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[PMID]:29499665
[Au] Autor:Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L
[Ad] Endereço:People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
[Ti] Título:Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis.
[So] Source:BMC Ophthalmol;18(1):65, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration.
[Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico
Substância Própria/metabolismo
Úlcera da Córnea/tratamento farmacológico
Reagentes para Ligações Cruzadas
Infecções Oculares Fúngicas/tratamento farmacológico
Fusariose/tratamento farmacológico
Fusarium/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Colágeno/metabolismo
Contagem de Colônia Microbiana
Úlcera da Córnea/metabolismo
Úlcera da Córnea/microbiologia
Modelos Animais de Doenças
Infecções Oculares Fúngicas/metabolismo
Infecções Oculares Fúngicas/microbiologia
Fusariose/metabolismo
Fusariose/microbiologia
Fusarium/isolamento & purificação
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0727-0


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[PMID]:27772645
[Au] Autor:Jeng BH; Farid M; Patel SV; Schwab IR
[Ad] Endereço:Baltimore, Maryland. Electronic address: bjeng@som.umaryland.edu.
[Ti] Título:Corneal Cross-linking for Keratoconus: A Look at the Data, the Food and Drug Administration, and the Future.
[So] Source:Ophthalmology;123(11):2270-2272, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Reagentes para Ligações Cruzadas
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
United States Food and Drug Administration/tendências
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Colágeno/metabolismo
Substância Própria/metabolismo
Aprovação de Drogas
Previsões
Seres Humanos
Ceratocone/metabolismo
Projetos de Pesquisa
Raios Ultravioleta
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29227514
[Au] Autor:Ganesh S; Brar S; Lazaridis A
[Ti] Título:Management and Outcomes of Retained Lenticules and Lenticule Fragments Removal After Failed Primary SMILE: A Case Series.
[So] Source:J Refract Surg;33(12):848-853, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the management of and report the outcomes following the removal of retained lenticules or lenticule fragments after a complicated small incision lenticule extraction (SMILE). METHODS: Three patients were referred for consultation due to intraoperative complications during SMILE. In case 1, the lenticule was torn during extraction and a central fragment was retained in the pocket. In case 2, the inferior part of the lenticule remained attached at the anterior plane and its detached, superior part was dislocated and folded at the inferior part of the pocket. In case 3, the lenticule was completely attached at the anterior plane. All cases underwent secondary surgery. The lenticule fragment was detached using the dissector's body and tip and was extracted using the advanced lenticule forceps. The retained lenticules were extracted after dissection of tissue bridges at the anterior plane and periphery. RESULTS: Postoperatively, all eyes showed improvement of visual acuity and topographic regularization of the anterior corneal curvature. Complete removal of lenticule remnants was accomplished in cases 1 and 2. In case 3, the photodisruption during primary SMILE was incomplete at a peripheral area next to the incision. A small peripheral fragment, corresponding to the described peripheral area, remained attached after the lenticule removal and was left in situ but did not have any impact on visual acuity and quality. CONCLUSIONS: Retained lenticules or lenticule fragments may induce irregular astigmatism and loss of visual acuity. Prompt removal restores visual acuity and induces the desired effect of the primary SMILE procedure. [J Refract Surg. 2017;33(12):848-853.].
[Mh] Termos MeSH primário: Astigmatismo/cirurgia
Substância Própria/patologia
Cirurgia da Córnea a Laser/efeitos adversos
Complicações Intraoperatórias
Transtornos da Visão/cirurgia
[Mh] Termos MeSH secundário: Adulto
Astigmatismo/etiologia
Astigmatismo/fisiopatologia
Substância Própria/diagnóstico por imagem
Cirurgia da Córnea a Laser/métodos
Topografia da Córnea
Feminino
Seres Humanos
Masculino
Refração Ocular/fisiologia
Reoperação
Tomografia de Coerência Óptica
Resultado do Tratamento
Transtornos da Visão/etiologia
Transtornos da Visão/fisiopatologia
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20171004-01


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[PMID]:29227513
[Au] Autor:Vinciguerra R; Romano V; Arbabi EM; Brunner M; Willoughby CE; Batterbury M; Kaye SB
[Ti] Título:In Vivo Early Corneal Biomechanical Changes After Corneal Cross-linking in Patients With Progressive Keratoconus.
[So] Source:J Refract Surg;33(12):840-846, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report early corneal biomechanical changes after corneal cross-linking (CXL) in patients with keratoconus. METHODS: Thirty-four eyes of 34 patients undergoing CXL for progressive keratoconus were included in this prospective clinical study. Dynamic corneal response (DCR) parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed at baseline (day of CXL) and after 1 month of follow-up; conversely, corneal tomography with the Pentacam (OCULUS Optikgeräte GmbH) was assessed at baseline and at 1, 3, and 6 months after CXL. RESULTS: At the last follow-up visit (123.7 ± 69.6 days), all morphological parameters including steepest point (Kmax) and thinnest corneal thickness (ThCT) indicated stabilization of keratoconus (P > .05). Comparative analyses showed a rise of corneal stiffness demonstrated by a significant increase of Stiffness Parameter A1 (SP-A1) and Highest Concavity (SP-HC) and a significant decrease of Inverse Concave Radius (1/R) and Deformation Amplitude Ratio (DA Ratio) (P < .05). There was a significant correlation between the preoperative keratoconus characteristics (Kmax, Belin/Ambrósio final D value [BAD-D], and ThCT) and the DCR parameters (P < .05). Kmax and BAD-D showed a significant positive correlation with DA Ratio, Deflection Amplitude (DefA), and 1/R and a significant negative correlation with SPA1 and SP-HC. ThCT showed a significant positive correlation with SP-A1 and SP-HC and a significant negative correlation with DA Ratio, DefA, and 1/R. CONCLUSIONS: This study suggests that the new DCR parameters of the Corvis ST are able to detect early changes in biomechanics following CXL and those that are measurable before corneal shape modifications take place. Based on these results, the authors suggest the use of these metrics to assess the early efficacy of cross-linking. [J Refract Surg. 2017;33(12):840-846.].
[Mh] Termos MeSH primário: Córnea/fisiologia
Reagentes para Ligações Cruzadas
Elasticidade/fisiologia
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Colágeno/metabolismo
Substância Própria/metabolismo
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/metabolismo
Ceratocone/fisiopatologia
Masculino
Estudos Prospectivos
Raios Ultravioleta
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170922-02


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[PMID]:29227511
[Au] Autor:Li M; Li M; Sun L; Ni K; Zhou X
[Ti] Título:Predictive Formula for Refraction of Autologous Lenticule Implantation for Hyperopia Correction.
[So] Source:J Refract Surg;33(12):827-833, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To create a formula to predict refractive correction of autologous lenticule implantation for correction of hyperopia (with myopia in one eye and hyperopia in the contralateral eye). METHODS: In this prospective study, 10 consecutive patients (20 eyes) who had myopia in one eye and hyperopia in the contralateral eye were included. The preoperative spherical equivalent was -3.31 ± 1.73 diopters (D) for the myopic eyes and +4.46 ± 1.97 D for the hyperopic eyes. For each patient, the myopic eye was treated with small incision lenticule extraction and the lenticule was subsequently implanted into the contralateral hyperopic eye. The average length of follow-up was 17 months. RESULTS: All of the operations were successful without complications. At the last visit, the efficacy index (postoperative uncorrected distance visual acuity/preoperative corrected distance visual acuity [CDVA]) of the hyperopic eyes was 0.94 ± 0.35 and the safety index (postoperative CDVA/preoperative CDVA) was 1.36 ± 0.38. No eyes lost any lines of visual acuity. Six of 10 (60%) of the implanted eyes were within ±1.00 D of the intended refractive target. A predictive formula was derived: Lenticule implantation achieved correction (D) (LAC) = 1.224 Lenticule refractive power (D) (LRP) - 0.063 (R =0.92, P < .001). On corneal topography, there was a significant increase in the corneal anterior surface keratometry value postoperatively, whereas the posterior surface keratometry value remained stable (P > .05). CONCLUSIONS: Autologous lenticule implantation could provide a reliable method of correcting hyperopia. The refractive correction formula may require further verification and adjustment. [J Refract Surg. 2017;33(12):827-833.].
[Mh] Termos MeSH primário: Substância Própria/transplante
Hiperopia/cirurgia
Refração Ocular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Topografia da Córnea
Feminino
Seguimentos
Seres Humanos
Hiperopia/fisiopatologia
Lasers de Excimer/uso terapêutico
Masculino
Microcirurgia
Miopia/cirurgia
Estudos Prospectivos
Tomografia de Coerência Óptica
Transplante Autólogo
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20171016-01


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[PMID]:29284455
[Au] Autor:Lee H; Kang DSY; Ha BJ; Choi JY; Kim EK; Seo KY; Kim TI
[Ad] Endereço:Department of Ophthalmology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.
[Ti] Título:Visual rehabilitation in moderate keratoconus: combined corneal wavefront-guided transepithelial photorefractive keratectomy and high-fluence accelerated corneal collagen cross-linking after intracorneal ring segment implantation.
[So] Source:BMC Ophthalmol;17(1):270, 2017 Dec 29.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate the effects of combined corneal wavefront-guided transepithelial photorefractive keratectomy (tPRK) and accelerated corneal collagen cross-linking (CXL) after intracorneal ring segment (ICRS) implantation in patients with moderate keratoconus. METHODS: Medical records of 23 eyes of 23 patients undergoing combined tPRK and CXL after ICRS implantation were retrospectively analyzed. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE), corneal indices based on Scheimpflug tomography, higher-order aberrations (HOAs), and corneal biomechanical properties were evaluated before and after ICRS implantation, and at 1, 3, and 6 months after combined tPRK and CXL. RESULTS: There were significant improvements in final logMAR UDVA and logMAR CDVA, and reductions in sphere, MRSE, and all corneal indices from baseline. Significant improvements in logMAR UDVA and reductions in sphere, MRSE, maximal keratometry, keratometry at the apex, mean keratometry, and keratoconus index were noted after ICRS implantation. After tPRK and CXL, significant improvements in logMAR UDVA and logMAR CDVA, and reductions in cylinder and all corneal indices were observed. There were significant improvements in final root mean square HOAs and coma aberrations from baseline, but no changes from baseline after ICRS implantation. Significant reductions in final radius and deformation amplitude from baseline were noted. CONCLUSIONS: Combined tPRK and accelerated CXL after ICRS implantation in moderate keratoconus appears to be a safe and effective treatment, providing an improvement in visual acuity, corneal indices, and HOAs. TRIAL REGISTRATION: retrospectively registered (identification no. NCT03355430 ). Date registered: 28/11/2017.
[Mh] Termos MeSH primário: Colágeno/uso terapêutico
Reagentes para Ligações Cruzadas/uso terapêutico
Ceratocone/terapia
Lentes Intraoculares
Fotoquimioterapia/métodos
Ceratectomia Fotorrefrativa/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Adulto
Substância Própria/patologia
Substância Própria/cirurgia
Topografia da Córnea
Feminino
Seguimentos
Seres Humanos
Ceratocone/diagnóstico
Ceratocone/fisiopatologia
Masculino
Implante de Prótese/métodos
Refração Ocular/fisiologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 9007-34-5 (Collagen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0666-1


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[PMID]:28450146
[Au] Autor:Brunette I; Roberts CJ; Vidal F; Harissi-Dagher M; Lachaine J; Sheardown H; Durr GM; Proulx S; Griffith M
[Ad] Endereço:Department of Ophthalmology, University of Montreal, 2900 Boul. Edouard-Montpetit, Montreal, QC H3T 1J4, Canada; Maisonneuve-Rosemont Hospital Research Center, 5415 Boul de l'Assomption, Montreal, QC H1T 2M4, Canada. Electronic address: i.brunett@videotron.ca.
[Ti] Título:Alternatives to eye bank native tissue for corneal stromal replacement.
[So] Source:Prog Retin Eye Res;59:97-130, 2017 Jul.
[Is] ISSN:1873-1635
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Corneal blindness is a major cause of blindness in the world and corneal transplantation is the only widely accepted treatment to restore sight in these eyes. However, it is becoming increasingly difficult for eye banks to meet the increasing demand for transplantable tissue, which is in part due to population aging. Donor tissue shortage is therefore a growing concern globally and there is a need for alternatives to human donor corneas. Biosynthetic corneal substitutes offer several significant advantages over native corneas: Large-scale production offers a powerful potential solution to the severe shortage of human donor corneas worldwide; Good manufacturing practices ensure sterility and quality control; Acellular corneal substitutes circumvent immune rejection induced by allogeneic cells; Optical and biomechanical properties of the implants can be adapted to the clinical need; and finally these corneal substitutes could benefit from new advances in biomaterials science, such as surface coating, functionalization and nanoparticles. This review highlights critical contributions from laboratories working on corneal stromal substitutes. It focuses on synthetic inert prostheses (keratoprostheses), acellular scaffolds with and without enhancement of endogenous regeneration, and cell-based replacements. Accent is put on the physical properties and biocompatibility of these biomaterials, on the functional and clinical outcome once transplanted in vivo in animal or human eyes, as well as on the main challenges of corneal stromal replacement. Regulatory and economic aspects are also discussed. All of these perspectives combined highlight the founding principles of the clinical application of corneal stromal replacement, a concept that has now become reality.
[Mh] Termos MeSH primário: Doenças da Córnea/cirurgia
Substância Própria/cirurgia
Transplante de Córnea/métodos
Bancos de Olhos/organização & administração
Engenharia Tecidual
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29242903
[Au] Autor:Seiler TG; Engler M; Beck E; Birngruber R; Kochevar IE
[Ad] Endereço:Wellman Center for Photomedicine-Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.
[Ti] Título:Interface Bonding With Corneal Crosslinking (CXL) After LASIK Ex Vivo.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6292-6298, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Interface bonding with corneal crosslinking (CXL) after LASIK using two different photosensitizers was studied ex vivo. Methods: A LASIK flap was created in enucleated rabbit eyes using a femtosecond laser. After the dissection, CXL was performed to seal the interface. In one group interface CXL was performed using rose bengal and green light, whereas in a second group riboflavin and UV-A light was used. In both groups irradiance, radiant exposure, dye concentration, and imbibition time was varied. In a control group, LASIK only was performed. After the procedures, the maximal shear-force required to separate the flap from the stroma was measured. Additionally, corneal transmission spectra were recorded. Results: Optimized parameters for rose bengal/green-light bonding lead to a 2.1-fold increase in shear-force compared with untreated control eyes (P < 0.01). The optimal parameter combination was: irradiance of 180 mW/cm2 for 14 minutes (total radiant exposure 150 J/cm2), rose bengal concentration 0.1%, and an imbibition time of 2 minutes. Optimized riboflavin/UV-A light parameters were 0.5% for 2 minutes with a radiant exposure of 8.1 J/cm2 obtained by an irradiance of 30 mW/cm2 for 4.5 minutes. These optimized parameters lead to a 2-fold increase compared with untreated control eyes (P < 0.01). Optical transmission experiments suggest safety for more posterior structures. Conclusions: Based on ex-vivo results, interface bonding after LASIK using crosslinking with either rose bengal or riboflavin increases the adhesion between flap and stromal bed. In vivo trials are needed to evaluate the temporal evolution of the effect.
[Mh] Termos MeSH primário: Colágeno/uso terapêutico
Substância Própria/efeitos dos fármacos
Reagentes para Ligações Cruzadas/farmacologia
Ceratomileuse Assistida por Excimer Laser In Situ
Fotoquimioterapia/métodos
Fármacos Fotossensibilizantes/uso terapêutico
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Substância Própria/patologia
Substância Própria/cirurgia
Modelos Animais de Doenças
Lasers de Excimer/uso terapêutico
Miopia/fisiopatologia
Miopia/cirurgia
Período Pós-Operatório
Coelhos
Refração Ocular
Riboflavina/uso terapêutico
Rosa Bengala
Retalhos Cirúrgicos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 1ZPG1ELY14 (Rose Bengal); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22426


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[PMID]:29216872
[Au] Autor:Li M; Yang D; Chen Y; Li M; Han T; Zhou X; Ni K
[Ad] Endereço:Key Lab of Myopia, Ministry of Health, Department of Ophthalmology, EYE & ENT Hospital of Fudan University, Shanghai, China.
[Ti] Título:Late-onset diffuse lamellar keratitis 4 years after femtosecond laser-assisted small incision lenticule extraction: a case report.
[So] Source:BMC Ophthalmol;17(1):244, 2017 Dec 08.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To report a first case of late-onset diffuse lamellar keratitis (DLK) occurring 4 years after femtosecond laser-assisted small incision lenticule extraction (SMILE). CASE PRESENTATION: A 41-year-old man who underwent SMILE 4 years prior developed DLK in the right eye 1 day after he was struck in the eye by a finger while playing with his son. Slim-lamp microscopy and anterior segment optical coherence tomography (AS-OCT) were used to evaluate the cornea of the right eye. Slit-lamp examination of the right eye revealed epithelial exfoliation and stage 3 DLK with diffuse, dot-like, granular haze in the interface between the cap and stromal bed. After intensive treatment with topical corticosteroids, the DLK resolved and corneal transparency was achieved. CONCLUSIONS: This case indicates that DLK can occur several years after SMILE. Ocular trauma may be a risk factor for the development of DLK. The prognosis is usually favorable with early diagnosis and treatment with topical corticosteroids.
[Mh] Termos MeSH primário: Substância Própria/cirurgia
Traumatismos Oculares/complicações
Ceratite/etiologia
Ceratomileuse Assistida por Excimer Laser In Situ
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0641-x


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[PMID]:28451758
[Au] Autor:Qiu J; Huang F; Wang Z; Xu J; Zhang C
[Ad] Endereço:Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
[Ti] Título:The evaluation of diagnostic efficiency for stromal herpes simplex keratitis by the combination of tear HSV-sIgA and HSV-DNA.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(7):1409-1415, 2017 Jul.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the differential diagnostic values for stromal herpes simplex keratitis (HSK) by using tear HSV-sIgA, tear HSV-DNA, and the combination. METHODS: Tear samples for both eyes and the paired serum were collected from 187 stromal HSK and 56 controls. Enzyme-linked immune sorbent assay (ELISA) was used to analyze the tear HSV-sIgA and serum IgG/IgM/IgA. The levels of tear HSV-DNA were measured by polymerase chain reaction (PCR). RESULTS: The positive rates for tear HSV-sIgA and HSV-DNA were 36.90% and 10.96% respectively in stromal HSK patients. Twelve showed positivity for both sIgA and DNA, while 46 cases were positive for sIgA or DNA. The sensitivity, specificity, PPV, and NPV for simultaneous measurement were 39.73%, 98.21%, 98.31%, and 38.46%. The total negative conversion rate of sIgA was 95.71%. CONCLUSIONS: The diagnostic efficiency of HSV-sIgA only is nearly equal to the combination of HSV-sIgA and HSV-DNA, and the positive result is optimum to achieve a reliable diagnosis of stromal HSK even in atypical or unsuspected cases.
[Mh] Termos MeSH primário: Substância Própria/patologia
DNA Viral/análise
Infecções Oculares Virais/diagnóstico
Imunoglobulina A Secretora/metabolismo
Ceratite Herpética/diagnóstico
Simplexvirus/genética
Lágrimas/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Substância Própria/diagnóstico por imagem
Substância Própria/virologia
Ensaio de Imunoadsorção Enzimática
Infecções Oculares Virais/metabolismo
Infecções Oculares Virais/virologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Ceratite Herpética/metabolismo
Ceratite Herpética/virologia
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Reprodutibilidade dos Testes
Estudos Retrospectivos
Lágrimas/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Immunoglobulin A, Secretory)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3653-6



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