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[PMID]:28808158
[Au] Autor:Han Z; Willer T; Li L; Pielsticker C; Rychlik I; Velge P; Kaspers B; Rautenschlein S
[Ad] Endereço:University of Veterinary Medicine Hannover, Clinic for Poultry, Hannover, Germany.
[Ti] Título:Influence of the Gut Microbiota Composition on Campylobacter jejuni Colonization in Chickens.
[So] Source:Infect Immun;85(11), 2017 Nov.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The -host interaction may be affected by the host's gut microbiota through competitive exclusion, metabolites, or modification of the immune response. To understand this interaction, colonization and local immune responses were compared in chickens with different gut microbiota compositions. Birds were treated with an antibiotic cocktail (AT) (experiments 1 and 2) or raised under germfree (GF) conditions (experiment 3). At 18 days posthatch (dph), they were orally inoculated either with 10 CFU of or with diluent. Cecal as well as systemic colonization, T- and B-cell numbers in the gut, and gut-associated tissue were compared between the different groups. Significantly higher numbers of CFU of were detected in the cecal contents of AT and GF birds, with higher colonization rates in spleen, liver, and ileum, than in birds with a conventional gut microbiota ( < 0.05). Significant upregulation of T and B lymphocyte numbers was detected in cecum, cecal tonsils, and bursa of Fabricius of AT or GF birds after inoculation compared to the respective controls ( < 0.05). This difference was less clear in birds with a conventional gut microbiota. Histopathological gut lesions were observed only in -inoculated AT and GF birds but not in microbiota-colonized -inoculated hatchmates. These results demonstrate that the gut microbiota may contribute to the control of colonization and prevent lesion development. Further studies are needed to identify key players of the gut microbiota and the mechanisms behind their protective role.
[Mh] Termos MeSH primário: Infecções por Campylobacter/veterinária
Campylobacter jejuni/imunologia
Microbioma Gastrointestinal/imunologia
Interações Hospedeiro-Patógeno/imunologia
Interações Microbianas/imunologia
Doenças das Aves Domésticas/imunologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Linfócitos B/imunologia
Linfócitos B/microbiologia
Bolsa de Fabricius/efeitos dos fármacos
Bolsa de Fabricius/imunologia
Bolsa de Fabricius/microbiologia
Infecções por Campylobacter/imunologia
Infecções por Campylobacter/microbiologia
Campylobacter jejuni/efeitos dos fármacos
Campylobacter jejuni/patogenicidade
Ceco/efeitos dos fármacos
Ceco/imunologia
Ceco/microbiologia
Galinhas
Contagem de Colônia Microbiana
Vida Livre de Germes/imunologia
Íleo/efeitos dos fármacos
Íleo/imunologia
Íleo/microbiologia
Fígado/efeitos dos fármacos
Fígado/imunologia
Fígado/microbiologia
Doenças das Aves Domésticas/microbiologia
Baço/efeitos dos fármacos
Baço/imunologia
Baço/microbiologia
Linfócitos T/imunologia
Linfócitos T/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


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[PMID]:28795263
[Au] Autor:Fan L; Li Z; Huang J; Yang Z; Xiao S; Wang X; Dang R; Zhang S
[Ad] Endereço:College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.
[Ti] Título:Dynamic distribution and tissue tropism of avian encephalomyelitis virus isolate XY/Q-1410 in experimentally infected Korean quail.
[So] Source:Arch Virol;162(11):3447-3458, 2017 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Avian encephalomyelitis (AE) is an important infectious poultry disease worldwide that is caused by avian encephalomyelitis virus (AEV). However, to date, the dynamic distribution of AEV in quails has not been well described. Quantitative real-time polymerase chain reaction (qPCR) and immunohistochemistry (IHC) assays were used to investigate the dynamic distribution and tissue tropism of AEV in experimentally infected Korean quail. AEV was detected in the cerebrum, cerebellum, proventriculus, intestine, liver, pancreas, spleen, bursa, lung and kidney as early as 3 days post-infection (dpi). The viral loads in the proventriculus, intestine, spleen and bursa were relatively higher than in other tissues. According to the qPCR results, AEV XY/Q-1410 infection lasted for at least 60 days in infected Korean quail. Immunohistochemistry-positive staining signals of AEV antigen were analysed by Image-Pro Plus software. A positive correlation between qPCR and IHC results was identified in most tissues. Our results provide an insight into the dynamic distribution of AEV in various tissues after infection. The distinct dynamic distribution of the viral genome in Korean quail in the early and late stages of infection suggests that AEV replication is affected by antibody levels and the maturity of the immune system of the host.
[Mh] Termos MeSH primário: Vírus da Encefalomielite Aviária/fisiologia
Infecções por Picornaviridae/veterinária
Doenças das Aves Domésticas/virologia
Codorniz
Tropismo Viral/fisiologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/virologia
Bolsa de Fabricius/virologia
Intestinos/virologia
Fígado/virologia
Pâncreas/virologia
Infecções por Picornaviridae/virologia
Proventrículo/virologia
Baço/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3504-0


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[PMID]:28569155
[Au] Autor:Kristeen-Teo YW; Yeap SK; Tan SW; Omar AR; Ideris A; Tan SG; Alitheen NB
[Ad] Endereço:Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
[Ti] Título:The effects of different velogenic NDV infections on the chicken bursa of Fabricius.
[So] Source:BMC Vet Res;13(1):151, 2017 May 31.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Virulent Newcastle disease virus (NDV) was reported to cause rapid depletion of chicken bursa of Fabricius. Severe pathological condition of the organ is commonly associated with high levels of virus replication, intense inflammatory response and also the degree of apoptosis. In this study, the responses of chicken bursa of Fabricius infected with two different strains of velogenic NDV, namely AF2240 and IBS002, were investigated by observing cell population changes, oxidative stress, viral replication and cytokine expression in the organ. Subsequently, apoptosis of enriched bursal IgM+ cells was determined to help us elucidate possible host pathogen relationships between the chicken bursa of Fabricius and NDV infection. RESULTS: The depletion of IgM+ cells and infiltration of macrophages were observed to be higher in bursa infected with AF2240 as compared to IBS002. In line with the increment of the macrophage population, higher nitric oxide (NO) and malondialdehyde (MDA) contents which indicated higher oxidative stress were also detected in bursa infected with NDV AF2240. In addition, higher pro-inflammatory cytokines and chemokine gene expression such as chicken CXCLi2, IL-18 and IFN-γ were observed in AF2240 infected bursa. Depletion of IgM+ cells was further confirmed with increased cell death and apoptosis of the cells in AF2240 infected bursa as compared to IBS002. However, it was found that the viral load for NDV strain IBS002 was comparatively higher than AF2240 although the magnitude of the pro- inflammatory cytokines expression and cell apoptosis was lower than AF2240. CONCLUSION: The results of our study demonstrated that infection of NDV strains AF2240 and IBS002 caused apoptosis in bursa IgM+ cells and its severity was associated with increased expression of pro-inflammatory cytokines/chemokine, macrophage infiltration and oxidative stress as the infection duration was prolonged. However, of the two viruses, we observed that NDV AF2240 induced a greater magnitude of apoptosis in chicken bursa IgM+ cells in comparison to IBS002. This might be due to the high level of oxidative stress and inflammatory cytokines/chemokine as well as lower IL10 expression which subsequently led to a high rate of apoptosis in the chicken bursa of Fabricius although the detected viral load of AF2240 was lower than IBS002.
[Mh] Termos MeSH primário: Bolsa de Fabricius/patologia
Bolsa de Fabricius/virologia
Doença de Newcastle/patologia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Sobrevivência Celular
Galinhas
Citocinas/metabolismo
Imunofenotipagem/veterinária
Vírus da Doença de Newcastle
Óxido Nítrico/metabolismo
Estresse Oxidativo
Doenças das Aves Domésticas/patologia
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Especificidade da Espécie
Carga Viral/veterinária
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1071-y


  4 / 2595 MEDLINE  
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[PMID]:28335412
[Au] Autor:Gómez-Espinosa D; Cervantes-Aguilar FJ; Del Río-García JC; Villarreal-Barajas T; Vázquez-Durán A; Méndez-Albores A
[Ad] Endereço:National Autonomous University of Mexico-Superior Studies Faculty at Cuautitlan (UNAM-FESC), Master in Animal Production and Health Sciences, Cuautitlan Izcalli 54714, Mexico. denisegoes1985@gmail.com.
[Ti] Título:Ameliorative Effects of Neutral Electrolyzed Water on Growth Performance, Biochemical Constituents, and Histopathological Changes in Turkey Poults during Aflatoxicosis.
[So] Source:Toxins (Basel);9(3), 2017 Mar 14.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Different in vitro and in silico approaches from our research group have demonstrated that neutral electrolyzed water (NEW) can be used to detoxify aflatoxins. The objective of this investigation was to evaluate the ability of NEW to detoxify B-aflatoxins (AFB1 and AFB2) in contaminated maize and to confirm detoxification in an in vivo experimental model. Batches of aflatoxin-contaminated maize were detoxified with NEW and mixed in commercial feed. A total of 240 6-day-old female large white Nicholas-700 turkey poults were randomly divided into four treatments of six replicates each (10 turkeys per replicate), which were fed ad libitum for two weeks with the following dietary treatments: (1) control feed containing aflatoxin-free maize (CONTROL); (2) feed containing the aflatoxin-contaminated maize (AF); (3) feed containing the aflatoxin-contaminated maize detoxified with NEW (AF + NEW); and (4) control feed containing aflatoxin-free maize treated with NEW (NEW). Compared to the control groups, turkey poults of the AF group significantly reduced body weight gain and increased feed conversion ratio and mortality rate; whereas turkey poults of the AF + NEW group did not present significant differences on productive parameters. In addition, alterations in serum biochemical constituents, enzyme activities, relative organ weight, gross morphological changes and histopathological studies were significantly mitigated by the aflatoxin-detoxification procedure. From these results, it is concluded that the treatment of aflatoxin-contaminated maize with NEW provided reasonable protection against the effects caused by aflatoxins in young turkey poults.
[Mh] Termos MeSH primário: Descontaminação/métodos
Micotoxicose
Perus
[Mh] Termos MeSH secundário: Aflatoxinas/metabolismo
Aflatoxinas/toxicidade
Animais
Aspartato Aminotransferases/sangue
Aspergillus flavus/isolamento & purificação
Aspergillus flavus/metabolismo
Proteínas Sanguíneas/metabolismo
Bolsa de Fabricius/efeitos dos fármacos
Bolsa de Fabricius/patologia
Eletrólise
Feminino
Fígado/efeitos dos fármacos
Fígado/patologia
Micotoxicose/metabolismo
Micotoxicose/patologia
Micotoxicose/veterinária
Baço/efeitos dos fármacos
Baço/patologia
Perus/sangue
Perus/crescimento & desenvolvimento
Água
Zea mays/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Blood Proteins); 059QF0KO0R (Water); EC 2.6.1.1 (Aspartate Aminotransferases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28284629
[Au] Autor:Ashayerizadeh A; Dastar B; Shams Shargh M; Sadeghi Mahoonak A; Zerehdaran S
[Ad] Endereço:Department of Animal and Poultry Nutrition, Faculty of Animal Science, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address: amin.ashayerizadeh@yahoo.com.
[Ti] Título:Fermented rapeseed meal is effective in controlling Salmonella enterica serovar Typhimurium infection and improving growth performance in broiler chicks.
[So] Source:Vet Microbiol;201:93-102, 2017 Mar.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of present experiment was to assess the effects of fermented rapeseed meal (FRSM) on Salmonella enterica serovar Typhimurium (S. Typhimurium) colonization and growth performance in broiler chicks. Two hundred forty day-old male Cobb 500 broiler chicks were divided into six experimental treatments with four replicates and 10 birds per each. The treatments were including two positive and negative controls which birds received a basal corn-soybean diet as well as four others which birds received the diets that rapeseed meal (RSM) or FRSM was replaced with soybean meal at 50 and 100% levels. All chicks except the negative control birds were challenged orally with 10 CFU of S. Typhimurium at 3days of age. Results showed that birds were fed FRSM had significantly greater lactic acid bacteria populations and lesser S. Typhimurium colonization in ileal and cecal sections compared to others (P<0.05). The less percentage of liver and bursa of fabricius was belonged to negative control group. At 10day, feeding chicks with diet containing FRSM, but not RSM, significantly decreased the organ invasion by S. Typhimurium (P<0.05). Heterophil to lymphocyte ratio was significantly lesser in chicks were fed FRSM compared to those fed RSM or positive control (P<0.05). Birds were fed FRSM had significantly higher weight gain and better feed conversion ratio compared to those birds were fed RSM (P<0.05). The findings of present experiment concerning positive effects of feeding FRSM on reducing S. Typhimurium and improving growth performance show that this processed protein source can be considered as a nutritional effective strategy to control Salmonella contamination in broiler chicks.
[Mh] Termos MeSH primário: Ração Animal/análise
Galinhas/crescimento & desenvolvimento
Salmonelose Animal/prevenção & controle
Salmonella typhimurium/fisiologia
[Mh] Termos MeSH secundário: Animais
Brassica rapa
Bolsa de Fabricius/microbiologia
Ceco/microbiologia
Galinhas/microbiologia
Fermentação
Íleo/microbiologia
Masculino
Distribuição Aleatória
Salmonelose Animal/microbiologia
Sorogrupo
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  6 / 2595 MEDLINE  
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[PMID]:28235061
[Au] Autor:Mehaisen GM; Eshak MG; Elkaiaty AM; Atta AM; Mashaly MM; Abass AO
[Ad] Endereço:Department of Animal Production, Faculty of Agriculture, Cairo University, Giza, Egypt.
[Ti] Título:Comprehensive growth performance, immune function, plasma biochemistry, gene expressions and cell death morphology responses to a daily corticosterone injection course in broiler chickens.
[So] Source:PLoS One;12(2):e0172684, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The massive meat production of broiler chickens make them continuously exposed to potential stressors that stimulate releasing of stress-related hormones like corticosterone (CORT) which is responsible for specific pathways in biological mechanisms and physiological activities. Therefore, this research was conducted to evaluate a wide range of responses related to broiler performance, immune function, plasma biochemistry, related gene expressions and cell death morphology during and after a 7-day course of CORT injection. A total number of 200 one-day-old commercial Cobb broiler chicks were used in this study. From 21 to 28 d of age, broilers were randomly assigned to one of 2 groups with 5 replicates of 20 birds each; the first group received a daily intramuscular injection of 5 mg/kg BW corticosterone dissolved in 0.5 ml ethanol:saline solution (CORT group), while the second group received a daily intramuscular injection of 0.5 ml ethanol:saline only (CONT group). Growth performance, including body weight (BW), daily weight gain (DG), feed intake (FI) and feed conversion ratio (FC), were calculated at 0, 3 and 7 d after the start of the CORT injections. At the same times, blood samples were collected in each group for hematological (TWBC's and H/L ratio), T- and B-lymphocytes proliferation and plasma biochemical assays (total protein, TP; free triiodothyronine hormone, fT3; aspartate amino transaminase, AST; and alanine amino transaminase, ALT). The liver, thymus, bursa of Fabricius and spleen were dissected and weighed, and the mRNA expression of insulin-like growth factor 1 gene (IGF-1) in liver and cell-death-program gene (caspase-9) in bursa were analyzed for each group and time; while the apoptotic/necrotic cells were morphologically detected in the spleen. From 28 to 35 d of age, broilers were kept for recovery period without CORT injection and the same sampling and parameters were repeated at the end (at 14 d after initiation of the CORT injection). In general, all parameters of broiler performance were negatively affected by the CORT injection. In addition, CORT treatment decreased the plasma concentration of fT3 and the mRNA expression of hepatic IGF-1. A significant increase in liver weight accompanied by an increase in plasma TP, AST and ALT was observed with CORT treatment, indicating an incidence of liver malfunction by CORT. Moreover, the relative weights of thymus, bursa and spleen decreased by the CORT treatment with low counts of TWBC's and low stimulation of T & B cells while the H/L ratio increased; indicating immunosuppressive effect for CORT treatment. Furthermore, high expression of caspase-9 gene occurred in the bursa of CORT-treated chickens, however, it was associated with a high necrotic vs. low apoptotic cell death pathway in the spleen. Seven days after termination of the CORT treatment in broilers, most of these aspects remained negatively affected by CORT and did not recover to its normal status. The current study provides a comprehensive view of different physiological modulations in broiler chickens by CORT treatment and may set the potential means to mount a successful defense against stress in broilers and other animals as well.
[Mh] Termos MeSH primário: Proteínas Aviárias/imunologia
Galinhas/imunologia
Corticosterona/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Carne
[Mh] Termos MeSH secundário: Alanina Transaminase/genética
Alanina Transaminase/imunologia
Criação de Animais Domésticos
Animais
Aspartato Aminotransferases/genética
Aspartato Aminotransferases/imunologia
Proteínas Aviárias/genética
Linfócitos B/citologia
Linfócitos B/efeitos dos fármacos
Linfócitos B/imunologia
Bolsa de Fabricius/efeitos dos fármacos
Bolsa de Fabricius/imunologia
Caspase 9/genética
Caspase 9/imunologia
Morte Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Galinhas/crescimento & desenvolvimento
Ingestão de Alimentos/efeitos dos fármacos
Imunidade Inata/efeitos dos fármacos
Injeções Intramusculares
Fator de Crescimento Insulin-Like I/genética
Fator de Crescimento Insulin-Like I/imunologia
Fígado/efeitos dos fármacos
Fígado/imunologia
Baço/efeitos dos fármacos
Baço/imunologia
Linfócitos T/citologia
Linfócitos T/efeitos dos fármacos
Linfócitos T/imunologia
Timo/efeitos dos fármacos
Timo/imunologia
Tri-Iodotironina/genética
Tri-Iodotironina/imunologia
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avian Proteins); 06LU7C9H1V (Triiodothyronine); 67763-96-6 (Insulin-Like Growth Factor I); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.4.22.- (Caspase 9); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172684


  7 / 2595 MEDLINE  
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[PMID]:28116627
[Au] Autor:Jiao X; Yang K; An Y; Teng X; Teng X
[Ad] Endereço:College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
[Ti] Título:Alleviation of lead-induced oxidative stress and immune damage by selenium in chicken bursa of Fabricius.
[So] Source:Environ Sci Pollut Res Int;24(8):7555-7564, 2017 Mar.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We investigated lead (Pb)-induced oxidative stress and immune damage in the chicken bursa of Fabricius (BF) and the ameliorative effect of selenium (Se). Seven-day-old male chickens were randomly divided into four groups and were provided standard diet and drinking water, Na SeO added to the standard diet and drinking water, standard diet and (CH COO) Pb added to drinking water, and Na SeO added to the standard diet and (CH COO) Pb added to drinking water for 30, 60, and 90 days. The presence of Pb inhibited total antioxidant capacity (T-AOC), glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) activities; decreased glutathione (GSH) content; increased malondialdehyde (MDA) and hydrogen peroxide (H O ) contents; inhibited interleukin (IL)-2 and interferon-γ (IFN-γ) messenger RNA (mRNA) expression; and increased IL-4, IL-6, IL-10, IL-12ß, and IL-17 mRNA expression. The presence of Se relieved all of the above Pb-induced changes. There were close correlations among GSH, CAT, T-AOC, SOD, GPx, MDA, and H O and among IL-2, IL-4, IL-6, IL-12ß, IL-17, and IFN-γ. Our data showed that Pb caused oxidative stress and immune damage in the chicken BF. Se alleviated Pb-induced oxidative stress and immune damage in the chicken BF.
[Mh] Termos MeSH primário: Bolsa de Fabricius/efeitos dos fármacos
Galinhas
Chumbo/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Selênio/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/análise
Citocinas/análise
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cytokines); 2P299V784P (Lead); H6241UJ22B (Selenium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8329-y


  8 / 2595 MEDLINE  
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[PMID]:28098787
[Au] Autor:Peng X; Bai S; Ding X; Zhang K
[Ad] Endereço:Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Ya'an 625014, Sichuan, China. pengxi197313@163.com.
[Ti] Título:Pathological Impairment, Cell Cycle Arrest and Apoptosis of Thymus and Bursa of Fabricius Induced by Aflatoxin-Contaminated Corn in Broilers.
[So] Source:Int J Environ Res Public Health;14(1), 2017 Jan 13.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the comparative effects of aflatoxin-contaminated corn on the thymus and bursa of Fabricius (BF) in chickens by detecting histopathological lesions, cell cycle phase distribution and apoptosis. A total of 900 COBB500 male broilers were randomly allocated into five groups. The experiment lasted for six weeks and the five dietary treatments consisted of uncontaminated corn (control), 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The gross changes showed the decreased size of the thymus and BF, as well as the pale color of the BF in the broilers after aflatoxin contaminated diet exposure. There were more nuclear debris in the thymus and BF of birds in the 50%, 75%, and 100% contaminated corn groups, but the pathological impairments of the BF were more obvious than those of the thymus, which showed as more obvious lymphocyte depletion and the proliferation of reticulocytes and fibroblasts. At 21 days of age, the percentage of thymocytes and BF cells in the G2M phase was increased in a dose-dependent manner in the four AFB-contaminated corn groups. However, at 42 days of age, dietary AFB1 induced cell cycle perturbation at the G0G1 phase in thymocytes, but at the G2M phase in BF cells. The increased percentage of apoptotic cells in the thymus and BF were similarly observed in the AFB groups. According to these results, the severity of histopathological lesions may be correlated with the different sensitivity of the two central immune organs when exposed to AFB; different arrested cell cycle phases suggest that different mechanisms may be involved in the lesions of the thymus and BF, which need to be further researched.
[Mh] Termos MeSH primário: Aflatoxina B1/toxicidade
Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Galinhas/microbiologia
Doenças Linfáticas/etiologia
Zea mays/microbiologia
[Mh] Termos MeSH secundário: Ração Animal/microbiologia
Animais
Bolsa de Fabricius/fisiopatologia
Dieta/veterinária
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


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[PMID]:28094577
[Au] Autor:Bhatti SA; Khan MZ; Saleemi MK; Saqib M; Khan A; Ul-Hassan Z
[Ad] Endereço:a Faculty of Veterinary Sciences , Bahauddin Zakariya University , Multan , Pakistan.
[Ti] Título:Protective role of bentonite against aflatoxin B - and ochratoxin A-induced immunotoxicity in broilers.
[So] Source:J Immunotoxicol;14(1):66-76, 2017 Dec.
[Is] ISSN:1547-6901
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate any ameliorative effects of bentonite (BN) against immuno-pathological alterations induced by dietary aflatoxin B (AFB ) or ochratoxin A (OTA) in broiler chicks. In one experiment, AFB (0.1, 0.2 or 0.6 mg/kg feed) was fed alone and par alley with bentonite clay (3.7 or 7.5 g/kg feed) to the broilers. In the second experiment, the broilers were given feed contaminated with OTA (0.15, 0.3 or 1.0 mg/kg feed) alone and in combination with bentonite clay (3.7, 7.5, or 15 g/kg feed). Experimental feedings were continued for 42 days. At various time points along the feeding schedule, immune system organ histologic status, as well as host humoral and cellular immune responses, were evaluated in all groups. The dietary addition of AFB and OTA alone significantly reduced immune responses in the birds as assessed by histological changes in the bursa of Fabricius and thymus, antibody responses to SRBC, in-vivo lympho-proliferative responses to Phytohemagglutinin-P (PHA-P) and, phagocytic function in situ. The dietary addition of BN significantly ameliorated the immunotoxicity of 0.1 and 0.2 mg/kg dietary AFB , however with a level of 0.6 mg AFB /kg only partial amelioration was seen. The co-treatment of birds exposed to OTA with BN at all levels only partially alleviated deleterious effects on histology and immune responses. Taken together, the results here suggested to us that dietary addition of BN could help ameliorate AFB -mediated immunotoxicities but could not afford such protection against OTA-induced immune damage.
[Mh] Termos MeSH primário: Antídotos/administração & dosagem
Bentonita/administração & dosagem
Bolsa de Fabricius/efeitos dos fármacos
Doenças Transmitidas por Alimentos/prevenção & controle
Timo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Aflatoxina B1/imunologia
Aflatoxina B1/toxicidade
Animais
Bolsa de Fabricius/imunologia
Proliferação Celular
Células Cultivadas
Galinhas
Dieta
Feminino
Imunidade Celular/efeitos dos fármacos
Imunidade Humoral/efeitos dos fármacos
Ocratoxinas/imunologia
Ocratoxinas/toxicidade
Fagocitose
Timo/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Ochratoxins); 1302-78-9 (Bentonite); 1779SX6LUY (ochratoxin A); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1080/1547691X.2016.1264503


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[PMID]:28030985
[Au] Autor:Nisha AR; Hazilawati H; Mohd Azmi ML; Noordin MM
[Ad] Endereço:a Department of Pathology and Microbiology, Faculty of Veterinary Medicine , Universiti Putra Malaysia , Serdang , Selangor , Malaysia.
[Ti] Título:DNA damage and adduct formation in immune organs of developing chicks by polycyclic aromatic hydrocarbons.
[So] Source:Toxicol Mech Methods;27(3):215-222, 2017 Mar.
[Is] ISSN:1537-6524
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polycyclic aromatic hydrocarbons (PAHs) are persistent pollutants and chemically a class of structurally similar chemical compounds characterized by the presence of fused aromatic rings. This research was undertaken to find out immunotoxic effects produced by pyrene, phenanthrene and fluoranthene. These chemicals were injected into developing chicks at three dose levels (0.2, 2 and 20 mg per kg) through allantioc route to rule out possible mechanisms involved in immunotoxicity. DNA adduct produced by PAHs in immune organs were analyzed by DNA adduct enzyme-linked immunosorbent assay (ELISA) kit and DNA damage was assessed by comet assay. A significant increase in the DNA adduct levels was found in thymus and bursa in 2 mg and 20 mg dose levels of pyrene, fluoranthene and phenanthrene treated groups, whereas those in spleen simulated the value of controls. Comet assay indicated that PAHs especially pyrene, fluoranthene and phenanthrene were capable of inducing increased level of comet parameters in thymus at all the dose levels. Bursa of Fabricius and spleen also showed a gradual rise in comet parameters corresponding to all dose levels, but the increase was more marked as in thymus. Thus, it can be concluded that DNA adducts produced by PAHs lead to single-strand breaks and reduced DNA repair, which ultimately begin a carcinogenic process. Hence, this experiment can be considered as a strong evidence of genotoxic potential of PAHs like pyrene, phenanthrene and fluoranthene in developing chicks.
[Mh] Termos MeSH primário: Bolsa de Fabricius/efeitos dos fármacos
Adutos de DNA/metabolismo
Dano ao DNA
Poluentes Ambientais/toxicidade
Hidrocarbonetos Aromáticos Policíclicos/toxicidade
Baço/efeitos dos fármacos
Timo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bolsa de Fabricius/embriologia
Bolsa de Fabricius/imunologia
Bolsa de Fabricius/metabolismo
Embrião de Galinha
Ensaio Cometa
Relação Dose-Resposta a Droga
Baço/embriologia
Baço/imunologia
Baço/metabolismo
Timo/embriologia
Timo/imunologia
Timo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Environmental Pollutants); 0 (Polycyclic Aromatic Hydrocarbons)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1080/15376516.2016.1273432



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