Base de dados : MEDLINE
Pesquisa : A10.165.887 [Categoria DeCS]
Referências encontradas : 2546 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 255 ir para página                         

  1 / 2546 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28456757
[Au] Autor:Fadel MG; Chatzikonstantinou M; Gilchrist C; Andrews B
[Ti] Título:Panniculus morbidus: obesity-related abdominal wall lymphoedema.
[So] Source:BMJ Case Rep;2017, 2017 Apr 29.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 52-year-old female patient presented with a massive abdominal wall swelling that adversely affected her lifestyle. Imaging revealed significant subcutaneous oedema and the presence of grossly distended veins. Subsequently, she underwent a 'toilet' panniculectomy and abdominoplasty. We describe the surgical technique used to retract the lymphoedematous tissue facilitating excisional surgery, and discuss the pathophysiology of this condition and the possible contribution of venous obstruction to the development of subcutaneous oedema.
[Mh] Termos MeSH primário: Parede Abdominal/patologia
Linfedema/complicações
Obesidade Mórbida/complicações
Obesidade Mórbida/diagnóstico
Tela Subcutânea/irrigação sanguínea
[Mh] Termos MeSH secundário: Parede Abdominal/cirurgia
Abdominoplastia/métodos
Feminino
Seres Humanos
Linfedema/cirurgia
Meia-Idade
Obesidade Mórbida/etiologia
Obesidade Mórbida/patologia
Tela Subcutânea/patologia
Tela Subcutânea/fisiopatologia
Resultado do Tratamento
Reino Unido/epidemiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  2 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29216591
[Au] Autor:Sun Y; Jensen H; Petersen NJ; Larsen SW; Østergaard J
[Ad] Endereço:Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic address: yu.sun@sund.ku.dk.
[Ti] Título:Concomitant monitoring of implant formation and drug release of in situ forming poly (lactide-co-glycolide acid) implants in a hydrogel matrix mimicking the subcutis using UV-vis imaging.
[So] Source:J Pharm Biomed Anal;150:95-106, 2018 Feb 20.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:For poly (lactide-co-glycolide acid) (PLGA)-based in situ forming implants, the rate of implant formation plays an important role in determining the overall drug release kinetics. Currently, in vitro techniques capable of characterizing the processes of drug release and implant formation at the same time are not available. A hydrogel-based in vitro experimental setup was recently developed requiring only microliter of formulation and forming a closed system potentially suitable for interfacing with various spectroscopic techniques. The aim of the present proof-of-concept study was to investigate the feasibility of concomitant UV imaging, Vis imaging and light microscopy for detailed characterization of the behavior of in situ forming PLGA implants in the hydrogel matrix mimicking the subcutis. The model compounds, piroxicam and α-lactalbumin were added to PLGA-1-methyl-2-pyrrolidinone and PLGA-triacetin solutions. Upon bringing the PLGA-solvent-compound pre-formulation in contact with the hydrogel, Vis imaging and light microscopy were applied to visualize the depot formation and UV imaging was used to quantify drug transport in the hydrogel. As compared to piroxicam, the α-lactalbumin invoked an acceleration of phase separation and an increase of implant size. α-Lactalbumin was released faster from the PLGA-1-methyl-2-pyrrolidinone system than the PLGA-triacetin system opposite to the piroxicam release pattern. A linear relationship between the rate of implant formation and initial compound release within the first 4h was established for the PLGA-NMP systems. This implies that phase separation may be one of the controlling factors in drug release. The rate of implant formation may be an important parameter for predicting and tailoring drug release. The approach combining UV imaging, Vis imaging and light microscopy may facilitate understanding of release processes and holds potential for becoming a useful tool in formulation development of in situ forming implants.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
Lactalbumina/administração & dosagem
Ácido Láctico/química
Piroxicam/administração & dosagem
Ácido Poliglicólico/química
[Mh] Termos MeSH secundário: Química Farmacêutica/métodos
Portadores de Fármacos/química
Implantes de Medicamento
Liberação Controlada de Fármacos
Hidrogéis
Pirrolidinonas/química
Espectrofotometria Ultravioleta/métodos
Análise Espectral/métodos
Tela Subcutânea/metabolismo
Triacetina/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Drug Implants); 0 (Hydrogels); 0 (Pyrrolidinones); 0 (polylactic acid-polyglycolic acid copolymer); 13T4O6VMAM (Piroxicam); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 9013-90-5 (Lactalbumin); JR9CE63FPM (N-methylpyrrolidone); XHX3C3X673 (Triacetin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  3 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28954095
[Au] Autor:Purim KSM; Peretti MC; Fillus J; Olandoski M
[Ad] Endereço:Discipline of Dermatology of the Medical School - Universidade Positivo (UP) - Curitiba (PR), Brazil.
[Ti] Título:Chromoblastomycosis: tissue modifications during itraconazole treatment.
[So] Source:An Bras Dermatol;92(4):478-483, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Background:: Histological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis. Objectives:: To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment. Methods:: A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Patients were classified into two groups: plaque or tumor lesions, and underwent periodic evaluations every four months during three years. Hematoxylin-eosin stain was used to analyze epidermal modifications, inflammatory infiltrate and fibrosis, and Fontana-Masson stain for parasite evaluation. Results:: Fontana-Masson stain was superior to hematoxylin-eosin stain in fungal count in the epidermis (mean difference=0.14; p<0.05). The most distinct mycosis tissue responses were registered in the dermis. Epidermal thinning, granulomatous infiltrate decrease or disappearance, fibrosis increase and quantitative/morphological changes occurred during treatment. Study limitations:: Patients could not be located to have their current skin condition examined. Conclusion:: Parasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/tratamento farmacológico
Doenças dos Trabalhadores Agrícolas/microbiologia
Antifúngicos/uso terapêutico
Cromoblastomicose/tratamento farmacológico
Itraconazol/uso terapêutico
Pele/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Doenças dos Trabalhadores Agrícolas/patologia
Biópsia
Cromoblastomicose/microbiologia
Cromoblastomicose/patologia
Feminino
Fungos/fisiologia
Interações Hospedeiro-Parasita/fisiologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Nitrato de Prata
Pele/microbiologia
Tela Subcutânea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fontana-Masson stain); 304NUG5GF4 (Itraconazole); 95IT3W8JZE (Silver Nitrate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  4 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28792959
[Au] Autor:Iuchi T; Kobayashi M; Tsuchiya S; Ohno N; Dai M; Matsumoto M; Ogai K; Sato A; Sawazaki T; Miyati T; Tanaka S; Sugama J
[Ad] Endereço:Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
[Ti] Título:Objective assessment of leg edema using ultrasonography with a gel pad.
[So] Source:PLoS One;12(8):e0182042, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ultrasonography (US) is useful for visual detection of edematous tissues to assess subcutaneous echogenicity. However, visualization of subcutaneous echogenicity is interpreted differently among operators because the evaluation is subjective and individual operators have unique knowledge. This study objectively assessed leg edema using US with a gel pad including fat for normalization of echogenicity in subcutaneous tissue. Five younger adults and four elderly people with leg edema were recruited. We compared assessments of US and limb circumference before and after the intervention of vibration to decrease edema in younger adults, and edema prior to going to sleep and reduced edema in the early morning in elderly people. These assessments were performed twice in elderly people by three operators and reliability, interrater differences, and bias were assessed. For US assessment, echogenicity in subcutaneous tissue was normalized to that of the gel pad by dividing the mean echogenicity of subcutaneous tissue by the mean echogenicity of the gel pad. In younger adults, the normalized subcutaneous echogenicity before the intervention was significantly higher than that after the intervention. In elderly people, echogenicity indicating edema was significantly higher than that after edema reduction. Edema was detected with accuracy rates of 76.9% in younger adults and 75.0% in elderly people. Meanwhile, limb circumference could be used to detect edema in 50.0% of healthy adults and 87.8% of elderly people. The intra-reliability was excellent (intraclass correlation coefficient > 0.9, p < 0.01), and the inter-reliability was good (intraclass correlation coefficient > 0.7, p < 0.01) for normalized subcutaneous echogenicity. Bland-Altman plots revealed that inter-rater differences and systematic bias were small. Normalized subcutaneous echogenicity with the pad can sensitively and objectively assess leg edema with high reliability. Therefore, this method has the potential to become a new gold standard for objective assessment of leg edema in clinical practice.
[Mh] Termos MeSH primário: Edema/diagnóstico por imagem
Gordura Subcutânea/diagnóstico por imagem
Tela Subcutânea/diagnóstico por imagem
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Pesos e Medidas Corporais/métodos
Erros de Diagnóstico
Edema/diagnóstico
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182042


  5 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28738938
[Au] Autor:Salfity HV; Valsangkar N; Schultz M; Salfity J; Stanton-Maxey KJ; Zarzaur B; Feliciano DV; Laughlin MR
[Ti] Título:Minimally Invasive Incision and Drainage Technique in the Treatment of Simple Subcutaneous Abscess in Adults.
[So] Source:Am Surg;83(7):699-703, 2017 Jul 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A minimally invasive (MI) approach using small incisions and vessel loops for drainage of simple perianal abscesses has been described in the pediatric population with decreased postoperative pain and comparable results to the traditional incision and drainage (I&D). The hypothesis was MI I&D will yield similar outcomes in adults. Patients who underwent I&D of perianal abscesses at an urban hospital from January 2008 to December 2015 were identified by Current Procedural Terminology code. Patients below 18 years of age, with inflammatory bowel diseases, or fistulae were excluded. Recurrences, readmissions, operative time, length of stay, complications, and costs were compared. There were 47 traditional and 96 MI I&D with no significant differences in demographics, average body mass index, and abscess size. No significant differences were noted in recurrences, readmissions, length of stay, operative time, or costs (P > 0.05). Postoperative complications occurred more frequently in the traditional group (P < 0.01) with a lower rate of follow-up (P < 0.05). MI I&D for simple anal abscesses in adults is associated with better compliance and fewer complications than the traditional approach. Although further studies are needed to determine if MI I&D confers superiority, this approach should be considered as first-line treatment for uncomplicated perirectal abscesses in adults.
[Mh] Termos MeSH primário: Abscesso/cirurgia
Doenças do Ânus/microbiologia
Doenças do Ânus/cirurgia
Drenagem/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos
Recidiva
Estudos Retrospectivos
Tela Subcutânea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  6 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28678965
[Au] Autor:Valentim D; Bueno CRE; Marques VAS; Vasques AMV; Cury MTS; Cintra LTA; Dezan E
[Ad] Endereço:Centro Universitário do Distrito Federal - UDF, School of Dentistry, Department of Endodontics, Brasilia, DF, Brazil.
[Ti] Título:Calcium hydroxide associated with a new vehicle: Psidium cattleianum leaf extracts. Tissue response evaluation.
[So] Source:Braz Oral Res;31:e43, 2017 Jul 03.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate edemogenic activity and subcutaneous inflammatory reaction induced by Psidium cattleianum leaf extracts associated with Ca(OH)2. Thirty male Wistar rats, split equally into three groups [aqueous extract + Ca(OH)2; ethanolic extract + Ca(OH)2; and propylene glycol + Ca(OH)2], were assessed every 3 h or 6 h (five animals in each period). Under general anesthesia, 0.2 mL of 1% Evans blue per 100 g of body weight was injected into the penile vein and each combination to be evaluated was subcutaneously injected into the dorsal region 30 min thereafter. Edemogenic activity was analyzed by spectrophotometry (λ=630 nm). For inflammatory reaction analysis, 50 rats received four polyethylene tubes (three experimental groups) and an empty tube (control group). The assessments were made at 7, 15, 30, 60, and 90 days, followed by hematoxylin-eosin staining and by the assignment of scores for evaluation of tissue response intensity. Ethanolic extract + Ca(OH)2 yielded the largest edemogenic activity at 3 h. Intergroup differences at 6 h were not significant. The histological analysis showed progressive repair over time (p<0.05) and aqueous and ethanolic extracts produced similar responses to those of the control and Ca(OH)2 + propylene glycol groups. Psidium cattleianum leaf extracts used as Ca(OH)2 vehicles evoked similar tissue response when compared to Ca(OH)2 associated with propylene glycol.
[Mh] Termos MeSH primário: Hidróxido de Cálcio/farmacologia
Extratos Vegetais/farmacologia
Psidium/química
Tela Subcutânea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/farmacologia
Portadores de Fármacos
Avaliação Pré-Clínica de Medicamentos
Etanol/farmacologia
Inflamação/tratamento farmacológico
Inflamação/patologia
Masculino
Teste de Materiais
Veículos Farmacêuticos/química
Veículos Farmacêuticos/farmacologia
Folhas de Planta/química
Propilenoglicol/farmacologia
Ratos Wistar
Reprodutibilidade dos Testes
Tela Subcutânea/patologia
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Drug Carriers); 0 (Pharmaceutical Vehicles); 0 (Plant Extracts); 059QF0KO0R (Water); 3K9958V90M (Ethanol); 6DC9Q167V3 (Propylene Glycol); PF5DZW74VN (Calcium Hydroxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


  7 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28594929
[Au] Autor:Vilaseca A; Campillo N; Torres M; Musquera M; Gozal D; Montserrat JM; Alcaraz A; Touijer KA; Farré R; Almendros I
[Ad] Endereço:Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
[Ti] Título:Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea.
[So] Source:PLoS One;12(6):e0179444, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigate the effects of intermittent hypoxia (IH), a characteristic feature of obstructive sleep apnea (OSA), on renal cancer progression in an animal and cell model. An in vivo mouse model (Balb/c, n = 50) of kidney cancer was used to assess the effect of IH on tumor growth, metastatic capacity, angiogenesis and tumor immune response. An in vitro model tested the effect of IH on RENCA cells, macrophages and endothelial cells. Tumor growth, metastatic capacity, circulating vascular endothelial growth factor (VEGF) and content of endothelial cells, tumor associated macrophages and their phenotype were assessed in the tumor. In vitro, VEGF cell expression was quantified.Although IH did not boost tumor growth, it significantly increased endothelial cells (p = 0.001) and circulating VEGF (p<0.001) in the in vivo model. Macrophages exposed to IH in vitro increased VEGF expression, whereas RENCA cells and endothelial cells did not. These findings are in keeping with previous clinical data suggesting that OSA has no effect on kidney cancer size and that the association observed between OSA and higher Fuhrman grade of renal cell carcinoma may be mediated though a proangiogenic process, with a key role of macrophages.
[Mh] Termos MeSH primário: Hipóxia/complicações
Neoplasias Renais/irrigação sanguínea
Neoplasias Renais/complicações
Neovascularização Patológica/patologia
Síndromes da Apneia do Sono/complicações
[Mh] Termos MeSH secundário: Animais
Carcinoma de Células Renais/irrigação sanguínea
Carcinoma de Células Renais/complicações
Carcinoma de Células Renais/patologia
Modelos Animais de Doenças
Hipóxia/genética
Hipóxia/patologia
Neoplasias Renais/genética
Neoplasias Renais/patologia
Macrófagos/patologia
Masculino
Camundongos Endogâmicos BALB C
Metástase Neoplásica
Neovascularização Patológica/genética
Síndromes da Apneia do Sono/genética
Síndromes da Apneia do Sono/patologia
Tela Subcutânea/patologia
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179444


  8 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28533883
[Au] Autor:Naim A; Benchekroune N; Bouchbika Z; Taoufiq N; Jouhadi H; Sahraoui S; Benider A
[Ad] Endereço:CHU Ibn Rochd, Université Mohammed VI des Sciences de la Santé, Hopital Cheikh Khalifa, Casablanca, Maroc.
[Ti] Título:[Subcutaneous myxoid liposarcoma].
[Ti] Título:Liposarcome myxoide sous cutané..
[So] Source:Pan Afr Med J;26:162, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Although myxoid liposarcomas (MLS) are the most common type of soft-tissue sarcomas in adults, their primary location in the superficial tissues is rare. So sarcomas are classified as superficial and deep-seated. They are distinct based on their location and their frequency as well as their prognosis which is relatively better in superficial sarcomas. We here report the case of a patient with subcutaneous liposarcoma in the right thigh. The diagnosis was confirmed by histology after clinical symptoms had evolved over 1 year. Treatment involved wide surgical resection followed by locoregional radiation therapy. Patient's evolution was marked by complete remission maintained after 32 months follow-up. This study highlights that superficial sarcomas are rare and this can cause a delay in diagnosis compromising their prognosis.
[Mh] Termos MeSH primário: Lipossarcoma Mixoide/patologia
Tela Subcutânea/patologia
Coxa da Perna/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Lipossarcoma Mixoide/diagnóstico
Lipossarcoma Mixoide/terapia
Prognóstico
Indução de Remissão
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.26.162.8494


  9 / 2546 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28444097
[Au] Autor:Novak GV; Hayashi K; Sampa K; Okumura Y; Ferreira GRV; Silva CA
[Ad] Endereço:Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
[Ti] Título:Chronic polyarthritis as the first manifestation of childhood systemic polyarteritis nodosa.
[So] Source:Einstein (Sao Paulo);15(1):96-99, 2017 Jan-Mar.
[Is] ISSN:2317-6385
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. We describe the case of a 4-year old girl who had additive and chronic polyarthritis with edema, tenderness, pain on motion and morning stiffness for 2 months. After 45 days, she also presented painful subcutaneous nodules and erythematous-violaceous lesions in the extensor region of upper and lower limbs. She was admitted to university hospital due to high fever, malaise, myalgia, anorexia, loss of weight (1kg), painful skin lesions and severe functional disability. She was bedridden by chronic polyarthritis with limitation on motion. Systolic and diastolic blood pressures were greater than 95th percentile for height. Urine protein/creatinine ratio was 0.39g/day, and immunological tests were negative. Anti-streptolysin O was 1,687UI/mL. Skin biopsy revealed necrotizing vasculitis in medium- and small-sized vessels compatible with polyarteritis nodosa. Therefore, we had the diagnosis of systemic polyarteritis nodosa. Prednisone 2mg/kg/day was administered with complete resolution of skin lesions and arthritis, and improvement of proteinuria (0.26g/day) after 15 days. The diagnosis of childhood systemic polyarteritis nodosa should be considered for patients with chronic polyarthritis associated to cutaneous vasculitis triggered by streptococcal infection. RESUMO Na poliarterite nodosa sistêmica pediátrica, a artrite caracteriza-se pelo padrão agudo, geralmente evanescente, com oligoartrite, e afeta principalmente joelhos e tornozelos. No entanto, a poliartrite crônica com rigidez matinal e simulando artrite idiopática juvenil ainda não foi relatada. Descrevemos o caso de uma menina de 4 anos que apresentou poliartrite crônica aditiva com edema, dor à palpação e movimento, e rigidez matinal por 2 meses. Após 45 dias, também apresentou nódulos subcutâneos dolorosos e lesões eritêmato-violáceas na região extensora dos membros superiores e inferiores. Foi internada no hospital universitário por conta de febre alta, mal-estar, mialgia, anorexia, perda de peso (1kg), lesões de pele muito dolorosas e incapacidade funcional grave. Estava restrita ao leito devido à poliartrite crônica com limitação do movimento. Pressões sistólica e diastólica foram maiores que percentil 95 para altura. Relação proteína/creatinina urinária estava 0,39g/dia, e os testes imunológicos foram negativos. Antiestreptolisina O era 1.687UI/mL. A biópsia de pele revelou vasculite necrosante de vasos de pequeno e médio calibre, compatível com poliarterite nodosa. Portanto, foi realizado o diagnóstico de poliarterite nodosa sistêmica. Foi administrada prednisona 2mg/kg/dia com resolução completa das lesões de pele e da artrite, além de melhora da proteinúria (0,26g/dia) após 15 dias. O diagnóstico de poliarterite nodosa sistêmica pediátrica deve ser considerado em pacientes com poliartrite crônica associado a lesões cutâneas vasculíticas, sendo a infecção estreptocócica um importante fator desencadeante.
[Mh] Termos MeSH primário: Artrite/etiologia
Artrite/patologia
Poliarterite Nodosa/complicações
Poliarterite Nodosa/patologia
[Mh] Termos MeSH secundário: Artrite/tratamento farmacológico
Pré-Escolar
Eritema/patologia
Feminino
Seres Humanos
Poliarterite Nodosa/tratamento farmacológico
Pele/patologia
Tela Subcutânea/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


  10 / 2546 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28420485
[Au] Autor:Llombart B; Serra-Guillén C; Rubio L; Nagore E; Requena C; Traves V; Calomarde L; Bancalari B; López-Guerrero JA; Guillen-Barona C; Sanmartín O
[Ad] Endereço:Dermatology Department, Instituto Valenciano de Oncologia, Valencia, Spain. Electronic address: beatriz.llombart@uv.es.
[Ti] Título:Subcutaneous dermatofibrosarcoma protuberans, a rare subtype with predilection for the head: A retrospective series of 18 cases.
[So] Source:J Am Acad Dermatol;77(3):503-511.e1, 2017 Sep.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare. OBJECTIVE: We sought to characterize the subcutaneous DFSP (SC-DFSP) variant and compare it with cutaneous DFSP (C-DFSP). METHODS: This work was a retrospective study of DFSP treated in our institution. RESULTS: Of 124 cases of DFSP, 18 were SC-DFSP (14.5%). Except for the deep location, the pathologic and genetic features were indistinguishable from the C-DFSP variant. Histologically, of 18 SC-DFSP cases, 13 were classic DFSP, 3 fibrosarcomatous DFSP (FS-DFSP), 1 Bednar tumor, and 1 giant-cell fibroblastoma. All tumors expressed CD34 and the COL1A1-PDGFB fusion transcripts. In our series, higher proportions of SC-DFSP tumors (61%) than C-DFSP tumors (8.5%) were located on the head (P < .001). Of the 20 DFSP tumors on the head (16.1%), 11 were SC-DFSP and 9 were C-DFSP. In addition, half the SC-DFSP tumors affected muscle or periosteum, compared with a quarter of the C-DFSP tumors (P = .009). SC-DFSP needed a higher number of Mohs stages than did C-DFSP (P = .009). Median follow-up time was 63 months, and 2 FS-DFSP tumors recurred (1 SC-DFSP, 1 C-DFSP). LIMITATIONS: Limitations include the retrospective aspect of the study. CONCLUSIONS: Most DFSP tumors involving the head were subcutaneous and required more complex surgery. Dermatologists should be aware of this atypical presentation, especially in lesions involving the head.
[Mh] Termos MeSH primário: Dermatofibrossarcoma/patologia
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias Cutâneas/patologia
Tela Subcutânea
[Mh] Termos MeSH secundário: Adolescente
Adulto
Dermatofibrossarcoma/classificação
Feminino
Neoplasias de Cabeça e Pescoço/classificação
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Neoplasias Cutâneas/classificação
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE



página 1 de 255 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde