Base de dados : MEDLINE
Pesquisa : A10.165.114.830.500.750 [Categoria DeCS]
Referências encontradas : 679 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 68 ir para página                         

  1 / 679 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29351564
[Au] Autor:Naran NH; Haagensen M; Crowther NJ
[Ad] Endereço:Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
[Ti] Título:Steatosis in South African women: How much and why?
[So] Source:PLoS One;13(1):e0191388, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Globally, steatosis is the commonest type of liver pathology and is closely associated with obesity and the metabolic syndrome. Obesity is common in urban African females but no data is available on hepatic fat content in this population group when compared to other ethnic groups. The aim of this study was therefore to compare hepatic fat content in woman from different ethnic groups in South Africa and to characterise the principle determinants of liver fat. MATERIALS AND METHODS: A convenience sample of 106 (48 Indian, 29 African and 29 Caucasian) female volunteers aged 20-60 years and having no history of cardiometabolic disorders were recruited. Hepatic fat was determined from CT scans using the liver-spleen attenuation ratio (LAR), which decreases with increasing levels of hepatic fat. Anthropometric and cardiometabolic parameters were measured with insulin resistance determined using the HOMA index and dysglycaemia defined as fasting glucose ≥5.60 mmol/L. RESULTS: The African subjects had significantly lower hepatic fat content (LAR as median [interquartile range]: 1.35 [1.28, 1.41]) than the Indian (1.22 [1.10, 1.35]; p<0.005) and Caucasian (1.27 [1.16, 1.33]; p<0.05) females even though they had significantly higher BMIs than both groups (p<0.0005 and p<0.05, respectively). Linear regression showed that: subcutaneous abdominal fat was a significant (unstandardised ß = 0.007; p = 0.03) negative, whilst insulin resistance (ß = -0.97; p = 0.01) and dysglycaemia (ß = -3.58; p = 0.01) were significant positive determinants of liver fat; higher hepatic fat levels in subjects with the metabolic syndrome were explained by insulin resistance and dysglycaemia. DISCUSSION: African ethnicity is associated with low liver fat content. Subcutaneous abdominal fat protects against steatosis, possibly by acting as a triglyceride reservoir. Insulin resistance and dysglycaemia lead to greater hepatic fat deposition and explain higher liver fat levels in subjects with the metabolic syndrome. These observations must be further investigated in longitudinal surveys.
[Mh] Termos MeSH primário: Fígado Gorduroso/patologia
[Mh] Termos MeSH secundário: Tecido Adiposo/diagnóstico por imagem
Tecido Adiposo/patologia
Adulto
Grupo com Ancestrais do Continente Africano
Antropometria
Índice de Massa Corporal
Estudos Transversais
Grupo com Ancestrais do Continente Europeu
Fígado Gorduroso/diagnóstico por imagem
Fígado Gorduroso/metabolismo
Feminino
Seres Humanos
Resistência à Insulina
Modelos Lineares
Fígado/diagnóstico por imagem
Fígado/patologia
Síndrome Metabólica/diagnóstico por imagem
Síndrome Metabólica/metabolismo
Síndrome Metabólica/patologia
Meia-Idade
África do Sul
Gordura Subcutânea Abdominal/diagnóstico por imagem
Gordura Subcutânea Abdominal/patologia
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191388


  2 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Lima, Fábio Bessa
Texto completo
[PMID]:28958474
[Au] Autor:Nunes PP; Andreotti S; de Fátima Silva F; Sertié RAL; Caminhotto RO; Komino ACM; Reis GB; Lima FB
[Ad] Endereço:Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: patricia.nunes@usp.br.
[Ti] Título:Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats.
[So] Source:Life Sci;190:29-35, 2017 Dec 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIM: Most studies developed to investigate the effects of glucocorticoids chronic treatment on white adipose tissue uses high doses of these hormones. This study analyzes some effects of a chronic, continuous and steady infusion of low-dose hydrocortisone and the relationship with lipid accumulation in white adipose depots in rats. MAIN METHODS: Nineteen male Wistar rats were divided into control (CON) and cortisol (CORT) groups. Along six weeks CORT group received continuous infusion of 0.6mg/kg/day of hydrocortisone, while CON group received saline. After euthanasia, subcutaneous and visceral (retroperitoneal and mesenteric) fat pads were excised, weighted and analyzed for: lipogenic enzymes activity; molecular changes of 11-hydroxysteroid dehydrogenase type 1 (11ßHSD1) enzyme; enzymes involved in lipid uptake, incorporation, and metabolism and in fatty acids esterification. Besides, morphometric cell analysis was performed. KEY FINDINGS: CORT group showed increased triglycerides, changes in lipoprotein profile and 26,8% increment in central subcutaneous (SC) mass, while visceral fat pads masses remained unchanged. Adipocytes from SC, only, presented increased fatty acid synthase, ATP-citrate lyase and glucose-6-phosphate dehydrogenase activity, in addition to reduced AMP-activated protein kinase and 11ßHSD1 enzymes content. SIGNIFICANCE: Chronic low-dose hydrocortisone treatment consequences seem to be different from those commonly seen in long term hypercortisolism. While high doses promote lipid accumulation in visceral depots, a low dose showed an increase in central SC depot only. This appears to involve an increment in lipid storage and in de novo lipogenesis enzymes activity.
[Mh] Termos MeSH primário: Glucocorticoides/administração & dosagem
Hidrocortisona/administração & dosagem
Gordura Intra-Abdominal/efeitos dos fármacos
Gordura Subcutânea Abdominal/efeitos dos fármacos
[Mh] Termos MeSH secundário: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1/metabolismo
Adipócitos/metabolismo
Animais
Relação Dose-Resposta a Droga
Ácidos Graxos/metabolismo
Glucocorticoides/farmacologia
Hidrocortisona/farmacologia
Metabolismo dos Lipídeos
Lipogênese
Masculino
Ratos
Ratos Wistar
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Glucocorticoids); 0 (Triglycerides); EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 1); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


  3 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28679624
[Au] Autor:Van Pelt DW; Guth LM; Wang AY; Horowitz JF
[Ad] Endereço:Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
[Ti] Título:Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults.
[So] Source:Am J Physiol Endocrinol Metab;313(4):E429-E439, 2017 Oct 01.
[Is] ISSN:1522-1555
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although the rate of fatty acid release from adipose tissue into the systemic circulation is very high in most obese adults, some obese adults maintain relatively low rates of fatty acid release, which helps protect them against the development of systemic insulin resistance. The primary aim of this study was to identify factors in adipose tissue that may underlie low vs. high rates of fatty acid mobilization in a relatively homogeneous cohort of obese adults. We measured systemic fatty acid rate of appearance (FA Ra) via C-palmitate isotope dilution, and we obtained subcutaneous abdominal adipose tissue samples from 30 obese adults (BMI: 38 ± 1 kg/m , age: 30 ± 2 yr) after an overnight fast. We then measured insulin sensitivity using a hyperinsulinemic-euglycemic clamp. Confirming our previous work, insulin sensitivity was inversely proportional to FA Ra ( = 0.50; < 0.001). Immunoblot analysis of subcutaneous adipose tissue samples revealed that, compared with obese adults with high FA Ra, those with low FA Ra had lower markers of lipase activation and higher abundance of glycerol-3-phosphate acyltransferase, which is a primary enzyme for fatty acid esterification. Microarray and pathway analysis provided evidence of lower fibrosis and lower SAPK/JNK pathway activation in obese adults with low FA Ra compared with those with high FA Ra. Our findings suggest that alterations in factors regulating triglyceride storage in adipose tissue, along with lower fibrosis and inflammatory pathway activation, may underlie maintenance of a relatively low FA Ra in obesity, which may help protect against the development of insulin resistance.
[Mh] Termos MeSH primário: Ácidos Graxos/metabolismo
Resistência à Insulina
Obesidade/metabolismo
Gordura Subcutânea Abdominal/metabolismo
[Mh] Termos MeSH secundário: Adulto
Isótopos de Carbono
Feminino
Fibrose
Técnica Clamp de Glucose
Glicerol-3-Fosfato O-Aciltransferase/metabolismo
Seres Humanos
Immunoblotting
Inflamação
Lipase/metabolismo
Sistema de Sinalização das MAP Quinases
Masculino
Gordura Subcutânea Abdominal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (Fatty Acids); EC 2.3.1.15 (Glycerol-3-Phosphate O-Acyltransferase); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1152/ajpendo.00084.2017


  4 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28663255
[Au] Autor:Rydén M; Arner P
[Ad] Endereço:From the Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. peter.arner@ki.se mikael.ryden@ki.se.
[Ti] Título:Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels.
[So] Source:Arterioscler Thromb Vasc Biol;37(9):1782-1787, 2017 Sep.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Fatty acids released via fat cell lipolysis can affect circulating lipid levels. However, the contribution of different lipolysis measures in adipose tissue is unknown and was presently examined in isolated subcutaneous adipocytes. APPROACH AND RESULTS: One thousand and sixty-six men and women were examined for lipolysis regulation in subcutaneous abdominal fat cells. Results were compared with fasting plasma levels of total cholesterol, high-density lipoprotein (HDL) cholesterol (HDL-C) and triglycerides. Spontaneous (basal) lipolysis and the effects of the major hormones stimulating (catecholamines and natriuretic peptides) and inhibiting lipolysis (insulin) were examined. Several statistically significant ( <0.0001) correlations between the different lipolysis parameters and plasma lipids were observed. However, physiologically relevant correlations (adjusted ≥0.05) were only evident between basal or insulin-inhibited lipolysis and plasma triglycerides or HDL-C. Together, these lipolysis measures explained 14% of the variation in triglycerides or HDL-C, respectively. In comparison, a combination of established factors associated with variations in plasma lipids, that is, age; body mass index; waist circumference; waist-to-hip ratio; sex; nicotine use; fat cell volume; and pharmacotherapy against diabetes mellitus; hypertension; or hyperlipidemia explained 17% and 28%, respectively, of the variations in plasma triglycerides and HDL-C. CONCLUSIONS: Subcutaneous fat cell lipolysis is an important independent contributor to interindividual variations in plasma lipids. High spontaneous lipolysis activity and resistance to the antilipolytic effect of insulin associate with elevated triglyceride and low HDL-C concentrations. Thus, although several other factors also play a role, subcutaneous adipose tissue may have a causal influence on dyslipidemia.
[Mh] Termos MeSH primário: Adipócitos Brancos/metabolismo
Lipídeos/sangue
Lipólise
Gordura Subcutânea Abdominal/metabolismo
[Mh] Termos MeSH secundário: Adipócitos Brancos/efeitos dos fármacos
Adolescente
Adulto
Idoso
Anti-Hipertensivos/uso terapêutico
Biomarcadores/sangue
HDL-Colesterol/sangue
Feminino
Seres Humanos
Hipoglicemiantes/uso terapêutico
Hipolipemiantes/uso terapêutico
Lipólise/efeitos dos fármacos
Masculino
Meia-Idade
Gordura Subcutânea Abdominal/efeitos dos fármacos
Triglicerídeos/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Biomarkers); 0 (Cholesterol, HDL); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Lipids); 0 (Triglycerides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.309759


  5 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28602265
[Au] Autor:Modarressi A; Müller CT; Montet X; Rüegg EM; Pittet-Cuénod B
[Ad] Endereço:Division of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, University of Geneva Faculty of Medicine, Geneva, Switzerland. Electronic address: ali.modarressi@hcuge.ch.
[Ti] Título:DIEP flap for breast reconstruction: Is abdominal fat thickness associated with post-operative complications?
[So] Source:J Plast Reconstr Aesthet Surg;70(8):1068-1075, 2017 Aug.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Some surgeons consider a high body mass index (BMI) or important abdominal fat excess as contraindications for breast reconstruction with free deep inferior epigastric perforator (DIEP) flap. This study aimed to identify factors associated with post-operative complications by using this type of flap, with an emphasis on BMI and abdominal subcutaneous fat thickness. METHODS: A retrospective chart review of 105 consecutive patients who underwent DIEP flap breast reconstruction at our institution was performed to assess post-operative complications. Among other risk factors, we specifically studied the influence of BMI and abdominal wall thickness on complication occurrence. Abdominal wall thickness was measured at 10 different points on the angio-computed tomography scan performed pre-operatively. RESULTS: Median age was 49.8 years (range, 27-69); average BMI was 25.57 kg/m (range, 18.07-41.91). Immediate breast reconstruction was performed for 35% of patients, and five patients (4.7%) underwent bilateral reconstruction. Twenty-six patients (24.8%) presented 29 post-operative complications; 12 concerned abdominal complications (delayed wound healing [n = 6] and seroma [n = 6]) and 17 were related to complications of the reconstructed breast (six minimal necrosis treated conservatively, eight minor necrosis requiring surgical debridement and three total flap loss). The complication rate was not correlated with increased BMI or abdominal wall thickness. The only factor that significantly predicts DIEP flap complications was pre-operative radiotherapy (odds ratio = 4.05; p = 0.03). CONCLUSIONS: No significant correlation was observed between BMI of 25-35 kg/m or abdominal wall thickness and post-operative complications of the donor site or DIEP flap. Therefore, these factors should not be considered as contraindication criteria.
[Mh] Termos MeSH primário: Mama/patologia
Mamoplastia/efeitos adversos
Retalho Perfurante/efeitos adversos
Retalho Perfurante/patologia
Complicações Pós-Operatórias/etiologia
Gordura Subcutânea Abdominal/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Angiografia por Tomografia Computadorizada
Feminino
Seres Humanos
Meia-Idade
Necrose
Complicações Pós-Operatórias/cirurgia
Radioterapia/efeitos adversos
Reoperação
Estudos Retrospectivos
Fatores de Risco
Gordura Subcutânea Abdominal/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  6 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28595579
[Au] Autor:Bahamondes F; Flores E; Cattaneo G; Bruna F; Conget P
[Ad] Endereço:Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana - Universidad del Desarrollo, Av. Las Condes 12,438, Lo Barnechea, Santiago, 7710162, Chile. fbahamondesg@ug.uchile.cl.
[Ti] Título:Omental adipose tissue is a more suitable source of canine Mesenchymal stem cells.
[So] Source:BMC Vet Res;13(1):166, 2017 Jun 08.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs. MSCs derived from distinct fat depots have shown dissimilarities in their accessibility and therapeutic potential. The aims of our work were to determine the suitability of omental adipose tissue as a source of MSCs, according to sampling success, cell yield and paracrine properties of isolated cells, and compared to subcutaneous adipose tissue. RESULTS: While sampling success of omental adipose tissue was 100% (14 collections from14 donors) for subcutaneous adipose tissue it was 71% (10 collections from 14 donors). MSCs could be isolated from both sources. Cell yield was significantly higher for omental than for subcutaneous adipose tissue (38 ± 1 vs. 30 ± 1 CFU-F/g tissue, p < 0.0001). No differences were observed between sources regarding cell proliferation potential (73 ± 1 vs. 74 ± 1 CDPL) and cell senescence (at passage 10, both cultures presented enlarged cells with cytoplasmic vacuoles and cellular debris). Omental- and subcutaneous-derived MSCs expressed at the same level bFGF, PDGF, HGF, VEGF, ANG1 and IL-10. Irrespective of the source, isolated MSCs induced proliferation, migration and vascularization of target cells, and inhibited the activation of T lymphocytes. CONCLUSION: Compared to subcutaneous adipose tissue, omental adipose tissue is a more suitable source of MSCs in dogs. Since it can be procured from donors with any body condition, its collection procedure is always feasible, its cell yield is high and the MSCs isolated from it have desirable differentiation and paracrine potentials.
[Mh] Termos MeSH primário: Tecido Adiposo/citologia
Separação Celular/veterinária
Cães/anatomia & histologia
Células Mesenquimais Estromais
Omento/citologia
[Mh] Termos MeSH secundário: Animais
Proliferação Celular
Separação Celular/métodos
Endotélio Vascular/citologia
Feminino
Células Mesenquimais Estromais/imunologia
Gordura Subcutânea Abdominal/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1053-0


  7 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Victora, Cesar Gomes
Texto completo
[PMID]:28582437
[Au] Autor:França GVA; De Lucia Rolfe E; Horta BL; Gigante DP; Yudkin JS; Ong KK; Victora CG
[Ad] Endereço:Post-graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil, Rua Marechal Deodoro, 1160-3° Piso, Bairro Centro-Pelotas, RS.
[Ti] Título:Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population.
[So] Source:PLoS One;12(6):e0179085, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We aimed to identify the independent associations of genomic ancestry and education level with abdominal fat distributions in the 1982 Pelotas birth cohort study, Brazil. In 2,890 participants (1,409 men and 1,481 women), genomic ancestry was assessed using genotype data on 370,539 genome-wide variants to quantify ancestral proportions in each individual. Years of completed education was used to indicate socio-economic position. Visceral fat depth and subcutaneous abdominal fat thickness were measured by ultrasound at age 29-31y; these measures were adjusted for BMI to indicate abdominal fat distributions. Linear regression models were performed, separately by sex. Admixture was observed between European (median proportion 85.3), African (6.6), and Native American (6.3) ancestries, with a strong inverse correlation between the African and European ancestry scores (ρ = -0.93; p<0.001). Independent of education level, African ancestry was inversely associated with both visceral and subcutaneous abdominal fat distributions in men (both P = 0.001), and inversely associated with subcutaneous abdominal fat distribution in women (p = 0.009). Independent of genomic ancestry, higher education level was associated with lower visceral fat, but higher subcutaneous fat, in both men and women (all p<0.001). Our findings, from an admixed population, indicate that both genomic ancestry and education level were independently associated with abdominal fat distribution in adults. African ancestry appeared to lower abdominal fat distributions, particularly in men.
[Mh] Termos MeSH primário: Escolaridade
Padrões de Herança
Gordura Intra-Abdominal/fisiologia
Gordura Subcutânea Abdominal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Africano
Índice de Massa Corporal
Brasil
Grupo com Ancestrais do Continente Europeu
Feminino
Seres Humanos
Índios Sul-Americanos
Modelos Lineares
Masculino
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179085


  8 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28572512
[Au] Autor:Sun XJ; Kim SP; Zhang D; Sun H; Cao Q; Lu X; Ying Z; Li L; Henry RR; Ciaraldi TP; Taylor SI; Quon MJ
[Ad] Endereço:From the Division of Endocrinology, Diabetes, and Nutrition, xsun@som.umaryland.edu.
[Ti] Título:Deletion of interleukin 1 receptor-associated kinase 1 ( ) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle.
[So] Source:J Biol Chem;292(29):12339-12350, 2017 Jul 21.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic inflammation may contribute to insulin resistance via molecular cross-talk between pathways for pro-inflammatory and insulin signaling. Interleukin 1 receptor-associated kinase 1 (IRAK-1) mediates pro-inflammatory signaling via IL-1 receptor/Toll-like receptors, which may contribute to insulin resistance, but this hypothesis is untested. Here, we used male null (k/o) mice to investigate the metabolic role of IRAK-1. C57BL/6 wild-type (WT) and k/o mice had comparable body weights on low-fat and high-fat diets (LFD and HFD, respectively). After 12 weeks on LFD (but not HFD), k/o mice ( WT) had substantially improved glucose tolerance (assessed by the intraperitoneal glucose tolerance test (IPGTT)). As assessed with the hyperinsulinemic euglycemic glucose clamp technique, insulin sensitivity was 30% higher in the k/o mice on chow diet, but the deletion did not affect IPGTT outcomes in mice on HFD, suggesting that the deletion did not overcome the impact of obesity on glucose tolerance. Moreover, insulin-stimulated glucose-disposal rates were higher in the k/o mice, but we detected no significant difference in hepatic glucose production rates (± insulin infusion). Positron emission/computed tomography scans indicated higher insulin-stimulated glucose uptake in muscle, but not liver, in k/o mice Moreover, insulin-stimulated phosphorylation of Akt was higher in muscle, but not in liver, from k/o mice In conclusion, deletion improved muscle insulin sensitivity, with the effect being most apparent in LFD mice.
[Mh] Termos MeSH primário: Intolerância à Glucose/metabolismo
Resistência à Insulina
Quinases Associadas a Receptores de Interleucina-1/metabolismo
Músculo Esquelético/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Biomarcadores/metabolismo
Cruzamentos Genéticos
Dieta com Restrição de Gorduras
Dieta Hiperlipídica/efeitos adversos
Endotélio Vascular/efeitos dos fármacos
Endotélio Vascular/enzimologia
Endotélio Vascular/metabolismo
Endotélio Vascular/fisiopatologia
Técnica Clamp de Glucose
Intolerância à Glucose/etiologia
Intolerância à Glucose/fisiopatologia
Intolerância à Glucose/prevenção & controle
Hemizigoto
Hipoglicemiantes/farmacologia
Insulina/farmacologia
Quinases Associadas a Receptores de Interleucina-1/genética
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/enzimologia
Obesidade/etiologia
Obesidade/fisiopatologia
Especificidade de Órgãos
Fosforilação/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/metabolismo
Gordura Subcutânea Abdominal/efeitos dos fármacos
Gordura Subcutânea Abdominal/enzimologia
Gordura Subcutânea Abdominal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hypoglycemic Agents); 0 (Insulin); EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases); EC 2.7.11.1 (Irak1 protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.779108


  9 / 679 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28494111
[Au] Autor:Rasmussen RW; Patibandla JR; Hopkins MP
[Ad] Endereço:Department of Obstetrics and Gynecology, Aultman Health Foundation, Northeast Ohio Medical University, Canton, OH, USA.
[Ti] Título:Evaluation of indicated non-cosmetic panniculectomy at time of gynecologic surgery.
[So] Source:Int J Gynaecol Obstet;138(2):207-211, 2017 Aug.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To report postoperative outcomes among patients undergoing indicated non-cosmetic panniculectomy at the time of gynecologic surgery. METHODS: Medical charts were retrospectively reviewed for patients who underwent panniculectomy coupled with gynecologic surgery at a university-affiliated hospital in the USA in 1990-2014. The data reviewed included age, body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), surgical procedure, estimated blood loss, pathology, wound complication, diabetes, hypertension, smoking, and readmission rate. One-way analysis of variance and logistic regression were used to evaluate the data. RESULTS: In total, 300 patients underwent panniculectomy; the mean age was 51 years and the mean BMI was 46. Overall, there were 94 (31.3%) complications, including 85 (28.3%) cases of superficial cellulitis and 9 (3.0%) cases of surgical-site infection. In logistic regression, diabetes, hypertension, and smoking were significant predictors of wound complications, identifying 78% of women who subsequently developed wound complications. CONCLUSION: Panniculectomy combined with gynecologic surgery was found to be safe and effective for obese patients, with an acceptable incidence of wound infection. History of diabetes, hypertension, and smoking increased the risk of postoperative wound complications. These factors will help to predict patients at risk of wound complication.
[Mh] Termos MeSH primário: Abdominoplastia
Doenças dos Genitais Femininos/cirurgia
Procedimentos Cirúrgicos em Ginecologia
Obesidade/cirurgia
Gordura Subcutânea Abdominal/cirurgia
Infecção da Ferida Cirúrgica/etiologia
[Mh] Termos MeSH secundário: Abdominoplastia/efeitos adversos
Adulto
Idoso
Idoso de 80 Anos ou mais
Índice de Massa Corporal
Feminino
Doenças dos Genitais Femininos/complicações
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos
Seres Humanos
Meia-Idade
Obesidade/complicações
Estudos Retrospectivos
Fatores de Risco
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12207


  10 / 679 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28323916
[Au] Autor:Manolopoulos KN; O'Reilly MW; Bujalska IJ; Tomlinson JW; Arlt W
[Ad] Endereço:Institute of Metabolism and Systems Research, University of Birmingham B15 2TT, United Kingdom.
[Ti] Título:Acute Hypercortisolemia Exerts Depot-Specific Effects on Abdominal and Femoral Adipose Tissue Function.
[So] Source:J Clin Endocrinol Metab;102(4):1091-1101, 2017 Apr 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Glucocorticoids have pleiotropic metabolic functions, and acute glucocorticoid excess affects fatty acid metabolism, increasing systemic lipolysis. Whether glucocorticoids exert adipose tissue depot-specific effects remains unclear. Objective: To provide an in vivo assessment of femoral and abdominal adipose tissue responses to acute glucocorticoid administration. Design and Outcome Measures: Nine healthy male volunteers were studied on two occasions, after a hydrocortisone infusion (0.2 mg/kg/min for 14 hours) and a saline infusion, respectively, given in randomized double-blind order. The subjects were studied in the fasting state and after a 75-g glucose drink with an in vivo assessment of femoral adipose tissue blood flow (ATBF) using radioactive xenon washout and of lipolysis and glucose uptake using the arteriovenous difference technique. In a separate study (same infusion design), eight additional healthy male subjects underwent assessment of fasting abdominal ATBF and lipolysis only. Lipolysis was assessed as the net release of nonesterified fatty acids (NEFAs) from femoral and abdominal subcutaneous adipose tissue. Results: Acute hypercortisolemia significantly increased basal and postprandial ATBF in femoral adipose tissue, but the femoral net NEFA release did not change. In abdominal adipose tissue, hypercortisolemia induced substantial increases in basal ATBF and NEFA release. Conclusions: Acute hypercortisolemia induces differential lipolysis and ATBF responses in abdominal and femoral adipose tissue, suggesting depot-specific glucocorticoid effects. Abdominal, but not femoral, adipose tissue contributes to the hypercortisolemia-induced systemic NEFA increase, with likely contributions from other adipose tissue sources and intravascular triglyceride hydrolysis.
[Mh] Termos MeSH primário: Tecido Adiposo/efeitos dos fármacos
Síndrome de Cushing/induzido quimicamente
Hidrocortisona/administração & dosagem
Lipólise/efeitos dos fármacos
Gordura Subcutânea Abdominal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Abdome
Absorciometria de Fóton
Tecido Adiposo/metabolismo
Adulto
Síndrome de Cushing/metabolismo
Método Duplo-Cego
Fêmur
Seres Humanos
Hidrocortisona/sangue
Masculino
Meia-Idade
Gordura Subcutânea Abdominal/metabolismo
Coxa da Perna
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3600



página 1 de 68 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde