Base de dados : MEDLINE
Pesquisa : A09.531.940 [Categoria DeCS]
Referências encontradas : 914 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 92 ir para página                         

  1 / 914 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28514374
[Au] Autor:Morozova SV; Savvateeva DM; Svistushkin VM; Toporkova LA
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119991.
[Ti] Título:[The role of the vomeronasal system in the formation of the human sexual behaviour].
[Ti] Título:Rol' vomeronazal'noi sistemy v formirovanii seksual'nogo povedeniia cheloveka..
[So] Source:Vestn Otorinolaringol;82(2):90-94, 2017.
[Is] ISSN:0042-4668
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This review deals with the structure and function of the vomeronasal system and evaluation of its influence on the sexual sphere of humans and animals. Special attention is given to the role of pheromones in the regulation of the sexual behaviour. The data concerning the function of the vomeronasal organ following surgical interventions in the nasal cavity are discussed.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Nasais/efeitos adversos
Transtornos das Sensações
Atrativos Sexuais/fisiologia
Comportamento Sexual/fisiologia
Órgão Vomeronasal
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Complicações Pós-Operatórias/fisiopatologia
Complicações Pós-Operatórias/psicologia
Transtornos das Sensações/etiologia
Transtornos das Sensações/fisiopatologia
Transtornos das Sensações/psicologia
Órgão Vomeronasal/anatomia & histologia
Órgão Vomeronasal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Sex Attractants)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201782190-94


  2 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28374006
[Au] Autor:Kunkhyen T; McCarthy EA; Korzan WJ; Doctor D; Han X; Baum MJ; Cherry JA
[Ad] Endereço:Department of Psychological and Brain Sciences, Boston University , Boston, MA 02215.
[Ti] Título:Optogenetic Activation of Accessory Olfactory Bulb Input to the Forebrain Differentially Modulates Investigation of Opposite versus Same-Sex Urinary Chemosignals and Stimulates Mating in Male Mice.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Surgical or genetic disruption of vomeronasal organ (VNO)-accessory olfactory bulb (AOB) function previously eliminated the ability of male mice to processes pheromones that elicit territorial behavior and aggression. By contrast, neither disruption significantly affected mating behaviors, although VNO lesions reduced males' investigation of nonvolatile female pheromones. We explored the contribution of VNO-AOB pheromonal processing to male courtship using optogenetic activation of AOB projections to the forebrain. Protocadherin-Cre male transgenic mice received bilateral AOB infections with channelrhodopsin2 (ChR2) viral vectors, and an optical fiber was implanted above the AOB. In olfactory choice tests, males preferred estrous female urine (EFU) over water; however, this preference was eliminated when diluted (5%) EFU was substituted for 100% EFU. Optogenetic AOB activation concurrent with nasal contact significantly augmented males' investigation compared to 5% EFU alone. Conversely, concurrent optogenetic AOB activation significantly reduced males' nasal investigation of diluted urine from gonadally intact males (5% IMU) compared to 5% IMU alone. These divergent effects of AOB optogenetic activation were lost when males were prevented from making direct nasal contact. Optogenetic AOB stimulation also failed to augment males' nasal investigation of deionized water or of food odors. Finally, during mating tests, optogenetic AOB stimulation delivered for 30 s when the male was in physical contact with an estrous female significantly facilitated the occurrence of penile intromission. Our results suggest that VNO-AOB signaling differentially modifies males' motivation to seek out female vs male urinary pheromones while augmenting males' sexual arousal leading to intromission and improved reproductive performance.
[Mh] Termos MeSH primário: Bulbo Olfatório/fisiologia
Percepção Olfatória/fisiologia
Comportamento Sexual Animal/fisiologia
Olfato/fisiologia
Percepção Social
Órgão Vomeronasal/fisiologia
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Odorantes
Condutos Olfatórios/fisiologia
Optogenética
Urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  3 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28192871
[Au] Autor:Mladina R; Antunovic R; Cingi C; Bayar Muluk N; Skitarelic N
[Ad] Endereço:Department of ENT Head and Neck Surgery, Clinical Hospital Center Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia.
[Ti] Título:Sinus septi nasi: Anatomical study.
[So] Source:Clin Anat;30(3):312-317, 2017 Apr.
[Is] ISSN:1098-2353
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to perform a pioneering investigation into the incidence of pneumatization in human skulls. A total of 93 human skulls (≥20 years of age, 69 males, 24 females) were included in the study. The skulls were scanned in a fixed position using cone beam computed tomography (CBCT). The pneumatized space parameters within the nasal septum-width, length, and height-were measured. Two types of finding were identified: (a) Pneumatization, named "sinus septi nasi" (SSN), and (b) "spongy bone" (SB). The results showed SSN in 32 of the 93 skulls (34.4%). The SSN formations were from 0.5 to 4.2 mm wide, 3.5 to 18.8 mm long, and 3.8 to 17.7 mm high. Tumefactions filled with SB were found in 61 of the 93 skulls (65.59%). These were not suitable for precise measurements since the outer borders were not strictly and well defined on CT scans (perhaps because of the preparation process). In conclusion, the perpendicular plate of the ethmoidal bone is not always compact bone; in 34.4% of cases, it shows a degree of pneumatization. In contrast, an enlarged formation filled with SB is present in 65.59% of cases. The possible sources of pneumatization of this little-investigated region are discussed: sphenoid sinus, frontal sinus, and vomeronasal organ. Clin. Anat. 30:312-317, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Osso Etmoide/anatomia & histologia
Seio Frontal/anatomia & histologia
Seio Maxilar/anatomia & histologia
Septo Nasal/anatomia & histologia
Seio Esfenoidal/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Osso Esponjoso/fisiologia
Tomografia Computadorizada de Feixe Cônico/métodos
Osso Etmoide/diagnóstico por imagem
Feminino
Seio Frontal/diagnóstico por imagem
Seres Humanos
Masculino
Seio Maxilar/diagnóstico por imagem
Septo Nasal/diagnóstico por imagem
Seio Esfenoidal/diagnóstico por imagem
Estatísticas não Paramétricas
Órgão Vomeronasal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1002/ca.22850


  4 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28188885
[Au] Autor:Pyrski M; Eckstein E; Schmid A; Bufe B; Weiss J; Chubanov V; Boehm U; Zufall F
[Ad] Endereço:Center for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
[Ti] Título:Trpm5 expression in the olfactory epithelium.
[So] Source:Mol Cell Neurosci;80:75-88, 2017 Apr.
[Is] ISSN:1095-9327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Ca -activated monovalent cation channel Trpm5 is a key element in chemotransduction of taste receptor cells of the tongue, but the extent to which Trpm5 channels are expressed in olfactory sensory neurons (OSNs) of the main olfactory epithelium (MOE) of adult mice as part of a specific pheromonal detection system is debated. Here, we used a novel Trpm5-IRES-Cre knockin strain to drive Cre recombinase expression, employed previously validated Trpm5 antibodies, performed in situ hybridization experiments to localize Trpm5 RNA, and searched extensively for Trpm5 splice variants in genetically-labeled, Trpm5-expressing MOE cells. In contrast to previous reports, we find no evidence for the existence in adult mouse OSNs of the classical Trpm5 channel known from taste cells. We show that Trpm5-expressing adult OSNs express a novel Trpm5 splice variant, Trpm5-9, that is unlikely to form a functional cation channel by itself. We also demonstrate that Trpm5 is transiently expressed in a subpopulation of mature OSNs in the embryonic olfactory epithelium, indicating that Trpm5 channels could play a specific role in utero during a narrow developmental time window. Ca imaging with GCaMP3 under the control of the Trpm5-IRES-Cre allele using a newly developed MOE wholemount preparation of the adult olfactory epithelium reveals that Trpm5-GCaMP3 OSNs comprise a heterogeneous group of sensory neurons many of which can detect general odorants. Together, these studies are essential for understanding the role of transient receptor potential channels in mammalian olfaction.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento/genética
Mucosa Olfatória/metabolismo
Canais de Cátion TRPM/metabolismo
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Animais Recém-Nascidos
Cálcio/metabolismo
Embrião de Mamíferos
Proteína GAP-43/metabolismo
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Proteínas dos Microfilamentos/metabolismo
Proteína de Marcador Olfatório/genética
Proteína de Marcador Olfatório/metabolismo
Mucosa Olfatória/citologia
Mucosa Olfatória/embriologia
Mucosa Olfatória/crescimento & desenvolvimento
Neurônios Receptores Olfatórios/metabolismo
RNA Mensageiro/metabolismo
Canais de Cátion TRPM/genética
Órgão Vomeronasal/embriologia
Órgão Vomeronasal/crescimento & desenvolvimento
Órgão Vomeronasal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GAP-43 Protein); 0 (Microfilament Proteins); 0 (Olfactory Marker Protein); 0 (Omp protein, mouse); 0 (RNA, Messenger); 0 (TRPM Cation Channels); 0 (Trpm5 protein, mouse); 0 (villin); 147336-22-9 (Green Fluorescent Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


  5 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28128447
[Au] Autor:Yohe LR; Abubakar R; Giordano C; Dumont E; Sears KE; Rossiter SJ; Dávalos LM
[Ad] Endereço:Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York, 11794.
[Ti] Título:Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss.
[So] Source:Evolution;71(4):923-935, 2017 Apr.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Comparative methods are often used to infer loss or gain of complex phenotypes, but few studies take advantage of genes tightly linked with complex traits to test for shifts in the strength of selection. In mammals, vomerolfaction detects chemical cues mediating many social and reproductive behaviors and is highly conserved, but all bats exhibit degraded vomeronasal structures with the exception of two families (Phyllostomidae and Miniopteridae). These families either regained vomerolfaction after ancestral loss, or there were many independent losses after diversification from an ancestor with functional vomerolfaction. In this study, we use the Transient receptor potential cation channel 2 (Trpc2) as a molecular marker for testing the evolutionary mechanisms of loss and gain of the mammalian vomeronasal system. We sequenced Trpc2 exon 2 in over 100 bat species across 17 of 20 chiropteran families. Most families showed independent pseudogenizing mutations in Trpc2, but the reading frame was highly conserved in phyllostomids and miniopterids. Phylogeny-based simulations suggest loss of function occurred after bat families diverged, and purifying selection in two families has persisted since bats shared a common ancestor. As most bats still display pheromone-mediated behavior, they might detect pheromones through the main olfactory system without using the Trpc2 signaling mechanism.
[Mh] Termos MeSH primário: Evolução Biológica
Quirópteros/fisiologia
Transdução de Sinais
Canais de Receptores Transientes de Potencial/genética
Órgão Vomeronasal/fisiologia
[Mh] Termos MeSH secundário: Animais
Quirópteros/genética
Evolução Molecular
Filogenia
Pseudogenes
Análise de Sequência de DNA
Canais de Receptores Transientes de Potencial/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transient Receptor Potential Channels)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13187


  6 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27990576
[Au] Autor:Syed AS; Sansone A; Hassenklöver T; Manzini I; Korsching SI
[Ad] Endereço:Institute of Genetics, Biocenter, University of Cologne, Zülpicher Strasse 47a, 50674, Cologne, Germany.
[Ti] Título:Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis.
[So] Source:Cell Mol Life Sci;74(9):1711-1719, 2017 May.
[Is] ISSN:1420-9071
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more 'modern', later diverging V2Rs, whereas more 'ancient', earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of Xenopus tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Metamorfose Biológica
Nariz/metabolismo
Receptores Odorantes/metabolismo
Órgão Vomeronasal/metabolismo
Água/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Larva/metabolismo
Masculino
Metamorfose Biológica/genética
Mucosa Olfatória/metabolismo
Neurônios Receptores Olfatórios/metabolismo
Transdução de Sinais
Olfato
Xenopus laevis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Receptors, Odorant); 059QF0KO0R (Water)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1007/s00018-016-2437-1


  7 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27840094
[Au] Autor:Orikasa C; Kondo Y; Katsumata H; Terada M; Akimoto T; Sakuma Y; Minami S
[Ad] Endereço:Institute for Advanced Medical Sciences, Nippon Medical School, Kanagawa 211-8533, Japan. Electronic address: orikasa@nms.ac.jp.
[Ti] Título:Vomeronasal signal deficiency enhances parental behavior in socially isolated male mice.
[So] Source:Physiol Behav;168:98-102, 2017 Jan 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We previously reported that social isolation promotes parental care in sexually naïve male mice. This effect was blocked by exposure to chemosensory and auditory social signals derived from males in an adjacent compartment. In the present study, we examined whether the chemosensory signals detected in the vomeronasal organ (VNO) are involved in parental behavior by using mice deficient for a VNO-specific ion channel (Trpc2 ) and thus impaired in VNO-input signaling. We housed virgin homozygous Trpc2 and heterozygous Trpc2 males for 3weeks during puberty (5-8weeks old) alone or in groups of 3-5 males. At 8weeks of age, the mice were placed with three pups in an observation cage and tested for parental behavior. The Trpc2 males housed under isolated conditions spent significantly longer in the vicinity of pups than did the Trpc2 males than had been group housed, whereas no isolation effect was observed in heterozygous Trpc2 males. Both Trpc2 knockout and isolation housing significantly increased the time males spent licking pups and crouching (arched back posture over pups to enable nursing), whereas only isolation housing increased the incidence of retrieval behavior. These results demonstrated that social signals transmitted not only through the VNO but also from other modalities, independent of each other, suppress the expression of parental behavior during puberty in sexually naïve males.
[Mh] Termos MeSH primário: Comportamento Paterno/fisiologia
Isolamento Social/psicologia
Órgão Vomeronasal/fisiopatologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Animais Recém-Nascidos
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Estatísticas não Paramétricas
Canais de Cátion TRPC/deficiência
Canais de Cátion TRPC/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TRPC Cation Channels); 0 (Trpc2 protein, mouse)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


  8 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27655939
[Au] Autor:Henkel B; Bintig W; Bhat SS; Spehr M; Neuhaus EM
[Ad] Endereço:Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University Jena, Drackendorfer Straße 1, 07743 Jena, Germany.
[Ti] Título:NHERF1 in Microvilli of Vomeronasal Sensory Neurons.
[So] Source:Chem Senses;42(1):25-35, 2017 Jan.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In most mammals, the vomeronasal system detects a variety of (semio)chemicals that mediate olfactory-driven social and sexual behaviors. Vomeronasal chemosensation depends on G protein-coupled receptors (V1R, V2R, and FPR-rs) that operate at remarkably low stimulus concentrations, thus, indicating a highly sensitive and efficient signaling pathway. We identified the PDZ domain-containing protein, Na /H exchanger regulatory factor-1 (NHERF1), as putative molecular organizer of signal transduction in vomeronasal neurons. NHERF1 is a protein that contains 2 PDZ domains and a carboxy-terminal ezrin-binding domain. It localizes to microvilli of vomeronasal sensory neurons and interacts with V1Rs. Furthermore, NHERF1 and Gα are closely colocalized. These findings open up new aspects of the functional organization and regulation of vomeronasal signal transduction by PDZ scaffolding proteins.
[Mh] Termos MeSH primário: Microvilosidades/química
Fosfoproteínas/análise
Células Receptoras Sensoriais/química
Trocadores de Sódio-Hidrogênio/análise
Órgão Vomeronasal/citologia
[Mh] Termos MeSH secundário: Animais
Camundongos
Camundongos Endogâmicos C57BL
Microvilosidades/metabolismo
Fosfoproteínas/genética
Fosfoproteínas/metabolismo
Células Receptoras Sensoriais/metabolismo
Trocadores de Sódio-Hidrogênio/genética
Trocadores de Sódio-Hidrogênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoproteins); 0 (Sodium-Hydrogen Exchangers); 0 (sodium-hydrogen exchanger regulatory factor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


