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[PMID]: 28748670 [Au] Autor: Taye M; Lee W; Caetano-Anolles K; Dessie T; Hanotte O; Mwai OA; Kemp S; Cho S; Oh SJ; Lee HK; Kim H [Ad] Endereço: Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea. [Ti] Título: Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance. [So] Source: Anim Sci J;88(12):1889-1901, 2017 Dec. [Is] ISSN: 1740-0929 [Cp] País de publicação: Australia [La] Idioma: eng [Ab] Resumo: As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods. We identified 296 (XP-EHH) and 327 (XP-CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study. [Mh] Termos MeSH primário: Bovinos/genética Bovinos/fisiologia Estudos de Associação Genética/veterinária Genoma/genética Seleção Genética/genética Termotolerância/genética [Mh] Termos MeSH secundário: Animais Ingestão de Alimentos/genética Ontologia Genética Cor de Cabelo/genética Haplótipos/genética Resposta ao Choque Térmico/genética Homozigoto Temperatura Alta Pressão Osmótica Estresse Oxidativo/genética Glândulas Sudoríparas Sudorese/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1111/asj.12851

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[PMID]: 28796813 [Au] Autor: Klaka P; Grüdl S; Banowski B; Giesen M; Sättler A; Proksch P; Welss T; Förster T [Ad] Endereço: Henkel AG & Co. KGaA, Düsseldorf, Germany. [Ti] Título: A novel organotypic 3D sweat gland model with physiological functionality. [So] Source: PLoS One;12(8):e0182752, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Dysregulated human eccrine sweat glands can negatively impact the quality-of-life of people suffering from disorders like hyperhidrosis. Inability of sweating can even result in serious health effects in humans affected by anhidrosis. The underlying mechanisms must be elucidated and a reliable in vitro test system for drug screening must be developed. Here we describe a novel organotypic three-dimensional (3D) sweat gland model made of primary human eccrine sweat gland cells. Initial experiments revealed that eccrine sweat gland cells in a two-dimensional (2D) culture lose typical physiological markers. To resemble the in vivo situation as close as possible, we applied the hanging drop cultivation technology regaining most of the markers when cultured in its natural spherical environment. To compare the organotypic 3D sweat gland model versus human sweat glands in vivo, we compared markers relevant for the eccrine sweat gland using transcriptomic and proteomic analysis. Comparing the marker profile, a high in vitro-in vivo correlation was shown. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), muscarinic acetylcholine receptor M3 (CHRM3), Na+-K+-Cl- cotransporter 1 (NKCC1), calcium-activated chloride channel anoctamin-1 (ANO1/TMEM16A), and aquaporin-5 (AQP5) are found at significant expression levels in the 3D model. Moreover, cholinergic stimulation with acetylcholine or pilocarpine leads to calcium influx monitored in a calcium flux assay. Cholinergic stimulation cannot be achieved with the sweat gland cell line NCL-SG3 used as a sweat gland model system. Our results show clear benefits of the organotypic 3D sweat gland model versus 2D cultures in terms of the expression of essential eccrine sweat gland key regulators and in the physiological response to stimulation. Taken together, this novel organotypic 3D sweat gland model shows a good in vitro-in vivo correlation and is an appropriate alternative for screening of potential bioactives regulating the sweat mechanism. [Mh] Termos MeSH primário: Glândulas Sudoríparas/citologia [Mh] Termos MeSH secundário: Acetilcolina/farmacologia Aquaporina 5/genética Aquaporina 5/metabolismo Aquaporina 5/secreção Biomarcadores/metabolismo Sinalização do Cálcio Técnicas de Cultura de Células Polaridade Celular Sobrevivência Celular Células Cultivadas Agonistas Colinérgicos/farmacologia Seres Humanos Modelos Biológicos Esferoides Celulares/citologia Esferoides Celulares/fisiologia Glândulas Sudoríparas/metabolismo Glândulas Sudoríparas/secreção Transcriptoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (AQP5 protein, human); 0 (Aquaporin 5); 0 (Biomarkers); 0 (Cholinergic Agonists); N9YNS0M02X (Acetylcholine) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171019 [Lr] Data última revisão: 171019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170811 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0182752

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[PMID]: 28636607 [Au] Autor: Kurata R; Futaki S; Nakano I; Fujita F; Tanemura A; Murota H; Katayama I; Okada F; Sekiguchi K [Ad] Endereço: Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Suita, Osaka University, Osaka, Japan. [Ti] Título: Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining. [So] Source: PLoS One;12(6):e0178709, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Because sweat secretion is facilitated by mechanical contraction of sweat gland structures, understanding their structure-function relationship could lead to more effective treatments for patients with sweat gland disorders such as heat stroke. Conventional histological studies have shown that sweat glands are three-dimensionally coiled tubular structures consisting of ducts and secretory portions, although their detailed structural anatomy remains unclear. To better understand the details of the three-dimensional (3D) coiled structures of sweat glands, a whole-mount staining method was employed to visualize 3D coiled gland structures with sweat gland markers for ductal luminal, ductal basal, secretory luminal, and myoepithelial cells. Imaging the 3D coiled gland structures demonstrated that the ducts and secretory portions were comprised of distinct tubular structures. Ductal tubules were occasionally bent, while secretory tubules were frequently bent and formed a self-entangled coiled structure. Whole-mount staining of complex coiled gland structures also revealed the detailed 3D cellular arrangements in the individual sweat gland compartments. Ducts were composed of regularly arranged cuboidal shaped cells, while secretory portions were surrounded by myoepithelial cells longitudinally elongated along entangled secretory tubules. Whole-mount staining was also used to visualize the spatial arrangement of blood vessels and nerve fibers, both of which facilitate sweat secretion. The blood vessels ran longitudinally parallel to the sweat gland tubules, while nerve fibers wrapped around secretory tubules, but not ductal tubules. Taken together, whole-mount staining of sweat glands revealed the 3D cell shapes and arrangements of complex coiled gland structures and provides insights into the mechanical contraction of coiled gland structures during sweat secretion. [Mh] Termos MeSH primário: Imagem Tridimensional/métodos Pele/citologia Glândulas Sudoríparas/citologia [Mh] Termos MeSH secundário: Biomarcadores/metabolismo Técnicas de Cultura de Células Forma Celular Células Cultivadas Células Epiteliais/metabolismo Imunofluorescência Seres Humanos Técnicas Imunoenzimáticas Pele/metabolismo Glândulas Sudoríparas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171004 [Lr] Data última revisão: 171004 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170622 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0178709

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[PMID]: 28598015 [Au] Autor: Ebenezer GJ; Liu Y; Judge DP; Cunningham K; Truelove S; Carter ND; Sebastian B; Byrnes K; Polydefkis M [Ad] Endereço: Department of Neurology, Johns Hopkins University. [Ti] Título: Cutaneous nerve biomarkers in transthyretin familial amyloid polyneuropathy. [So] Source: Ann Neurol;82(1):44-56, 2017 Jul. [Is] ISSN: 1531-8249 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To determine the utility of skin biopsies as a biomarker of disease severity in subjects with amyloid neuropathy. METHODS: Five groups of patients were studied: (1) transthyretin (TTR) familial amyloidotic polyneuropathy (FAP; n = 20), (2) TTR mutation carriers without peripheral neuropathy (TTR-noPN; n = 10), (3) healthy controls (n = 20), (4) diabetic neuropathy disease controls (n = 20), and (5) patients with light-chain (AL) amyloid (n = 2). All subjects underwent neurological examination and 3mm skin biopsies. Sections were stained with anti-PGP9.5, anti-TTR, and Congo red. Intraepidermal (IENFD), sweat gland (SGNFD), and pilomotor nerve fiber densities (PMNFD) were measured. Correlations between the amount of amyloid present (amyloid burden), fiber subtype, and Neuropathy Impairment Score in the Lower Limbs (NIS-LL) were evaluated. RESULTS: IENFD, SGNFD, and PMNFD were all significantly reduced in TTR-FAP patients versus healthy controls, whereas TTR-noPN subjects had intermediate reductions. Lower nerve fiber densities were associated with NIS-LL (p < 0.001). Congo red staining revealed brilliant red amyloid deposits confirmed by apple-green birefringence within dermal collagen, sweat glands, and arrector pili that engulfed axons. The diagnostic sensitivity and specificity to detect amyloid in skin were 70% and 100%. Both AL amyloidosis and 2 of 10 TTR-noPN subjects were Congo red-positive. Amyloid burden correlated with IENFD (r = -0.63), SGNFD (r = -0.67), PMNFD (r = -0.50), and NIS-LL (r = -0.57). Wild-type TTR staining was less prominent in TTR-FAP patients. INTERPRETATION: Cutaneous amyloid was detected in 70% of TTR-FAP and 20% of TTR-noPN subjects. Amyloid burden correlated strongly with reductions in IENFD, SGNFD, PMNFD, and NIS-LL. Skin is an attractive tissue to establish an amyloid diagnosis, and amyloid burden has potential as a biomarker to detect treatment effect in TTR-FAP drug trials. Ann Neurol 2017;82:44-56. [Mh] Termos MeSH primário: Neuropatias Amiloides Familiares/metabolismo Neuropatias Amiloides Familiares/patologia Amiloide/metabolismo Fibras Nervosas/patologia Pele/metabolismo Pele/patologia Glândulas Sudoríparas/metabolismo [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Neuropatias Amiloides Familiares/genética Biomarcadores/metabolismo Estudos de Casos e Controles Neuropatias Diabéticas/metabolismo Neuropatias Diabéticas/patologia Feminino Heterozigoto Seres Humanos Masculino Meia-Idade Mutação/genética Pré-Albumina/genética Índice de Gravidade de Doença Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amyloid); 0 (Biomarkers); 0 (Prealbumin) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170610 [St] Status: MEDLINE [do] DOI: 10.1002/ana.24972

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[PMID]: 28581222 [Au] Autor: Pontiggia L [Ad] Endereço: Tissue Biology Research Unit, Department of Surgery, University Children's Hospital, August Forel Strasse 7, Zürich, 8008, Switzerland. [Ti] Título: Eccrine sweat gland regeneration: still a story of 'blood, toil, tears and sweat'. [So] Source: Br J Dermatol;176(6):1435-1436, 2017 06. [Is] ISSN: 1365-2133 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Glândulas Écrinas Suor [Mh] Termos MeSH secundário: Seres Humanos Regeneração Glândulas Sudoríparas Sudorese [Pt] Tipo de publicação: JOURNAL ARTICLE; COMMENT [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170606 [St] Status: MEDLINE [do] DOI: 10.1111/bjd.15564

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[PMID]: 28538882 [Au] Autor: Delort S; Marchi E; Corrêa MA [Ad] Endereço: Graduate program of the Faculdade de Medicina de Jundiaí (FMJ) - Jundiaí (SP), Brazil. [Ti] Título: Oxybutynin as an alternative treatment for hyperhidrosis. [So] Source: An Bras Dermatol;92(2):217-220, 2017 Mar-Apr. [Is] ISSN: 1806-4841 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Hyperhidrosis is the excessive production of sweating, which can be primary and focal or secondary to various pathologies. The exact cause of primary focal hyperhidrosis is still unknown, although a genetic basis is recognized, and its prevalence varies from 1% to 2.8%. The most affected sites are the armpits, palms, soles and face. It causes much discomfort, affects the quality of life, and is estimated to be undervalued by health professionals. Many treatment options are proposed, both clinical and surgical. The aim of this review is to focus on the treatment of hyperhidrosis with oxybutynin, an anticholinergic drug originally used to control overactive bladder. [Mh] Termos MeSH primário: Hiperidrose/tratamento farmacológico Ácidos Mandélicos/uso terapêutico Antagonistas Muscarínicos/uso terapêutico [Mh] Termos MeSH secundário: Seres Humanos Ácidos Mandélicos/efeitos adversos Antagonistas Muscarínicos/efeitos adversos Glândulas Sudoríparas/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Mandelic Acids); 0 (Muscarinic Antagonists); K9P6MC7092 (oxybutynin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171006 [Lr] Data última revisão: 171006 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170525 [St] Status: MEDLINE

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[PMID]: 28441468 [Au] Autor: Plochocki JH; Ruiz S; Rodriguez-Sosa JR; Hall MI [Ad] Endereço: Department of Anatomy, Midwestern University, Glendale, Arizona, United States of America. [Ti] Título: Histological study of white rhinoceros integument. [So] Source: PLoS One;12(4):e0176327, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In this study, we report findings from a microscopic analysis of the white rhinoceros (Ceratotherium simum) integumentary ultrastructure. Skin samples from the cheek, shoulder, flank and rump were taken from a 46-year-old female southern white rhinoceros and examined using H&E and elastic histological stains. The epidermis was thickest in the flank (1.003 mm) followed by the rump, cheek and shoulder. The stratum corneum comprised more than half the epidermal thickness. Numerous melanin granules were found in the basal and spinosum layers. The epidermal-dermal junction was characterized by abundant papillary folds increasing surface contact between integument layers. Most of the dermal thickness consisted of organized collagen bundles with scattered elastic fibers. Collagen fiber bundles were thickest in the flank (210.9 µm) followed by shoulder, rump and cheek. Simple coiled sweat glands were present in the dermis, but hair and sebaceous glands were absent. Together, these data suggest the white rhinoceros has a unique integumentary system among large terrestrial herbivores. [Mh] Termos MeSH primário: Tegumento Comum/anatomia & histologia Perissodáctilos/anatomia & histologia Pele/anatomia & histologia Glândulas Sudoríparas/anatomia & histologia [Mh] Termos MeSH secundário: Animais Colágeno/ultraestrutura Epiderme/anatomia & histologia Epiderme/ultraestrutura Feminino Pele/ultraestrutura Glândulas Sudoríparas/ultraestrutura [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 9007-34-5 (Collagen) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170426 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0176327

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[PMID]: 28282662 [Au] Autor: Zhang W; Wei Y; Jiang H; Xu J; Yu D [Ad] Endereço: The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China. [Ti] Título: R3 versus R4 Thoracoscopic Sympathectomy for Severe Palmar Hyperhidrosis. [So] Source: Thorac Cardiovasc Surg;65(6):491-496, 2017 Sep. [Is] ISSN: 1439-1902 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Thoracoscopic sympathectomy (TS) was the preferred surgical treatment for palmar hyperhidrosis (PH), but postoperative complications such as compensatory sweating (CS) were common. This study was projected to compare R3 versus R4 TS for treating severe PH. From April 2009 and March 2015, 106 consecutive patients with severe PH underwent bilateral R3 ( = 62) or R4 ( = 44) TS at The Second Affiliated Hospital of Nanchang University. The patients were followed up to evaluate symptom resolution, postoperative complications, satisfaction level, and severity of CS. The 106 patients underwent 212 sympathecotomies and were cured with no severe complications or perioperative mortality. The incidence of minor side effects (such as pneumothorax, gustatory sweating, moist hands, and bradycardia) was similar in both groups. More patients had overdry hands in the R3 group than in the R4 group (6/62 vs. 0/44; = 0.040). More CS occurred in the R3 group as compared with the R4 group (42/62 vs. 23/44; = 0.156). The incidence of moderate-to-severe CS was higher in the R3 group than in the R4 group (14/62 vs. 4/40; = 0.045). Most patients were satisfied with the results, except for three (5.84%) in the R3 group and one (2.27%) in the R4 group. PH can be effectively treated by either R3 or R4 TS, with high rates of patient satisfaction. R4 sympathectomy appears to be associated with less severe CS and should be the choice of denervation level. [Mh] Termos MeSH primário: Hiperidrose/cirurgia Glândulas Sudoríparas/inervação Sudorese Simpatectomia/métodos Sistema Nervoso Simpático/cirurgia Toracoscopia [Mh] Termos MeSH secundário: Adolescente Adulto China Feminino Mãos Hospitais Universitários Seres Humanos Hiperidrose/diagnóstico Hiperidrose/fisiopatologia Masculino Satisfação do Paciente Complicações Pós-Operatórias/etiologia Complicações Pós-Operatórias/fisiopatologia Complicações Pós-Operatórias/prevenção & controle Qualidade de Vida Estudos Retrospectivos Simpatectomia/efeitos adversos Sistema Nervoso Simpático/fisiopatologia Toracoscopia/efeitos adversos Fatores de Tempo Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170311 [St] Status: MEDLINE [do] DOI: 10.1055/s-0037-1600113

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[PMID]: 28282661 [Au] Autor: Dobosz L; Cwalina N; Stefaniak T [Ad] Endereço: Department of General, Endocrine and Transplant Surgery, Gdanski Uniwersytet Medyczny, Ringgold Standard Institution, Gdansk, Poland. [Ti] Título: Influence of Body Mass Index on Compensatory Sweating in Patients after Thoracic Sympathectomy due to Palmar Hyperhidrosis. [So] Source: Thorac Cardiovasc Surg;65(6):497-502, 2017 Sep. [Is] ISSN: 1439-1902 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Thoracic sympathectomy (TS) is one of the most effective methods of treatment of primary hyperhidrosis. One of the side effects of this procedure is compensatory sweating (CS). The aim of our study was to evaluate the influence of body mass index (BMI) on CS in patients after TS due to palmar hyperhidrosis. Data from 157 patients with palmar hyperhidrosis who underwent TS were collected. The patients were subsequently divided in two groups according to their initial BMI: group A, BMI < 25 kg/m , and group B, BMI ≥ 25 kg/m . Objective (gravimetry) and subjective (VAS) measurements of the intensity of hyperhidrosis were taken from the patients' bodies prior to surgery, as well as 3 and 12 months after TS. Average palmar hyperhidrosis levels before the surgery did not differ significantly between the two groups (238.65 vs. 190.15; = 0.053). A statistically significant decrease in palmar hyperhidrosis was noted in both groups, both 3 and 12 months after surgery (238.65 vs. 11.86 vs. 13.5; < 0.05, and 190.15 vs. 16.67 vs. 11.81; < 0.05, respectively). The intensity of sweating over the abdomino-lumbar area differed significantly between the groups before the surgery, both in subjective (1.71 vs. 3.61; < 0.05) and objective (13.57 vs. 35.95; < 0.05) evaluations. Three months after surgical intervention, an intensification of CS was observed in both the groups; however, no statistically significant differences were observed between the two sets of patients (VAS: 4.58 vs. 5.16; = 0.38; gravimetry: 33.87 vs. 53.89; = 0.12). Twelve months after TS, CS was higher in the group with an initial BMI ≥ 25 kg/m , both in subjective and objective evaluations (3.23 vs. 4.94; = 0.03 and 18.08 vs. 80.21; = 0.026, respectively). Patients with a BMI ≥ 25 kg/m experience more severe CS after TS, both in subjective and objective evaluations. [Mh] Termos MeSH primário: Índice de Massa Corporal Hiperidrose/cirurgia Obesidade/complicações Complicações Pós-Operatórias/etiologia Glândulas Sudoríparas/inervação Sudorese Simpatectomia/efeitos adversos Nervos Torácicos/cirurgia [Mh] Termos MeSH secundário: Adulto Feminino Rubor Mãos Seres Humanos Hiperidrose/diagnóstico Hiperidrose/fisiopatologia Masculino Obesidade/diagnóstico Complicações Pós-Operatórias/fisiopatologia Fatores de Risco Índice de Gravidade de Doença Simpatectomia/métodos Nervos Torácicos/fisiopatologia Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170311 [St] Status: MEDLINE [do] DOI: 10.1055/s-0037-1599797

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[PMID]: 28258566 [Au] Autor: Delporte C [Ad] Endereço: Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium. cdelport@ulb.ac.be. [Ti] Título: Aquaporins and Gland Secretion. [So] Source: Adv Exp Med Biol;969:63-79, 2017. [Is] ISSN: 0065-2598 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Aquaporins (AQPs ) are expressed in most exocrine and endocrine secretory glands. Consequently, summarizing the expression and functions of AQPs in secretory glands represents a daunting task considering the important number of glands present in the body, as well as the number of mammalian AQPs - thirteen. The roles played by AQPs in secretory processes have been investigated in many secretory glands. However, despite considerable research, additional studies are clearly needed to pursue our understanding of the role played by AQPs in secretory processes. This book chapter will focus on summarizing the current knowledge on AQPs expression and function in the gastrointestinal tract , including salivary glands, gastric glands, Duodenal Brunner's gland, liver and gallbladder, intestinal goblets cells, exocrine and endocrine pancreas, as well as few other secretory glands including airway submucosal glands, lacrimal glands, mammary glands and eccrine sweat glands. [Mh] Termos MeSH primário: Aquaporinas/metabolismo Células Eucarióticas/metabolismo Mucosa Gástrica/secreção Glândulas Mamárias Humanas/secreção Glândulas Salivares/secreção [Mh] Termos MeSH secundário: Animais Aquaporinas/química Aquaporinas/genética Transporte Biológico Glândulas Duodenais/metabolismo Glândulas Duodenais/secreção Células Eucarióticas/citologia Mucosa Gástrica/metabolismo Expressão Gênica Seres Humanos Ilhotas Pancreáticas/metabolismo Ilhotas Pancreáticas/secreção Aparelho Lacrimal/metabolismo Aparelho Lacrimal/secreção Glândulas Mamárias Humanas/metabolismo Pâncreas Exócrino/metabolismo Pâncreas Exócrino/secreção Subunidades Proteicas/química Subunidades Proteicas/genética Subunidades Proteicas/metabolismo Glândulas Salivares/metabolismo Glândulas Sudoríparas/metabolismo Glândulas Sudoríparas/secreção [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Nm] Nome de substância: 0 (Aquaporins); 0 (Protein Subunits) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170907 [Lr] Data última revisão: 170907 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170305 [St] Status: MEDLINE [do] DOI: 10.1007/978-94-024-1057-0_4

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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