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  1 / 17135 MEDLINE  
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[PMID]:28452708
[Au] Autor:Chaudhry S; Chaudhry S; Qureshi T; Batra PS
[Ad] Endereço:Rush Medical College, Rush University, Chicago, Illinois, USA.
[Ti] Título:Evolution of sinonasal symptoms and mucosal healing after minimally invasive pituitary surgery.
[So] Source:Am J Rhinol Allergy;31(2):117-121, 2017 Mar 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Minimally invasive pituitary surgery (MIPS) via endoscopy has become widely accepted as the surgical paradigm of choice for pituitary pathology. The objective of the current study was to analyze the evolution of symptom scores and mucosal healing after MIPS. METHODS: The 22-item Sino-Nasal Outcome Test (SNOT-22) scores and objective endoscopic data of 52 patients were reviewed in a longitudinal manner. Scaled averages of the SNOT-22 and endoscopic scores from different time points were compared with baseline scores by using nonparametric testing. The time to baseline for endoscopic examinations was also analyzed by using Kaplan-Meier curves. RESULTS: The rhinologic symptoms subdomain of the SNOT-22 scores showed statistically significant worsening between baseline and 2 weeks after surgery (p = 0.03). Follow-up SNOT-22 scores after 2 weeks showed no significant differences compared with baseline scores, with an overall trend toward improvement in patient symptoms during the subsequent period. Similar analysis for the endoscopic data illustrated statistically significant differences from the baseline scores up to 16 weeks after surgery. The overall trend showed a worsened endoscopic examination, initially with a spike at ∼8 to 10 weeks (p = 0.03) and with a subsequent return to baseline. The Kaplan-Meier estimate curve demonstrated a median time to return to baseline endoscopy at 18.9 weeks (95% confidence interval, 14.9-38.3 weeks). CONCLUSION: The longitudinal data exhibited subjective improvement of patient outcomes based on SNOT-22 scores within 2-4 weeks after MIPS. However, the objective endoscopic data revealed a lag in improvement of the examination, typically at 16-20 weeks, which underscores ongoing careful endoscopic assessment and management to ensure proper mucosal healing beyond just subjective symptoms as the gauge to postoperative recovery.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Minimamente Invasivos
Seios Paranasais/cirurgia
Hipófise/cirurgia
Neoplasias Hipofisárias/cirurgia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Endoscopia
Feminino
Seres Humanos
Masculino
Meia-Idade
Membrana Mucosa/patologia
Seios Paranasais/patologia
Hipófise/patologia
Neoplasias Hipofisárias/patologia
Período Pós-Operatório
Qualidade de Vida
Estudos Retrospectivos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2017.31.4407


  2 / 17135 MEDLINE  
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[PMID]:29185092
[Au] Autor:Ma M; Dai J; Xu T; Yu S; Yu H; Tang H; Yan J; Wu X; Yu J; Chi Z; Si L; Cui C; Sheng X; Kong Y; Guo J
[Ad] Endereço:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China.
[Ti] Título:Analysis of TSC1 mutation spectrum in mucosal melanoma.
[So] Source:J Cancer Res Clin Oncol;144(2):257-267, 2018 Feb.
[Is] ISSN:1432-1335
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Mucosal melanoma is a relatively rare subtype of melanoma for which no clearly established therapeutic strategy exists. The genes of the mTOR signalling pathway have drawn great attention as key targets for cancer treatment, including melanoma. In this study, we aimed to investigate the mutation status of the upstream mTOR regulator TSC1 and evaluated its correlation with the clinicopathological features of mucosal melanoma. METHODS: We collected 91 mucosal melanoma samples for detecting TSC1 mutations. All the coding exons of TSC1 were amplified by PCR and subjected to Sanger sequencing. Expression level of TSC1 encoding protein (hamartin) was detected by immunohistochemistry. The activation of mTOR pathway was determined by evaluating the phosphorylation status of S6RP and 4E-BP1. RESULTS: The overall mutation frequency of TSC1 was found to be 17.6% (16/91 patients). TSC1 mutations were more inclined to occur in advanced mucosal melanoma (stages III and IV). In the 16 patients with TSC1 mutations, 14 different mutations were detected, affecting 11 different exons. TSC1 mutations were correlated with upregulation of S6RP phosphorylation but were unrelated to 4E-BP1 phosphorylation or hamartin expression. Mucosal melanoma patients with TSC1 mutations had a worse outcome than patients without TSC1 mutations (24.0 versus 34.0 months, P = 0.007). CONCLUSIONS: Our findings suggest that TSC1 mutations are frequent in mucosal melanoma. TSC1 mutations can activate the mTOR pathway through phospho-S6RP and might be a poor prognostic predictor of mucosal melanoma. Our data implicate the potential significance of TSC1 mutations for effective and specific drug therapy for mucosal melanoma.
[Mh] Termos MeSH primário: Melanoma/genética
Mutação
Proteínas Supressoras de Tumor/genética
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Análise Mutacional de DNA
Feminino
Seres Humanos
Masculino
Melanoma/metabolismo
Melanoma/patologia
Meia-Idade
Membrana Mucosa/patologia
Estadiamento de Neoplasias
Fosfoproteínas/metabolismo
Prognóstico
Proteína S6 Ribossômica/metabolismo
Serina-Treonina Quinases TOR/metabolismo
Proteínas Supressoras de Tumor/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (EIF4EBP1 protein, human); 0 (Phosphoproteins); 0 (Ribosomal Protein S6); 0 (Tumor Suppressor Proteins); 0 (tuberous sclerosis complex 1 protein); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00432-017-2550-z


  3 / 17135 MEDLINE  
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[PMID]:29311119
[Au] Autor:Clemente JC; Manasson J; Scher JU
[Ad] Endereço:Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[Ti] Título:The role of the gut microbiome in systemic inflammatory disease.
[So] Source:BMJ;360:j5145, 2018 01 08.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. Renewed interest in the human microbiome and its metabolites, as well as notable advances in host mucosal immunology, has opened multiple avenues of research to potentially modulate inflammatory responses. The complexity and interdependence of these diet-microbe-metabolite-host interactions are rapidly being unraveled. Importantly, most of the progress in the field comes from new knowledge about the functional properties of these microorganisms in physiology and their effect in mucosal immunity and distal inflammation. This review summarizes the preclinical and clinical evidence on how dietary, probiotic, prebiotic, and microbiome based therapeutics affect our understanding of wellness and disease, particularly in autoimmunity.
[Mh] Termos MeSH primário: Doenças Autoimunes/microbiologia
Comportamento Alimentar/fisiologia
Microbioma Gastrointestinal/imunologia
Inflamação/microbiologia
Doenças Inflamatórias Intestinais/microbiologia
Membrana Mucosa/microbiologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/imunologia
Transplante de Microbiota Fecal/métodos
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Inflamação/imunologia
Doenças Inflamatórias Intestinais/imunologia
Doenças Inflamatórias Intestinais/patologia
Microbiota
Membrana Mucosa/imunologia
Prebióticos
Probióticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Prebiotics)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5145


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[PMID]:29310440
[Au] Autor:Kodama H; Kumai Y; Nishimoto K; Toya Y; Miyamaru S; Furushima S; Yumoto E
[Ad] Endereço:1 Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, Kumamoto, Japan.
[Ti] Título:The Ferret as a Surgical Model for Vocal Fold Scar Creation and Treatment.
[So] Source:Ann Otol Rhinol Laryngol;127(3):146-154, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To develop a vocal fold (VF) scarring procedure in the ferret, characterize the scars histologically, and test the injectability of the lamina propria (LP). Secondarily, to compare laryngeal anatomy of the ferret with rat and rabbit. MATERIALS AND METHODS: The larynges of 18 male ferrets were prepared by unilateral scarring, and normal larynges from 6 female Wistar rats and 5 male albino rabbits were used for comparative purposes. For scarring, the right VF were electrocauterized, ablating the entire LP. Prior to harvesting the larynges at 4 and 16 weeks, each ferret was re-anesthetized, and in 3 animals, India ink was injected into the LPs of both normal and scarred VFs. RESULTS: Laryngoscopic methods and instrumentation for precise visualization, scarring, and injection were developed. The scarred VFs had reduced hyaluronic acid and increased collagen type I, III, and fibronectin compared with normal VFs. The 2 timepoints (4 and 16 weeks) differed significantly only in collagen type III level (levels were higher at 4 weeks). Injected ink migrated from scarred LP to muscle layer just beneath the scarred tissue 3 hours after injection. CONCLUSION: The ferret is a promising species for creation and experimental treatment of vocal fold scar.
[Mh] Termos MeSH primário: Cicatriz
Eletrocoagulação/métodos
Laringoscopia
Membrana Mucosa
Prega Vocal/cirurgia
[Mh] Termos MeSH secundário: Animais
Cicatriz/etiologia
Cicatriz/metabolismo
Cicatriz/patologia
Colágeno Tipo I/análise
Colágeno Tipo III/análise
Feminino
Furões
Fibronectinas/análise
Laringoscopia/instrumentação
Laringoscopia/métodos
Modelos Anatômicos
Membrana Mucosa/patologia
Membrana Mucosa/cirurgia
Coelhos
Ratos
Prega Vocal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 0 (Collagen Type III); 0 (Fibronectins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417750165


  5 / 17135 MEDLINE  
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[PMID]:28455406
[Au] Autor:Petersen KB; Kjaergaard T
[Ad] Endereço:Department of ENT, Aarhus University Hospital, Aarhus C, Denmark.
[Ti] Título:Role of narrow band imaging in the diagnostics of sinonasal pathology.
[So] Source:BMJ Case Rep;2017, 2017 Apr 28.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Malignancies of the nasal cavity and paranasal sinuses are well known, but have uncommon presentations. Late diagnosis and local extension are significant prognostic factors associated with a poorer treatment outcome. Thus, refinements of the diagnostic procedures to enhance the sensitivity of the clinical evaluation are desirable. We here describe a case of endonasal lymphoma, in which the lesion was hardly visible and initially ignored at ordinary white light (WLI) nasoendoscopy, but easily recognisable, clearly pathogenic and well demarcated when illuminated with narrow band imaging (NBI) at a later session. In general, with regard to mucosal-derived pathology of the upper aerodigestive tract, the diagnostic gain of NBI-assisted endoscopy in comparison with that of WLI has been proved in several articles. The focus has however been on neoplasm in laryngopharynx and oesophagus. The authors recommend broadening the use of NBI to include all evaluations of nasal mucosa, when malignancy is suspected.
[Mh] Termos MeSH primário: Linfonodos/diagnóstico por imagem
Linfoma não Hodgkin/patologia
Membrana Mucosa/patologia
Imagem de Banda Estreita/métodos
Cavidade Nasal/diagnóstico por imagem
Invasividade Neoplásica/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Endoscopia/métodos
Fluordesoxiglucose F18/metabolismo
Seres Humanos
Luz
Linfonodos/patologia
Linfoma não Hodgkin/complicações
Masculino
Mediastino/diagnóstico por imagem
Mediastino/patologia
Cavidade Nasal/patologia
Pescoço/diagnóstico por imagem
Pescoço/patologia
Invasividade Neoplásica/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  6 / 17135 MEDLINE  
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[PMID]:29220358
[Au] Autor:Dorta-Estremera S; Nehete PN; Yang G; He H; Nehete BP; Shelton KA; Barry MA; Sastry KJ
[Ad] Endereço:The University of Texas MD Anderson Cancer Center, Department of Immunology, Houston, TX, United States of America.
[Ti] Título:Minimally invasive monitoring of CD4 T cells at multiple mucosal tissues after intranasal vaccination in rhesus macaques.
[So] Source:PLoS One;12(12):e0188807, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies in nonhuman primates (NHP) for prospective immune cell monitoring subsequent to infection and/or vaccination usually rely on periodic sampling of the blood samples with only occasional collections of biopsies from mucosal tissues because of safety concerns and practical constraints. Here we present evidence in support of cytobrush sampling of oral, rectal, and genital mucosal tissues as a minimally invasive approach for the phenotypic analyses of different T cells subsets de novo as well as prospectively after intranasal immunization in rhesus macaques. Significant percentages of viable lymphocytes were obtained consistently from both naïve and chronically SIV-infected rhesus macaques. The percentages of CD3+ T cells in the blood were significantly higher compared to those in the mucosal tissues analyzed in the naïve animals, while in the SIV+ animals the CD3+ T cells were significantly elevated in the rectal tissues, relative to all other sites analyzed. In the naïve, but not SIV+ macaques, the rectal and vaginal mucosal tissues, compared to oral mucosa and blood, showed higher diversity and percentages of CD4+ T cells expressing the HIV entry co-receptor CCR5 and mucosal specific adhesion (CD103) as well as activation (HLA-DR) and proliferation (Ki67) markers. Sequential daily cytobrush sampling from the oral, rectal, and genital mucosal tissues was performed in SIV+ animals from an ongoing study where they were administered intranasal immunization with adenoviral vectored vaccines incorporating the green fluorescent protein (GFP) reporter gene. We detected a transient increase in GFP+ CD4 T cells in only oral mucosa suggesting limited mucosal trafficking. In general, CD4+ and CD8+ T cells expressing Ki67 transiently increased in all mucosal tissues, but those expressing the CCR5, HLA-DR, and CD103 markers exhibited minor changes. We propose the minimally invasive cytobrush sampling as a practical approach for effective and prospective immune monitoring of the oral-genital mucosal tissues in NHP.
[Mh] Termos MeSH primário: Contagem de Linfócito CD4
Linfócitos T CD4-Positivos/imunologia
Macaca mulatta/imunologia
Membrana Mucosa/imunologia
Vacinas Virais/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Feminino
Citometria de Fluxo
Masculino
Síndrome de Imunodeficiência Adquirida dos Símios/imunologia
Vacinas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Vaccines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188807


  7 / 17135 MEDLINE  
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[PMID]:28459043
[Au] Autor:Yadav MK; Chae SW; Go YY; Im GJ; Song JJ
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of MedicineSeoul, South Korea.
[Ti] Título: Multi-Species Biofilms of Methicillin-Resistant and and Their Host Interaction during Colonization of an Otitis Media Rat Model.
[So] Source:Front Cell Infect Microbiol;7:125, 2017.
[Is] ISSN:2235-2988
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:(SA) and (PA) are known to cause biofilm-related infections. MRSA and PA have been frequently isolated from chronically infected wounds, cystic fibrosis, chronic suppurative otitis media (CSOM), and from indwelling medical devices, and these bacteria co-exist; however, their interaction with each-other or with the host is not well known. In this study, we investigated MRSA and PA multi-species biofilm communities and their interaction with the host during colonization using an OM rat-model. biofilm formation and colonization were studied using CV-microtiter plate assay and OM rat-model respectively. The biofilms were viewed under scanning electron microscope and bacteria were enumerated using cfu counts. The differential gene expressions of rat mucosa colonized with single or multi-species of MRSA or PA were studied using RNA-sequencing of total transcriptome. In multi-species biofilms PA partially inhibited SA growth. However, no significant inhibition of MRSA was detected during colonization of multi-species in rat bullae. A total of 1,797 genes were significantly ( < 0.05) differentially expressed in MRSA or PA or MRSA + PA colonized rat middle ear mucosa with respect to the control. The poly-microbial colonization of MRSA and PA induced the differential expression of a significant number of genes that are involved in immune response, inflammation, signaling, development, and defense; these were not expressed with single species colonization by either MRSA or PA. Genes involved in defense, immune response, inflammatory response, and developmental process were exclusively up-regulated, and genes that are involved in nervous system signaling, development and transmission, regulation of cell growth and development, anatomical and system development, and cell differentiation were down-regulated after multi-species inoculation. These results indicate that poly-microbial colonization induces a host response that is different from that induced by single species infection.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Coinfecção
Interações Hospedeiro-Patógeno
Staphylococcus aureus Resistente à Meticilina/fisiologia
Otite Média/microbiologia
Pseudomonas aeruginosa/fisiologia
[Mh] Termos MeSH secundário: Animais
Doença Crônica
Coinfecção/genética
Coinfecção/microbiologia
Coinfecção/patologia
Contagem de Colônia Microbiana
Modelos Animais de Doenças
Orelha Média/microbiologia
Orelha Média/patologia
Regulação da Expressão Gênica
Genes Bacterianos/genética
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Microscopia Eletrônica de Varredura
Membrana Mucosa/microbiologia
Otite Média/patologia
Infecções por Pseudomonas/microbiologia
Infecções por Pseudomonas/patologia
Pseudomonas aeruginosa/genética
Pseudomonas aeruginosa/patogenicidade
Ratos
Infecções Estafilocócicas/microbiologia
Infecções Estafilocócicas/patologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.3389/fcimb.2017.00125


  8 / 17135 MEDLINE  
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[PMID]:28468673
[Au] Autor:Haddow AD; Nasar F; Schellhase CW; Moon RD; Padilla SL; Zeng X; Wollen-Roberts SE; Shamblin JD; Grimes EC; Zelko JM; Linthicum KJ; Bavari S; Pitt ML; Trefry JC
[Ad] Endereço:United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA. andrew.d.haddow.ctr@mail.mil.
[Ti] Título:Low potential for mechanical transmission of Ebola virus via house flies (Musca domestica).
[So] Source:Parasit Vectors;10(1):218, 2017 May 03.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ebola virus (EBOV) infection results in high morbidity and mortality and is primarily transmitted in communities by contact with infectious bodily fluids. While clinical and experimental evidence indicates that EBOV is transmitted via mucosal exposure, the ability of non-biting muscid flies to mechanically transmit EBOV following exposure to the face had not been assessed. RESULTS: To investigate this transmission route, house flies (Musca domestica Linnaeus) were used to deliver an EBOV/blood mixture to the ocular/nasal/oral facial mucosa of four cynomolgus macaques (Macaca fascicularis Raffles). Following exposure, macaques were monitored for evidence of infection through the conclusion of the study, days 57 and 58. We found no evidence of systemic infection in any of the exposed macaques. CONCLUSIONS: The results of this study indicate that there is a low potential for the mechanical transmission of EBOV via house flies - the conditions in this study were not sufficient to initiate infection.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/transmissão
Moscas Domésticas/virologia
Insetos Vetores/virologia
[Mh] Termos MeSH secundário: Animais
Olho/virologia
Face/virologia
Fezes/virologia
Doença pelo Vírus Ebola/sangue
Doença pelo Vírus Ebola/virologia
Macaca fascicularis
Mucosa Bucal/virologia
Membrana Mucosa/virologia
Nariz/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2149-x


  9 / 17135 MEDLINE  
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[PMID]:29254592
[Au] Autor:Carrara M; Cusumano D; Giandini T; Tenconi C; Mazzarella E; Grisotto S; Massari E; Mazzeo D; Cerrotta A; Pappalardi B; Fallai C; Pignoli E
[Ad] Endereço:Medical Physics Unit, IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy. Electronic address: mauro.carrara@istitutotumori.mi.it.
[Ti] Título:Comparison of different treatment planning optimization methods for vaginal HDR brachytherapy with multichannel applicators: A reduction of the high doses to the vaginal mucosa is possible.
[So] Source:Phys Med;44:58-65, 2017 Dec.
[Is] ISSN:1724-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. METHODS: Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. RESULTS: The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. CONCLUSIONS: Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa.
[Mh] Termos MeSH primário: Braquiterapia
Membrana Mucosa/efeitos da radiação
Dose de Radiação
Planejamento da Radioterapia Assistida por Computador/métodos
Vagina/efeitos da radiação
[Mh] Termos MeSH secundário: Neoplasias do Endométrio/radioterapia
Feminino
Seres Humanos
Dosagem Radioterapêutica
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:28455268
[Au] Autor:Moon Y
[Ad] Endereço:Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sciences, Pusan National University School of Medicine, Yangsan, South Korea; Research Institute for Basic Sciences and Medical Research Institute, Pusan National University, Busan, South Korea; Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Busan, South Korea. Electronic address: moon@pnu.edu.
[Ti] Título:NSAID-activated gene 1 and its implications for mucosal integrity and intervention beyond NSAIDs.
[So] Source:Pharmacol Res;121:122-128, 2017 Jul.
[Is] ISSN:1096-1186
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In spite of the beneficial actions of non-steroid anti-inflammatory drugs (NSAIDs) in epithelial inflammation and cancers, their use is limited because of their cyclooxygenase-dependent or independent gastrointestinal toxicity. As an eicosanoid-independent mediator, NSAID-activated gene 1 (NAG-1) has been assessed for its involvement in cellular integrity and pathogenesis in mucosal inflammation and carcinogenesis. At the cellular levels, NAG-1 is involved in the cell growth regulation (cell death, cell cycle arrest, or proliferation) in epithelial and mesenchymal tissues. Moreover, NAG-1 can modulate inflammatory responses in either direct or indirect manner, which ultimately affects fibrogenic and tumorigenic processes in various disease states. Finally, NAG-1 has been assessed for its contribution to cellular behavior, such as the mobility of epithelial and malignant cells in response to the external insults or oncogenic stimulation in the mucosa. This review on the "Yin-Yang" nature of NAG-1-mediated responses provides comprehensive insights into therapeutic and diagnostic interventions for mucosal health and integrity in the human body.
[Mh] Termos MeSH primário: Carcinogênese/imunologia
Fator 15 de Diferenciação de Crescimento/imunologia
Mucosite/imunologia
Membrana Mucosa/imunologia
[Mh] Termos MeSH secundário: Animais
Carcinogênese/patologia
Movimento Celular
Proliferação Celular
Fibrose
Fator 15 de Diferenciação de Crescimento/análise
Seres Humanos
Inflamação/imunologia
Inflamação/patologia
Mucosite/patologia
Membrana Mucosa/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (GDF15 protein, human); 0 (Growth Differentiation Factor 15)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE



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