  9 / 914 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27651427
[Au] Autor:Westberry JM; Meredith M
[Ad] Endereço:Present address: Department of Biology, University of St. Thomas, St. Paul, MN 555105, USA.
[Ti] Título:Characteristic Response to Chemosensory Signals in GABAergic Cells of Medial Amygdala Is Not Driven by Main Olfactory Input.
[So] Source:Chem Senses;42(1):13-24, 2017 Jan.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemosensory stimuli from same species (conspecific) and different species (heterospecific) elicit categorically different immediate-early gene (IEG) response patterns in medial amygdala in male hamsters and mice. All heterospecific stimuli activate anterior medial amygdala (MeA) but only especially salient heterospecific stimuli, such as those from predators activate posterior medial amygdala (MeP). We previously reported that characteristic patterns of response in separate populations of cells in MeA and MeP distinguish between different conspecific stimuli. Both gamma aminobutyric acid (GABA)-immunoreactive (ir) cells and GABA-receptor-ir cells make this distinction. Here, using zinc sulfate lesions of the main olfactory epithelium, we show evidence that main olfactory input does not contribute to the characteristic patterns of response in GABA-ir cells of male hamster amygdala, either for conspecific or heterospecific stimuli. Some GABAergic cells are output neurons carrying information from medial amygdala to behavioral executive regions of basal forebrain. Thus, the differential response to different conspecific signals can lead to differential activation of downstream circuits based on nonolfactory input. Finally, we show that an intact vomeronasal organ is necessary and sufficient to produce the characteristic patterns of response to conspecific and heterospecific chemosensory stimuli in hamster medial amygdala. Although main olfactory input may be critical in species with less prominent vomeronasal input for equivalent medial amygdala responses, work presented here suggests that hamster medial amygdala uses primarily vomeronasal input to discriminate between important unlearned conspecific social signals, to distinguish them from the social signals of other species, and may convey that information to brain circuits eliciting appropriate social behavior.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/metabolismo
Neurônios GABAérgicos/metabolismo
Condutos Olfatórios/metabolismo
Órgão Vomeronasal/metabolismo
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/efeitos dos fármacos
Tonsila do Cerebelo/patologia
Animais
Comportamento Animal
Cricetinae
Neurônios GABAérgicos/efeitos dos fármacos
Neurônios GABAérgicos/patologia
Masculino
Condutos Olfatórios/efeitos dos fármacos
Órgão Vomeronasal/efeitos dos fármacos
Sulfato de Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7733-02-0 (Zinc Sulfate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE


  10 / 914 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27423908
[Au] Autor:Kondoh D; Kamikawa A; Sasaki M; Kitamura N
[Ad] Endereço:Laboratory of Veterinary Anatomy, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
[Ti] Título:Localization of α1-2 Fucose Glycan in the Mouse Olfactory Pathway.
[So] Source:Cells Tissues Organs;203(1):20-28, 2017.
[Is] ISSN:1422-6421
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Glycoconjugates in the olfactory system play critical roles in neuronal formation, and α1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity. Histochemical findings of α1-2Fuc glycan in the mouse olfactory system detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed the main olfactory and vomeronasal pathways in male and female ICR and C57BL/6J mice aged 3-4 months using UEA-I. Ulex europaeus agglutinin-I reacted with most receptor cells arranged mainly at the basal region of the olfactory epithelium. The olfactory nerve layer and glomerular layer of the main olfactory bulb were speckled with positive UEA-I staining, and positive fibers were scattered from the glomerular to the internal plexiform layer. The lateral olfactory tract and rostral migratory stream were also positive for UEA-I. We identified superficial short-axon cells, interneurons of the external plexiform layer, external, middle and internal tufted cells, mitral cells and granule cells as the origins of the UEA-I-positive fibers in the main olfactory bulb. The anterior olfactory nucleus, anterior piriform cortex and olfactory tubercle were negative for UEA-I. Most receptor cells in the vomeronasal epithelium and most glomeruli of the accessory olfactory bulb were positive for UEA-I. Our findings indicated that α1-2Fuc glycan is located within the primary and secondary, but not the ternary, pathways of the main olfactory system, in local circuits of the main olfactory bulb and within the primary, but not secondary, pathway of the vomeronasal system.
[Mh] Termos MeSH primário: Fucose/metabolismo
Condutos Olfatórios/metabolismo
Lectinas de Plantas/metabolismo
Polissacarídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos ICR
Bulbo Olfatório/metabolismo
Mucosa Olfatória/metabolismo
Órgão Vomeronasal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Lectins); 0 (Polysaccharides); 0 (Ulex europaeus lectins); 28RYY2IV3F (Fucose)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160718
[St] Status:MEDLINE
[do] DOI:10.1159/000447009



página 1 de 92 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde