterior/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Edema da Córnea/fisiopatologia
Edema da Córnea/cirurgia
Seres Humanos
Ceratoplastia Penetrante
Masculino
Meia-Idade
Ruptura Espontânea
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151123
[Lr] Data última revisão:
151123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE



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