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[PMID]:28721837
[Au] Autor:Torres SJ; Robinson S; Orellana L; O'Connell SL; Grimes CA; Mundell NL; Dunstan DW; Nowson CA; Daly RM
[Ad] Endereço:1School of Exercise and Nutrition Sciences,Institute for Physical Activity and Nutrition,Deakin University,Geelong,VIC 3220,Australia.
[Ti] Título:Effects of progressive resistance training combined with a protein-enriched lean red meat diet on health-related quality of life in elderly women: secondary analysis of a 4-month cluster randomised controlled trial.
[So] Source:Br J Nutr;117(11):1550-1559, 2017 Jun.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Resistance training (RT) and increased dietary protein are recommended to attenuate age-related muscle loss in the elderly. This study examined the effect of a lean red meat protein-enriched diet combined with progressive resistance training (RT+Meat) on health-related quality of life (HR-QoL) in elderly women. In this 4-month cluster randomised controlled trial, 100 women aged 60-90 years (mean 73 years) from self-care retirement villages participated in RT twice a week and were allocated either 160 g/d (cooked) lean red meat consumed across 2 meals/d, 6 d/week or ≥1 serving/d (25-30 g) carbohydrates (control group, CRT). HR-QoL (SF-36 Health Survey questionnaire), lower limb maximum muscle strength and lean tissue mass (LTM) (dual-energy X-ray absorptiometry) were assessed at baseline and 4 months. In all, ninety-one women (91 %) completed the study (RT+Meat (n 48); CRT (n 43)). Mean protein intake was greater in RT+Meat than CRT throughout the study (1·3 (sd 0·3) v. 1·1 (sd 0·3) g/kg per d, P<0·05). Exercise compliance (74 %) was not different between groups. After 4 months there was a significant net benefit in the RT+Meat compared with CRT group for overall HR-QoL and the physical component summary (PCS) score (P<0·01), but there were no changes in either group in the mental component summary (MCS) score. Changes in lower limb muscle strength, but not LTM, were positively associated with changes in overall HR-QoL (muscle strength, ß: 2·2 (95 % CI 0·1, 4·3), P<0·05). In conclusion, a combination of RT and increased dietary protein led to greater net benefits in overall HR-QoL in elderly women compared with RT alone, which was because of greater improvements in PCS rather than MCS.
[Mh] Termos MeSH primário: Dieta
Proteínas na Dieta/farmacologia
Nível de Saúde
Força Muscular
Aptidão Física
Carne Vermelha
Treinamento de Resistência
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Idoso de 80 Anos ou mais
Compartimentos de Líquidos Corporais
Proteínas na Dieta/administração & dosagem
Comportamento Alimentar
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Meia-Idade
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/fisiologia
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001507


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[PMID]:28679554
[Au] Autor:Kjølbæk L; Sørensen LB; Søndertoft NB; Rasmussen CK; Lorenzen JK; Serena A; Astrup A; Larsen LH
[Ad] Endereço:Department of Nutrition, Exercise and Sports, Faculty of Science, and louisekjoelbaek@nexs.ku.dk.
[Ti] Título:Protein supplements after weight loss do not improve weight maintenance compared with recommended dietary protein intake despite beneficial effects on appetite sensation and energy expenditure: a randomized, controlled, double-blinded trial.
