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Pesquisa : A11.284.187.167 [Categoria DeCS]
Referências encontradas : 120 [refinar]
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  1 / 120 MEDLINE  
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[PMID]:26884154
[Au] Autor:van Wolferen M; Wagner A; van der Does C; Albers SV
[Ad] Endereço:Molecular Biology of Archaea, Institute of Biology II - Microbiology, University of Freiburg, 79104 Freiburg, Germany.
[Ti] Título:The archaeal Ced system imports DNA.
[So] Source:Proc Natl Acad Sci U S A;113(9):2496-501, 2016 Mar 01.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intercellular transfer of DNA is a phenomenon that occurs in all domains of life and is a major driving force of evolution. Upon UV-light treatment, cells of the crenarchaeal genus Sulfolobus express Ups pili, which initiate cell aggregate formation. Within these aggregates, chromosomal DNA, which is used for the repair of DNA double-strand breaks, is exchanged. Because so far no clear homologs of bacterial DNA transporters have been identified among the genomes of Archaea, the mechanisms of archaeal DNA transport have remained a puzzling and underinvestigated topic. Here we identify saci_0568 and saci_0748, two genes from Sulfolobus acidocaldarius that are highly induced upon UV treatment, encoding a transmembrane protein and a membrane-bound VirB4/HerA homolog, respectively. DNA transfer assays showed that both proteins are essential for DNA transfer between Sulfolobus cells and act downstream of the Ups pili system. Our results moreover revealed that the system is involved in the import of DNA rather than the export. We therefore propose that both Saci_0568 and Saci_0748 are part of a previously unidentified DNA importer. Given the fact that we found this transporter system to be widely spread among the Crenarchaeota, we propose to name it the Crenarchaeal system for exchange of DNA (Ced). In this study we have for the first time to our knowledge described an archaeal DNA transporter.
[Mh] Termos MeSH primário: Archaea/metabolismo
DNA Arqueal/metabolismo
[Mh] Termos MeSH secundário: Archaea/genética
Cromossomos de Archaea
DNA Arqueal/genética
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Archaeal)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1513740113


  2 / 120 MEDLINE  
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[PMID]:26339031
[Au] Autor:Schumacher MA; Tonthat NK; Lee J; Rodriguez-Castañeda FA; Chinnam NB; Kalliomaa-Sanford AK; Ng IW; Barge MT; Shaw PL; Barillà D
[Ad] Endereço:Department of Biochemistry, Duke University School of Medicine, 243 Nanaline H. Duke, Box 3711, Durham, NC 27710, USA. maria.schumacher@duke.edu daniela.barilla@york.ac.uk.
[Ti] Título:Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.
[So] Source:Science;349(6252):1120-4, 2015 Sep 04.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here, we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system uses three proteins: ParA; an atypical ParB adaptor; and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ParA motor, which contains a bacteria-like Walker motif. The C domain of ParB harbors structural similarity to CenpA, which dictates eukaryotic segregation. Thus, this archaeal system combines bacteria-like and eukarya-like components, which suggests the possible conservation of DNA segregation principles across the three domains of life.
[Mh] Termos MeSH primário: Proteínas Arqueais/química
Centrômero/química
Segregação de Cromossomos
Cromossomos de Archaea/genética
DNA Arqueal/genética
Sulfolobus/genética
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Proteínas Arqueais/genética
Autoantígenos/química
Autoantígenos/genética
Bactérias/genética
Centrômero/genética
Proteína Centromérica A
Proteínas Cromossômicas não Histona/química
Proteínas Cromossômicas não Histona/genética
Segregação de Cromossomos/genética
DNA Arqueal/química
DNA Super-Helicoidal/química
DNA Super-Helicoidal/genética
Kluyveromyces/genética
Conformação de Ácido Nucleico
Estrutura Terciária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Archaeal Proteins); 0 (Autoantigens); 0 (Centromere Protein A); 0 (Chromosomal Proteins, Non-Histone); 0 (DNA, Archaeal); 0 (DNA, Superhelical)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150905
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaa9046


