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[PMID]:29208834
[Au] Autor:Shekhawat N; Goyal K
[Ad] Endereço:Department of Ophthalmology, SMS Medical College and Attached Hospitals, Jaipur, Rajasthan, India.
[Ti] Título:Sutureless glueless intrascleral fixation of posterior chamber intraocular lens: Boon for aphakic.
[So] Source:Indian J Ophthalmol;65(12):1454-1458, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report results of intrascleral fixation of 3-piece IOL without the help of suture and glue. METHODS: Study included intrascleral fixation of haptic in 50 eyes by T-fixation technique. Preoperative and postoperative visual acuity, slit lamp and fundus examination, applanation tonometry, keratometry, biometry, optical coherence tomography, Scheimpflug imaging were done for extensive evaluation. Qualitative and quantitative data were summarized in the form of proportion and mean and standard deviation, respectively. The significance of difference was measured by Chi-square test or unpaired t-test or ANOVA whichever is appropriate. P < 0.05 was considered as statistically significant. RESULTS: There was one case in which haptic broke during handshake maneuver and another IOL was required. Postoperative complications included corneal edema (4%), increased intraocular pressure (6%), cystoid macular edema (2%), decentration (4%), and dislocation (2%), which were all managed to the level of good visual recovery. There was no significant change in corneal astigmatism. There was significant change found in best-corrected visual acuity and uncorrected visual acuity after surgery. CONCLUSION: This modified technique seems to be a good alternative in IOL implantation in eyes with deficient capsules in view of the decrease in the learning time and surgical time and risk for complications.
[Mh] Termos MeSH primário: Afacia Pós-Catarata/cirurgia
Implante de Lente Intraocular/métodos
Segmento Posterior do Olho/cirurgia
Esclera/cirurgia
Procedimentos Cirúrgicos sem Sutura/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Adesivos
Afacia Pós-Catarata/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Desenho de Prótese
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adhesives)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_620_17


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[PMID]:28822760
[Au] Autor:Lopez NN; Patel GC; Raychaudhuri U; Aryal S; Phan TN; Clark AF; Millar JC
[Ad] Endereço:North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center (UNTHSC), 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
[Ti] Título:Anterior chamber perfusion versus posterior chamber perfusion does not influence measurement of aqueous outflow facility in living mice by constant flow infusion.
[So] Source:Exp Eye Res;164:95-108, 2017 Nov.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mice are now routinely utilized in studies of aqueous humor outflow dynamics. In particular, conventional aqueous outflow facility (C) is routinely measured via perfusion of the aqueous chamber by a number of laboratories. However, in mouse eyes perfused ex-vivo, values for C are variable depending upon whether the perfusate is introduced into the posterior chamber (PC) versus the anterior chamber (AC). Perfusion via the AC leads to posterior bowing of the iris, and traction on the iris root/scleral spur, which may increase C. Perfusion via the PC does not yield this effect. But the equivalent situation in living mice has not been investigated. We sought to determine whether AC versus PC perfusion of the living mouse eye may lead to different values for C. All experiments were conducted in C57BL/6J mice (all ♀) between the ages of 20 and 30 weeks. Mice were divided into groups of 3-4 animals each. In all groups, both eyes were perfused. C was measured in groups 1 and 2 by constant flow infusion (from a 50 µL microsyringe) via needle placement in the AC, and in the PC, respectively. To investigate the effect of ciliary muscle (CM) tone on C, groups 3 and 4 were perfused live via the AC or PC with tropicamide (muscarinic receptor antagonist) added to the perfusate at a concentration of 100 µM. To investigate immediate effect of euthanasia, groups 5 and 6 were perfused 15-30 min after death via the AC or PC. To investigate the effect of CM tone on C immediately following euthanasia, groups 7 and 8 were perfused 15-30 min after death via the AC or PC with tropicamide added to the perfusate at a concentration of 100 µM. C in Groups 1 (AC perfusion) and 2 (PC perfusion) was computed to be 19.5 ± 0.8 versus 21.0 ± 2.1 nL/min/mmHg, respectively (mean ± SEM, p > 0.4, not significantly different). In live animals in which tropicamide was present in the perfusate, C in Group 3 (AC perfusion) was significantly greater than C in Group 4 (PC perfusion) (22.0 ± 4.0 versus 14.0 ± 2.0 nL/min/mmHg, respectively, p = 0.0021). In animals immediately following death, C in groups 5 (AC perfusion) and 6 (PC perfusion) was computed to be 21.2 ± 2.0 versus 22.8 ± 1.4 nL/min/mmHg, respectively (mean ± SEM, p = 0.1196, not significantly different). In dead animals in which tropicamide was present in the perfusate, C in group 7 (AC perfusion) was greater than C in group 8 (PC perfusion) (20.6 ± 1.4 versus 14.2 ± 2.6 nL/min/mmHg, respectively, p < 0.0001). C in eyes in situ in living mice or euthanized animals within 15-30 min post mortem is not significantly different when measured via AC perfusion or PC perfusion. In eyes of live or freshly euthanized mice, C is greater when measured via AC versus PC perfusion when tropicamide (a mydriatic and cycloplegic agent) is present in the perfusate.
[Mh] Termos MeSH primário: Câmara Anterior/fisiologia
Humor Aquoso/fisiologia
Pressão Intraocular/fisiologia
Segmento Posterior do Olho/fisiologia
[Mh] Termos MeSH secundário: Animais
Câmara Anterior/efeitos dos fármacos
Câmara Anterior/metabolismo
Humor Aquoso/metabolismo
Modelos Animais de Doenças
Feminino
Pressão Intraocular/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Antagonistas Muscarínicos/farmacologia
Segmento Posterior do Olho/efeitos dos fármacos
Segmento Posterior do Olho/metabolismo
Malha Trabecular/metabolismo
Tropicamida/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscarinic Antagonists); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170821
[St] Status:MEDLINE


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[PMID]:28800647
[Au] Autor:Siegfried CJ; Shui YB; Tian B; Nork TM; Heatley GA; Kaufman PL
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.
[Ti] Título:Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4003-4014, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study is to evaluate effects of vitrectomy (PPV) and lens extraction with intraocular lens implantation (PE/IOL) on molecular oxygen (pO2) distribution, aqueous humor antioxidant-oxidant balance, aqueous humor dynamics, and histopathologic changes in the trabecular meshwork (TM) in the older macaque monkey. Methods: Six rhesus monkeys underwent PPV followed by PE/IOL. pO2, outflow facility, and intraocular pressure (IOP) were measured. Aqueous and vitreous humor specimens were analyzed for antioxidant status and 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative damage. TM specimens were obtained for immunohistochemical and quantitative PCR analysis. Results: pO2 at baseline revealed steep gradients in the anterior chamber and low levels in the posterior chamber (PC) and around the lens. Following PPV and PE/IOL, pO2 significantly increased in the PC, around the IOL, and angle. IOP increased following both surgical interventions, with no change in outflow facility. Histopathologic analysis did not show changes in TM cell quantification, but there was an increase in 8-OHdG. Quantitative PCR did not reveal significant differences in glaucoma-related gene expression. Aqueous and vitreous humor analysis revealed decreased ascorbate and total reactive antioxidant potential and increased 8-OHdG in the aqueous humor only in the surgical eyes. Conclusions: Oxygen distribution in the older rhesus monkey is similar to humans at baseline and following surgical interventions. Our findings of histopathologic changes of TM oxidative damage and alterations in the oxidant-antioxidant balance suggest a potential correlation of increased oxygen exposure with oxidative stress/damage and the development of open angle glaucoma.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Humor Aquoso/metabolismo
Implante de Lente Intraocular
Cristalino/cirurgia
Oxigênio/metabolismo
Vitrectomia
[Mh] Termos MeSH secundário: Envelhecimento/fisiologia
Animais
Segmento Anterior do Olho/metabolismo
Ácido Ascórbico/metabolismo
Desoxiguanosina/análogos & derivados
Desoxiguanosina/metabolismo
Pressão Intraocular/fisiologia
Macaca mulatta
Reação em Cadeia da Polimerase
Segmento Posterior do Olho/metabolismo
Pseudofacia/metabolismo
Malha Trabecular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); G9481N71RO (Deoxyguanosine); PQ6CK8PD0R (Ascorbic Acid); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21890


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[PMID]:28739419
[Au] Autor:Nicholson L; Vazquez-Alfageme C; Patrao NV; Triantafyllopolou I; Bainbridge JW; Hykin PG; Sivaprasad S
[Ad] Endereço:National Institute for Health Research Moorfields Biomedical Research Centre, Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, United Kingdom.
[Ti] Título:Retinal Nonperfusion in the Posterior Pole Is Associated With Increased Risk of Neovascularization in Central Retinal Vein Occlusion.
[So] Source:Am J Ophthalmol;182:118-125, 2017 Oct.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To review the definition of ischaemic central retinal vein occlusion (CRVO) and stratify the risk of neovascular complication based on wider areas of visible retinal non-perfusion. DESIGN: Retrospective consecutive case series and image analysis study. METHODS: Setting: Moorfields Eye Hospital, London, United Kingdom. STUDY POPULATION: Forty-two consecutive treatment-naïve eyes with CRVO imaged with ultra-widefield angiography with a minimum of 12 months follow-up. OBSERVATION PROCEDURE: The spatial location and total area of retinal nonperfusion (measured in disc areas, DA) were determined using the validated concentric rings method. The area was corrected for projection distortion. The images were graded by 2 retinal physicians and average measurements used. MAIN OUTCOME MEASURES: Development of neovascular complications. RESULTS: The percentage of eyes developing new vessels increased from none in eyes with less than 10 DA of nonperfusion in total to 14.3% in eyes with 10-30 DA, 20.0% for 30-75 DA, and 80% risk with 75-150 DA of nonperfusion. From 13 (31.0%) eyes with a perfused posterior pole (an area encompassing a 5 disc diameter radius centered at the fovea) and more than 10 DA of nonperfusion isolated in the periphery (beyond the posterior pole), only 1 (7.7%) eye developed new vessels, odds ratio (OR) 0.12 [95% confidence interval (CI): 0.01, 1.03]. Comparatively, for 13 (31.0%) eyes with more than 10 DA of nonperfusion in the posterior pole, 11 (84.6%) developed new vessels, OR 74.25 [95% CI: 9.26, 595.30], P < .001. CONCLUSION: With ultra-widefield angiography, we have ascertained that posterior pole nonperfusion of more than 10 DA remains the key risk factor for new vessel development compared to areas of nonperfusion confined to the periphery.
[Mh] Termos MeSH primário: Isquemia/diagnóstico
Segmento Posterior do Olho/patologia
Neovascularização Retiniana/diagnóstico
Oclusão da Veia Retiniana/diagnóstico
Veia Retiniana/patologia
Vasos Retinianos/patologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Angiofluoresceinografia
Seres Humanos
Isquemia/complicações
Masculino
Meia-Idade
Neovascularização Retiniana/etiologia
Oclusão da Veia Retiniana/complicações
Estudos Retrospectivos
Fatores de Risco
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28738419
[Au] Autor:Shinohara K; Shimada N; Moriyama M; Yoshida T; Jonas JB; Yoshimura N; Ohno-Matsui K
[Ad] Endereço:Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
[Ti] Título:Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3750-3758, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To examine posterior staphylomas by widefield optical coherence tomography (WF-OCT) and three-dimensional magnetic resonance imaging (3D-MRI). Methods: Highly myopic patients (myopic refractive error >8.0 diopters or axial length >26.5 mm) who had previously undergone orbital 3D-MRI were examined by WF-OCT. Results: The study included 100 eyes of 57 patients with a mean age of 67.9 ± 10.7 years (range, 44-85 years) and mean axial length of 30.0 ± 2.3 mm (range, 25.1-36.5 mm). All staphylomas detected on the 3D-MRI, except for two very large staphylomas, were visualized on the WF-OCT images. Morphologic hallmarks of the staphylomas were smoothly configured staphyloma border with a gradual thinning of the choroid and an inward protrusion of the sclera at the staphyloma edge. Comparing the detectability of the staphylomas on the WF-OCT images versus 3D-MRI revealed no significant difference between both techniques (P = 0.12; χ2 test). Comparing the staphyloma classification between both techniques showed a good concordance with a concordance index kappa of 0.61 (95% confidence interval: 0.50-0.72). A spatial relationship between the staphylomatous areas and the macula and optic nerve head was observed by WF-OCT. Conclusions: WF-OCT can provide tomographic images of posterior staphylomas in a resolution and size unachievable so far, and may replace 3D-MRI in assessing posterior staphylomas. Future studies using WF-OCT may explore the detailed morphologic characteristics of posterior staphylomas and give clues to the etiology of staphylomas.
[Mh] Termos MeSH primário: Miopia Degenerativa/diagnóstico por imagem
Segmento Posterior do Olho/diagnóstico por imagem
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Corioide/diagnóstico por imagem
Corioide/patologia
Dilatação Patológica
Feminino
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Segmento Posterior do Olho/patologia
Estudos Prospectivos
Esclera/diagnóstico por imagem
Esclera/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22319


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[PMID]:28643720
[Au] Autor:Mohan A; Kaur N; Sharma V
[Ad] Endereço:Department of Community Ophthalmology, Global Hospital Institute of Ophthalmology, Sirohi, Rajasthan, India.
[Ti] Título:Inferior subconjunctival dislocation of posterior chamber intraocular lens after blunt trauma.
[So] Source:Indian J Ophthalmol;65(6):521-523, 2017 Jun.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Traumatic subconjunctival dislocation of the posterior chamber intraocular lens (PCIOL) is a rare and emergency condition. Here, we report an interesting variation of rare case of inferior subconjuctival dislocation of PCIOL in a 75-year-old female patient following blunt trauma to her right eye with cow's head. All the previous literature with subconjuctival dislocation of PCIOL has reported the superior dislocation of intraocular lens. Inferior subconjunctival dislocation has never been reported in previous literature.
[Mh] Termos MeSH primário: Traumatismos Oculares/complicações
Migração de Corpo Estranho/etiologia
Lentes Intraoculares
Segmento Posterior do Olho/cirurgia
Ferimentos não Penetrantes/complicações
[Mh] Termos MeSH secundário: Idoso
Túnica Conjuntiva
Remoção de Dispositivo
Traumatismos Oculares/diagnóstico
Feminino
Migração de Corpo Estranho/diagnóstico
Migração de Corpo Estranho/cirurgia
Seres Humanos
Ferimentos não Penetrantes/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_359_16


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[PMID]:28573991
[Au] Autor:Rishi P; Rishi E; Maitray A
[Ad] Endereço:Department of Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
[Ti] Título:Surgical refixation of posteriorly dislocated intraocular lens with scleral-tuck technique.
[So] Source:Indian J Ophthalmol;65(5):365-370, 2017 May.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report the outcomes of surgical refixation of posteriorly dislocated intraocular lens (IOL) using scleral-tuck method, and to compare the "scleral groove" and the "scleral flap" techniques used. STUDY DESIGN: Single-center, retrospective, interventional, comparative study. METHODS: Medical records of patients undergoing closed globe scleral refixation of posteriorly dislocated posterior chamber IOL (PCIOLs) by scleral-tuck method using two different techniques ("scleral groove" vs. "scleral flap" technique) were reviewed. This approach involved retrieving the dislocated PCIOL, externalizing the haptics through 2 sclerotomies created in paralimbal lamellar scleral grooves, or under lamellar scleral flaps and tucking the haptics into limbus-parallel scleral tunnels. No specific haptic architecture, haptic suturing, or large incisions were needed. Main outcome measures included best-corrected visual acuity (BCVA), final mean refractive error, and intra- and post-operative complications. RESULTS: Thirteen eyes of 13 patients (scleral groove, n = 6; scleral flap, n = 7 eyes) with a mean follow-up of 20.6 months were included. BCVA in all eyes was maintained or improved postoperatively, with three eyes (23%) showing ≥2 line improvement. Median astigmatic error at 6-week follow-up was -1.25 D cylinder (range: -0.5 D--2.0 D) which remained stable till final follow-up. All IOLs remained stable and well centered. None of the eyes had a recurrent dislocation, retinal detachment, endophthalmitis, or glaucoma. Both techniques were comparable in terms of postoperative BCVA, and refraction. CONCLUSION: Intrascleral haptic fixation by scleral-tuck method is reliable and effective for secure IOL refixation of posteriorly dislocated IOLs, providing good IOL centration and stability with minimal surgically-induced astigmatism. Both techniques (scleral groove and scleral flap) appear to have similar outcomes in the short term.
[Mh] Termos MeSH primário: Migração do Implante de Lente Intraocular/cirurgia
Segmento Posterior do Olho/cirurgia
Complicações Pós-Operatórias
Esclera/cirurgia
Retalhos Cirúrgicos
Técnicas de Sutura
Acuidade Visual
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Migração do Implante de Lente Intraocular/diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_960_16


