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  1 / 2084 MEDLINE  
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[PMID]:28465725
[Au] Autor:McEwen LM; Morin AM; Edgar RD; MacIsaac JL; Jones MJ; Dow WH; Rosero-Bixby L; Kobor MS; Rehkopf DH
[Ad] Endereço:Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Ave, Vancouver, Canada.
[Ti] Título:Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.
[So] Source:Epigenetics Chromatin;10:21, 2017.
[Is] ISSN:1756-8935
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population's unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. METHODS: In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya ( = 48) and non-Nicoya (other Costa Rican regions,  = 47) using the Infinium HumanMethylation450 microarray. RESULTS: We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. CONCLUSIONS: Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.
[Mh] Termos MeSH primário: Metilação de DNA
Longevidade/genética
Linfócitos/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Linfócitos T CD4-Positivos/citologia
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD8-Positivos/citologia
Linfócitos T CD8-Positivos/metabolismo
Costa Rica
Ilhas de CpG
Estudos Transversais
DNA/química
DNA/isolamento & purificação
DNA/metabolismo
Epigenômica
Feminino
Seres Humanos
Linfócitos/citologia
Masculino
Meia-Idade
Células T Matadoras Naturais/citologia
Células T Matadoras Naturais/metabolismo
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s13072-017-0128-2


  2 / 2084 MEDLINE  
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[PMID]:29346401
[Au] Autor:van Puijvelde GHM; Foks AC; van Bochove RE; Bot I; Habets KLL; de Jager SC; Ter Borg MND; van Osch P; Boon L; Vos M; de Waard V; Kuiper J
[Ad] Endereço:Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
[Ti] Título:CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice.
[So] Source:PLoS One;13(1):e0190962, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (Ang II). We demonstrate that a deficiency in CD1d dependent NKT cells under hyperlipidemic conditions (LDLr-/-CD1d-/- mice) results in a strong decline in the severity of angiotensin II induced aneurysm formation when compared with LDLr-/- mice. In addition, we show that Ang II amplifies the activation of NKT cells both in vivo and in vitro. We also provide evidence that type I NKT cells contribute to AAA development by inducing the expression of matrix degrading enzymes in vSMCs and macrophages, and by cytokine dependently decreasing vSMC viability. Altogether, these data prove that CD1d-dependent NKT cells contribute to AAA development in the Ang II-mediated aneurysm model by enhancing aortic degradation, establishing that therapeutic applications which target NKT cells can be a successful way to prevent AAA development.
[Mh] Termos MeSH primário: Antígenos CD1d/genética
Aneurisma da Aorta Abdominal/prevenção & controle
Receptores de LDL/genética
[Mh] Termos MeSH secundário: Angiotensina II/administração & dosagem
Animais
Apoptose/imunologia
Citometria de Fluxo
Ativação Linfocitária
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Músculo Liso Vascular/imunologia
Músculo Liso Vascular/patologia
Células NIH 3T3
Células T Matadoras Naturais/imunologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD1d); 0 (Cd1d1 protein, mouse); 0 (Receptors, LDL); 11128-99-7 (Angiotensin II)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190962


  3 / 2084 MEDLINE  
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[PMID]:29381934
[Au] Autor:He M; Jia J; Zhang J; Beejadhursing R; Mwamaka Sharifu L; Yu J; Wang S; Feng L
[Ad] Endereço:Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
[Ti] Título:Pregnancy-associated hemophagocytic lymphohistiocytosis secondary to NK/T cells lymphoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(47):e8628, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hemophagocytic lymphohistiocytosis (HLH) occurs primarily in pediatric population, or secondary to malignancy, infection, or autoimmune disease. This disease is rare and prognosis is generally poor. Only a small number of cases during pregnancy have been reported in literature. PATIENT CONCERNS: We report a case of pregnancy-associated HLH secondary to natural killer (NK)/T cells lymphoma. She was admitted at 30 weeks and 3 days of pregnancy with complaints of abdominal pain and fever as high as 39.2°C. The patient was found to have splenomegaly, pancytopenia, and acute hepatic failure. DIAGNOSES: A subsequent bone marrow biopsy revealed focal hemophagocytosis and atypical lymphoid cells. The splenic pulp also contained a large number of tissue cells proliferating and devouring mature red blood cells, lymphocytes, and cell debris. On the basis of these findings, we diagnosed the case as pregnancy-associated hemophagocytic lymphohistiocytosis secondary to NK/T cells lymphoma. INTERVENTIONS: Treatment consisted with dexamethasone and etoposide in combination with rituximab. OUTCOMES: Due to timely termination of pregnancy, the neonate was in good condition. However, the patient died on the 18th day postoperation due to multiorgan failure. LESSONS: We recommend that HLH be considered as differential diagnosis in a pregnant patient complaining of persistent fever, cytopenia, or declining clinical condition despite delivery of the baby. Prompt diagnosis and treatment is essential and fetal outcomes should also be considered. The decision to terminate a pregnancy and initiate chemotherapy during pregnancy with malignancy-associated HLH (M-HLH) needs to be further investigated in a larger cohort.
[Mh] Termos MeSH primário: Dexametasona/administração & dosagem
Etoposídeo/administração & dosagem
Linfo-Histiocitose Hemofagocítica
Linfoma
Células T Matadoras Naturais/patologia
Complicações Neoplásicas na Gravidez
Rituximab/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos/administração & dosagem
Exame de Medula Óssea/métodos
Diagnóstico Diferencial
Evolução Fatal
Feminino
Seres Humanos
Linfo-Histiocitose Hemofagocítica/diagnóstico
Linfo-Histiocitose Hemofagocítica/tratamento farmacológico
Linfo-Histiocitose Hemofagocítica/etiologia
Linfo-Histiocitose Hemofagocítica/fisiopatologia
Linfoma/complicações
Linfoma/patologia
Gravidez
Complicações Neoplásicas na Gravidez/diagnóstico
Complicações Neoplásicas na Gravidez/patologia
Complicações Neoplásicas na Gravidez/fisiopatologia
Complicações Neoplásicas na Gravidez/cirurgia
Resultado da Gravidez
Baço/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 4F4X42SYQ6 (Rituximab); 6PLQ3CP4P3 (Etoposide); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008628


  4 / 2084 MEDLINE  
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[PMID]:29227067
[Au] Autor:Tsutsui H
[Ti] Título:Role of Natural Killer T Cells in Cardiac Remodeling and Failure and the Development of Novel Therapeutic Strategy.
[So] Source:Fukuoka Igaku Zasshi;107(10):177-84, 2016 10.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no previous studies have determined the pathophysiological role of iNKT cells in post-MI LV remodeling. We thus examined whether the activation of iNKT cells might affect the development of LV remodeling and failure. After creation of MI, mice received the injection of either a-galactosylceramide (aGC), the activator of iNKT cells, or phosphate-buffered saline 1 and 4 days after surgery, and were followed during 28 days. Survival rate was significantly higher in MI +aGC than MI + PBS. LV cavity dilatation and dysfunction were significantly attenuated inMI +aGC, despite comparable infarct size, accompanied by a decrease in myocyte hypertrophy, interstitial fibrosis, and apoptosis. The infiltration of iNKT cells were increased during early phase in noninfarcted LV from MI and aGC further enhanced them. It also enhanced LV interleukin (IL)-10 gene expression at 7 days, which persisted until 28 days. AntiIL-10 receptor antibody abrogated these protective effects of aGC on MI remodeling. The administration of aGC into iNKT cell-deficient Ja18(-/-) mice had no such effects, suggesting that aGC was a specific activator of iNKT cells. iNKT cells play a protective role against post-MI LV remodeling and failure through the enhanced expression of cardioprotective cytokines such as IL-10.
[Mh] Termos MeSH primário: Insuficiência Cardíaca/fisiopatologia
Coração/fisiopatologia
Células T Matadoras Naturais
[Mh] Termos MeSH secundário: Animais
Ensaios Clínicos como Assunto
Insuficiência Cardíaca/imunologia
Insuficiência Cardíaca/patologia
Seres Humanos
Inflamação/imunologia
Ativação Linfocitária
Células T Matadoras Naturais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  5 / 2084 MEDLINE  
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[PMID]:28452930
[Au] Autor:Faure-Dupuy S; Lucifora J; Durantel D
[Ad] Endereço:Cancer Research Center of Lyon (CRCL), INSERM, U1052, CNRS, University of Lyon, UMR-5286, 69003 Lyon, France. suzanne.faure-dupuy@inserm.fr.
[Ti] Título:Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts.
[So] Source:Viruses;9(5), 2017 04 28.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of the interaction between HBV and innate immune cells is instrumental to: (1) better understand the conditions of establishment and maintenance of HBV infections in this secondary lymphoid organ; (2) define the role of these innate immune cells in treatment failure and pathogenesis; and (3) design novel immune-therapeutic concepts based on the activation/restoration of innate cell functions and/or innate effectors. This review will summarize and discuss the current knowledge we have on this interplay between HBV and liver innate immunity.
[Mh] Termos MeSH primário: Vírus da Hepatite B/imunologia
Hepatite B/imunologia
Hepatite B/terapia
Imunidade Inata
Fígado/imunologia
Fígado/virologia
[Mh] Termos MeSH secundário: Animais
Células Dendríticas/imunologia
Vírus da Hepatite B/fisiologia
Hepatite B Crônica/imunologia
Hepatite B Crônica/terapia
Interações Hospedeiro-Patógeno
Seres Humanos
Células Matadoras Naturais/imunologia
Fígado/citologia
Camundongos
Células T Matadoras Naturais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  6 / 2084 MEDLINE  
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[PMID]:28468680
[Au] Autor:Ferraz R; Cunha CF; Pimentel MIF; Lyra MR; Pereira-Da-Silva T; Schubach AO; Da-Cruz AM; Bertho AL
[Ad] Endereço:Laboratory of Immunoparasitology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
[Ti] Título:CD3 CD4 CD8 (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.
[So] Source:Parasit Vectors;10(1):219, 2017 May 03.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a fundamental role in this process. The aim of this study is to better understand the role of cytotoxicity mediated mechanisms that occur during the immune response in the CL lesion milieu, considering distinct cytotoxic-related CD107a cells, such as CD8 , CD4 , CD4 CD8 (double-negative, DN) and CD4 CD8 (double-positive, DP) T lymphocytes, as well as NK and NKT cells. METHODS: Lesion derived cells were assessed for T cell subpopulations and NK cells, as well as CD107a expression by flow cytometry. In addition, cytometric bead array (CBA) was used to quantify cytokines and granzyme B concentrations in supernatants from macerated lesions. RESULTS: Flow cytometry analyses revealed that NKT cells are the major CD107a-expressing cell population committed to cytotoxicity in CL lesion, although we also observed high frequencies of CD4 and DN T cells expressing CD107a. Analysing the pool of CD107a -cell populations, we found a higher distribution of DN T cells (44%), followed by approximately 25% of NKT cells. Interestingly, NK and CD8 T cells represented only 3 and 4% of the total-CD107a -cell pool, respectively. CONCLUSIONS: The cytotoxicity activity that occurs in the lesion milieu of CL patients seems to be dominated by DN T and NKT cells. These findings suggest the need for a reevaluation of the role of classical-cytotoxic NK and CD8 T cells in the pathogenesis of CL, implicating an important role for other T cell subpopulations.
[Mh] Termos MeSH primário: Citotoxicidade Imunológica
Leishmaniose Cutânea/imunologia
Proteína 1 de Membrana Associada ao Lisossomo/imunologia
Células T Matadoras Naturais/imunologia
Subpopulações de Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Adulto
Antígenos de Protozoários/imunologia
Biópsia
Brasil/epidemiologia
Citocinas/biossíntese
Citocinas/genética
Feminino
Citometria de Fluxo
Granzimas/análise
Seres Humanos
Leishmania braziliensis/imunologia
Leishmaniose Cutânea/epidemiologia
Proteína 1 de Membrana Associada ao Lisossomo/genética
Masculino
Meia-Idade
Pele/imunologia
Pele/parasitologia
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (Cytokines); 0 (Lysosomal-Associated Membrane Protein 1); EC 3.4.21.- (GZMB protein, human); EC 3.4.21.- (Granzymes)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2152-2


  7 / 2084 MEDLINE  
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[PMID]:28465341
[Au] Autor:Gorini F; Azzimonti L; Delfanti G; Scarfò L; Scielzo C; Bertilaccio MT; Ranghetti P; Gulino A; Doglioni C; Di Napoli A; Capri M; Franceschi C; Caligaris-Cappio F; Ghia P; Bellone M; Dellabona P; Casorati G; de Lalla C
[Ad] Endereço:Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
[Ti] Título:Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis.
[So] Source:Blood;129(26):3440-3451, 2017 06 29.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5 B lymphocytes in blood, bone marrow, and lymphoid organs. CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in tumor surveillance. We investigated the impact of iNKT cells in the natural history of the disease in the Eµ-Tcl1 (Tcl1) CLL mouse model and 68 CLL patients. We found that Tcl1-CLL cells express CD1d and that iNKT cells critically delay disease onset but become functionally impaired upon disease progression. In patients, disease progression correlates with high CD1d expression on CLL cells and impaired iNKT cells. Conversely, disease stability correlates with negative or low CD1d expression on CLL cells and normal iNKT cells, suggesting indirect leukemia control. iNKT cells indeed hinder CLL survival in vitro by restraining CD1d-expressing nurse-like cells, a relevant proleukemia macrophage population. Multivariable analysis identified iNKT cell frequency as an independent predictor of disease progression. Together, these results support the contribution of iNKT cells to CLL immune surveillance and highlight iNKT cell frequency as a prognostic marker for disease progression.
[Mh] Termos MeSH primário: Vigilância Imunológica
Leucemia Linfocítica Crônica de Células B/imunologia
Células T Matadoras Naturais/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Antígenos CD1d/sangue
Progressão da Doença
Feminino
Seres Humanos
Leucemia Linfocítica Crônica de Células B/patologia
Contagem de Linfócitos
Masculino
Camundongos
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD1d); 0 (CD1D protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2016-11-751065


  8 / 2084 MEDLINE  
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[PMID]:28743554
[Au] Autor:Macho-Fernandez E; Chekkat N; Ehret C; Thomann JS; De Giorgi M; Spanedda MV; Bourel-Bonnet L; Betbeder D; Heurtault B; Faveeuw C; Fournel S; Frisch B; Trottein F
[Ad] Endereço:Univ. Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France; Centre National de la Recherche Scientifique, UMR 8204, F-59000 Lille, France; Institut National de la Santé et de la Recherche Médicale U1019, F-59000 Lille, France; Centre Hospitalier Universit
[Ti] Título:Solubilization of α-galactosylceramide in aqueous medium: Impact on Natural Killer T cell activation and antitumor responses.
[So] Source:Int J Pharm;530(1-2):354-363, 2017 Sep 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The potent antitumor effect of α-galactosylceramide (α-GalCer) is based on its recognition by invariant Natural Killer T cells (iNKT) after its capture and presentation by antigen presenting cells including dendritic cells (DCs). Synthetic α-GalCer has already been tested in advanced cancer patients but no or only moderate clinical responses were obtained. To optimize α-GalCer efficacy, we have postulated that alternative formulations impacting its molecular organization in aqueous medium could modify DC uptake and iNKT-based immune responses. To this end, we have developed two strategies: (1) the formulation of α-GalCer in non-cationic liposomes and (2) the synthesis of a water-soluble α-GalCer analogue by anchoring a polyethyleneglycol moiety on its sugar head. The biological activities of these new preparations were compared to that induced by the classically used Polysorbate 20 α-GalCer micelles. Both formulations retained their uptake by DCs and activated iNKT cells both in vitro and in vivo. Despite a lower cytokine production, the formulations induced a potent immune response able to control lung murine carcinoma. In conclusion, it is possible to increase α-GalCer solubility in aqueous solution without limiting its antitumor properties.
[Mh] Termos MeSH primário: Antineoplásicos/química
Galactosilceramidas/química
Neoplasias Pulmonares/tratamento farmacológico
Ativação Linfocitária/efeitos dos fármacos
Células T Matadoras Naturais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Portadores de Fármacos/química
Lipossomos/química
Neoplasias Pulmonares/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drug Carriers); 0 (Galactosylceramides); 0 (Liposomes); 0 (alpha-galactosylceramide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  9 / 2084 MEDLINE  
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[PMID]:29182669
[Au] Autor:McKnight CG; Morris SC; Perkins C; Zhu Z; Hildeman DA; Bendelac A; Finkelman FD
[Ad] Endereço:Division of Immunology, Allergy and Rheumatology, Department of Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.
[Ti] Título:NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.
[So] Source:PLoS One;12(11):e0188221, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CD1d-deficiency results in a selective deletion of NKT cells in mice that is reported to prevent murine allergic airway disease (AAD). Because we find 2-3 fold lower basal IL-4 production in CD1d- mice than in wild-type (WT) mice, we hypothesized that the contribution made by NKT cells to AAD would depend on the strength of the stimulus used to induce the disease. Consequently, we compared CD1d-deficient mice to WT mice in the development of AAD, using several models of disease induction that differed in the type and dose of allergen, the site of sensitization and the duration of immunization. Surprisingly we found equivalent allergic inflammation and airway disease in WT and CD1d- mice in all models investigated. Consistent with this, NKT cells constituted only ~2% of CD4+ T cells in the lungs of mice with AAD, and IL-4-transcribing NKT cells did not expand with disease induction. Concerned that the congenital absence of NKT cells might have caused a compensatory shift within the immune response, we administered an anti-CD1d monoclonal Ab (mAb) to block NKT function before airway treatments, before or after systemic sensitization to antigen. Such Ab treatment did not affect disease severity. We suggest that the differences reported in the literature regarding the significance of NKT cells in the induction of allergic airway disease may have less to do with the methods used to study the disease and more to do with the animals themselves and/or the facilities used to house them.
[Mh] Termos MeSH primário: Asma/imunologia
Interleucina-4/biossíntese
Células T Matadoras Naturais/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos CD1d/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Ovalbumina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1d); 0 (CD1d antigen, mouse); 207137-56-2 (Interleukin-4); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188221


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[PMID]:29182664
[Au] Autor:Thanapati S; Ganu MA; Tripathy AS
[Ad] Endereço:Hepatitis Group, National Institute of Virology, Pune, Pashan, Pune, Maharashtra, India.
[Ti] Título:Differential inhibitory and activating NK cell receptor levels and NK/NKT-like cell functionality in chronic and recovered stages of chikungunya.
[So] Source:PLoS One;12(11):e0188342, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The role of natural killer (NK; CD3-CD56+)/NKT (CD3+CD56+)-like cells in chikungunya virus (CHIKV) disease progression/recovery remains unclear. Here, we investigated the expression profiles and function of NK and NKT-like cells from 35 chronic chikungunya patients, 30 recovered individuals, and 69 controls. Percentage of NKT-like cells was low in chronic chikungunya patients. NKp30+, CD244+, DNAM-1+, and NKG2D+ NK cell percentages were also lower (MFI and/or percentage), while those of CD94+ and NKG2A+ NKT-like cells were higher (MFI and/or percentage) in chronic patients than in recovered subjects. IFN-γ and TNF-α expression on NKT-like cells was high in the chronic patients, while only IFN-γ expression on NK cells was high in the recovered individuals. Furthermore, percentage of perforin+NK cells was low in the chronic patients. Lower cytotoxic activity was observed in the chronic patients than in the controls. CD107a expression on NK and NKT-like cells post anti-CD94/anti-NKG2A blocking was comparable among the patients and controls. Upregulated inhibitory and downregulated activating NK receptor expressions on NK/NKT-like cells, lower perforin+ and CD107a+NK cells are likely responsible for inhibiting the NK and NKT-like cell function in the chronic stage of chikungunya. Therefore, deregulation of NKR expression might underlie CHIKV-induced chronicity.
[Mh] Termos MeSH primário: Febre de Chikungunya/imunologia
Células Matadoras Naturais/imunologia
Células T Matadoras Naturais/imunologia
Receptores de Células Matadoras Naturais/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Seres Humanos
Interferon gama/metabolismo
Células Matadoras Naturais/metabolismo
Masculino
Meia-Idade
Células T Matadoras Naturais/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Natural Killer Cell); 0 (Tumor Necrosis Factor-alpha); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188342



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