[So] Source:Am J Clin Nutr;106(2):684-697, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:: High-protein diets increase weight loss (WL) during energy restriction; therefore, it has been suggested that additional protein intake may improve weight maintenance (WM) after WL. We investigated the effect of protein supplements from either whey with or without calcium or soy on WM success after WL compared with that of a control. In a randomized, controlled, double-blinded trial, 220 participants aged 18-60 y with body mass index (in kg/m ) from 27.6 to 40.4 were included. The study was initiated with an 8-wk WL period followed by a 24-wk WM period. During WM, participants consumed the following isocaloric supplements (45-48 g/d): whey and calcium (whey+), whey, soy, or maltodextrin (control). Data were collected at baseline, before WM, and after WM (weeks 0, 8, and 32, respectively) and included body composition, blood biochemistry, and blood pressure. Meal tests were performed to investigate diet-induced-thermogenesis (DIT) and appetite sensation. Compliance was tested by 24-h urinary nitrogen excretion. A total of 151 participants completed the WM period. The control and 3 protein supplements did not result in different mean ± SD weight regains (whey+: 2.19 ± 4.6 kg; whey: 2.01 ± 4.6 kg; soy: 1.76 ± 4.7 kg; and control: 2.23 ± 3.8 kg; = 0.96), fat mass regains (whey+: 0.46 ± 4.5 kg; whey: 0.11 ± 4.1 kg; soy: 0.15 ± 4.1 kg; and control: 0.54 ± 3.3 kg; = 0.96), or improvements in lean body mass (whey+: 1.87 ± 1.7 kg; whey: 1.94 ± 1.3 kg; soy: 1.58 ± 1.4 kg; and control: 1.74 ± 1.4 kg; = 0.50) during WM. Changes in blood pressure and blood biochemistry were not different between groups. Compared with the control, protein supplementation resulted in higher DIT (∼30 kJ/2.5 h) and resting energy expenditure (243 kJ/d) and an anorexigenic appetite-sensation profile. Protein supplementation does not result in improved WM success, or blood biochemistry after WL compared with the effects of normal dietary protein intake (0.8-1.0 g · kg · d ). This trial was registered at clinicaltrials.gov as NCT01561131.
[Mh] Termos MeSH primário: Apetite/efeitos dos fármacos
Manutenção do Peso Corporal/fisiologia
Proteínas na Dieta/farmacologia
Suplementos Nutricionais
Metabolismo Energético/efeitos dos fármacos
Obesidade
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Adulto
Composição Corporal
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Cálcio na Dieta/farmacologia
Proteínas na Dieta/administração & dosagem
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Refeições
Meia-Idade
Obesidade/dietoterapia
Sobrepeso/dietoterapia
Recomendações Nutricionais
Proteínas de Soja/farmacologia
Termogênese/efeitos dos fármacos
Proteínas do Soro do Leite/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Calcium, Dietary); 0 (Dietary Proteins); 0 (Soybean Proteins); 0 (Whey Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.129528


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[PMID]:28659299
[Au] Autor:Bell KA; Wagner CL; Feldman HA; Shypailo RJ; Belfort MB
[Ad] Endereço:Division of Newborn Medicine and kbell7@partners.org.
[Ti] Título:Associations of infant feeding with trajectories of body composition and growth.
[So] Source:Am J Clin Nutr;106(2):491-498, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extent to which breastfeeding is protective against later-life obesity is controversial. Little is known about differences in infant body composition between breastfed and formula-fed infants, which may reflect future obesity risk. We aimed to assess associations of infant feeding with trajectories of growth and body composition from birth to 7 mo in healthy infants. We studied 276 participants from a previous study of maternal vitamin D supplementation during lactation. Mothers used monthly feeding diaries to report the extent of breastfeeding. We measured infants' anthropometrics and used dual-energy X-ray absorptiometry to assess body composition at 1, 4, and 7 mo. We compared changes in infant size ( scores for weight, length, and body mass index [BMI (in kg/m )]) and body composition (fat and lean mass, body fat percentage) between predominantly breastfed and formula-fed infants, adjusting in linear regression for sex, gestational age, race/ethnicity, maternal BMI, study site, and socioeconomic status. In this study, 214 infants (78%) were predominantly breastfed (median duration: 7 mo) and 62 were exclusively formula fed. Formula-fed infants had lower birth-weight scores than breastfed infants (-0.22 ± 0.86 and 0.16 ± 0.88, respectively; < 0.01) but gained more in weight and BMI through 7 mo of age (weight score difference: 0.37; 95% CI: 0.04, 0.71; BMI score difference: 0.35; 95% CI: 0, 0.69), with no difference in linear growth ( score difference: 0.05; 95% CI: -0.24, 0.34). Formula-fed infants gained more lean mass (difference: 303 g; 95% CI: 137, 469 g) than breastfed infants, but not fat mass (difference: -42 g; 95% CI: -299, 215 g). Formula-fed infants gained weight more rapidly and out of proportion to linear growth than did predominantly breastfed infants. These differences were attributable to greater accretion of lean mass, rather than fat mass. Any later obesity risk associated with infant feeding does not appear to be explained by differential adiposity gains in infancy.
[Mh] Termos MeSH primário: Composição Corporal
Aleitamento Materno
Dieta
Fórmulas Infantis
Fenômenos Fisiológicos da Nutrição do Lactente
Leite Humano
Ganho de Peso
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Tecido Adiposo/metabolismo
Adulto
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Peso Corporal
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Obesidade/metabolismo
Obesidade/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.151126


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[PMID]:28659296
[Au] Autor:Perng W; Ringham BM; Glueck DH; Sauder KA; Starling AP; Belfort MB; Dabelea D
[Ad] Endereço:Departments of Nutritional Sciences and perngwei@umich.edu dana.dabelea@ucdenver.
[Ti] Título:An observational cohort study of weight- and length-derived anthropometric indicators with body composition at birth and 5 mo: the Healthy Start study.
[So] Source:Am J Clin Nutr;106(2):559-567, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite widespread use of weight- and length-based anthropometric indexes as proxies for adiposity, little is known regarding the extent to which they correspond with fat mass (FM) or fat-free mass (FFM) during infancy. This study aimed to examine associations of 3 derived indicators-weight-for-age score (WFAZ), weight-for-length score (WFLZ), and body mass index score (BMIZ)-with FM, percentage of FM, and FFM measured by air-displacement plethysmography during the first 5 mo of life. Applying prospectively collected data from 1027 infants in a Colorado prebirth cohort, we used multivariate regression to evaluate associations between the derived indicators and body composition at birth and at 5 mo, and with change (Δ) during follow-up. At birth, all 3 derived indicators were more strongly associated with FFM than with FM. Each unit of WFAZ corresponded with 0.342 kg FFM (95% CI: 0.331, 0.351 kg FFM), compared with 0.121 kg FM (95% CI: 0.114, 0.128 kg FM) ( < 0.0001); similar trends were observed for WFLZ and BMIZ. By 5 mo, WFLZ and BMIZ were more strongly associated with FM than with FFM, whereas WFAZ correlated similarly with the 2 components of body composition. ΔWFLZ and ΔBMIZ were both more strongly related to ΔFM than to ΔFFM; however, a direct comparison of the 2 indexes with respect to change in the percentage of FM indicated that ΔBMIZ was the optimal proxy of adiposity gain ( < 0.0001, pairwise difference). Weight- and length-based indexes are poor surrogates for newborn adiposity. However, at 5 mo, WFLZ and BMIZ are suitable proxies of FM. When assessing adiposity gain, ΔBMIZ is the best indicator of fat accrual during the first 5 postnatal months. This trial was registered at clinicaltrials.gov as NCT02273297.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Adiposidade
Composição Corporal
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Peso Corporal
Obesidade/metabolismo
[Mh] Termos MeSH secundário: Adulto
Antropometria
Biomarcadores
Peso ao Nascer
Estatura
Estudos de Coortes
Colorado
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estado Nutricional
Obesidade/etiologia
Pletismografia
Gravidez
Ganho de Peso
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.149617


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[PMID]:28637773
[Au] Autor:Ruys CA; van de Lagemaat M; Finken MJ; Lafeber HN
[Ad] Endereço:Departments of Pediatrics/Neonatology and c.ruys@vumc.nl.
[Ti] Título:Follow-up of a randomized trial on postdischarge nutrition in preterm-born children at age 8 y.
[So] Source:Am J Clin Nutr;106(2):549-558, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Early nutritional interventions may modulate health risks in preterm-born infants. Previously, we showed that preterm-born infants fed an isocaloric protein- and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained more lean mass than did those fed term formula (TF). Long-term follow-up of randomized nutritional trials is important to test the hypothesis that short-term positive effects on health are sustainable. The aim of this follow-up study was to compare body size, body composition, and metabolic health at age 8 y in preterm-born children who were randomly assigned to receive either PDF or TF from term age until 6-mo CA. A total of 79 of 152 children (52%) from the original randomized controlled trial were enrolled for follow-up at age 8 y. Weight, height, and head circumference were measured by using standard methods. Body composition, including fat mass, lean mass, bone mineral content, and bone mineral density, was determined by dual-energy X-ray absorptiometry. Blood pressure was measured in the supine position by using an automatic device. Metabolic variables, including glucose, insulin, insulin-like growth factor I, triglycerides, cholesterol, cortisol, and leptin, were measured after an overnight fast. Nutritional habits at age 8 y were assessed by using a 3-d nutritional diary. At age 8 y, no differences were found in body size, body composition, bone variables, and metabolic health variables when comparing children fed PDF with those fed TF. Adjustment for known and possible confounders did not change these results. In this follow-up study in preterm-born children, we showed that the favorable effects of PDF at 6-mo CA either were not maintained or could not be confirmed because of attrition at the age of 8 y. We suggest that future research should focus on nutritional interventions in the pre- and postdischarge period as a continuum rather than as separate entities. This trial was registered at www.trialregister.nl as NTR 2972 (follow-up study [STEP-2 (Study Towards the Effects of Post-discharge Nutrition 2)]) and NTR 55 [original randomized controlled trial (STEP)].
[Mh] Termos MeSH primário: Dieta
Proteínas na Dieta/farmacologia
Alimentos Fortificados
Fórmulas Infantis/química
Recém-Nascido Prematuro/crescimento & desenvolvimento
Minerais/farmacologia
Estado Nutricional/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Glicemia/metabolismo
Composição Corporal/efeitos dos fármacos
Compartimentos de Líquidos Corporais/metabolismo
Tamanho Corporal/efeitos dos fármacos
Densidade Óssea
Criança
Feminino
Seguimentos
Hormônios/sangue
Seres Humanos
Lactente
Fenômenos Fisiológicos da Nutrição do Lactente
Recém-Nascido
Recém-Nascido Prematuro/metabolismo
Lipídeos/sangue
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Proteins); 0 (Hormones); 0 (Lipids); 0 (Minerals)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.145375


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[PMID]:28382898
[Au] Autor:Kerr A; Slater GJ; Byrne N
[Ad] Endereço:1School of Health and Sport Sciences,University of the Sunshine Coast,Sippy Downs,QLD 4556,Australia.
[Ti] Título:Impact of food and fluid intake on technical and biological measurement error in body composition assessment methods in athletes.
[So] Source:Br J Nutr;117(4):591-601, 2017 Feb.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two, three and four compartment (2C, 3C and 4C) models of body composition are popular methods to measure fat mass (FM) and fat-free mass (FFM) in athletes. However, the impact of food and fluid intake on measurement error has not been established. The purpose of this study was to evaluate standardised (overnight fasted, rested and hydrated) v. non-standardised (afternoon and non-fasted) presentation on technical and biological error on surface anthropometry (SA), 2C, 3C and 4C models. In thirty-two athletic males, measures of SA, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance spectroscopy (BIS) and air displacement plethysmography (BOD POD) were taken to establish 2C, 3C and 4C models. Tests were conducted after an overnight fast (duplicate), about 7 h later after ad libitum food and fluid intake, and repeated 24 h later before and after ingestion of a specified meal. Magnitudes of changes in the mean and typical errors of measurement were determined. Mean change scores for non-standardised presentation and post meal tests for FM were substantially large in BIS, SA, 3C and 4C models. For FFM, mean change scores for non-standardised conditions produced large changes for BIS, 3C and 4C models, small for DXA, trivial for BOD POD and SA. Models that included a total body water (TBW) value from BIS (3C and 4C) were more sensitive to TBW changes in non-standardised conditions than 2C models. Biological error is minimised in all models with standardised presentation but DXA and BOD POD are acceptable if acute food and fluid intake remains below 500 g.
[Mh] Termos MeSH primário: Absorciometria de Fóton/métodos
Atletas
Composição Corporal
Ingestão de Líquidos
Ingestão de Energia
Pletismografia/métodos
Esportes/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo
Adolescente
Adulto
Compartimentos de Líquidos Corporais
Água Corporal
Ingestão de Alimentos
Impedância Elétrica
Jejum
Seres Humanos
Masculino
Refeições
Meia-Idade
Modelos Biológicos
Avaliação Nutricional
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000551


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[PMID]:28287328
[Au] Autor:Havenetidis K; Paxinos T; Kardaris D; Bissas A
[Ad] Endereço:a Human Performance-Rehabilitation Laboratory, Faculty of Physical & Cultural Education , Hellenic Army Academy , Vari , Attiki , Greece.
[Ti] Título:Prognostic potential of body composition indices in detecting risk of musculoskeletal injury in army officer cadet profiles.
[So] Source:Phys Sportsmed;45(2):114-119, 2017 May.
[Is] ISSN:2326-3660
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: High values in most of the body composition indices have been related to musculoskeletal injuries, but limited data exists on the accuracy of these diagnoses when detecting musculoskeletal injuries in military populations. METHODS: The suitability of body fat percentage, body mass index, fat mass index and fat free mass index to identify injury risk was examined in a group of army officer recruits. All body composition diagnoses were measured in 268 male army officer recruits prior to the commencement of basic combat training. Musculoskeletal injury was identified using codes from the International Classification of Diseases. The area under the curve, in the receiver operating characteristic curve, was used to quantify the overall ability to discriminate between those who were injured and those who were not. RESULTS: The statistics indicated that all indices, apart from body mass index, had a significant possibility to detect musculoskeletal injury potential (p < 0.05; 61%-63%). The respective cut-off points used to classify individuals as injured were for body fat percentage >22, for fat mass index >6.5 and for fat free mass index <16.5. CONCLUSION: Body mass index values can not similarly detect the possibility of occurrence of musculoskeletal injuries in army officer recruits, just as other body composition diagnoses related to fat mass or/and free fat mass. However, the cut off-points related to the overall diagnostic performance of each body composition index should be used with caution and in accordance with the aims of each experimental setting.
[Mh] Termos MeSH primário: Tecido Adiposo
Composição Corporal
Índice de Massa Corporal
Militares
Doenças Musculoesqueléticas/etiologia
Condicionamento Físico Humano
Ferimentos e Lesões/etiologia
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Compartimentos de Líquidos Corporais
Seres Humanos
Masculino
Doenças Musculoesqueléticas/diagnóstico
Aptidão Física
Prognóstico
Curva ROC
Valores de Referência
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1080/00913847.2017.1298977


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[PMID]:28251936
[Au] Autor:Fletcher G; Eves FF; Glover EI; Robinson SL; Vernooij CA; Thompson JL; Wallis GA
[Ad] Endereço:School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom; and.
[Ti] Título:Dietary intake is independently associated with the maximal capacity for fat oxidation during exercise.
[So] Source:Am J Clin Nutr;105(4):864-872, 2017 Apr.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Substantial interindividual variability exists in the maximal rate of fat oxidation (MFO) during exercise with potential implications for metabolic health. Although the diet can affect the metabolic response to exercise, the contribution of a self-selected diet to the interindividual variability in the MFO requires further clarification. We sought to identify whether recent, self-selected dietary intake independently predicts the MFO in healthy men and women. The MFO and maximal oxygen uptake ([Formula: see text]O max) were determined with the use of indirect calorimetry in 305 healthy volunteers [150 men and 155 women; mean ± SD age: 25 ± 6 y; body mass index (BMI; in kg/m ): 23 ± 2]. Dual-energy X-ray absorptiometry was used to assess body composition with the self-reported physical activity level (SRPAL) and dietary intake determined in the 4 d before exercise testing. To minimize potential confounding with typically observed sex-related differences (e.g., body composition), predictor variables were mean-centered by sex. In the analyses, hierarchical multiple linear regressions were used to quantify each variable's influence on the MFO. The mean absolute MFO was 0.55 ± 0.19 g/min (range: 0.19-1.13 g/min). A total of 44.4% of the interindividual variability in the MFO was explained by the [Formula: see text]O max, sex, and SRPAL with dietary carbohydrate (carbohydrate; negative association with the MFO) and fat intake (positive association) associated with an additional 3.2% of the variance. When expressed relative to fat-free mass (FFM), the MFO was 10.8 ± 3.2 mg · kg FFM · min (range: 3.5-20.7 mg · kg FFM · min ) with 16.6% of the variability explained by the [Formula: see text]O max, sex, and SRPAL; dietary carbohydrate and fat intakes together explained an additional 2.6% of the variability. Biological sex was an independent determinant of the MFO with women showing a higher MFO [men: 10.3 ± 3.1 mg · kg FFM · min (3.5-19.9 mg · kg FFM · min ); women: 11.2 ± 3.3 mg · kg FFM · min (4.6-20.7 mg · kg FFM · min ); < 0.05]. Considered alongside other robust determinants, dietary carbohydrate and fat intake make modest but independent contributions to the interindividual variability in the capacity to oxidize fat during exercise. This trial was registered at clinicaltrials.gov as NCT02070055.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Dieta
Carboidratos da Dieta/farmacologia
Gorduras na Dieta/farmacologia
Metabolismo Energético
Exercício/fisiologia
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adulto
Composição Corporal
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Calorimetria Indireta
Carboidratos da Dieta/metabolismo
Gorduras na Dieta/metabolismo
Teste de Esforço
Feminino
Seres Humanos
Masculino
Oxirredução
Consumo de Oxigênio
Valores de Referência
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.133520


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[PMID]:28228420
[Au] Autor:Das SK; Roberts SB; Bhapkar MV; Villareal DT; Fontana L; Martin CK; Racette SB; Fuss PJ; Kraus WE; Wong WW; Saltzman E; Pieper CF; Fielding RA; Schwartz AV; Ravussin E; Redman LM; CALERIE-2 Study Group
[Ad] Endereço:Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; sai.das@tufts.edu.
[Ti] Título:Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.
