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[PMID]:28916522
[Au] Autor:Cross SN; Potter JA; Aldo P; Kwon JY; Pitruzzello M; Tong M; Guller S; Rothlin CV; Mor G; Abrahams VM
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510; and.
[Ti] Título:Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
[So] Source:J Immunol;199(8):2885-2895, 2017 Oct 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chorioamnionitis, premature rupture of fetal membranes (FMs), and subsequent preterm birth are associated with local infection and inflammation, particularly IL-1ß production. Although bacterial infections are commonly identified, other microorganisms may play a role in the pathogenesis. Because viral pandemics, such as influenza, Ebola, and Zika, are becoming more common, and pregnant women are at increased risk for associated complications, this study evaluated the impact that viral infection had on human FM innate immune responses. This study shows that a herpes viral infection of FMs sensitizes the tissue to low levels of bacterial LPS, giving rise to an exaggerated IL-1ß response. Using an ex vivo human FM explant system and an in vivo mouse model of pregnancy, we report that the mechanism by which this aggravated inflammation arises is through the inhibition of the TAM receptor, MERTK, and activation of the inflammasome. The TAM receptor ligand, growth arrest specific 6, re-establishes the normal FM response to LPS by restoring and augmenting TAM receptor and ligand expression, as well as by preventing the exacerbated IL-1ß processing and secretion. These findings indicate a novel mechanism by which viruses alter normal FM immune responses to bacteria, potentially giving rise to adverse pregnancy outcomes.
[Mh] Termos MeSH primário: Membranas Extraembrionárias/imunologia
Gammaherpesvirinae/imunologia
Infecções por Herpesviridae/imunologia
Herpesvirus Humano 2/imunologia
Inflamassomos/metabolismo
Nascimento Prematuro/imunologia
Proteínas Proto-Oncogênicas/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Corioamnionite
Feminino
Infecções por Herpesviridae/complicações
Seres Humanos
Imunização
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Interleucina-1beta/metabolismo
Lipopolissacarídeos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Gravidez
Nascimento Prematuro/etiologia
Proteínas Proto-Oncogênicas/genética
Receptores Proteína Tirosina Quinases/genética
c-Mer Tirosina Quinase
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammasomes); 0 (Intercellular Signaling Peptides and Proteins); 0 (Interleukin-1beta); 0 (Lipopolysaccharides); 0 (Proto-Oncogene Proteins); 0 (growth arrest-specific protein 6); EC 2.7.10.1 (MERTK protein, human); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (c-Mer Tyrosine Kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700870


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[PMID]:28281278
[Au] Autor:Steenhaut P; Hubinont C; Bernard P; Debiève F
[Ad] Endereço:Department of Obstetrics, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
[Ti] Título:Retrospective comparison of perinatal outcomes following emergency cervical cerclage with or without prolapsed membranes.
[So] Source:Int J Gynaecol Obstet;137(3):260-264, 2017 Jun.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare perinatal outcomes following emergency cerclage between patients with singleton pregnancies with prolapsed and non-prolapsed membranes. METHODS: The present retrospective cohort study included data from women who underwent physical examination-indicated emergency cerclage at between 15 and 25 weeks of pregnancy at Saint Luc University Hospital, Brussels, Belgium, between January 1, 2000, and December 31, 2014. Outcomes were compared based on the presence of prolapsed or non-prolapsed membranes. The primary outcome measures were the duration of pregnancy at delivery and the interval between cerclage and delivery. Secondary outcomes included delivery weight, fetal or neonatal death, and neonatal morbidity, including neonatal intensive care unit admission. RESULTS: Data were included from 140 patients with cervical dilation of at least 1 cm; 85 women had non-prolapsed membranes and 55 women had prolapsed membranes. Among patients with non-prolapsed membranes, the mean duration of pregnancy at delivery was later (P<0.001), the latency between cerclage and delivery was longer (P<0.001), neonatal survival was higher (P=0.036), mean delivery weight was higher (P<0.001), the prevalence of preterm delivery was lower (P<0.001), and severe neonatal morbidity and neonatal intensive care unit admission were lower (P<0.001). CONCLUSION: Having non-prolapsed membranes was associated with improved perinatal outcomes following emergency cerclage.
[Mh] Termos MeSH primário: Cerclagem Cervical
Incompetência do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adulto
Emergências
Membranas Extraembrionárias/fisiopatologia
Feminino
Seres Humanos
Gravidez
Resultado da Gravidez
Prolapso
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12144


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[PMID]:28258575
[Au] Autor:Martínez N; Damiano AE
[Ad] Endereço:Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO)- CONICET- Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Aquaporins in Fetal Development.
[So] Source:Adv Exp Med Biol;969:199-212, 2017.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Water homeostasis during fetal development is of crucial physiologic importance. The successful formation and development of the placenta is critical to maintain normal fetal growth and homeostasis. The expression of several aquaporins (AQPs ) was found from blastocyst stages to term placenta and fetal membranes. Therefore, AQPs are proposed to play important roles in normal pregnancy, fetal growth, and homeostasis of amniotic fluid volume, and water handling in other organs. However, the functional importance of AQPs in fetal development remains to be elucidated.
[Mh] Termos MeSH primário: Aquaporina 1/metabolismo
Blastocisto/metabolismo
Membranas Extraembrionárias/metabolismo
Desenvolvimento Fetal/fisiologia
Placenta/metabolismo
Água/metabolismo
[Mh] Termos MeSH secundário: Líquido Amniótico/química
Líquido Amniótico/metabolismo
Animais
Aquaporina 1/genética
Gonadotropina Coriônica/genética
Gonadotropina Coriônica/metabolismo
Membranas Extraembrionárias/crescimento & desenvolvimento
Feminino
Feto
Regulação da Expressão Gênica
Seres Humanos
Insulina/genética
Insulina/metabolismo
Gravidez
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (AQP1 protein, human); 0 (Chorionic Gonadotropin); 0 (Insulin); 0 (Protein Isoforms); 059QF0KO0R (Water); 146410-94-8 (Aquaporin 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1007/978-94-024-1057-0_13


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[PMID]:28232601
[Au] Autor:Garrido-Gomez T; Ona K; Kapidzic M; Gormley M; Simón C; Genbacev O; Fisher SJ
[Ad] Endereço:Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA.
[Ti] Título:Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.
[So] Source:Development;144(5):767-777, 2017 03 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pre-eclampsia (PE), which affects ∼8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related increase in production of PAPPA1, which releases IGF1 from its binding protein. IGF1 enhanced proliferation of smooth chorion CTBs, a possible explanation for expansion of this layer, which may partially compensate for the placental deficits.
[Mh] Termos MeSH primário: Córion/metabolismo
Placenta/metabolismo
Placentação
Pré-Eclâmpsia/metabolismo
Trofoblastos/metabolismo
[Mh] Termos MeSH secundário: Adulto
Proliferação Celular
Córion/citologia
Membranas Extraembrionárias/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Seres Humanos
Queratinas/metabolismo
Estresse Oxidativo
Placenta/citologia
Pré-Eclâmpsia/patologia
Gravidez
Proteína Plasmática A Associada à Gravidez/metabolismo
Ligação Proteica
Transcrição Genética
Transcriptoma
Trofoblastos/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
68238-35-7 (Keratins); EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A); EC 3.4.24.79 (PAPPA1 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1242/dev.146100


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[PMID]:28225815
[Au] Autor:Choi YS; Park YB; Ha CW; Kim JA; Heo JC; Han WJ; Oh SY; Choi SJ
[Ad] Endereço:Department of Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South Korea.
[Ti] Título:Different characteristics of mesenchymal stem cells isolated from different layers of full term placenta.
[So] Source:PLoS One;12(2):e0172642, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The placenta is a very attractive source of mesenchymal stem cells (MSCs) for regenerative medicine due to readily availability, non-invasive acquisition, and avoidance of ethical issues. Isolating MSCs from parts of placenta tissue has obtained growing interest because they are assumed to exhibit different proliferation and differentiation potentials due to complex structures and functions of the placenta. The objective of this study was to isolate MSCs from different parts of the placenta and compare their characteristics. METHODS: Placenta was divided into amniotic epithelium (AE), amniotic membrane (AM), chorionic membrane (CM), chorionic villi (CV), chorionic trophoblast without villi (CT-V), decidua (DC), and whole placenta (Pla). Cells isolated from each layer were subjected to analyses for their morphology, proliferation ability, surface markers, and multi-lineage differentiation potential. MSCs were isolated from all placental layers and their characteristics were compared. FINDINGS: Surface antigen phenotype, morphology, and differentiation characteristics of cells from all layers indicated that they exhibited properties of MSCs. MSCs from different placental layers had different proliferation rates and differentiation potentials. MSCs from CM, CT-V, CV, and DC had better population doubling time and multi-lineage differentiation potentials compared to those from other layers. CONCLUSIONS: Our results indicate that MSCs with different characteristics can be isolated from all layers of term placenta. These finding suggest that it is necessary to appropriately select MSCs from different placental layers for successful and consistent outcomes in clinical applications.
[Mh] Termos MeSH primário: Membranas Extraembrionárias/citologia
Células Mesenquimais Estromais/citologia
Placenta/citologia
[Mh] Termos MeSH secundário: Diferenciação Celular
Proliferação Celular
Forma Celular
Feminino
Seres Humanos
Gravidez
Nascimento a Termo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172642


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[PMID]:28178058
[Au] Autor:Boggess KA; Tita A; Jauk V; Saade G; Longo S; Clark EA; Esplin S; Cleary K; Wapner R; Letson K; Owens M; Blackwell S; Beamon C; Szychowski JM; Andrews W; Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium
[Ad] Endereço:University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; the University of Alabama at Birmingham, Birmingham, Alabama; the University of Texas Medical Branch, Galveston, Texas; Oshner Health System, New Orleans, Louisiana; the University of Utah and Intermountain Health-LC, Salt Lake City, Utah; Columbia University, New York, New York; Mission Hospital, Asheville, North Carolina; the University of Mississippi at Jackson, Jackson, Mississippi, the University of Houston at Houston, Houston, Texas; and WakeMed Physician Practices, Raleigh, North Carolina.
[Ti] Título:Risk Factors for Postcesarean Maternal Infection in a Trial of Extended-Spectrum Antibiotic Prophylaxis.
[So] Source:Obstet Gynecol;129(3):481-485, 2017 Mar.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To identify maternal clinical risk factors for postcesarean maternal infection in a randomized clinical trial of preincision extended-spectrum antibiotic prophylaxis. METHODS: We conducted a planned secondary analysis of a randomized clinical trial. Patients were 24 weeks of gestation or greater and delivered by cesarean after a minimum of 4 hours of ruptured membranes or labor. All participants received standard preincision prophylaxis and were randomized to receive azithromycin or placebo. The primary outcome for this analysis is maternal infection: a composite outcome of endometritis, wound infection (superficial or deep), or other infections occurring up to 6 weeks postpartum. Maternal clinical characteristics associated with maternal infection, after controlling for azithromycin assignment, were identified. These maternal factors were included in a multivariable logistic regression model for maternal infection. RESULTS: Of 2,013 patients, 1,019 were randomized to azithromycin. Overall, 177 (8.8%) had postcesarean maternal infection. In the final adjusted model, compared with the reference groups, women of black race-ethnicity, with a nontransverse uterine incision, with duration of membrane rupture greater than 6 hours, and surgery duration greater than 49 minutes, were associated higher odds of maternal infection (all with adjusted odds ratios [ORs] of approximately 2); azithromycin was associated with lower odds of maternal infection (adjusted OR 0.4, 95% confidence interval 0.3-0.6). CONCLUSION: Despite preincision azithromycin-based extended-spectrum antibiotic prophylaxis, postcesarean maternal infection remains a significant source of morbidity. Recognition of risk factors may help guide innovative prevention strategies. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, https://clinicaltrials.gov, NCT012235546.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Antibioticoprofilaxia
Azitromicina/uso terapêutico
Cesárea/efeitos adversos
Endometrite/prevenção & controle
Infecção da Ferida Cirúrgica/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Afroamericanos/estatística & dados numéricos
Quimioterapia Combinada
Endometrite/etiologia
Membranas Extraembrionárias
Feminino
Seres Humanos
Trabalho de Parto
Duração da Cirurgia
Período Pós-Operatório
Gravidez
Fatores de Risco
Infecção da Ferida Cirúrgica/etiologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 83905-01-5 (Azithromycin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000001899


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[PMID]:28173875
[Au] Autor:Chatgilialoglu A; Rossi M; Alviano F; Poggi P; Zannini C; Marchionni C; Ricci F; Tazzari PL; Taglioli V; Calder PC; Bonsi L
[Ad] Endereço:Remembrane Srl, Imola, Italy.
[Ti] Título:Restored in vivo-like membrane lipidomics positively influence in vitro features of cultured mesenchymal stromal/stem cells derived from human placenta.
[So] Source:Stem Cell Res Ther;8(1):31, 2017 Feb 07.
[Is] ISSN:1757-6512
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The study of lipid metabolism in stem cell physiology has recently raised great interest. The role of lipids goes beyond the mere structural involvement in assembling extra- and intra-cellular compartments. Nevertheless, we are still far from understanding the impact of membrane lipidomics in stemness maintenance and differentiation patterns. In the last years, it has been reported how in vitro cell culturing can modify membrane lipidomics. The aim of the present work was to study the membrane fatty acid profile of mesenchymal stromal cells (MSCs) derived from human fetal membranes (hFM-MSCs) and to correlate this to specific biological properties by using chemically defined tailored lipid supplements (Refeed®). METHODS: Freshly isolated hFM-MSCs were characterized for their membrane fatty acid composition. hFM-MSCs were cultivated in vitro following a classical protocol and their membrane fatty acid profile at different passages was compared to the profile in vivo. A tailored Refeed® lipid supplement was developed with the aim of reducing the differences created by the in vitro cultivation and was tested on cultured hFM-MSCs. Cell morphology, viability, proliferation, angiogenic differentiation, and immunomodulatory properties after in vitro exposure to the tailored Refeed® lipid supplement were investigated. RESULTS: A significant modification of hFM-MSC membrane fatty acid composition occurred during in vitro culture. Using a tailored lipid supplement, the fatty acid composition of cultured cells remained more similar to their in vivo counterparts, being characterized by a higher polyunsaturated and omega-6 fatty acid content. These changes in membrane composition had no effect on cell morphology and viability, but were linked with increased cell proliferation rate, angiogenic differentiation, and immunomodulatory properties. In particular, Refeed®-supplemented hFM-MSCs showed greater ability to express fully functional cell membrane molecules. CONCLUSIONS: Culturing hFM-MSCs alters their fatty acid composition. A tailored lipid supplement is able to improve in vitro hFM-MSC functional properties by recreating a membrane environment more similar to the physiological counterpart. This approach should be considered in cell therapy applications in order to maintain a higher cell quality during in vitro passaging and to influence the outcome of cell-based therapeutic approaches when cells are administered to patients.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Membrana Celular/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
Células Mesenquimais Estromais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Diferenciação Celular
Membrana Celular/química
Proliferação Celular
Suplementos Nutricionais
Membranas Extraembrionárias/citologia
Membranas Extraembrionárias/efeitos dos fármacos
Membranas Extraembrionárias/metabolismo
Ácidos Graxos/análise
Ácidos Graxos/metabolismo
Ácidos Graxos Monoinsaturados/análise
Ácidos Graxos Monoinsaturados/metabolismo
Ácidos Graxos Insaturados/análise
Ácidos Graxos Insaturados/metabolismo
Feminino
Seres Humanos
Lipídeos de Membrana/análise
Lipídeos de Membrana/metabolismo
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/metabolismo
Placenta/citologia
Placenta/efeitos dos fármacos
Placenta/metabolismo
Gravidez
Cultura Primária de Células
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Unsaturated); 0 (Membrane Lipids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1186/s13287-017-0487-4


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[PMID]:28145572
[Au] Autor:Blackburn DG; Anderson KE; Aronson KW; Burket MK; Chin JF; San-Francisco SK; Callard IP
[Ad] Endereço:Department of Biology, and Electron Microscopy Facility, Trinity College, Hartford, Connecticut, 06106.
[Ti] Título:Placentation in watersnakes I: Placental histology and development in North American Nerodia (Colubridae: Natricinae).
[So] Source:J Morphol;278(5):665-674, 2017 May.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As part of a broad survey of placental structure, function, and evolution in reptilian sauropsids paraffin-section histology was used to study microscopic anatomy of the uterus and fetal membranes of three species of North American watersnakes (Nerodia: Colubridae). The pre-ovulatory uterus is poorly vascularized with inactive shell glands. These shell glands are activated during vitellogenesis but regress during pregnancy. Two placentas develop through apposition of the uterine lining to the chorioallantois and the yolk sac omphalopleure. Fetal and maternal components of the chorioallantoic placenta are progressively vascularized during development. Their epithelia are attenuated, but (contrary to a previous report), epithelia of neither the uterus nor the chorion are eroded. The fetal portion of the yolk sac placenta is an omphalallantois, formed of avascular omphalopleure, isolated yolk mass, and allantois. This placenta is progressively replaced by chorioallantoic placenta during mid- to late-development through depletion of the isolated yolk mass. The chorioallantoic placenta is anatomically specialized for maternal-fetal gas exchange, and its expansion during development reflects the growing needs of the fetus for gas exchange. The yolk sac placenta is morphologically unsuited for gas exchange, but may serve other functions in maternal-fetal exchange.
[Mh] Termos MeSH primário: Colubridae/anatomia & histologia
Placenta/embriologia
Placentação/fisiologia
[Mh] Termos MeSH secundário: Alantoide/embriologia
Alantoide/ultraestrutura
Animais
Evolução Biológica
Córion/embriologia
Córion/ultraestrutura
Membranas Extraembrionárias/ultraestrutura
Feminino
Mamíferos
Placenta/ultraestrutura
Gravidez
Estados Unidos
Saco Vitelino/embriologia
Saco Vitelino/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20663


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[PMID]:28141950
[Au] Autor:Bayrak M; Gul A; Goynumer G
[Ad] Endereço:a Istanbul Medeniyet University Goztepe Education and Research Hospital , Istanbul , Turkey.
[Ti] Título:Rescue cerclage when foetal membranes prolapse into the vagina.
[So] Source:J Obstet Gynaecol;37(4):471-475, 2017 May.
[Is] ISSN:1364-6893
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A cross-sectional study was conducted to evaluate the efficacy of rescue cerclage in patients with a dilated cervix and prolapsed foetal membranes. Thirty-five patients presenting with cervical dilatation and prolapsed foetal membranes were included in the study. A McDonald cerclage was placed in 27 patients. The duration of pregnancy prolongation and the number of deliveries after 28 weeks were evaluated. The median prolongation of pregnancy after cerclage placement differed significantly between the cerclage and bed-rest groups (64 days versus 13.5 days). Of the 27 patients who had cerclage, 17 (63%) delivered after 28 weeks of gestation, whereas all patients in the bed-rest group delivered before 28 weeks of gestation. The take-home baby rate was 63% in the cerclage group. When pregnancies were complicated by cervical dilatation with membrane prolapse into the vagina, placement of a McDonald cerclage in appropriately selected patients can be a beneficial therapeutic option. Impact statement Although the effectiveness and safety of rescue cerclage is controversial, our study provides strong support for the notion that cervical cerclage accompanied by long-term broad-spectrum antibiotics improves the perinatal outcomes in singleton gestations with membrane prolapsed into the vagina. Further prospective randomised trial is required to prove these findings.
[Mh] Termos MeSH primário: Cerclagem Cervical/métodos
Nascimento Prematuro/prevenção & controle
Incompetência do Colo do Útero/terapia
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Repouso em Cama
Estudos Transversais
Membranas Extraembrionárias
Feminino
Idade Gestacional
Seres Humanos
Gravidez
Prolapso
Estatísticas não Paramétricas
Fatores de Tempo
Tocolíticos/uso terapêutico
Vagina
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Tocolytic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1080/01443615.2016.1268574


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[PMID]:28110748
[Au] Autor:Hafez S
[Ad] Endereço:Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States; Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA, United States. Electronic address: shafez@vt.edu.
[Ti] Título:Comparative Placental Anatomy: Divergent Structures Serving a Common Purpose.
[So] Source:Prog Mol Biol Transl Sci;145:1-28, 2017.
[Is] ISSN:1878-0814
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The placenta, one of the most important transient organs, forms by the apposition of fetal membranes and maternal tissues. Its role is to mediate physiological exchanges between mother and fetus. The word "apposition" covers a wide range of structural variations. It includes approximation, adhesion, interdigitation, or actual fusion between fetal and maternal tissues. Formation of the placenta establishes hemotropic nutrition for the fetus: essential metabolites must be provided to maintain the growing fetus, and these must come to it via the maternal circulatory system. Equally important, the placenta also provides oxygen and removes metabolic waste products from fetal blood. Nutritive and excretory roles of the placenta are not its only functions: it also has immune and endocrine activities. Nutrient and gas transport, waste removal, immunological protection of the fetus, and hormonal secretion influencing the maternal metabolism are all complex functions. They may also to some extent be conflicting purposes; hence, the placenta is a complex fetal organ. It is structurally adapted to perform its roles somewhat differently in different species, but the set of functions remain the same. Understandably, the placenta has been the subject of extensive research, and it will continue be an important topic thanks to its complexity. The intent of this chapter is to provide a simple description of placental anatomy using classic categories and to describe anatomical species variations in humans, important domestic animals, and the major laboratory species.
[Mh] Termos MeSH primário: Placenta/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Membranas Extraembrionárias/metabolismo
Feminino
Feto/irrigação sanguínea
Seres Humanos
Placenta/irrigação sanguínea
Gravidez
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE



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