  3 / 120 MEDLINE  
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[PMID]:25952670
[Au] Autor:Spaans SK; van der Oost J; Kengen SW
[Ad] Endereço:Laboratory of Microbiology, Wageningen University, PO Box 8033, 6700 EJ, Wageningen, The Netherlands, sebastiaan.spaans@wur.nl.
[Ti] Título:The chromosome copy number of the hyperthermophilic archaeon Thermococcus kodakarensis KOD1.
[So] Source:Extremophiles;19(4):741-50, 2015 Jul.
[Is] ISSN:1433-4909
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The euryarchaeon Thermococcus kodakarensis is a well-characterized anaerobic hyperthermophilic heterotroph and due to the availability of genetic engineering systems it has become one of the model organisms for studying Archaea. Despite this prominent role among the Euryarchaeota, no data about the ploidy level of this species is available. While polyploidy has been shown to exist in various Euryarchaeota, especially Halobacteria, the chromosome copy number of species belonging to one of the major orders within that phylum, i.e., the Thermococcales (including Thermococcus spp. and Pyrococcus spp.), has never been determined. This prompted us to investigate the chromosome copy number of T. kodakarensis. In this study, we demonstrate that T. kodakarensis is polyploid with a chromosome copy number that varies between 7 and 19 copies, depending on the growth phase. An apparent correlation between the presence of histones and polyploidy in Archaea is observed.
[Mh] Termos MeSH primário: Cromossomos de Archaea/genética
Thermococcus/genética
[Mh] Termos MeSH secundário: Cromossomos de Archaea/metabolismo
Thermococcus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:150509
[St] Status:MEDLINE
[do] DOI:10.1007/s00792-015-0750-5


  4 / 120 MEDLINE  
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[PMID]:25931116
[Au] Autor:Efremov AK; Qu Y; Maruyama H; Lim CJ; Takeyasu K; Yan J
[Ad] Endereço:From the Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore, the Centre for Bioimaging Sciences, National University of Singapore, Singapore 117546, Singapore.
[Ti] Título:Transcriptional Repressor TrmBL2 from Thermococcus kodakarensis Forms Filamentous Nucleoprotein Structures and Competes with Histones for DNA Binding in a Salt- and DNA Supercoiling-dependent Manner.
[So] Source:J Biol Chem;290(25):15770-84, 2015 Jun 19.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Architectural DNA proteins play important roles in the chromosomal DNA organization and global gene regulation in living cells. However, physiological functions of some DNA-binding proteins from archaea remain unclear. Recently, several abundant DNA-architectural proteins including histones, Alba, and TrmBL2 have been identified in model euryarchaeon Thermococcus kodakarensis. Although histones and Alba proteins have been previously characterized, the DNA binding properties of TrmBL2 and its interplay with the other major architectural proteins in the chromosomal DNA organization and gene transcription regulation remain largely unexplored. Here, we report single-DNA studies showing that at low ionic strength (<300 mM KCl), TrmBL2 binds to DNA largely in non-sequence-specific manner with positive cooperativity, resulting in formation of stiff nucleoprotein filamentous patches, whereas at high ionic strength (>300 mM KCl) TrmBL2 switches to more sequence-specific interaction, suggesting the presence of high affinity TrmBL2-filament nucleation sites. Furthermore, in vitro assays indicate the existence of DNA binding competition between TrmBL2 and archaeal histones B from T. kodakarensis, which can be strongly modulated by DNA supercoiling and ionic strength of surrounding solution. Overall, these results advance our understanding of TrmBL2 DNA binding properties and provide important insights into potential functions of architectural proteins in nucleoid organization and gene regulation in T. kodakarensis.
[Mh] Termos MeSH primário: Proteínas Arqueais/metabolismo
Cromossomos de Archaea/metabolismo
DNA Arqueal/metabolismo
DNA Super-Helicoidal/metabolismo
Histonas/metabolismo
Proteínas Repressoras/metabolismo
Thermococcus/metabolismo
[Mh] Termos MeSH secundário: Proteínas Arqueais/genética
Cromossomos de Archaea/genética
DNA Arqueal/genética
DNA Super-Helicoidal/genética
Histonas/genética
Proteínas Repressoras/genética
Thermococcus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Archaeal Proteins); 0 (DNA, Archaeal); 0 (DNA, Superhelical); 0 (Histones); 0 (Repressor Proteins)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150502
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M114.626705


  5 / 120 MEDLINE  
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[PMID]:25455016
[Au] Autor:Maus I; Wibberg D; Stantscheff R; Stolze Y; Blom J; Eikmeyer FG; Fracowiak J; König H; Pühler A; Schlüter A
[Ad] Endereço:Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
[Ti] Título:Insights into the annotated genome sequence of Methanoculleus bourgensis MS2(T), related to dominant methanogens in biogas-producing plants.
[So] Source:J Biotechnol;201:43-53, 2015 May 10.
[Is] ISSN:1873-4863
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The final step of the biogas production process, the methanogenesis, is frequently dominated by members of the genus Methanoculleus. In particular, the species Methanoculleus bourgensis was identified to play a role in different biogas reactor systems. The genome of the type strain M. bourgensis MS2(T), originally isolated from a sewage sludge digestor, was completely sequenced to analyze putative adaptive genome features conferring competitiveness within biogas reactor environments to the strain. Sequencing and assembly of the M. bourgensis MS2(T) genome yielded a chromosome with a size of 2,789,773 bp. Comparative analysis of M. bourgensis MS2(T) and Methanoculleus marisnigri JR1 revealed significant similarities. The absence of genes for a putative ammonium uptake system may indicate that M. bourgensis MS2(T) is adapted to environments rich in ammonium/ammonia. Specific genes featuring predicted functions in the context of osmolyte production were detected in the genome of M. bourgensis MS2(T). Mapping of metagenome sequences derived from a production-scale biogas plant revealed that M. bourgensis MS2(T) almost completely comprises the genetic information of dominant methanogens present in the biogas reactor analyzed. Hence, availability of the M. bourgensis MS2(T) genome sequence may be valuable regarding further research addressing the performance of Methanoculleus species in agricultural biogas plants.
[Mh] Termos MeSH primário: Biocombustíveis
Genoma Arqueal/genética
Methanomicrobiaceae/genética
[Mh] Termos MeSH secundário: Cromossomos de Archaea/genética
DNA Arqueal/genética
Nitrogênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biofuels); 0 (DNA, Archaeal); N762921K75 (Nitrogen)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150406
[Lr] Data última revisão:
150406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  6 / 120 MEDLINE  
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[PMID]:25343855
[Au] Autor:Alduina R; Pisciotta A
[Ad] Endereço:Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via delle Scienze, Ed. 16, Palermo, 90128, Italy, valeria.alduina@unipa.it.
[Ti] Título:Pulsed field gel electrophoresis and genome size estimates.
[So] Source:Methods Mol Biol;1231:1-14, 2015.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulsed field gel electrophoresis (PFGE) is a quick and reliable procedure to resolve DNA molecules larger than 30 kb by applying an electric field that periodically changes direction. This technique can be used to estimate genome size of a microorganism, to reveal if a genome is circular or linear, to indicate the presence of megaplasmids, and to show if a strain contains only one or more chromosomes.
[Mh] Termos MeSH primário: Archaea/genética
Bactérias/genética
Eletroforese em Gel de Campo Pulsado/métodos
Tamanho do Genoma
Genoma Arqueal
Genoma Bacteriano
[Mh] Termos MeSH secundário: Composição de Bases
Cromossomos de Archaea/química
Cromossomos Bacterianos/química
DNA Arqueal/química
DNA Arqueal/genética
DNA Bacteriano/química
DNA Bacteriano/genética
Eletroforese em Gel de Ágar
Mapeamento Físico do Cromossomo
Plasmídeos/química
Plasmídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Archaeal); 0 (DNA, Bacterial)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141025
[Lr] Data última revisão:
141025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141026
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-1720-4_1


  7 / 120 MEDLINE  
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[PMID]:25732343
[Au] Autor:Samson RY; Bell SD
[Ad] Endereço:Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, Ind., USA.
[Ti] Título:Archaeal chromosome biology.
[So] Source:J Mol Microbiol Biotechnol;24(5-6):420-7, 2014.
[Is] ISSN:1660-2412
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Knowledge of the chromosome biology of archaeal species has grown considerably in the last 15 years, since the publication of the first full archaeal genome sequences. A number of model organisms have been studied, revealing a striking variety of mechanisms and modes of genome duplication and segregation. While clear sequence relationships between archaeal and eukaryotic replication proteins are well known, some archaea also seem to possess organizational parameters for replication and segregation that reveal further striking parallels to eukaryotes.
[Mh] Termos MeSH primário: Archaea/fisiologia
Cromossomos de Archaea/metabolismo
Replicação do DNA
[Mh] Termos MeSH secundário: Archaea/genética
Proteínas Arqueais/metabolismo
Segregação de Cromossomos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Archaeal Proteins)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150304
[St] Status:MEDLINE
[do] DOI:10.1159/000368854


  8 / 120 MEDLINE  
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[PMID]:25732333
[Au] Autor:Graumann PL
[Ad] Endereço:SYNMIKRO, LOEWE Center for Synthetic Microbiology, and Department of Chemistry, Philipps University Marburg, Marburg, Germany.
[Ti] Título:Chromosome architecture and segregation in prokaryotic cells.
[So] Source:J Mol Microbiol Biotechnol;24(5-6):291-300, 2014.
[Is] ISSN:1660-2412
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Mh] Termos MeSH primário: Archaea/genética
Bactérias/genética
Segregação de Cromossomos
Cromossomos de Archaea/metabolismo
Cromossomos Bacterianos/metabolismo
[Mh] Termos MeSH secundário: Archaea/fisiologia
Cromossomos de Archaea/ultraestrutura
Cromossomos Bacterianos/ultraestrutura
Modelos Biológicos
Células Procarióticas/fisiologia
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150303
[Lr] Data última revisão:
150303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150304
[St] Status:MEDLINE
[do] DOI:10.1159/000369100


  9 / 120 MEDLINE  
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[PMID]:25277654
[Au] Autor:He F; Chen L; Peng X
[Ad] Endereço:Archaea Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK2200 Copenhagen N, Denmark.
[Ti] Título:First experimental evidence for the presence of a CRISPR toxin in sulfolobus.
[So] Source:J Mol Biol;426(22):3683-8, 2014 Nov 11.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (cas) genes constitute the adaptive immune system in bacteria and archaea. Although the CRISPR-Cas systems have been hypothesized to encode potential toxins, no experimental data supporting the hypothesis are available in the literature. In this work, we provide the first experimental evidence for the presence of a toxin gene in the type I-A CRISPR system of hyperthermophilic archaeon Sulfolobus. csa5, under the control of its native promoter in a shuttle vector, could not be transformed into CRISPR-deficient mutant Sulfolobus solfataricus Sens1, demonstrating a strong toxicity in the cells. A single-amino-acid mutation destroying the intersubunit bridge of Csa5 attenuated the toxicity, indicative of the importance of Csa5 oligomerization for its toxicity. In line with the absence of Csa5 toxicity in S. solfataricus InF1 containing functional CRISPR systems, the expression of csa5 is repressed in InF1 cells. Induced from the arabinose promoter in Sens1 cells, Csa5 oligomers resistant to 1% SDS co-occur with chromosome degradation and cell death, reinforcing the connection between Csa5 oligomerization and its toxicity. Importantly, a rudivirus was shown to induce Csa5 expression and the formation of SDS-resistant Csa5 oligomers in Sulfolobus cells. This demonstrates that the derepression of csa5 and the subsequent Csa5 oligomerization take place in native virus-host systems. Thus, csa5 is likely to act as a suicide gene under certain circumstances to inhibit virus spreading.
[Mh] Termos MeSH primário: Proteínas Associadas a CRISPR/metabolismo
Sistemas CRISPR-Cas
Sulfolobus solfataricus/metabolismo
[Mh] Termos MeSH secundário: Apoptose
Western Blotting
Proteínas Associadas a CRISPR/genética
Cromossomos de Archaea/metabolismo
DNA Arqueal/metabolismo
Técnicas de Inativação de Genes
Mutação/genética
Regiões Promotoras Genéticas/genética
Rudiviridae/patogenicidade
Sulfolobus solfataricus/crescimento & desenvolvimento
Sulfolobus solfataricus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CRISPR-Associated Proteins); 0 (DNA, Archaeal)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141004
[St] Status:MEDLINE


  10 / 120 MEDLINE  
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[PMID]:24733558
[Au] Autor:Zerulla K; Chimileski S; Näther D; Gophna U; Papke RT; Soppa J
[Ad] Endereço:Institute for Molecular Biosciences, Biocentre, Goethe-University, Frankfurt, Germany.
[Ti] Título:DNA as a phosphate storage polymer and the alternative advantages of polyploidy for growth or survival.
[So] Source:PLoS One;9(4):e94819, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Haloferax volcanii uses extracellular DNA as a source for carbon, nitrogen, and phosphorous. However, it can also grow to a limited extend in the absence of added phosphorous, indicating that it contains an intracellular phosphate storage molecule. As Hfx. volcanii is polyploid, it was investigated whether DNA might be used as storage polymer, in addition to its role as genetic material. It could be verified that during phosphate starvation cells multiply by distributing as well as by degrading their chromosomes. In contrast, the number of ribosomes stayed constant, revealing that ribosomes are distributed to descendant cells, but not degraded. These results suggest that the phosphate of phosphate-containing biomolecules (other than DNA and RNA) originates from that stored in DNA, not in rRNA. Adding phosphate to chromosome depleted cells rapidly restores polyploidy. Quantification of desiccation survival of cells with different ploidy levels showed that under phosphate starvation Hfx. volcanii diminishes genetic advantages of polyploidy in favor of cell multiplication. The consequences of the usage of genomic DNA as phosphate storage polymer are discussed as well as the hypothesis that DNA might have initially evolved in evolution as a storage polymer, and the various genetic benefits evolved later.
[Mh] Termos MeSH primário: Biopolímeros/metabolismo
DNA Arqueal/metabolismo
Haloferax volcanii/crescimento & desenvolvimento
Haloferax volcanii/metabolismo
Viabilidade Microbiana
Fosfatos/metabolismo
Poliploidia
[Mh] Termos MeSH secundário: Cromossomos de Archaea/genética
Dessecação
Genoma Arqueal/genética
Haloferax volcanii/efeitos dos fármacos
Haloferax volcanii/genética
Espaço Intracelular/metabolismo
Viabilidade Microbiana/efeitos dos fármacos
Peso Molecular
Nitrogênio/metabolismo
Fosfatos/farmacologia
Fósforo/metabolismo
RNA Ribossômico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Biopolymers); 0 (DNA, Archaeal); 0 (Phosphates); 0 (RNA, Ribosomal); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:150806
[Lr] Data última revisão:
150806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140416
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0094819



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