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[PMID]:29348470
[Au] Autor:Li H; Wu G; Fang Q; Zhang M; Hui X; Sheng B; Wu L; Bao Y; Li P; Xu A; Jia W
[Ad] Endereço:Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
[Ti] Título:Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat.
[So] Source:Nat Commun;9(1):272, 2018 01 18.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 levels positively correlate with the SAT area in insulin-sensitive obese individuals. FGF21 knockout mice (FGF21KO) show less SAT mass and are more insulin-resistant when fed a high-fat diet. Replenishment of recombinant FGF21 to a level equivalent to that in obesity restores SAT mass and reverses insulin resistance in FGF21KO, but not in adipose-specific ßklotho knockout mice. Moreover, transplantation of SAT from wild-type to FGF21KO mice improves insulin sensitivity in the recipients. Mechanistically, circulating FGF21 upregulates adiponectin in SAT, accompanied by an increase of M2 macrophage polarization. We propose that elevated levels of endogenous FGF21 in obesity serve as a defense mechanism to protect against systemic insulin resistance.
[Mh] Termos MeSH primário: Fatores de Crescimento de Fibroblastos/genética
Resistência à Insulina/genética
Obesidade/genética
Gordura Subcutânea/metabolismo
[Mh] Termos MeSH secundário: Adiponectina/metabolismo
Animais
Dieta Hiperlipídica
Fatores de Crescimento de Fibroblastos/sangue
Fatores de Crescimento de Fibroblastos/metabolismo
Camundongos Endogâmicos C57BL
Camundongos Knockout
Obesidade/sangue
Obesidade/metabolismo
Proteínas Recombinantes/farmacologia
Gordura Subcutânea/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adiponectin); 0 (Recombinant Proteins); 0 (fibroblast growth factor 21); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02677-9


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[PMID]:29339725
[Au] Autor:Velazquez-Villegas LA; Perino A; Lemos V; Zietak M; Nomura M; Pols TWH; Schoonjans K
[Ad] Endereço:Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
[Ti] Título:TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue.
[So] Source:Nat Commun;9(1):245, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT) under multiple environmental cues including cold exposure and prolonged high-fat diet feeding. Moreover, administration of TGR5-selective bile acid mimetics to thermoneutral housed mice leads to the appearance of beige adipocyte markers and increases mitochondrial content in the scWAT of Tgr5 mice but not in their Tgr5 littermates. This phenotype is recapitulated in vitro in differentiated adipocytes, in which TGR5 activation increases free fatty acid availability through lipolysis, hence fuelling ß-oxidation and thermogenic activity. TGR5 signalling also induces mitochondrial fission through the ERK/DRP1 pathway, further improving mitochondrial respiration. Taken together, these data identify TGR5 as a druggable target to promote beiging with potential applications in the management of metabolic disorders.
[Mh] Termos MeSH primário: Tecido Adiposo Bege/metabolismo
Tecido Adiposo Branco/metabolismo
Dinâmica Mitocondrial
Receptores Acoplados a Proteínas-G/metabolismo
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos Bege/metabolismo
Adipócitos Brancos/metabolismo
Tecido Adiposo Bege/citologia
Tecido Adiposo Branco/citologia
Animais
Diferenciação Celular/genética
Linhagem Celular
Ácidos Graxos não Esterificados/metabolismo
Seres Humanos
Camundongos
Camundongos Knockout
Receptores Acoplados a Proteínas-G/genética
Transdução de Sinais/genética
Gordura Subcutânea/citologia
Gordura Subcutânea/metabolismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); 0 (Gpbar1 protein, mouse); 0 (Receptors, G-Protein-Coupled)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02068-0


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[PMID]:28282742
[Au] Autor:Henrique RS; Bustamante AV; Freitas DL; Tani G; Katzmarzyk PT; Maia JA
[Ad] Endereço:a Higher School of Physical Education , University of Pernambuco , Recife , Brazil.
[Ti] Título:Tracking of gross motor coordination in Portuguese children.
[So] Source:J Sports Sci;36(2):220-228, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the tracking of gross motor coordination (GMC) and to profile children at 6 years of age who consistently showed higher stability patterns in different levels of GMC. The participants were 245 children (123 boys and 122 girls) who were assessed longitudinally from 6 to 9 years of age. GMC was assessed using the Korperkoordinationtest fur Kinder (KTK) test battery. Anthropometry, physical activity, and health- and performance-related physical fitness were also measured. Cohen's kappa (κ) was used to estimate tracking. Tracking was poor for all GMC tests (0.17 ≤ κ ≤ 0.38) and moderate for the GMC motor quotient (MQ) in both boys and girls (0.44 ≤ κ ≤ 0.45). Instability at the extremes was low in GMC tests and negligible for MQ. Children who consistently showed high GMC levels during the 4 years of follow-up were lighter, had lower body mass index and subcutaneous fat, and showed higher scores in physical fitness tests at 6 years of age than those who consistently had low GMC levels. In conclusion, GMC showed low-to-moderate tracking over time in childhood. However, children who consistently demonstrated high GMC levels over time had healthier profiles at 6 years of age.
[Mh] Termos MeSH primário: Destreza Motora/fisiologia
[Mh] Termos MeSH secundário: Antropometria
Índice de Massa Corporal
Criança
Interpretação Estatística de Dados
Exercício/fisiologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Aptidão Física/fisiologia
Portugal
Gordura Subcutânea/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1297534


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[PMID]:27778168
[Au] Autor:Docimo S; Lee Y; Chatani P; Rogers AM; Lacqua F
[Ad] Endereço:Division of Bariatric, Foregut, and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook Medicine, Stony Brook, NY, USA. sdocimo@gmail.com.
[Ti] Título:Visceral to subcutaneous fat ratio predicts acuity of diverticulitis.
[So] Source:Surg Endosc;31(7):2808-2812, 2017 Jul.
[Is] ISSN:1432-2218
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There is an association between obesity and more complicated diverticular disease. We hypothesize that this link may be due to an increased level of visceral fat rather than an elevated body mass index alone. Adipose tissue secretes inflammatory cytokines, and chronic inflammation may account for the link between obesity and a more severe presentation of diverticular disease. We have applied a quantitative measure of visceral fat content in a series of patients admitted with diverticulitis, comparing those who required emergent versus elective surgical procedures for diverticulitis. METHODS: We performed a retrospective review of all adult patients who underwent emergent or elective surgery at our institution for diverticulitis from 2010 to 2014. Data were collected on demographics, comorbidities, operative findings, complications, and length of stay. Radiologic measurements of adiposity were obtained from preoperative CT scans. Visceral fat areas and subcutaneous fat areas were measured, and the V/S ratio was calculated. RESULTS: Thirty-four patients underwent emergent and 32 patients underwent elective surgery. The mean age was 66.3 years for the emergent and 57.11 for the elective group (p = 0.04178). The perinephric, visceral, subcutaneous fat, and V/S ratio for the emergent group were 1.71, 185.22, 338.22, and 0.56 and were 1.11, 127.18, 295.28, and 0.46 for the elective group. The difference between the V/S ratio for each group was significant (p = 0.0238). The emergent group had an average LOS of 16.11 days compared to 5.15 for the elective group (p = <0.00001). The complication rate was significantly higher (p = 0.024) in the emergent group (n = 12, 35.2 %) compared to the elective group (n = 4, 12.5 %). CONCLUSION: Our study demonstrates a clinically significant link between visceral fat and severity of presentation of diverticulitis. Patients with higher V/S fat ratios were more likely to require emergency surgery and have more complications and a longer LOS.
[Mh] Termos MeSH primário: Diverticulite/diagnóstico
Gordura Intra-Abdominal
Gravidade do Paciente
Gordura Subcutânea
[Mh] Termos MeSH secundário: Adulto
Idoso
Técnicas de Apoio para a Decisão
Diverticulite/cirurgia
Procedimentos Cirúrgicos Eletivos
Emergências
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s00464-016-5290-2


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[PMID]:29339527
[Au] Autor:Ghanim H; Dhindsa S; Abuaysheh S; Batra M; Kuhadiya ND; Makdissi A; Chaudhuri A; Dandona P
[Ad] Endereço:Division of Endocrinology, Diabetes and MetabolismState University of New York at Buffalo, Williamsville, New York, USA.
[Ti] Título:Diminished androgen and estrogen receptors and aromatase levels in hypogonadal diabetic men: reversal with testosterone.
[So] Source:Eur J Endocrinol;178(3):277-283, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: One-third of males with type 2 diabetes (T2DM) have hypogonadism, characterized by low total and free testosterone concentrations. We hypothesized that this condition is associated with a compensatory increase in the expression of androgen receptors (AR) and that testosterone replacement reverses these changes. We also measured estrogen receptor and aromatase expression. MATERIALS AND METHODS: This is a randomized double-blind placebo-controlled trial. Thirty-two hypogonadal and 32 eugonadal men with T2DM were recruited. Hypogonadal men were randomized to receive intramuscular testosterone or saline every 2 weeks for 22 weeks. We measured AR, ERα and aromatase expression in peripheral blood mononuclear cells (MNC), adipose tissue and skeletal muscle in hypogonadal and eugonadal males with T2DM at baseline and after 22 weeks of treatment in those with hypogonadism. RESULTS: The mRNA expression of and aromatase in adipose tissue from hypogonadal men was significantly lower as compared to eugonadal men, and it increased significantly to levels comparable to those in eugonadal patients with T2DM following testosterone treatment. mRNA expression was also significantly lower in MNC from hypogonadal patients compared to eugonadal T2DM patients. Testosterone administration in hypogonadal patients also restored mRNA and nuclear extract protein levels from MNC to that in eugonadal patients. In the skeletal muscle, AR mRNA and protein expression are lower in men with hypogonadism. Testosterone treatment restored AR expression levels to that comparable to levels in eugonadal men. CONCLUSIONS: We conclude that, contrary to our hypothesis, the expression of AR, ERα and aromatase is significantly diminished in hypogonadal men as compared to eugonadal men with type 2 diabetes. Following testosterone replacement, there is a reversal of these deficits.
[Mh] Termos MeSH primário: Androgênios/uso terapêutico
Aromatase/genética
Diabetes Mellitus Tipo 2/metabolismo
Receptor alfa de Estrogênio/genética
Hipogonadismo/tratamento farmacológico
Leucócitos Mononucleares/metabolismo
Receptores Androgênicos/genética
Testosterona/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Aromatase/metabolismo
Western Blotting
Diabetes Mellitus Tipo 2/complicações
Método Duplo-Cego
Receptor alfa de Estrogênio/metabolismo
Seres Humanos
Hipogonadismo/complicações
Hipogonadismo/genética
Hipogonadismo/metabolismo
Masculino
Meia-Idade
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Receptores Androgênicos/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Gordura Subcutânea/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (AR protein, human); 0 (Androgens); 0 (Estrogen Receptor alpha); 0 (RNA, Messenger); 0 (Receptors, Androgen); 0 (estrogen receptor alpha, human); 3XMK78S47O (Testosterone); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0673


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[PMID]:28468326
[Au] Autor:Sarr O; Strohm RJ; MacDonald TL; Gaudio N; Reed JK; Foute-Nelong J; Dyck DJ; Mutch DM
[Ad] Endereço:Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. osarr@uoguelph.ca.
[Ti] Título:Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling.
[So] Source:Int J Mol Sci;18(5), 2017 May 02.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Adipose tissue plays a key role in the development of type-2 diabetes via the secretion of adipokines. The current study investigated if secretion media derived from intact visceral (VAT) and subcutaneous (SAT) adipose tissues from extremely obese men and women differently suppressed insulin signaling in human skeletal myotubes derived from a healthy, non-diabetic male and female donor, respectively. Adipose tissue samples were collected from men and women during laparoscopic bariatric surgery. In general, secretion media collected from both SAT and VAT depots caused impaired insulin signaling in myotubes, independent of sex. In females, this was true regardless of the protein kinase B (Akt) phosphorylation site (Akt and Akt ) assessed ( < 0.01). In males, both SAT and VAT secretion media reduced Akt activation in insulin-stimulated myotubes compared to controls ( < 0.001); however, only the VAT secretion media impaired Akt phosphorylation. Independent of sex, 13 out of 18 detected cytokines, chemokines, and growth factors were more abundant in VAT versus SAT secretion media ( < 0.01). Both SAT and VAT secretion media from obese men and women acutely suppress insulin signaling in myotubes, despite different secretion profiles. We propose that this crosstalk model will help to extend our understanding of the interplay between adipose and muscle, as well as the pathogenesis of type-2 diabetes.
[Mh] Termos MeSH primário: Adipocinas/metabolismo
Insulina/metabolismo
Gordura Intra-Abdominal/metabolismo
Fibras Musculares Esqueléticas/metabolismo
Obesidade Mórbida/metabolismo
Transdução de Sinais
Gordura Subcutânea/metabolismo
[Mh] Termos MeSH secundário: Adulto
Células Cultivadas
Quimiocinas/metabolismo
Meios de Cultivo Condicionados/farmacologia
Feminino
Seres Humanos
Resistência à Insulina
Masculino
Meia-Idade
Fibras Musculares Esqueléticas/efeitos dos fármacos
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Chemokines); 0 (Culture Media, Conditioned); 0 (Insulin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:28468137
[Au] Autor:Lee SS; Huang YH; Lin TY; Chou CK; Takahashi H; Lai CS; Lin SD; Lin TM
[Ad] Endereço:*Department of Plastic Surgery, Kaohsiung Medical University †Charming Institute of Aesthetic and Regenerative Surgery (CIARS) ‡Division of Traumatology, Department of Emergency, Kaohsiung Medical University §Yuan's General Hospital ||Department of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
[Ti] Título:Long-Term Outcome of Microautologous Fat Transplantation to Correct Temporal Depression.
[So] Source:J Craniofac Surg;28(3):629-634, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results. METHODS: Microautologous fat transplantation was performed on 208 patients during the 4-year period starting in January 2010. Fat was harvested by liposuction, processed and refined by centrifugation at 1200 g for 3 minutes. Then purified fat was microtransplanted to the temporal fossa with the assistance of an instrument, MAFT-Gun. The patients were followed up regularly and photographs were taken for comparison. RESULTS: On average, the MAFT procedure took 48 minutes to complete. The average delivered fat was 6.8 ±â€Š0.2 mL/6.5 ±â€Š0.3 mL for the right/left side. The average follow-up period was 18 months. No complication including skin necrosis, vascular compromise, nodulation, fibrosis, and asymmetry was noted. The patient-rated satisfaction 5-point Likert scale demonstrated that 81.3% of all patients had favorable results (38.5% very satisfied and 42.8% satisfied). CONCLUSIONS: The concept and technique of MAFT along with the micro- and precise controlling instrument enabled surgeons to perform fat grafting accurately and consistently. In comparison with other strategies for volume restoration, the MAFT procedure demonstrated the patients' high satisfaction with the long-term results. Therefore, the potential of MAFT as an alternative strategy in sunken temporal fossa in Asians was emphasized.
[Mh] Termos MeSH primário: Técnicas Cosméticas
Gordura Subcutânea/transplante
[Mh] Termos MeSH secundário: Adulto
Face
Feminino
Seguimentos
Seres Humanos
Lipectomia
Masculino
Meia-Idade
Satisfação do Paciente/estatística & dados numéricos
Estudos Retrospectivos
Transplante Autólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003410


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[PMID]:29197590
[Au] Autor:Li X; Wang Y; Guo J; Zhong T; Li L; Zhang H; Wang L
[Ad] Endereço:Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, PR China.
[Ti] Título:Identification and expression patterns of adipokine genes during adipocyte differentiation in the Tibetan goat (Capra hircus).
[So] Source:Gene;643:17-25, 2018 Feb 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Adipokines are secreted by adipose tissue and play an important role in the regulation of lipid metabolism. However, the information regarding adipokines in goats is limited. PPARγ is a key gene in adipocyte differentiation and activates adipokine genes. Rosiglitazone is a PPARγ agonist and can promote the expression of PPARγ to increase the expression of lipogenesis-related genes. Therefore, investigation of the relationship between rosiglitazone and adipokines will help us to better understand the function of PPARγ in lipid metabolism in Tibetan goats. In this study, we cloned the resistin (RETN), apelin (APLN), fibroblast growth factor 21 (FGF21), and visfatin (NAMPT) genes from non-pregnant female Tibetan goat adipose tissue. APLN and NAMPT were predominantly expressed in the kidney, and FGF21 was expressed at the highest levels in the liver in vivo. In fat tissues, the highest expression levels of FGF21 and RETN were detected in omental fat, whereas their expression in perirenal and subcutaneous fat was extremely weak. APLN and NAMPT were abundantly expressed in omental and subcutaneous fat in vivo. In addition, the four adipokines had different expression profiles during goat adipocyte differentiation in vitro. Oil red O staining showed that rosiglitazone could promote adipocyte differentiation and lipid droplet formation. In addition, rosiglitazone significantly increased the expression of FGF21 and RETN (p<0.05) but decreased the expression of APLN and NAMPT (p<0.05). These results suggest that the four adipocytokine genes may have different roles during goat adipocyte differentiation. And PPARγ could regulate the expression of the four adipokines, but the detailed regulatory mechanism still needs to be elucidated.
[Mh] Termos MeSH primário: Adipocinas/genética
Cabras/genética
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/metabolismo
Adipogenia/genética
Adipocinas/metabolismo
Tecido Adiposo/metabolismo
Animais
Apelina/genética
Apelina/metabolismo
Diferenciação Celular/genética
Feminino
Fatores de Crescimento de Fibroblastos/genética
Fatores de Crescimento de Fibroblastos/metabolismo
Cabras/metabolismo
Metabolismo dos Lipídeos
Camundongos
Nicotinamida Fosforribosiltransferase/genética
Nicotinamida Fosforribosiltransferase/metabolismo
Obesidade/genética
Resistina/genética
Resistina/metabolismo
Gordura Subcutânea/metabolismo
Tiazolidinedionas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Apelin); 0 (Resistin); 0 (Thiazolidinediones); 0 (fibroblast growth factor 21); 05V02F2KDG (rosiglitazone); 62031-54-3 (Fibroblast Growth Factors); EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE


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[PMID]:29280867
[Au] Autor:Villanueva NL; Del Vecchio DA; Afrooz PN; Carboy JA; Rohrich RJ
[Ad] Endereço:Dallas, Texas; and Boston, Mass. From the Department of Plastic Surgery, University of Texas Southwestern Medical Center; Back Bay Plastic Surgery; and Dallas Plastic Surgery Institute.
[Ti] Título:Staying Safe during Gluteal Fat Transplantation.
[So] Source:Plast Reconstr Surg;141(1):79-86, 2018 01.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gluteal augmentation with fat transplantation is increasing in demand but has been associated with a concerning number of fatality reports. Despite these reports, various surgeons have safely performed gluteal fat transplantation on a large number of patients with no reported mortality. The important aspects of safely performing gluteal fat transplantation are reviewed. Proper patient selection, favorable instrumentation, patient positioning, proper technique, and knowledge of anatomy are critical to improving the safety of this procedure. Adherence to these key principles should allow a reduction in mortality from this procedure, which would safely allow its continued offering in the setting of increasingly high demand.
[Mh] Termos MeSH primário: Nádegas/cirurgia
Técnicas Cosméticas
Segurança do Paciente
Gordura Subcutânea/transplante
[Mh] Termos MeSH secundário: Nádegas/anatomia & histologia
Técnicas Cosméticas/efeitos adversos
Seres Humanos
Lipectomia/efeitos adversos
Lipectomia/métodos
Posicionamento do Paciente
Seleção de Pacientes
Cuidados Pós-Operatórios/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003934


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[PMID]:28574591
[Au] Autor:Mattiucci D; Maurizi G; Izzi V; Cenci L; Ciarlantini M; Mancini S; Mensà E; Pascarella R; Vivarelli M; Olivieri A; Leoni P; Poloni A
[Ad] Endereço:Dipartimento Scienze Cliniche e Molecolari, Clinica di Ematologia, Università Politecnica delle Marche, Ancona, Italy.
[Ti] Título:Bone marrow adipocytes support hematopoietic stem cell survival.
[So] Source:J Cell Physiol;233(2):1500-1511, 2018 Feb.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In bone marrow (BM), hematopoietic elements are mingled with adipocytes (BM-A), which are the most abundant stromal component in the niche. BM-A progressively increase with aging, eventually occupying up to 50% of BM cavities. In this work, the role played by BM-A was explored by studying primary human BM-A isolated from hip surgery patients at the molecular level, through microarray analysis, and at the functional level, by assessing their relationship with primary human hematopoietic stem cells (HSC) by the long-term culture initiating cell (LTC-IC) assay. Findings demonstrated that BM-A are capable of supporting HSC survival in the LTC-IC assay, since after 5 weeks of co-culture, HSC were still able to proliferate and differentiate. Furthermore, critical molecules such as C-X-C motif chemokine 12 (CXCL12), interleukin (IL)-8, colony-stimulating factor 3 (CSF3), and leukaemia inhibitory factor (LIF), were expressed at similar levels in BM-A and in primary human BM mesenchymal stromal cells (BM-MSC), whereas IL-3 was higher in BM-A. Interestingly, BM-A displayed a different gene expression profile compared with subcutaneous adipose tissue adipocytes (AT-A) collected from abdominal surgery patients, especially in terms of regulation of lipid metabolism, stemness genes, and white-to-brown differentiation pathways. Accordingly, analysis of the gene pathways involved in hematopoiesis regulation showed that BM-A are more closely related to BM-MSC than to AT-A. The present data suggest that BM-A play a supporting role in the hematopoietic niche and directly sustain HSC survival.
[Mh] Termos MeSH primário: Adipócitos/fisiologia
Células da Medula Óssea/fisiologia
Comunicação Celular
Células-Tronco Hematopoéticas/fisiologia
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Idoso
Idoso de 80 Anos ou mais
Células da Medula Óssea/metabolismo
Proliferação Celular
Sobrevivência Celular
Células Cultivadas
Quimiocina CXCL12/metabolismo
Técnicas de Cocultura
Fatores Estimuladores de Colônias/metabolismo
Feminino
Hematopoese
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Interleucina-8/metabolismo
Fator Inibidor de Leucemia/metabolismo
Masculino
Meia-Idade
Fenótipo
Transdução de Sinais
Nicho de Células-Tronco
Gordura Subcutânea/citologia
Gordura Subcutânea/fisiologia
Fatores de Tempo
Transcriptoma
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCL12 protein, human); 0 (Chemokine CXCL12); 0 (Colony-Stimulating Factors); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (LIF protein, human); 0 (Leukemia Inhibitory Factor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.26037



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