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[PMID]:27770633
[Au] Autor:Lee NM; Erisken C; Iskratsch T; Sheetz M; Levine WN; Lu HH
[Ad] Endereço:Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States.
[Ti] Título:Polymer fiber-based models of connective tissue repair and healing.
[So] Source:Biomaterials;112:303-312, 2017 01.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Physiologically relevant models of wound healing are essential for understanding the biology of connective tissue repair and healing. They can also be used to identify key cellular processes and matrix characteristics critical for the design of soft tissue grafts. Modeling the various stages of repair post tendon injury, polymer meshes of varying fiber diameter (nano-1 (390 nm) < nano-2 (740 nm) < micro (1420 nm)) were produced. Alignment was also introduced in the nano-2 group to model matrix undergoing biological healing rather than scar formation. The response of human tendon fibroblasts on these model substrates were evaluated over time as a function of fiber diameter and alignment. It was observed that the repair models of unaligned nanoscale fibers enhanced cell growth and collagen synthesis, while these outcomes were significantly reduced in the mature repair model consisting of unaligned micron-sized fibers. Organization of paxillin and actin on unaligned meshes was enhanced on micro- compared to nano-sized fibers, while the expression and activity of RhoA and Rac1 were greater on nanofibers. In contrast, aligned nanofibers promoted early cell organization, while reducing excessive cell growth and collagen production in the long term. These results show that the early-stage repair model of unaligned nanoscale fibers elicits a response characteristic of the proliferative phase of wound repair, while the more mature model consisting of unaligned micron-sized fibers is more representative of the remodeling phase by supporting cell organization while suppressing growth and biosynthesis. Interestingly, introduction of fiber alignment in the nanofiber model alters fibroblast response from repair to healing, implicating matrix alignment as a critical design factor for circumventing scar formation and promoting biological healing of soft tissue injuries.
[Mh] Termos MeSH primário: Células do Tecido Conjuntivo/citologia
Células do Tecido Conjuntivo/fisiologia
Nanofibras/química
Polímeros/química
Traumatismos dos Tendões/fisiopatologia
Tecidos Suporte
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Idoso
Células Cultivadas
Tecido Conjuntivo/fisiologia
Feminino
Fibroblastos/citologia
Fibroblastos/fisiologia
Seres Humanos
Masculino
Meia-Idade
Nanofibras/ultraestrutura
Traumatismos dos Tendões/patologia
Engenharia Tecidual/instrumentação
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  2 / 18406 MEDLINE  
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[PMID]:29303942
[Au] Autor:Jordan DR; Stoica B; Dutton JJ
[Ti] Título:Re: Commentary on "Localizing the Lost Rectus Muscle Using the Connective Tissue Framework: Revisiting the Tunnel Technique".
[So] Source:Ophthal Plast Reconstr Surg;34(1):93-94, 2018 Jan/Feb.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Músculos Oculomotores
Estrabismo
[Mh] Termos MeSH secundário: Tecido Conjuntivo
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000001034


  3 / 18406 MEDLINE  
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[PMID]:29188700
[Au] Autor:Kumar NS; Sowmya N; Singh VP; Verma
[Ti] Título:Dual Role of Subepithelial Connective Tissue Grafting in Regeneration of Periodontal Attachment Apparatus.
[So] Source:Dent Update;44(5):459-61, 2017 May.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Periodontal plastic and aesthetic surgery are gaining significant momentum owing to the increasing aesthetic demands by patients. Along with the fulfilment of aesthetic needs, it is imperative that clinicians also enhance function. From these two important viewpoints, subepithelial connective tissue grafting remains an optimum treatment choice for periodontists when treating gingival recession defects accompanied by periodontal attachment apparatus breakdown. Clinical relevance: Subepithelial connective tissue grafting is a successful procedure in its dual role of gingival recession coverage and predictable periodontal regeneration.
[Mh] Termos MeSH primário: Tecido Conjuntivo/transplante
Regeneração Tecidual Guiada Periodontal/métodos
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Regeneração
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  4 / 18406 MEDLINE  
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[PMID]:29265419
[Au] Autor:Bogdanowicz DR; Lu HH
[Ad] Endereço:Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York.
[Ti] Título:Designing the stem cell microenvironment for guided connective tissue regeneration.
[So] Source:Ann N Y Acad Sci;1410(1):3-25, 2017 Dec.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adult mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine because of their ability to self-renew and their capacity for multilineage differentiation and tissue regeneration. For connective tissues, such as ligaments or tendons, MSCs are vital to the modulation of the inflammatory response following acute injury while also interacting with resident fibroblasts to promote cell proliferation and matrix synthesis. To date, MSC injection for connective tissue repair has yielded mixed results in vivo, likely due to a lack of appropriate environmental cues to effectively control MSC response and promote tissue healing instead of scar formation. In healthy tissues, stem cells reside within a complex microenvironment comprising cellular, structural, and signaling cues that collectively maintain stemness and modulate tissue homeostasis. Changes to the microenvironment following injury regulate stem cell differentiation, trophic signaling, and tissue healing. Here, we focus on models of the stem cell microenvironment that are used to elucidate the mechanisms of stem cell regulation and inspire functional approaches to tissue regeneration. Recent studies in this frontier area are highlighted, focusing on how microenvironmental cues modulate MSC response following connective tissue injury and, more importantly, how this unique cell environment can be programmed for stem cell-guided tissue regeneration.
[Mh] Termos MeSH primário: Tecido Conjuntivo/fisiologia
Células Mesenquimais Estromais/citologia
Regeneração
Nicho de Células-Tronco
[Mh] Termos MeSH secundário: Animais
Tecido Conjuntivo/metabolismo
Seres Humanos
Transplante de Células-Tronco Mesenquimais/métodos
Células Mesenquimais Estromais/metabolismo
Modelos Biológicos
Medicina Regenerativa/métodos
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13553


  5 / 18406 MEDLINE  
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[PMID]:28742248
[Au] Autor:Horn D; Siebert E; Seidel U; Rost I; Mayer K; Abou Jamra R; Mitter D; Kornak U
[Ad] Endereço:Institut für Medizinische Genetik und Humangenetik, Charité-Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Biallelic COL3A1 mutations result in a clinical spectrum of specific structural brain anomalies and connective tissue abnormalities.
[So] Source:Am J Med Genet A;173(9):2534-2538, 2017 Sep.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vascular Ehlers-Danlos syndrome (type IV) is an autosomal dominant disorder caused by heterozygous variants of COL3A1. We identified biallelic COL3A1 variants in two unrelated families. In a 3-year-old female with developmental delay the nonsense variant c.1282C>T, p.(Arg428*) was detected in combination the c.2057delC, p.(Pro686Leufs*105) frame shift variant. Both compound heterozygous variants were novel. This patient was born with bilateral clubfoot, joint laxity, and dysmorphic facial features. At the age of 2 years she developed an aneurysmal brain hemorrhage. Cerebral MRI showed a peculiar pattern of profound cerebral abnormalities including bilateral frontoparietal polymicrogyria of the cobblestone variant. In the second family, the two affected siblings were homozygous for the missense variant c.145C
[Mh] Termos MeSH primário: Colágeno Tipo III/genética
Deficiências do Desenvolvimento/genética
Síndrome de Ehlers-Danlos/genética
Malformações do Desenvolvimento Cortical/genética
[Mh] Termos MeSH secundário: Encéfalo/anormalidades
Encéfalo/diagnóstico por imagem
Encéfalo/fisiopatologia
Pré-Escolar
Códon sem Sentido
Tecido Conjuntivo/diagnóstico por imagem
Tecido Conjuntivo/fisiopatologia
Deficiências do Desenvolvimento/diagnóstico por imagem
Deficiências do Desenvolvimento/fisiopatologia
Síndrome de Ehlers-Danlos/diagnóstico por imagem
Síndrome de Ehlers-Danlos/fisiopatologia
Feminino
Heterozigoto
Seres Humanos
Masculino
Malformações do Desenvolvimento Cortical/diagnóstico por imagem
Malformações do Desenvolvimento Cortical/fisiopatologia
Mutação de Sentido Incorreto
Linhagem
Fenótipo
Receptores Acoplados a Proteínas-G/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (COL3A1 protein, human); 0 (Codon, Nonsense); 0 (Collagen Type III); 0 (GPR56 protein, human); 0 (Receptors, G-Protein-Coupled)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38345


  6 / 18406 MEDLINE  
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[PMID]:28887577
[Au] Autor:Kii I; Ito H
[Ad] Endereço:Common Facilities Unit, Integrated Research Group, Compass to Healthy Life Research Complex Program, RIKEN Cluster for Science and Technology Hub, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. isao.kii@riken.jp.
[Ti] Título:Periostin and its interacting proteins in the construction of extracellular architectures.
[So] Source:Cell Mol Life Sci;74(23):4269-4277, 2017 Dec.
[Is] ISSN:1420-9071
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Periostin is a matricellular protein that is composed of a multi-domain structure with an amino-terminal EMI domain, a tandem repeat of four FAS 1 domains, and a carboxyl-terminal domain. These distinct domains have been demonstrated to bind to many proteins including extracellular matrix proteins (Collagen type I and V, fibronectin, tenascin, and laminin), matricellular proteins (CCN3 and ßig-h3), and enzymes that catalyze covalent crosslinking between extracellular matrix proteins (lysyl oxidase and BMP-1). Adjacent binding sites on periostin have been suggested to put the interacting proteins in close proximity, promoting intermolecular interactions between each protein, and leading to their assembly into extracellular architectures. These extracellular architectures determine the mechanochemical properties of connective tissues, in which periostin plays an important role in physiological homeostasis and disease progression. In this review, we introduce the proteins that interact with periostin, and discuss how the multi-domain structure of periostin functions as a scaffold for the assembly of interacting proteins, and how it underlies construction of highly sophisticated extracellular architectures.
[Mh] Termos MeSH primário: Moléculas de Adesão Celular/genética
Tecido Conjuntivo/metabolismo
Domínios e Motivos de Interação entre Proteínas
Mapeamento de Interação de Proteínas
[Mh] Termos MeSH secundário: Proteína Morfogenética Óssea 1/genética
Proteína Morfogenética Óssea 1/metabolismo
Moléculas de Adesão Celular/metabolismo
Colágeno/genética
Colágeno/metabolismo
Tecido Conjuntivo/anatomia & histologia
Fibronectinas/genética
Fibronectinas/metabolismo
Expressão Gênica
Seres Humanos
Laminina/genética
Laminina/metabolismo
Proteína Sobre-Expressa em Nefroblastoma/genética
Proteína Sobre-Expressa em Nefroblastoma/metabolismo
Ligação Proteica
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Proteoglicanas/metabolismo
Transdução de Sinais
Tenascina/genética
Tenascina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cell Adhesion Molecules); 0 (Fibronectins); 0 (LAMC2 protein, human); 0 (Laminin); 0 (NOV protein, human); 0 (Nephroblastoma Overexpressed Protein); 0 (POSTN protein, human); 0 (Protein Isoforms); 0 (Proteoglycans); 0 (Tenascin); 9007-34-5 (Collagen); EC 3.4.24.19 (BMP1 protein, human); EC 3.4.24.19 (Bone Morphogenetic Protein 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE
[do] DOI:10.1007/s00018-017-2644-4


  7 / 18406 MEDLINE  
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[PMID]:28767917
[Au] Autor:Peretti AL; Antunes JS; Lovison K; Kunz RI; Castor LRG; Brancalhão RMC; Bertolini GRF; Ribeiro LFC
[Ad] Endereço:Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brazil.
[Ti] Título:Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury.
[So] Source:Einstein (Sao Paulo);15(2):186-191, 2017 Apr-Jun.
