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  1 / 1010 MEDLINE  
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[PMID]:29439700
[Au] Autor:Jian W; Shen Y; Chen Y; Tian M; Zhou X
[Ad] Endereço:The Eye and ENT Hospital of Fudan University, Shanghai, China.
[Ti] Título:Ocular dimensions of the Chinese adolescents with keratoconus.
[So] Source:BMC Ophthalmol;18(1):43, 2018 Feb 13.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents. METHODS: One hundred and six KC eyes of 53 (42 boys and 11 girls) KC adolescents (age 15.5 ± 1.7 years, range 11 to 18) were involved in this retrospective study. The eye with more severe KC (Severe Group) of each patient was compared with their less affected eye (Mild Group). Optical axial length (OAL) was measured by optical coherence biometry (IOL-master). Central corneal thickness, anterior chamber depth (ACD), flat keratometry value, steep keratometry value, and maximum keratometry value were assessed with an anterior segment analyzer (Pentacam HR). Anterior segment length (ASL) was manually measured from the 25 scheimpflug images captured by the Pentacam HR with the mean value recorded. The posterior segment length (PSL) was calculated with the formula "PSL = OAL-ASL". RESULTS: The mean ACD, OAL, ASL, and PSL values of the Severe Group were 3.51 ± 0.32 mm, 24.76 ± 1.24 mm, 4.01 ± 0.30 mm and 20.76 ± 1.15 mm.While those of the Mild Group were 3.36 ± 0.29 mm, 24.97 ± 1.40 mm, 3.94 ± 0.35 mm and 21.03 ± 1.31 mm. The Severe Group has significantly higher ACD (t = 4.539, P < 0.001) value but lower OAL (t = - 3.120, P = 0.003) and PSL (t = - 4.537, P < 0.001) values when compared with those of the Mild Group. For the Severe Group, the Kmax values were significantly correlated with the SE values (R = - 0.385, P = 0.004), the ACD values (R = 0.375, P = 0.006), the ASL values (R = 0.308, P = 0.025) and the PSL values (R = - 0.317, P = 0.021), but not with the OAL values (R = - 0.220, P = 0.114). In the Mild Group, the Kmax values were negatively correlated with the SE (R = - 0.577, P < 0.001), OAL(R = - 0.533, P < 0.001), and PSL (R = - 0.523, P < 0.001) values, but not with ACD (R = - 0.110, P = 0.434) or ASL (R = - 0.182, P = 0.192) values. CONCLUSIONS: For adolescent KC, the more keratoconic eyes may be characterized by deeper ACD but shorter OAL and PSL, when compared with the less affected ones.
[Mh] Termos MeSH primário: Câmara Anterior/patologia
Comprimento Axial do Olho/patologia
Ceratocone/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Asiático/etnologia
Biometria
Criança
China/epidemiologia
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/epidemiologia
Masculino
Refração Ocular
Estudos Retrospectivos
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0713-6


  2 / 1010 MEDLINE  
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[PMID]:29217026
[Au] Autor:Al Nosair G; Khandekar R; Al-Shamrani M; Edward DP
[Ad] Endereço:King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
[Ti] Título:Ciliary body location in eyes with and without primary congenital glaucoma.
[So] Source:Can J Ophthalmol;52(6):578-582, 2017 Dec.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the location of ciliary body (CB) in children with and without primary congenital glaucoma (PCG). METHODS: In this cross-sectional study, we enrolled Saudi children who were less than 5 years old. CB distance (CBD) was measured and compared in eyes with PCG (PCG group) and without PCG (control group). CBD was measured with a caliper and defined as the distance between the edge of the corneoscleral limbus and the anterior edge of CB as delineated by transillumination. The difference in the CBD between groups was correlated with the axial length, corneal thickness, and corneal diameter. RESULTS: CBD was measured in 15 eyes in the PCG and control groups. The mean CBD (1.6 ± 0.4 mm) in the PCG group was significantly greater than that in the control group (1.3 ± 0.3 mm) (p < 0.001). The mean difference in the CBD of 2 groups was 0.33 mm (95% CI 0.15-0.54). In PCG eyes, the CBD was farthest in the superior quadrant (1.7 mm) followed by inferior (1.6 mm), temporal (1.6 mm), and nasal (1.5 mm) quadrants. The variability in CBD between quadrants in PCG eyes was greater than that in the control group. CBD in the PCG group showed a significant correlation with increasing axial length (p = 0.05), corneal thickness (p < 0.001), and corneal diameter (p = 0.0002). CONCLUSIONS: The CBD from the limbus was greater in PCG eyes compared to the controls and varied significantly in different quadrants. The knowledge regarding the greater CBD and its variability in PCG eyes could enable better planning of surgical treatment in congenital glaucoma.
[Mh] Termos MeSH primário: Corpo Ciliar/patologia
Hidroftalmia/patologia
[Mh] Termos MeSH secundário: Comprimento Axial do Olho/patologia
Pré-Escolar
Córnea/patologia
Paquimetria Corneana
Estudos Transversais
Feminino
Seres Humanos
Lactente
Pressão Intraocular
Limbo da Córnea
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  3 / 1010 MEDLINE  
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[PMID]:29228915
[Au] Autor:Suwan Y; Jiamsawad S; Tantraworasin A; Geyman L; Supakontanasan W; Teekhasaenee C
[Ad] Endereço:From the Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
[Ti] Título:Qualitative and quantitative evaluation of acute angle-closure mechanisms.
[So] Source:BMC Ophthalmol;17(1):246, 2017 Dec 11.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To evaluate ocular biometric parameters in different subtypes of acute angle closure and compared to fellow eyes of AAC and PACS eyes. METHODS: This is a retrospective chart review study. A total of 167 eyes (96 patients) consisting of 71 AAC eyes, 71 fellow eyes of AAC, and 25 PACS eyes were recruited. All patients underwent ocular examination and biometry. The mechanism of AAC was confirmed by ultrasound biomicroscopy. We then subdivided AAC eyes into four subgroups: crowded-angle (CR), lens subluxation (LS) pupillary block (PB), and plateau iris syndrome (PL). Outcome variables included anterior chamber depth (ACD), lens thickness (LT), vitreal length (VL), axial length (AL), lens position and relative lens position (LP and RLP, respectively), and lens axial length factor (LAF). RESULTS: Among the three groups, ACD was shallower in AAC eyes than fellow eyes of AAC and PACS eyes (p < 0.01 for both) and AAC eyes demonstrated a lesser LP and RLP. The LT, VL, AL, and LAF were not significantly different among the three groups. Among the four subgroups, LS displayed the most shallow ACD (p = 0.01). The lens position in PL was greater than in CR and LS (p < 0.05 and <0.01, respectively). CONCLUSIONS: AAC eyes had a more anterior lens position than fellow eyes and PACS eyes, though lens thickness did not differ among the groups. As such, an anterior lens position may offer more sensitive prognostication regarding future development of AAC compared to lens thickness.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Fechado/patologia
[Mh] Termos MeSH secundário: Idoso
Análise de Variância
Câmara Anterior/diagnóstico por imagem
Comprimento Axial do Olho/diagnóstico por imagem
Biometria/métodos
Feminino
Glaucoma de Ângulo Fechado/diagnóstico por imagem
Seres Humanos
Cristalino/diagnóstico por imagem
Masculino
Meia-Idade
Estudos Retrospectivos
Corpo Vítreo/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0635-8


  4 / 1010 MEDLINE  
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[PMID]:29049731
[Au] Autor:Kato K; Kondo M; Nagashima R; Sugawara A; Sugimoto M; Matsubara H; McCulloch DL; Ikesugi K
[Ad] Endereço:Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
[Ti] Título:Factors Affecting Mydriasis-Free Flicker ERGs Recorded With Real-Time Correction for Retinal Illuminance: Study of 150 Young Healthy Subjects.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5280-5286, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: A small, full-field flicker electroretinogram (ERG) recording system was recently developed to record flicker ERGs without mydriasis (RETeval). The device delivers a stimulus with constant retinal illuminance by adjusting the retinal luminance to compensate for changes in the pupillary area. The purpose of this study was to determine what factors affect the fundamental components of the flicker ERGs recorded by RETeval in young healthy subjects. Methods: Flicker ERGs were recorded with the RETeval system from 150 eyes of 150 young healthy subjects (age, 20-29 years). Univariate and multivariate linear regression analyses were performed to identify the factors that affected the implicit times and amplitudes of the fundamental component of the flicker ERGs. The independent variables included age, sex, refractive error, axial length, and pupillary area. Results: Multivariate regression analyses indicated that a longer axial length (P = 0.03) and larger pupillary area (P = 0.008) were independent factors that were significantly associated with longer implicit times of the fundamental component of the flicker ERGs. Multivariate regression analyses also showed that the female sex (P = 0.03) was an independent factor, which was significantly associated with larger amplitude fundamental component of the flicker ERGs. Conclusions: These results indicate that the fundamental components of the RETeval flicker ERGs are significantly affected by the axial length, pupillary area, and sex of young healthy subjects. The results also suggest that it would be better to compensate for the Stiles-Crawford effect when flicker ERGs are recorded with natural pupils.
[Mh] Termos MeSH primário: Pupila/fisiologia
Retina/fisiologia
[Mh] Termos MeSH secundário: Adulto
Comprimento Axial do Olho/anatomia & histologia
Eletrorretinografia
Feminino
Voluntários Saudáveis
Seres Humanos
Iluminação
Masculino
Estimulação Luminosa/métodos
Estudos Prospectivos
Retina/efeitos da radiação
Células Fotorreceptoras Retinianas Cones
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22587


  5 / 1010 MEDLINE  
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[PMID]:29049726
[Au] Autor:Sakaguchi K; Higashide T; Udagawa S; Ohkubo S; Sugiyama K
[Ad] Endereço:Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
[Ti] Título:Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5251-5262, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program. Sectoral structure-function relationships based on the Garway-Heath map were compared between VD and thickness using a semipartial correlation coefficient (sr) and partial residual plots determined by multiple linear regression models controlling for the effects of sex, age, axial length, disc area, beta- and gamma- parapapillary atrophy (PPA) zones, and signal strength index (SSI). Results: For all VF sectors, the sr2 of VD was largest when the VD sector corresponded to the VF sector (sr2: 0.17-0.39). In contrast, in only three sectors was the sr2 of thickness largest when the thickness sector corresponded to the VF sector (sr2: 0.02-0.34): the inferior temporal, temporal, and superior temporal sectors. The partial residual plots against VD showed more linear relationships with VF sensitivity than those against thickness in the qualitative evaluation of fitting by locally weighted scatterplot smoothing. Eyes with larger SSI had higher VD, whereas eyes with a larger extension of the PPA zone into the VD measurement area had lower VD. Conclusions: Peripapillary RNFL VD and thickness have different characteristic sectoral structure-function relationships in glaucoma.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/fisiopatologia
Fibras Nervosas/patologia
Disco Óptico/irrigação sanguínea
Células Ganglionares da Retina/patologia
Vasos Retinianos/patologia
[Mh] Termos MeSH secundário: Comprimento Axial do Olho/patologia
Estudos Transversais
Feminino
Glaucoma de Ângulo Aberto/diagnóstico
Gonioscopia
Seres Humanos
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Hipertensão Ocular/diagnóstico
Hipertensão Ocular/fisiopatologia
Tomografia de Coerência Óptica
Tonometria Ocular
Testes de Campo Visual/métodos
Campos Visuais/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21955


  6 / 1010 MEDLINE  
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[PMID]:28911990
[Au] Autor:Ohno-Matsui K; Fang Y; Uramoto K; Shinohara K; Yokoi T; Ishida T; Jonas JB
[Ad] Endereço:Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: k.ohno.oph@tmd.ac.jp.
