|
[PMID]: | 22287734 |
[Au] Autor: | Lin CY; Ho CM; Bau DT; Yang SF; Liu SH; Lin PH; Lin TH; Tien N; Shih MC; Lu JJ |
[Ad] Endereço: | Department of Laboratory Medicine, Linkou Chang-Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan 333, Taiwan, ROC. |
[Ti] Título: | Evaluation of breast cancer susceptibility loci on 2q35, 3p24, 17q23 and FGFR2 genes in Taiwanese women with breast cancer. |
[So] Source: | Anticancer Res;32(2):475-82, 2012 Feb. | [Is] ISSN: | 1791-7530 |
[Cp] País de publicação: | Greece |
[La] Idioma: | eng |
[Ab] Resumo: | AIM: Breast cancer is the most common cancer in women. In recent years, mounting evidence has identified the possibility that 2q35, 3p24, 17q23 and fibroblast growth factor receptor 2 (FGFR2) may be genetic susceptibility loci for breast cancer. This study aimed to evaluate the association of four polymorphic genotypes in these loci with breast cancer in Taiwanese women. PATIENTS AND METHODS: Eighty-eight patients with breast cancer and 70 controls without breast cancer were selected. Polymorphic variants of 2q35-rs13387042, 3p24-rs4973768, 17q23-rs650490 and FGFR2-rs2981578 were analyzed to test for their association with breast cancer susceptibility. The 2q35, 17q23 and FGFR2 polymorphisms were detected using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and the 3p24 polymorphism was detected using an amplification-created restriction site method. RESULTS: The distribution of genotypes of 2q35 were significantly different between the breast cancer group and the control group (p=0.035), while the distributions for 3p24, 17q23, and FGFR2 did not produce statistically significant differences (p>0.05). In addition, allele A of 2q35 conferred a higher risk for breast cancer risk than allele G (odds ratio, OR=2.95, 95% confidence interval, CI=1.29-6.71, p=0.008). Furthermore, the genotypic distribution of 2q35 was not significantly different among patients with different tumor stages, or from different specimen type. CONCLUSION: The 2q35 allele A may be a potential biomarker for breast cancer risk, but further confirmation is required to determine its role in breast carcinogenesis. Blood samples can be used for determining the genotypes for 2q35-rs13387042 in patients for risk of breast cancer. |
[Mh] Termos MeSH primário: |
Neoplasias da Mama/genética Cromossomos Humanos 1-3 Cromossomos Humanos Par 17 Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/genética
|
[Mh] Termos MeSH secundário: |
Adulto Idoso Idoso de 80 Anos ou mais Alelos Neoplasias da Mama/enzimologia Neoplasias da Mama/patologia Estudos de Casos e Controles Cromossomos Humanos Par 2 Cromossomos Humanos Par 3 Feminino Predisposição Genética para Doença Seres Humanos Meia-Idade Estadiamento de Neoplasias Reação em Cadeia da Polimerase Polimorfismo de Fragmento de Restrição Polimorfismo de Nucleotídeo Único Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/metabolismo Taiwan
|
[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| EC 2.7.10.1 (FGFR2 protein, human); EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 2) |
[Em] Mês de entrada: | 1203 |
[Cu] Atualização por classe: | 120605 |
[Lr] Data última revisão:
| 120605 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 120131 |
[St] Status: | MEDLINE |
|
|
|