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[PMID]:29289260
[Au] Autor:Bilgir O; Gökçen B; Bilgir F; Guler A; Calan M; Yuksel A; Aslanipour B; Aksit M; Bozkaya G
[Ad] Endereço:Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey. Electronic address: oktaybilgir@gmail.com.
[Ti] Título:Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes.
[So] Source:Am J Med Sci;355(1):37-43, 2018 Jan.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. MATERIAL AND METHODS: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical impedance method. RESULTS: Circulating MIF levels were found to be elevated in subjects with prediabetes compared to controls (26.46 ± 16.98 versus 17.44 ± 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices of homeostasis model assessment of insulin resistance. In linear regression model, an independent association was found between MIF levels and metabolic parameters, including BMI, visceral fat mass and homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses revealed that the odds ratio for prediabetes was higher in subjects in the highest quartile of MIF compared to those in the lowest quartile, after adjusting for potential confounders. CONCLUSIONS: Increased MIF levels are associated with the elevation of prediabetic risk.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Proteína C-Reativa/metabolismo
Resistência à Insulina/fisiologia
Gordura Intra-Abdominal/metabolismo
Oxirredutases Intramoleculares/sangue
Fatores Inibidores da Migração de Macrófagos/sangue
Estado Pré-Diabético/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Glicemia/metabolismo
Estudos Transversais
Feminino
Seres Humanos
Gordura Intra-Abdominal/patologia
Masculino
Meia-Idade
Estado Pré-Diabético/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Macrophage Migration-Inhibitory Factors); 9007-41-4 (C-Reactive Protein); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.2.1 (MIF protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


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[PMID]:27778168
[Au] Autor:Docimo S; Lee Y; Chatani P; Rogers AM; Lacqua F
[Ad] Endereço:Division of Bariatric, Foregut, and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook Medicine, Stony Brook, NY, USA. sdocimo@gmail.com.
[Ti] Título:Visceral to subcutaneous fat ratio predicts acuity of diverticulitis.
[So] Source:Surg Endosc;31(7):2808-2812, 2017 Jul.
[Is] ISSN:1432-2218
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There is an association between obesity and more complicated diverticular disease. We hypothesize that this link may be due to an increased level of visceral fat rather than an elevated body mass index alone. Adipose tissue secretes inflammatory cytokines, and chronic inflammation may account for the link between obesity and a more severe presentation of diverticular disease. We have applied a quantitative measure of visceral fat content in a series of patients admitted with diverticulitis, comparing those who required emergent versus elective surgical procedures for diverticulitis. METHODS: We performed a retrospective review of all adult patients who underwent emergent or elective surgery at our institution for diverticulitis from 2010 to 2014. Data were collected on demographics, comorbidities, operative findings, complications, and length of stay. Radiologic measurements of adiposity were obtained from preoperative CT scans. Visceral fat areas and subcutaneous fat areas were measured, and the V/S ratio was calculated. RESULTS: Thirty-four patients underwent emergent and 32 patients underwent elective surgery. The mean age was 66.3 years for the emergent and 57.11 for the elective group (p = 0.04178). The perinephric, visceral, subcutaneous fat, and V/S ratio for the emergent group were 1.71, 185.22, 338.22, and 0.56 and were 1.11, 127.18, 295.28, and 0.46 for the elective group. The difference between the V/S ratio for each group was significant (p = 0.0238). The emergent group had an average LOS of 16.11 days compared to 5.15 for the elective group (p = <0.00001). The complication rate was significantly higher (p = 0.024) in the emergent group (n = 12, 35.2 %) compared to the elective group (n = 4, 12.5 %). CONCLUSION: Our study demonstrates a clinically significant link between visceral fat and severity of presentation of diverticulitis. Patients with higher V/S fat ratios were more likely to require emergency surgery and have more complications and a longer LOS.
[Mh] Termos MeSH primário: Diverticulite/diagnóstico
Gordura Intra-Abdominal
Gravidade do Paciente
Gordura Subcutânea
[Mh] Termos MeSH secundário: Adulto
Idoso
Técnicas de Apoio para a Decisão
Diverticulite/cirurgia
Procedimentos Cirúrgicos Eletivos
Emergências
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s00464-016-5290-2


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[PMID]:29391089
[Au] Autor:Pandrangi V; Mandel D; Gellada N; Mieses D; Kallman C; Zaghiyan K; Fleshner P
[Ad] Endereço:Divisions of Colon and Rectal Surgery and Diagnostic Radiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
[Ti] Título:Abdominal Visceral Fat Area and Chronic Pouchitis after Ileal Pouch-Anal Anastomosis.
[So] Source:Am Surg;83(10):1029-1032, 2017 Oct 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic pouchitis (CP) after ileal pouch-anal anastomosis is a significant clinical problem. Adipose tissues produce antiinflammatory cytokines and chemokines. We evaluated the association between abdominal visceral fat area (VFA) and CP. Patients with a preoperative CT evaluation were included. The diagnosis of CP was confirmed in all cases by endoscopy with afferent ileal limb intubation. Patients were allocated into groups of high VFA and low VFA. The study cohort of 52 patients had a median body mass index of 22 (range, 14-32). Indications for surgery were medically refractory disease in 46 (88%) patients and cancer/dysplasia in six (12%) patients. Median VFA was 27.1 (range, 1-144). Six (12%) patients developed CP. Low VFA patients were significantly younger (29 vs 45 years; P < 0.0001), had lower body mass index (20.4 vs 24.7; P < 0.0001), had surgery more commonly for medically refractory disease than for cancer or dysplasia (100 vs 77%; P = 0.02), and had a higher incidence of CP than high VFA patients (23 vs 0%; P = 0.02). Multiple linear regression analysis demonstrated that only low VFA was associated with CP (P = 0.009). An association is present between VFA and CP after ileal pouch-anal anastomosis, implicating adipocytes in the pathogenesis of inflammatory bowel disease.
[Mh] Termos MeSH primário: Adiposidade
Gordura Intra-Abdominal/anatomia & histologia
Complicações Pós-Operatórias/etiologia
Pouchite/etiologia
Proctocolectomia Restauradora
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Feminino
Seguimentos
Seres Humanos
Incidência
Gordura Intra-Abdominal/diagnóstico por imagem
Modelos Lineares
Masculino
Meia-Idade
Complicações Pós-Operatórias/epidemiologia
Pouchite/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:28458349
[Au] Autor:Matsutani T; Tamura K; Kutsukake M; Matsuda A; Tachikawa E; Uchida E
[Ad] Endereço:Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School.
[Ti] Título:Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice.
[So] Source:Biol Pharm Bull;40(5):638-644, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Pioglitazone improves sepsis-induced organ injury accompanied with anti-inflammatory effects on visceral adipose tissue. However, its action in adipose immune cells remains to be ascertained. We investigated the effects of pioglitazone on visceral adipose macrophage population and polarisation in cecal ligation and puncture (CLP)-induced sepsis mice. Eight-week-old male mice were assigned to 3 groups: 1) sham-operated group, 2) CLP group, or 3) pioglitazone-treated CLP group. Pioglitazone (10 mg/kg) was injected intraperitonally for 7 d and CLP surgery was performed. Visceral adipose tissues were collected 24 h after the surgery. mRNA expression of several macrophage markers (inducible nitric oxide synthase (iNOS) for M1, arginase1 (Arg1) and interleukin (IL)-10 for M2, CD163 and F4/80 for mature macrophages) and inflammatory adipokines (IL-6, monocyte chemoattractant protein-1: MCP-1) was quantified by real-time RT-PCR. Tissue sections were subjected to the immunohistochemical analysis and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay. CLP significantly enhanced Arg1, IL-10 and iNOS mRNA expressions as compared with the sham group, and pioglitazone significantly increased the mRNA level of CD163 and F4/80 in CLP mice. Expression of IL-6 and MCP-1 stimulated by CLP was reduced by pioglitazone treatment. Increased CD11b/c- and CD163-positive cells as well as apoptotic cells were observed in the CLP group and the pioglitazone-treated group. The data indicate that M1/M2 macrophage activation of visceral adipose tissues is induced in CLP-induced mice, and the function of macrophages recruited from surrounding organs may be modulated by pioglitazone treatment.
[Mh] Termos MeSH primário: Hipoglicemiantes/farmacologia
Gordura Intra-Abdominal/patologia
Macrófagos/efeitos dos fármacos
Sepse/patologia
Tiazolidinedionas/farmacologia
[Mh] Termos MeSH secundário: Adipocinas/metabolismo
Animais
Arginase/análise
Biomarcadores/análise
Ceco
Quimiocina CCL2/metabolismo
Hipoglicemiantes/administração & dosagem
Injeções Intraperitoneais
Interleucina-10/sangue
Ligadura
Masculino
Camundongos
Punções
Tiazolidinedionas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Biomarkers); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Hypoglycemic Agents); 0 (IL10 protein, mouse); 0 (Thiazolidinediones); 130068-27-8 (Interleukin-10); EC 3.5.3.1 (Arg1 protein, mouse); EC 3.5.3.1 (Arginase); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00883


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[PMID]:29374741
[Au] Autor:Yamane H; Abe T; Amano H; Hanada K; Minami T; Kobayashi T; Fukuda T; Yonehara S; Nakahara M; Ohdan H; Noriyuki T
[Ad] Endereço:Department of Surgery, Onomichi General Hospital, Onomichi, Japan.
[Ti] Título:Visceral Adipose Tissue and Skeletal Muscle Index Distribution Predicts Severe Pancreatic Fistula Development After Pancreaticoduodenectomy.
[So] Source:Anticancer Res;38(2):1061-1066, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: In this study, we investigated the effect of body composition on pancreatic fistula (PF) development after pancreaticoduodenectomy (PD). MATERIALS AND METHODS: All consecutive patients with pancreatic and extrahepatic biliary malignancy following PD who were treated between 2006 and 2016 were enrolled. RESULTS: PF developed in 30.3% of cases (30/99 patients), including a grade B PF in 25.3% of cases (25/99 patients) and a grade C PF in 5.1% of cases (5/99 patients). Univariate analysis identified that body mass index ≥25 kg/m , visceral adipose tissue area (VATA)/skeletal muscle index (SMI) ≥2.0, pancreatic duct diameter ≤3 mm, and drain amylase concentration (Amy) on postoperative day (POD) 1 ≥5000 U/L were significantly associated with PF (grade B, C) after PD. Multivariate analysis indicated that VATA/SMI ≥2.0 (p=0.009), pancreatic duct diameter ≤3 mm (p=0.003), and drain Amy on POD1 ≥5000 U/L (p=0.032) were independent risk factors for PF. CONCLUSION: Elevated VATA/SMI was the only preoperative key factor for PF after PD.
[Mh] Termos MeSH primário: Gordura Intra-Abdominal/patologia
Músculo Esquelético/patologia
Fístula Pancreática/diagnóstico
Neoplasias Pancreáticas/cirurgia
Pancreaticoduodenectomia/efeitos adversos
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma Ductal Pancreático/patologia
Carcinoma Ductal Pancreático/cirurgia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Fístula Pancreática/etiologia
Neoplasias Pancreáticas/patologia
Prognóstico
Curva ROC
Estudos Retrospectivos
Taxa de Sobrevida
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


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[PMID]:28745024
[Au] Autor:Maskarinec G; Lim U; Jacobs S; Monroe KR; Ernst T; Buchthal SD; Shepherd JA; Wilkens LR; Le Marchand L; Boushey CJ
[Ad] Endereço:University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
[Ti] Título:Diet Quality in Midadulthood Predicts Visceral Adiposity and Liver Fatness in Older Ages: The Multiethnic Cohort Study.
[So] Source:Obesity (Silver Spring);25(8):1442-1450, 2017 Aug.
[Is] ISSN:1930-739X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The relationship of diet quality assessed by established indices (HEI-2010, AHEI-2010, aMED, DASH) with adiposity measures was examined, especially visceral adipose tissue (VAT) and nonalcoholic fatty liver (NAFL). METHODS: Close to 2,000 participants of the Multiethnic Cohort completed validated food frequency questionnaires at cohort entry (1993-1996) and clinic visit (2013-2016) when they underwent whole-body dual-energy x-ray absorptiometry and abdominal magnetic resonance imaging scans. Linear regression was used to estimate mean values of adiposity measures by dietary index tertiles at baseline and standardized regression coefficients (ß ) after adjusting for total adiposity and other covariates. Logistic regression of VAT and NAFL on dietary indices was also performed. RESULTS: Higher dietary quality scores at cohort entry were inversely related to all adiposity measures, with the strongest associations for percent liver fat (ß = -0.14 to -0.08), followed by VAT (ß = -0.11 to -0.05), BMI (ß = -0.11 to -0.06), and total body fat (ß = -0.09 to -0.05). Odds ratios adjusted for total adiposity ranged between 0.57 and 0.77 for NAFL and between 0.41 and 0.65 for high VAT when comparing the highest versus lowest tertiles of diet quality. CONCLUSIONS: These longitudinal findings indicate that maintaining a high-quality diet during mid-to-late adulthood may prevent adverse metabolic consequences related to VAT and NAFL.
[Mh] Termos MeSH primário: Adiposidade
Dieta
Grupos Étnicos
Qualidade dos Alimentos
Gordura Intra-Abdominal/patologia
Fígado/patologia
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Idoso
Antropometria
Imagem Corporal
Estudos de Coortes
Exercício
Feminino
Seres Humanos
Estilo de Vida
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Hepatopatia Gordurosa não Alcoólica/fisiopatologia
Avaliação Nutricional
Estudos Prospectivos
Reprodutibilidade dos Testes
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/oby.21868


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[PMID]:28468326
[Au] Autor:Sarr O; Strohm RJ; MacDonald TL; Gaudio N; Reed JK; Foute-Nelong J; Dyck DJ; Mutch DM
[Ad] Endereço:Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. osarr@uoguelph.ca.
[Ti] Título:Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling.
[So] Source:Int J Mol Sci;18(5), 2017 May 02.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Adipose tissue plays a key role in the development of type-2 diabetes via the secretion of adipokines. The current study investigated if secretion media derived from intact visceral (VAT) and subcutaneous (SAT) adipose tissues from extremely obese men and women differently suppressed insulin signaling in human skeletal myotubes derived from a healthy, non-diabetic male and female donor, respectively. Adipose tissue samples were collected from men and women during laparoscopic bariatric surgery. In general, secretion media collected from both SAT and VAT depots caused impaired insulin signaling in myotubes, independent of sex. In females, this was true regardless of the protein kinase B (Akt) phosphorylation site (Akt and Akt ) assessed ( < 0.01). In males, both SAT and VAT secretion media reduced Akt activation in insulin-stimulated myotubes compared to controls ( < 0.001); however, only the VAT secretion media impaired Akt phosphorylation. Independent of sex, 13 out of 18 detected cytokines, chemokines, and growth factors were more abundant in VAT versus SAT secretion media ( < 0.01). Both SAT and VAT secretion media from obese men and women acutely suppress insulin signaling in myotubes, despite different secretion profiles. We propose that this crosstalk model will help to extend our understanding of the interplay between adipose and muscle, as well as the pathogenesis of type-2 diabetes.
[Mh] Termos MeSH primário: Adipocinas/metabolismo
Insulina/metabolismo
Gordura Intra-Abdominal/metabolismo
Fibras Musculares Esqueléticas/metabolismo
Obesidade Mórbida/metabolismo
Transdução de Sinais
Gordura Subcutânea/metabolismo
[Mh] Termos MeSH secundário: Adulto
Células Cultivadas
Quimiocinas/metabolismo
Meios de Cultivo Condicionados/farmacologia
Feminino
Seres Humanos
Resistência à Insulina
Masculino
Meia-Idade
Fibras Musculares Esqueléticas/efeitos dos fármacos
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Chemokines); 0 (Culture Media, Conditioned); 0 (Insulin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:29267320
[Au] Autor:Kashiwagi K; Inoue N; Yoshida T; Bessho R; Yoneno K; Imaeda H; Ogata H; Kanai T; Sugino Y; Iwao Y
[Ad] Endereço:Center for Preventive Medicine, Keio University Hospital, Tokyo, Japan.
[Ti] Título:The impact of visceral adipose tissue as best predictor for difficult colonoscopy and the clinical utility of a long small-caliber scope as rescue.
[So] Source:PLoS One;12(12):e0189817, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There have been many reports about a variety of factors associated with incomplete colonoscopy or difficult colonoscopy with long cecal intubation time (CIT). The aim of this retrospective study was to analyze the factors related to difficult colonoscopy under conscious sedation and demonstrate the clinical utility of a small-caliber scope as rescue by using the data from a large number of subjects who underwent health check-ups. METHODS: Consecutive 1036 cases over a 12-month period (April 2015 to March 2016) were enrolled and 619 subjects were divided into two groups: Easy colonoscopy (CS) Group (CIT ≤ 10 min); Difficult CS Group (CIT > 10 min or incomplete colonoscopy by a standard scope). The two groups were compared by subjects and colonoscopy characteristics with univariate analysis followed by multivariate logistic regression analysis. Reasons for incomplete colonoscopy were also assessed. RESULTS: Cecal intubation rate increased from 97.9% to 99.9% (1007/1008) by the rescue scope. Main reasons for incomplete colonoscopy were tortuosity in the left hemicolon (38%), redundancy in the right hemicolon (29%), pain (19%) and fixation (14%). Moreover, 95% (20/21) of rescue colonoscopies were completed without additional sedation. Higher BMI (21 kg/m2 ≤ BMI) and intermediate visceral adipose tissue (VAT) (75 cm2 ≤ VAT < 150 cm2) were significantly associated with easy CS (80.7% vs 19.3%, P = 0.004; 56.3% vs 43.7%, P = 0.001) by univariate analysis. Age, gender, and VAT, not BMI, were independently associated with difficult colonoscopy by multivariate analysis (OR (95% CI), P: 0.964 (0.942, 0.985), 0.001; 1.845 (1.101, 3.091), 0.020; 2.347 (1.395, 3.951), 0.001). Subgroup analysis by gender also showed VAT as the best predictor for both genders. CONCLUSION: Difficult colonoscopy was significantly associated with advancing age, female gender and, lower (< 75 cm2) or higher (150 cm2 ≤) VAT. These subjects may benefit from having complete and more comfortable colonoscopy examinations by using the small-caliber scope rather than the standard scope.
[Mh] Termos MeSH primário: Colonoscopia/instrumentação
Gordura Intra-Abdominal
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189817


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[PMID]:28462823
[Au] Autor:Chabanova E; Fonvig CE; Bøjsøe C; Holm JC; Thomsen HS
[Ad] Endereço:Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: Elizaveta.Chabanova@regionh.dk.
[Ti] Título:H MRS Assessment of Hepatic Fat Content: Comparison Between Normal- and Excess-weight Children and Adolescents.
[So] Source:Acad Radiol;24(8):982-987, 2017 Aug.
[Is] ISSN:1878-4046
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE AND OBJECTIVES: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. MATERIALS AND METHODS: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. RESULTS: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity. The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. CONCLUSIONS: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.
[Mh] Termos MeSH primário: Fígado Gorduroso/diagnóstico por imagem
Gordura Intra-Abdominal/diagnóstico por imagem
Obesidade/diagnóstico por imagem
Espectroscopia de Prótons por Ressonância Magnética
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Seres Humanos
Peso Corporal Ideal
Masculino
Sobrepeso/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29277814
[Au] Autor:Miyamoto Y; Oki E; Emi Y; Tokunaga S; Shimokawa M; Ogata Y; Akagi Y; Sakamoto Y; Tanaka T; Saeki H; Maehara Y; Baba H
[Ad] Endereço:Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
[Ti] Título:Low Visceral Fat Content Is a Negative Predictive Marker for Bevacizumab in Metastatic Colorectal Cancer.
[So] Source:Anticancer Res;38(1):491-499, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:AIM: This study aimed to clarify the predictive impact of visceral fat on response to bevacizumab in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: Pretreatment computed tomography was used to measure visceral fat area (VFA) and patients with mCRC receiving first-line chemotherapy with/without bevacizumab were divided by median VFA value into two groups: high VFA and low VFA. RESULTS: In the bevacizumab-treated group, patients with low VFA had significantly shorter overall survival (OS) than patients with high VFA in univariate (median=21.1 vs. 38.9 months; hazard ratio=1.70, 95% confidence interval=1.06-2.70, p=0.03) and multivariate analysis (hazard ratio=1.85, 95% confidence interval=1.15-3.03, p=0.01). No significant differences were seen in OS between groups treated with chemotherapy alone. The VFA had a marginally significant modifying effect on the relationship between bevacizumab and OS (p for interaction=0.07). CONCLUSION: Our findings provide the first evidence that a low VFA might be a negative predictive marker for response to bevacizumab in patients with mCRC.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Bevacizumab/uso terapêutico
Camptotecina/análogos & derivados
Neoplasias Colorretais/tratamento farmacológico
Gordura Intra-Abdominal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/fisiologia
Camptotecina/uso terapêutico
Neoplasias Colorretais/mortalidade
Neoplasias Colorretais/patologia
Feminino
Fluoruracila/uso terapêutico
Seres Humanos
Leucovorina/uso terapêutico
Masculino
Meia-Idade
Obesidade/patologia
Compostos Organoplatínicos/uso terapêutico
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Biomarkers, Tumor); 0 (Organoplatinum Compounds); 2S9ZZM9Q9V (Bevacizumab); Q573I9DVLP (Leucovorin); U3P01618RT (Fluorouracil); XT3Z54Z28A (Camptothecin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE



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