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Pesquisa : A10.336.899.480 [Categoria DeCS]
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  1 / 1271 MEDLINE  
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[PMID]:28648603
[Au] Autor:Chee MK; Jo SK; Sohn KC; Kim CD; Lee JH; Lee YH
[Ad] Endereço:Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, South Korea.
[Ti] Título:Effects of Brn2 overexpression on eccrine sweat gland development in the mouse paw.
[So] Source:Biochem Biophys Res Commun;490(3):901-905, 2017 Aug 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eccrine sweat glands regulate body temperature by secreting water and electrolytes. In humans, eccrine sweat glands are ubiquitous in the skin, except in the lips and external genitalia. In mice, eccrine sweat glands are present only in the paw pad. Brn2 is a protein belonging to a large family of transcription factors. A few studies have examined Brn2 in melanoma cells and epidermal keratinocytes. This study investigated changes in the skin in the K5-Brn2 transgenic mouse, which overexpresses Brn2 and contains the keratin 5 promotor. Interestingly, the volume of eccrine sweat glands was reduced markedly in the K5-Brn2 transgenic mouse compared with the wild-type, while the expression of aquaporin 5, important molecule in sweat secretion, was increased in each sweat gland cell, probably to compensate for the reduction in gland development. However, sweating response to a pilocarpine injection in the hind paw was significantly decreased in the K5-Brn2 transgenic mouse compared with the wild-type. The paw epidermis was thicker in the K5-Brn2 transgenic mouse compared with the wild-type. Taken together, eccrine sweat gland development and sweat secretion were suppressed markedly in the K5-Brn2 transgenic mouse. These results may be associated with dominant development of the epidermis by Brn2 overexpression in the paw skin.
[Mh] Termos MeSH primário: Glândulas Écrinas/crescimento & desenvolvimento
Epiderme/crescimento & desenvolvimento
Proteínas do Tecido Nervoso/genética
Fatores do Domínio POU/genética
Regulação para Cima
[Mh] Termos MeSH secundário: Animais
Glândulas Écrinas/fisiologia
Epiderme/fisiologia
Seres Humanos
Queratina-5/genética
Camundongos
Camundongos Transgênicos
Tamanho do Órgão
Regiões Promotoras Genéticas
Sudorese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Keratin-5); 0 (Nerve Tissue Proteins); 0 (POU Domain Factors); 147258-11-5 (Pou3f2 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  2 / 1271 MEDLINE  
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[PMID]:28581222
[Au] Autor:Pontiggia L
[Ad] Endereço:Tissue Biology Research Unit, Department of Surgery, University Children's Hospital, August Forel Strasse 7, Zürich, 8008, Switzerland.
[Ti] Título:Eccrine sweat gland regeneration: still a story of 'blood, toil, tears and sweat'.
[So] Source:Br J Dermatol;176(6):1435-1436, 2017 06.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Glândulas Écrinas
Suor
[Mh] Termos MeSH secundário: Seres Humanos
Regeneração
Glândulas Sudoríparas
Sudorese
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15564


  3 / 1271 MEDLINE  
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[PMID]:28343568
[Au] Autor:Machado-Moreira CA; Taylor NA
[Ad] Endereço:Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia.
[Ti] Título:Thermogenic and psychogenic recruitment of human eccrine sweat glands: Variations between glabrous and non-glabrous skin surfaces.
[So] Source:J Therm Biol;65:145-152, 2017 Apr.
[Is] ISSN:0306-4565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human eccrine sweat-gland recruitment and secretion rates were investigated from the glabrous (volar) and non-glabrous hand surfaces during psychogenic (mental arithmetic) and thermogenic stimuli (mild hyperthermia). It was hypothesised that these treatments would activate glands from both skin surfaces, with the non-thermal stimulus increasing secretion rates primarily by recruiting more sweat glands. Ten healthy men participated in two seated, resting trials in temperate conditions (25-26°C). Trials commenced under normothermic conditions during which the first psychogenic stress was applied. That was followed by passive heating (0.5°C mean body temperature elevation) and thermal clamping, with a second cognitive challenge then applied. Sudomotor activity was evaluated from both hands, with colourimetry used to identify activated sweat glands, skin conductance to determine the onset of precursor sweating and ventilated sweat capsules to measure rates of discharged sweating. From glandular activation and sweat rate data, sweat-gland outputs were derived. These psychogenic and thermogenic stimuli activated sweat glands from both the glabrous and non-glabrous skin surfaces, with the former dominating at the glabrous skin and the latter at the non-glabrous surface. Indeed, those stimuli individually accounted for ~90% of the site-specific maximal number of activated sweat glands observed when both stimuli were simultaneously applied. During the normothermic psychological stimulation, sweating from the glabrous surface was elevated via a 185% increase in the number of activated glands within the first 60s. The hypothetical mechanism for this response may involve the serial activation of additional eccrine sweat glands during the progressive evolution of psychogenic sweating.
[Mh] Termos MeSH primário: Glândulas Écrinas/fisiologia
Fenômenos Fisiológicos da Pele
Sudorese
[Mh] Termos MeSH secundário: Adulto
Temperatura Corporal
Regulação da Temperatura Corporal
Frequência Cardíaca
Calefação
Seres Humanos
Masculino
Estresse Psicológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


  4 / 1271 MEDLINE  
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[PMID]:28121719
[Au] Autor:Jakobiec FA; Qureshi S; Zakka FR; Tu Y; Lee NG
[Ad] Endereço:*David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and †Albert Einstein School of Medicine, Bronx, New York, U.S.A.
[Ti] Título:Eyelid Eccrine Cyst: An Exceptional Lesion Among Dominant Apocrine Cysts.
[So] Source:Ophthal Plast Reconstr Surg;33(5):e128-e131, 2017 Sep/Oct.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 71-year-old woman developed a small bluish lesion beneath the cilia of the left lower eyelid. Excision and microscopic examination disclosed a cyst with an intimately associated eccrine sweat gland. Immunohistochemistry demonstrated that the cyst's epithelium was strongly CK5/6, CK14, CK7 weakly positive, and gross cystic disease fluid protein-15 and smooth muscle actin negative. This is the first immunohistochemically proven eccrine cyst of the eyelid skin. Apocrine cysts develop only at the eyelid margin where the glands of Moll are located. They immunostain positively for cytoplasmic gross cystic disease fluid protein-15 in the adlumenal cells and smooth muscle actin in an outer myoepithelial (abluminal) layer.
[Mh] Termos MeSH primário: Glândulas Apócrinas/patologia
Cistos/diagnóstico
Glândulas Écrinas/patologia
Doenças Palpebrais/diagnóstico
Pálpebras/patologia
[Mh] Termos MeSH secundário: Idoso
Biópsia
Diagnóstico Diferencial
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000855


  5 / 1271 MEDLINE  
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[PMID]:28093664
[Au] Autor:Li X; Li H; Zhang M; Chen L; Zhang B
[Ad] Endereço:Burn and Plastic Surgery, The Second Affiliated Hospital, Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong, People's Republic of China.
[Ti] Título:Cell proliferation and differentiation during the three dimensional reconstitution of eccrine sweat glands.
[So] Source:J Mol Histol;48(2):113-120, 2017 Apr.
[Is] ISSN:1567-2387
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to characterize the cell proliferation and proliferating cell types during three-dimensional reconstitution of eccrine sweat glands. Eccrine sweat gland cells suspended in Matrigel were injected subcutaneously into the inguinal regions of nude mice. At 1, 2, 4, 6, 8, 14, 21, 28, 35 and 42 days post-implantation, Matrigel plugs were immunostained for Ki67, to detect cycling cells, and the Ki67 labeling index at different time points was calculated. Three pairs of antibodies, Ki67/K7, Ki67/K14 and Ki67/α-SMA, were used to identify proliferating cell types in the plugs, on days 28, 35 and 42, by immunofluorescence double staining. The Ki67 labeling index on the first day of implantation was 30.53%, rapidly reached a peak value of 81.43% at 2 days post-implantation, and then decreased gradually to a low of 2.87% at 42 days. Double immunofluorescence staining showed that K14/Ki67 double-stained cells accounted for 80% of the Ki67-positive cells, whereas K7/Ki67 and α-SMA/Ki67 double-stained cells each accounted for 10% of the Ki67-positive population on days 28, 35, or 42 post-implantation. We conclude that eccrine sweat gland cells rapidly enter the cell cycle after implantation, but quickly show decreased cell proliferation and increased cell differentiation.
[Mh] Termos MeSH primário: Diferenciação Celular
Proliferação Celular
Glândulas Écrinas/citologia
[Mh] Termos MeSH secundário: Animais
Ciclo Celular
Células Cultivadas
Colágeno
Combinação de Medicamentos
Glândulas Écrinas/transplante
Seres Humanos
Antígeno Ki-67/análise
Laminina
Camundongos
Camundongos Nus
Proteoglicanas
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Ki-67 Antigen); 0 (Laminin); 0 (Proteoglycans); 119978-18-6 (matrigel); 9007-34-5 (Collagen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1007/s10735-017-9710-y


  6 / 1271 MEDLINE  
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[PMID]:28010819
[Au] Autor:Church A; Lee F; Buono MJ
[Ad] Endereço:San Diego State University, San Diego, CA 92182, United States.
[Ti] Título:Transition duration of ingested deuterium oxide to eccrine sweat during exercise in the heat.
[So] Source:J Therm Biol;63:88-91, 2017 Jan.
[Is] ISSN:0306-4565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The time necessary for the initial appearance of ingested water as sweat during exercise in the heat remains unknown. Based on the current literature, we estimated fluid transition through the body, from ingestion to appearance as sweat, to have a minimum time duration of approximately three minutes. The purpose of this study was to test this prediction and identify the time necessary for the initial enrichment of deuterium oxide (D O) in sweat following ingestion during exercise in the heat. Eight participants performed moderate intensity (40% of maximal oxygen uptake) treadmill exercise in an environmental chamber (40°C, 40% rH) to induce active sweating. After fifteen minutes, while continuing to walk, participants consumed D O (0.15mlkg ) in a final volume of 50ml water. Scapular sweat samples were collected one minute prior to and ten minutes post-ingestion. Samples were analyzed for sweat D O concentration using isotope ratio mass spectrometry and compared to baseline. Mean±SD ∆ sweat D O concentration at minutes one and two post-ingestion were not significantly higher than baseline (0min). Minutes three (9±3ppm) through ten (23±11ppm) post-ingestion had ∆ sweat D O concentrations significantly (P<0.05) higher than baseline. Such results suggest that ingested water rapidly transports across the mucosal membrane of the alimentary canal into the vasculature space, enters the extravascular fluid, and is actively secreted by the eccrine sweat glands onto the surface of the skin for potential evaporation in as little as three minutes during exercise in the heat.
[Mh] Termos MeSH primário: Óxido de Deutério/farmacocinética
Glândulas Écrinas/secreção
Exercício
Temperatura Alta
Sudorese
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Óxido de Deutério/administração & dosagem
Feminino
Seres Humanos
Masculino
Consumo de Oxigênio
Suor/metabolismo
Suor/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
J65BV539M3 (Deuterium Oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


  7 / 1271 MEDLINE  
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[PMID]:28005641
[Au] Autor:Sanchez Petitto G; Sarwari NM; Jain P; Swaby M; Bhattacharjee M
[Ad] Endereço:From the University of Texas Health Science Center at Houston, Houston, TX.
[Ti] Título:FDG PET/CT in Malignant Eccrine Spiradenoma.
[So] Source:Clin Nucl Med;42(2):125-126, 2017 Feb.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malignant eccrine spiradenoma is very rare skin appendageal cancer. We report a 64-year-old man who presented with a 6-month history of a rapidly growing mass in his groin. Physical examination revealed a 10-cm, ulcerated, fungating mass involving the entire right ilioinguinal region. PET/CT scan demonstrated intense FDG-avid lesion in the inguinal region. Histopathology of the lesion was compatible with malignant eccrine spiradenoma. He required extensive tumor resection followed by chemotherapy and radiotherapy.
[Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Neoplasias das Glândulas Sudoríparas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Glândulas Écrinas/diagnóstico por imagem
Glândulas Écrinas/patologia
Fluordesoxiglucose F18
Seres Humanos
Canal Inguinal/diagnóstico por imagem
Canal Inguinal/patologia
Masculino
Meia-Idade
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001501


  8 / 1271 MEDLINE  
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[PMID]:27986141
[Au] Autor:Ushigome Y; Sato Y; Shimoda Y; Yamazaki Y; Shiohara T
[Ad] Endereço:Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan. Electronic address: yukko@ks.kyorin-u.ac.jp.
[Ti] Título:Localized hypohidrosis is an unrecognized sequela of herpes zoster.
[So] Source:J Am Acad Dermatol;76(1):160-162, 2017 Jan.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Glândulas Écrinas/química
Herpes Zoster/complicações
Hipo-Hidrose/fisiopatologia
Hipo-Hidrose/virologia
Peptídeos/análise
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Derme/química
Seres Humanos
Meia-Idade
Sudorese
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Peptides); 0 (dermcidin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


  9 / 1271 MEDLINE  
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[PMID]:27787633
[Au] Autor:Li H; Chen L; Zhang M; Zhang B
[Ad] Endereço:Burn and Plastic Surgery, The Second Affiliated Hospital, Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong Province, China. lihaihong1051@126.com.
[Ti] Título:Foxa1 gene and protein in developing rat eccrine sweat glands.
[So] Source:J Mol Histol;48(1):1-7, 2017 Feb.
[Is] ISSN:1567-2387
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To investigate the development of eccrine sweat glands and the expression of Foxa1 genes and proteins in the course of development, the footpads from E15.5 to E21.5, P1-P12, P14, P21, P28 and P56 rats were subjected to immunofluorescence staining of FoxA1 and double immunofluorescence staining of K14/α-SMA, FoxA1/K7 and FoxA1/α-SMA, and were processed for Foxa1 gene detection by RT-qPCR. The results showed that rat eccrine sweat gland germs was first observed emerging from the basal layer of epidermis at E19.5, and then elongated downward into the dermis, forming straight ducts by E21.5. Early development of the secretory segments appeared at P1. The Foxa1 gene was not expressed in rat footpads until P2, but from P2 to P5, its expression up-regulated sharply, and thereafter maintained at a high level until adulthood. FoxA1 protein was first observed at P6 in eccrine sweat glands, four days after initial detection of Foxa1 gene transcripts. In skin, FoxA1-positive cells were present exclusively in secretory coils, with 95% being K7-positive secretory cells and 5% being α-SMA-positive myoepithelial cells. We conclude that Foxa1 can be used as a marker of eccrine sweat glands in skin and also as a marker of secretory coils, and Foxa1 is related to the development of secretory coils.
[Mh] Termos MeSH primário: Glândulas Écrinas/embriologia
Glândulas Écrinas/metabolismo
Fator 3-alfa Nuclear de Hepatócito/genética
Fator 3-alfa Nuclear de Hepatócito/metabolismo
Organogênese/genética
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Animais
Biomarcadores
Feminino
Expressão Gênica
Imuno-Histoquímica
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Biomarkers); 0 (Foxa1 protein, rat); 0 (Hepatocyte Nuclear Factor 3-alpha)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1007/s10735-016-9700-5


  10 / 1271 MEDLINE  
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[PMID]:27496254
[Au] Autor:Kubba F; De La Fouchardière A; Scott A; Teixeira F
[Ad] Endereço:Department of Histopathology, Ealing Hospital, London North West Healthcare Trust, Middlesex, UK.
[Ti] Título:Acral syringotropic melanomas with florid eccrine duct hyperplasia, a report of two cases.
[So] Source:Histopathology;70(2):316-317, 2017 Jan.
[Is] ISSN:1365-2559
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Pé/patologia
Melanoma/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Glândulas Écrinas
Feminino
Seres Humanos
Hiperplasia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1111/his.13055



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