[Ti] Título:Peri-dome Choroidal Deepening in Highly Myopic Eyes With Dome-Shaped Maculas.
[So] Source:Am J Ophthalmol;183:134-140, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine characteristics of peri-dome choroidal deepening (PDCD) surrounding dome-shaped maculas (DSMs) in highly myopic eyes. DESIGN: Observational case series. METHODS: Applying swept-source optical coherence tomography, we examined the posterior pole of highly myopic eyes with DSMs. RESULTS: The study included 91 highly myopic eyes (67 patients; mean age: 60.0 ± 15.1 years; mean axial length: 30.0 ± 7.4 mm) with a mean dome height of the DSM of 232 ± 132 µm. PDCDs were detected in 53 (58%) eyes. Subfoveal choroidal thickness was significantly thinner in eyes with vs without PDCDs (35 ± 29 µm vs 62 ± 48 µm; P = .016), while both groups did not vary significantly (all P ≥ .25) in age, axial length, and dome height. In contrast to peripapillary intrachoroidal cavitations (ICCs), PDCDs consisted of a widened choroid without large low-reflective suprachoroidal spaces. Unlike peripapillary ICCs or macular ICCs, PDCDs were not associated with caving of the overlying retina or backward bowing of the sclera. In the region of the PDCDs, the Bruch membrane (BM) was shorter than the inner scleral surface. Defects of the BM overlying the PDCDs were detected in 20 (38%) eyes. CONCLUSIONS: PDCDs were common findings in highly myopic eyes with DSMs. PDCDs may be associated with a dome-induced inward push of the BM at the top of the DSM, leading to a compression of the subfoveal choroid and, owing to an increased strain of the BM on the dome's slopes, to a relative detachment of BM in the peri-dome region.
[Mh] Termos MeSH primário: Comprimento Axial do Olho/patologia
Corioide/patologia
Macula Lutea/patologia
Miopia Degenerativa/diagnóstico
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Lâmina Basilar da Corioide/patologia
Feminino
Angiofluoresceinografia
Fundo de Olho
Seres Humanos
Masculino
Meia-Idade
Epitélio Pigmentado da Retina/patologia
Estudos Retrospectivos
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


  7 / 1010 MEDLINE  
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[PMID]:28887137
[Au] Autor:Ahn J; Ahn SE; Yang KS; Kim SW; Oh J
[Ad] Endereço:Department of Ophthalmology, Korea University College of Medicine, 73, Inchon-ro, Sungbuk-gu, Seoul 02841, South Korea.
[Ti] Título:Effects of a high level of illumination before sleep at night on chorioretinal thickness and ocular biometry.
[So] Source:Exp Eye Res;164:157-167, 2017 Nov.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The choroid is affected by many factors. One of the factors, change in illumination has been suggested to influence choroidal thickness. However, the effects of bright light before sleep at night on the human eye are not well established. The purpose of this study was to investigate the effects of a high level of illumination in the evening on ocular measurements. Twenty-seven men with myopia spent seven consecutive nights in the sleep laboratory. During the first two nights, subjects were exposed to light at 150 lux between 20:00 and midnight. Then, for five consecutive nights, they were exposed to ambient light at 1000 lux between 20:00 and midnight. Ocular parameters and their diurnal variations were compared between the two periods and the effects of a high level of illumination were analyzed. After subjects were exposed to 1000 lux of illumination, axial length increased with borderline significance (p = 0.064). Macular volume and retinal thickness did not change. However, subfoveal choroidal thickness after exposure to 1000 lux of illumination (245.37 ± 52.84 µm) was significantly lower than that after 150 lux of illumination (268.00 ± 57.10 µm), (p < 0.001). Significant diurnal variations were found in mean keratometry (p = 0.039), intraocular pressure (IOP, p = 0.003), ocular perfusion pressure (OPP, p < 0.0001), macular volume (p = 0.019), and subfoveal choroidal thickness (p < 0.0001). A high level of illumination had significant effects on only IOP and OPP (p = 0.027 and 0.017, respectively). Bright light exposure before sleep at an intensity as high as 1000 lux reduced subfoveal choroidal thickness in healthy young men. In conclusion, diurnal variation in choroidal thickness can be affected by bright light exposure before sleep.
[Mh] Termos MeSH primário: Comprimento Axial do Olho/efeitos da radiação
Corioide/efeitos da radiação
Ritmo Circadiano/fisiologia
Iluminação/efeitos adversos
Miopia/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Comprimento Axial do Olho/anatomia & histologia
Corioide/anatomia & histologia
Seres Humanos
Pressão Intraocular/efeitos da radiação
Masculino
Retina/efeitos da radiação
Tomografia de Coerência Óptica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE


  8 / 1010 MEDLINE  
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[PMID]:28813575
[Au] Autor:Li SZ; Yu WY; Choi KY; Lam CH; Lakshmanan Y; Wong FS; Chan HH
[Ad] Endereço:Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region.
[Ti] Título:Subclinical Decrease in Central Inner Retinal Activity Is Associated With Myopia Development in Children.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4399­4406, 2017 08 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate the characteristics of retinal electrophysiological activity in relation to early myopia development in children. Methods: Fifty-six children aged 6 to 9 years with emmetropic refractive error (defined as ≥ -0.5 diopter [D] and ≤ +0.5 D) were recruited. Cycloplegic refraction, axial length, and global flash multifocal electroretinogram (MOFO mfERG) at 49% and 96% contrast levels were recorded in all children at their first visit. The refraction and axial length measurements were repeated after 1 year. The amplitudes and implicit times of the direct component (DC) and the induced component (IC) of the MOFO mfERG obtained at the initial visit were analyzed. Correlations between the MOFO mfERG parameters and changes in refractive error and axial length were investigated. Results: The mean spherical equivalent refractive error and axial length of the eyes of the children at the first visit were +0.19 ± 0.33 D and 23.14 ± 0.6 mm, respectively. After 1 year, the mean refractive error increased by -0.55 ± 0.53 D, whereas axial length increased by 0.37 ± 0.22 mm. The changes in refractive error and axial length were significantly correlated with the central IC amplitudes at 49% contrast level measured at the initial visit (ρ = 0.46, P < 0.001 and ρ = -0.34, P = 0.01, respectively). Conclusions: The prospective changes we have shown are believed to derive from central inner retina. These changes appear to precede myopia and could be a potential reference for juvenile myopia development.
[Mh] Termos MeSH primário: Miopia/fisiopatologia
Retina/fisiopatologia
[Mh] Termos MeSH secundário: Comprimento Axial do Olho/fisiopatologia
Criança
Eletrorretinografia
Feminino
Seres Humanos
Masculino
Estimulação Luminosa
Estudos Prospectivos
Refração Ocular/fisiologia
Testes Visuais
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21279


  9 / 1010 MEDLINE  
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[PMID]:28767664
[Au] Autor:Bai HX; Mao Y; Shen L; Xu XL; Gao F; Zhang ZB; Li B; Jonas JB
[Ad] Endereço:Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
[Ti] Título:Bruch´s membrane thickness in relationship to axial length.
[So] Source:PLoS One;12(8):e0182080, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length. METHODS: Human globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histological slides were histomorphometrically examined applying a digitized image analysis system. RESULTS: The study included 104 eyes with a mean axial length of 27.9±3.2 mm (range:22.6mm-36.5mm). In eyes without congenital glaucoma, BM was significantly thickest (P<0.001) at the ora serrata, followed by the posterior pole, the midpoint between equator and posterior pole (MBEPP), and finally the equator. BM thickness was not significantly correlated with axial length (ora serrata: P = 0.93; equator:P = 0.31; MBEPP:P = 0.15; posterior pole:P = 0.35). RPE cell density in the pre-equatorial region (P = 0.02; regression coefficient r = -0.24) and in the retro-equatorial region (P = 0.03; r = -0.22) decreased with longer axial length, while RPE cell density at the ora serrata (P = 0.35), the MBEPP (P = 0.06; r = -0.19) and the posterior pole (P = 0.38) was not significantly correlated with axial length. Highly myopic eyes with congenital glaucoma showed a tendency towards lower BM thickness and lower RPE cell density at all locations. CONCLUSIONS: BM thickness, in contrast to scleral and choroidal thickness, was independent of axial length in eyes without congenital glaucoma. In association with an axial elongation associated decrease in the RPE cell density in the midperiphery, the findings support the notion of a biomechanical role BM may play in the process of emmetropization/myopization.
[Mh] Termos MeSH primário: Comprimento Axial do Olho/anatomia & histologia
Lâmina Basilar da Corioide/anatomia & histologia
Neoplasias Oculares/cirurgia
Glaucoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Comprimento Axial do Olho/patologia
Fenômenos Biomecânicos
Lâmina Basilar da Corioide/patologia
Enucleação Ocular
Neoplasias Oculares/patologia
Feminino
Glaucoma/patologia
Seres Humanos
Masculino
Meia-Idade
Miopia/patologia
Epitélio Pigmentado da Retina/anatomia & histologia
Epitélio Pigmentado da Retina/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182080


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[PMID]:28697750
[Au] Autor:Terasaki H; Yamashita T; Yoshihara N; Kii Y; Sakamoto T
[Ad] Endereço:Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
[Ti] Título:Association of lifestyle and body structure to ocular axial length in Japanese elementary school children.
[So] Source:BMC Ophthalmol;17(1):123, 2017 Jul 12.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study is to determine whether the lifestyle and body stature are significantly associated with the axial length (AL) of the eyes of Japanese third grade students. METHODS: A prospective, cross sectional, observational study was performed on 122 third grade students consisting of 61 boys and 61 girls ages 8 to 9 years. The AL, body height, body weight, and body mass index (BMI) were measured. The lifestyle was determined by activities such as the daily duration of indoor studying, television viewing, use of computers and smart phones, outdoor activity time, bed time, Japanese or Western dietary habits, and parental myopia were investigated by a questionnaire with three or five grade levels. The relationship between AL and the questionnaire variables were analyzed by Spearman's correlation analyses. RESULTS: Westernized dietary habits (r = -0.24, P = 0.01), duration of computer and smart phone use (r = 0.24, P = 0.008), parental myopia (r = 0.39, P < 0.001), body weight (r = 0.26, P = 0.005), and BMI (r = 0.23, P = 0.011) were significantly correlated with the AL. Multiple logistic regression analyses showed that the sex [r = -0.48; 95% confidence interval (CI) -0.80 to -0.17, P = 0.003], body weight (r = 0.04; 95% CI 0.02 to 0.07, P = 0.038), westernized dietary habits (r = -0.30; 95% CI -0.55 to -0.05, P = 0.021), and parental myopia (r = 0.40; 95% CI 0.20 to 0.61, P < 0.001) were significantly and independently correlated with the AL. CONCLUSIONS: The body weight and parental myopia and westernized dietary habits are factors significantly associated with myopia. Changing from Japanese food style to westernized food style might increase the risk of progression of school myopia.
[Mh] Termos MeSH primário: Comprimento Axial do Olho
Composição Corporal
Estilo de Vida
Miopia/fisiopatologia
Refração Ocular/fisiologia
Instituições Acadêmicas
Estudantes
[Mh] Termos MeSH secundário: Criança
Estudos Transversais
Feminino
Seguimentos
Seres Humanos
Incidência
Japão/epidemiologia
Masculino
Miopia/epidemiologia
Estudos Prospectivos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0519-y



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