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[PMID]:28494491
[Au] Autor:de Cogan F; Hill LJ; Lynch A; Morgan-Warren PJ; Lechner J; Berwick MR; Peacock AFA; Chen M; Scott RAH; Xu H; Logan A
[Ad] Endereço:Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
[Ti] Título:Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2578-2590, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. Methods: CPP toxicity was investigated in cell cultures. Ivit concentrations of ranibizumab and bevacizumab after topical administration were measured using ELISA. The biological efficacy of topical anti-VEGF + CPP complexes was compared with ivit anti-VEGF injections using an established model of CNV. Results: CPPs were nontoxic in vitro. In vivo, after topical eye drop delivery, CPPs were present in the rat anterior chamber within 6 minutes. A single application of CPP + bevacizumab eye drop delivered clinically relevant concentrations of bevacizumab to the posterior chamber of the rat eye in vivo. Similarly, clinically relevant levels of CPP + ranibizumab and CPP + bevacizumab were detected in the porcine vitreous and retina ex vivo. In an established model of CNV, mice treated with either a single ivit injection of anti-VEGF, twice daily CPP + anti-VEGF eye drops or daily dexamethasone gavage for 10 days all had significantly reduced areas of CNV when compared with lasered eyes without treatment. Conclusions: CPPs are nontoxic to ocular cells and can be used to deliver therapeutically relevant doses of ranibizumab and bevacizumab by eye drop to the posterior segment of mouse, rat, and pig eyes. The CPP + anti-VEGF drug complexes were cleared from the retina within 24 hours, suggesting a daily eye drop dosing regimen. Daily, topically delivered anti-VEGF with CPP was as efficacious as a single ivit injection of anti-VEGF in reducing areas of CNV in vivo.
[Mh] Termos MeSH primário: Bevacizumab/administração & dosagem
Peptídeos Penetradores de Células
Sistemas de Liberação de Medicamentos
Degeneração Macular/tratamento farmacológico
Ranibizumab/administração & dosagem
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Inibidores da Angiogênese/administração & dosagem
Animais
Células Cultivadas
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Angiofluoresceinografia
Seres Humanos
Degeneração Macular/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Soluções Oftálmicas
Segmento Posterior do Olho
Ratos
Ratos Sprague-Dawley
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Cell-Penetrating Peptides); 0 (Ophthalmic Solutions); 0 (Vascular Endothelial Growth Factor A); 2S9ZZM9Q9V (Bevacizumab); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20072


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[PMID]:28351054
[Au] Autor:Moisseiev E; Loewenstein A
[Ti] Título:Drug Delivery to the Posterior Segment of the Eye.
[So] Source:Dev Ophthalmol;58:87-101, 2017.
[Is] ISSN:1662-2790
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Drug delivery into the posterior segment of the eye is complicated by the existence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the barrier, and local drug delivery (including transcorneal, transscleral, and intravitreal). The most commonly used method for drug delivery into the posterior segment is by intravitreal injection. Other routes that can be used to achieve therapeutic drug levels in the posterior segment include topical, iontophoretic, and juxtascleral delivery. Extended-release intravitreal drug delivery systems can achieve sustained therapeutic levels with the goal of providing a prolonged clinical benefit with significantly fewer interventions.
[Mh] Termos MeSH primário: Barreira Hematoaquosa
Sistemas de Liberação de Medicamentos/instrumentação
Edema Macular/tratamento farmacológico
Segmento Posterior do Olho
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
Seres Humanos
Edema Macular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1159/000455276


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[PMID]:28292776
[Au] Autor:Goukon H; Kamiya K; Shimizu K; Igarashi A
[Ad] Endereço:Department of Ophthalmology, University of Kitasato School of Medicine, Kanagawa, Japan.
[Ti] Título:Comparison of corneal endothelial cell density and morphology after posterior chamber phakic intraocular lens implantation with and without a central hole.
[So] Source:Br J Ophthalmol;101(11):1461-1465, 2017 Nov.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To compare the corneal endothelial cells after posterior chamber phakic intraocular lens with and without a central hole (hole implantable collamer lens (ICL) and conventional ICL) implantation for the correction of moderate to high myopia. METHODS: This retrospective study evaluated 34 eyes of 34 patients who underwent hole ICL implantation and 25 eyes of 25 patients who underwent conventional ICL implantation. Preoperatively and 3 months, and 1 and 2 years postoperatively, we compared the central corneal endothelial cell density (ECD), coefficient of variation in cell size (CV) and the percentage of hexagonal cells (HEX) between the two groups using a non-contact specular microscope (EM-3000, Tomey). Preoperatively and 2 years postoperatively, we also compared them in the peripheral regions. RESULTS: The mean central ECD loss was 0.3% and 1.1%, 2 years after hole ICL and conventional ICL implantation, respectively (Mann-Whitney U test, p=0.72). There were no significant changes in central ECD, CV or HEX at any time points either after hole ICL or conventional ICL implantation, and a significant decrease only in terms of ECD in the superior regions after conventional ICL implantation. CONCLUSIONS: Both ICLs do not induce a significant change in the density, polymegethism or polymorphism of corneal endothelial cells even 2 years postoperatively, except for the density in the superior regions after conventional ICL implantation. However, hole ICL implantation may have advantages over conventional ICL implantation only in terms of the density in the superior regions, possibly because preoperative laser iridotomies are unnecessary.
[Mh] Termos MeSH primário: Epitélio Posterior/patologia
Implante de Lente Intraocular/métodos
Miopia/cirurgia
Lentes Intraoculares Fácicas
Segmento Posterior do Olho/cirurgia
[Mh] Termos MeSH secundário: Adulto
Contagem de Células
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Miopia/patologia
Desenho de Prótese
Estudos Retrospectivos
Fatores de Tempo
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309363



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