[Is] ISSN:2317-6385
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:Objective: To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods: Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results: The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion: The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle. Objetivo: Avaliar a ação da vanilina (Vanilla planifolia) sobre a morfologia dos músculos tibial anterior e sóleo após lesão nervosa periférica. Métodos: Ratos Wistar foram divididos em quatro grupos, com sete animais cada, sendo Grupo Controle, Grupo Vanilina, Grupo Lesão e Grupo Lesão + Vanilina. Os animais dos Grupos Lesão e Grupo Lesão + Vanilina foram submetidos à lesão nervosa por meio da compressão do nervo isquiático, e os Grupos Vanilina e Grupo Lesão + Vanilina foram tratados diariamente com doses orais de vanilina (150mg/kg) do 3o ao 21o dia após a indução da lesão nervosa. Ao término do experimento, os músculos tibial anterior e sóleo foram dissecados e seguiram o processamento de rotina em microscopia de luz, para posterior análise morfológica. Resultados: A compressão nervosa promoveu alterações morfológicas características de denervação, sendo que o tratamento com vanilina foi responsável por respostas distintas nos músculos estudados. Para o tibial anterior, houve aumento do número de células satélites, núcleos centrais e atrofia das fibras, bem como desorganização fascicular. Já no sóleo, houve apenas aumento da vascularização, sem exacerbação das alterações morfológicas nas fibras. Conclusão: O tratamento com vanilina promoveu o aumento da vascularização intramuscular para os músculos estudados, com potencial pró-inflamatório para o tibial anterior, o que não ocorreu no músculo sóleo.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzaldeídos/farmacologia
Tecido Conjuntivo/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Neuropatia Ciática/patologia
[Mh] Termos MeSH secundário: Animais
Tecido Conjuntivo/patologia
Seres Humanos
Masculino
Modelos Animais
Fibras Musculares Esqueléticas/efeitos dos fármacos
Músculo Esquelético/patologia
Distribuição Aleatória
Ratos Wistar
Neuropatia Ciática/reabilitação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzaldehydes); CHI530446X (vanillin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  8 / 18406 MEDLINE  
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[PMID]:28766355
[Au] Autor:Nadazdyova A; Samohyl M; Stefankova E; Pintesova S; Stanko P
[Ti] Título:Human race as indicator of 3D planning of soft tissue of face and multidisciplinary approach.
[So] Source:Bratisl Lek Listy;118(7):431-436, 2017.
[Is] ISSN:0006-9248
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to determine the optimal parameters for 3D soft tissue planning for ortognatic treatment by gender and increases the effectiveness of multidisciplinary cooperation. METHODS: Craniofacial parameters which were analysed: nose breadth (al-al), bi-entocanthion breadth (en-en), bi-zygomatic breadth (zy-zy), bi-gonial breadth (go-go), total facial height (n-gn), mouth breadth (ch-ch), morphologic face height (sn-gn), upper-lip height (Ls-Stm), lower-lip height (Stm-Li) and pupils - mid-face (right). The statistically significant level was determined at p values < 0.05. RESULTS: We have determined the optimal parameters of chosen proportions for men and women as the common goal for ortodontist and maxilofacial surgeon. The gender and age influenced the variability of following parameters: bi-gonial breadth, total facial height and morphologic face height. CONCLUSION: The soft tissue values for craniofacial parameters can be used to identify the surgical-orthodontic goal for patient - europoid race. Due to the immigration and the mix of races it is necessary to take this fact into account (Tab. 3, Fig. 1, Ref. 41).
[Mh] Termos MeSH primário: Pontos de Referência Anatômicos/anatomia & histologia
Tecido Conjuntivo/anatomia & histologia
Imagem Tridimensional/métodos
[Mh] Termos MeSH secundário: Adulto
Antropometria
Cefalometria
Face/anatomia & histologia
Feminino
Seres Humanos
Lábio/anatomia & histologia
Masculino
Nariz/anatomia & histologia
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.4149/BLL_2017_084


  9 / 18406 MEDLINE  
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[PMID]:28738420
[Au] Autor:Girkin CA; Fazio MA; Yang H; Reynaud J; Burgoyne CF; Smith B; Wang L; Downs JC
[Ad] Endereço:Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
[Ti] Título:Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3759-3769, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods: A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1.5 × 1.5 × 1.5 µm voxel resolution with an automated episcopic fluorescence technique. The load-bearing ONH connective tissue surfaces were manually delineated in 3D using custom software. Results: The lamina cribrosa and peripapillary sclera were significantly thinner in AD eyes adjusting for age and sex (LC was 24 ± 11 µm thinner; P = 0.0350; scleral was 56 ± 22 µm thinner; P = 0.0097). The lamina cribrosa was significantly thinner in females (23 ± 11 µm thinner; P = 0.0425). Age was not significantly associated with any morphologic parameter in the ED group. However, increasing age was associated with an increase in scleral thickness (1.3 µm/year, P = 0.0499) and an increase in LC depth (2.3 µm/year, P = 0.0035) in the AD group. The sclera was thickest in the superior and temporal regions while the LC was thinnest superiorly. Conclusions: Substantial sectorial and racial differences in LC and scleral morphology were observed, as well as increasing LC depth and scleral thickness with age in the AD group. Results suggest greater age-related remodeling of the load-bearing ONH connective tissues in eyes from AD individuals that could explain, in part, the greater predilection to glaucomatous injury seen in aged AD populations.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano
Grupo com Ancestrais do Continente Europeu
Disco Óptico/anatomia & histologia
Esclera/anatomia & histologia
[Mh] Termos MeSH secundário: Fatores Etários
Tecido Conjuntivo
Feminino
Voluntários Saudáveis
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem Tridimensional
Pressão Intraocular
Masculino
Meia-Idade
Fatores Sexuais
Doadores de Tecidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21842


  10 / 18406 MEDLINE  
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[PMID]:28734525
[Au] Autor:Mazo C; Alegre E; Trujillo M
[Ad] Endereço:University of Valle, Computer and Systems Engineering School, Cali, Colombia. Electronic address: claudia.mazo@correounivalle.edu.co.
[Ti] Título:Classification of cardiovascular tissues using LBP based descriptors and a cascade SVM.
[So] Source:Comput Methods Programs Biomed;147:1-10, 2017 Aug.
[Is] ISSN:1872-7565
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Histological images have characteristics, such as texture, shape, colour and spatial structure, that permit the differentiation of each fundamental tissue and organ. Texture is one of the most discriminative features. The automatic classification of tissues and organs based on histology images is an open problem, due to the lack of automatic solutions when treating tissues without pathologies. METHOD: In this paper, we demonstrate that it is possible to automatically classify cardiovascular tissues using texture information and Support Vector Machines (SVM). Additionally, we realised that it is feasible to recognise several cardiovascular organs following the same process. The texture of histological images was described using Local Binary Patterns (LBP), LBP Rotation Invariant (LBPri), Haralick features and different concatenations between them, representing in this way its content. Using a SVM with linear kernel, we selected the more appropriate descriptor that, for this problem, was a concatenation of LBP and LBPri. Due to the small number of the images available, we could not follow an approach based on deep learning, but we selected the classifier who yielded the higher performance by comparing SVM with Random Forest and Linear Discriminant Analysis. Once SVM was selected as the classifier with a higher area under the curve that represents both higher recall and precision, we tuned it evaluating different kernels, finding that a linear SVM allowed us to accurately separate four classes of tissues: (i) cardiac muscle of the heart, (ii) smooth muscle of the muscular artery, (iii) loose connective tissue, and (iv) smooth muscle of the large vein and the elastic artery. The experimental validation was conducted using 3000 blocks of 100 × 100 sized pixels, with 600 blocks per class and the classification was assessed using a 10-fold cross-validation. RESULTS: using LBP as the descriptor, concatenated with LBPri and a SVM with linear kernel, the main four classes of tissues were recognised with an AUC higher than 0.98. A polynomial kernel was then used to separate the elastic artery and vein, yielding an AUC in both cases superior to 0.98. CONCLUSION: Following the proposed approach, it is possible to separate with very high precision (AUC greater than 0.98) the fundamental tissues of the cardiovascular system along with some organs, such as the heart, arteries and veins.
[Mh] Termos MeSH primário: Tecido Conjuntivo
Músculo Liso
Miocárdio
Máquina de Vetores de Suporte
[Mh] Termos MeSH secundário: Algoritmos
Artérias
Análise Discriminante
Seres Humanos
Veias
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE



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