[So] Source:Am J Clin Nutr;105(4):913-927, 2017 Apr.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition. We evaluated the effect of a 2-y CR regimen on body composition including the influence of sex and body mass index (BMI; in kg/m ) among participants enrolled in CALERIE-2 (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), a multicenter, randomized controlled trial. Participants were 218 nonobese (BMI: 21.9-28.0) adults aged 21-51 y who were randomly assigned to 25% CR (CR, = 143) or ad libitum control (AL, = 75) in a 2:1 ratio. Measures at baseline and 12 and 24 mo included body weight, waist circumference, fat mass (FM), fat-free mass (FFM), and appendicular mass by dual-energy X-ray absorptiometry; activity-related energy expenditure (AREE) by doubly labeled water; and dietary protein intake by self-report. Values are expressed as means ± SDs. The CR group achieved 11.9% ± 0.7% CR over 2-y and had significant decreases in weight (-7.6 ± 0.3 compared with 0.4 ± 0.5 kg), waist circumference (-6.2 ± 0.4 compared with 0.9 ± 0.5 cm), FM (-5.4 ± 0.3 compared with 0.5 ± 0.4 kg), and FFM (-2.0 ± 0.2 compared with -0.0 ± 0.2 kg) at 24 mo relative to the AL group (all between-group < 0.001). Moreover, FFM as a percentage of body weight at 24 mo was higher, and percentage of FM was lower in the CR group than in the AL. AREE, but not protein intake, predicted preservation of FFM during CR ( < 0.01). Men in the CR group lost significantly more trunk fat ( = 0.03) and FFM expressed as a percentage of weight loss ( < 0.001) than women in the CR group. Two years of CR had broadly favorable effects on both whole-body and regional adiposity that could facilitate health span in humans. The decrements in FFM were commensurate with the reduced body mass; although men in the CR group lost more FFM than the women did, the percentage of FFM in the men in the CR group was higher than at baseline. CALERIE was registered at clinicaltrials.gov as NCT00427193.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Composição Corporal
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Restrição Calórica
Ingestão de Energia
Perda de Peso
[Mh] Termos MeSH secundário: Adiposidade
Adulto
Peso Corporal
Dieta
Metabolismo Energético
Feminino
Seres Humanos
Longevidade
Masculino
Fatores Sexuais
Tempo
Tronco
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.137232


  10 / 1147 MEDLINE  
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[PMID]:28179224
[Au] Autor:Mangano KM; Sahni S; Kiel DP; Tucker KL; Dufour AB; Hannan MT
[Ad] Endereço:Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA; kelsey_mangano@uml.edu.
[Ti] Título:Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study.
[So] Source:Am J Clin Nutr;105(3):714-722, 2017 Mar.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns. We examined the prospective association of novel dietary protein food clusters (derived from established dietary pattern techniques) with appendicular lean mass (ALM), quadriceps strength (QS), and bone mineral density (BMD) in 2986 men and women, aged 19-72 y, from the Framingham Third Generation Study. Total protein intake was estimated by food-frequency questionnaire in 2002-2005. A cluster analysis was used to classify participants into mutually exclusive groups, which were determined by using the percentage of contribution of food intake to overall protein intake. General linear modeling was used to ) estimate the association between protein intake (grams per day) and BMD, ALM, appendicular lean mass normalized for height (ALM/ht ), and QS (2008-2011) and to ) calculate adjusted least-squares mean outcomes across quartiles of protein (grams per day) and protein food clusters. The mean ± SD age of subjects was 40 ± 9 y; 82% of participants met the Recommended Daily Allowance (0.8 g · kg body weight · d ). The following 6 dietary protein food clusters were identified: fast food and full-fat dairy, fish, red meat, chicken, low-fat milk, and legumes. BMD was not different across quartiles of protein intake ( -trend range = 0.32-0.82); but significant positive trends were observed for ALM, ALM/ht ( < 0.001), and QS ( = 0.0028). Individuals in the lowest quartile of total protein intake (quartile 1) had significantly lower ALM, ALM/ht , and QS than did those in the higher quartiles of intake (quartiles 2-4; ( ranges = 0.0001-0.003, 0.0007-0.003, and 0.009-0.05, respectively). However, there were no associations between protein clusters and any musculoskeletal outcome in adjusted models. In a protein-replete cohort of adults, dietary protein is associated with ALM and QS but not with BMD. In this study, dietary protein food patterns do not provide further insight into beneficial protein effects on muscle outcomes.
[Mh] Termos MeSH primário: Compartimentos de Líquidos Corporais/metabolismo
Dieta
Proteínas na Dieta/farmacologia
Comportamento Alimentar
Força Muscular/efeitos dos fármacos
Músculo Quadríceps/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Idoso
Densidade Óssea
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/metabolismo
Estudos Transversais
Proteínas na Dieta/administração & dosagem
Extremidades
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Músculo Quadríceps/fisiologia
Recomendações Nutricionais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.136762



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