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Pesquisa : A11.329.372.300 [Categoria DeCS]
Referências encontradas : 830 [refinar]
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[PMID]:28719466
[Au] Autor:Makise N; Yoshida A; Komiyama M; Nakatani F; Yonemori K; Kawai A; Fukayama M; Hiraoka N
[Ad] Endereço:Departments of *Pathology and Clinical Laboratories §Urology ∥Musculoskeletal Oncology ¶Medical Oncology, National Cancer Center Hospital ‡Rare Cancer Center, National Cancer Center Hospital †Department of Pathology, the University of Tokyo, Tokyo, Japan.
[Ti] Título:Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features.
[So] Source:Am J Surg Pathol;41(11):1523-1531, 2017 Nov.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dedifferentiated liposarcoma (DDLPS) demonstrates a variety of growth patterns, and their histologic resemblance to other spindle cell mesenchymal tumors has been widely recognized. However, epithelioid morphology in DDLPS has only rarely been documented. Here, we report 6 cases of DDLPS with striking epithelioid/epithelial features. The patients were 5 men and 1 woman with a median age of 61 years. All tumors were located in the internal trunk. During follow-up of 1 to 41 months, local recurrence, distant metastases, and tumor-related death occurred in 4, 2, and 4 patients, respectively. Beside well-differentiated liposarcoma component and conventional high-grade spindle cell morphology, all tumors focally exhibited growth comprising small or large epithelioid cells in diffuse or sheet-like proliferation. Rhabdoid cells were present in 2 cases. All 5 tumors tested harbored MDM2 amplification. Cytokeratin and/or epithelial membrane antigen were at least focally positive in all 5 tumors tested. One case contained a small focus of novel heterologous epithelial differentiation with acinar structures, wherein cytokeratin, MOC31, and claudin-4 were diffusely expressed and H3K27me3 expression was lost. DDLPS with epithelioid/epithelial features may lead to misdiagnosis of carcinoma or mesothelioma, and their diagnosis should be based on correlation with clinicopathologic and molecular findings. The epithelioid morphology in DDLPS may suggest an aggressive behavior based on this small series. In addition, we document 2 cases of MDM2-amplified undifferentiated neoplasm with epithelioid features in the internal trunk that lacked association with well-differentiated liposarcoma histology and showed rapid clinical course. Whether these latter tumors belong to DDLPS with epithelioid features requires further study.
[Mh] Termos MeSH primário: Desdiferenciação Celular
Células Epiteliais/patologia
Células Epitelioides/patologia
Lipossarcoma/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Claudina-4/análise
Diagnóstico Diferencial
Progressão da Doença
Células Epiteliais/química
Células Epitelioides/química
Feminino
Amplificação de Genes
Histonas/análise
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Queratinas/análise
Lipossarcoma/mortalidade
Lipossarcoma/secundário
Lipossarcoma/terapia
Masculino
Metilação
Meia-Idade
Mucina-1/análise
Recidiva Local de Neoplasia
Valor Preditivo dos Testes
Proteínas Proto-Oncogênicas c-mdm2/genética
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CLDN4 protein, human); 0 (Claudin-4); 0 (Histones); 0 (MUC1 protein, human); 0 (Mucin-1); 68238-35-7 (Keratins); EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000910


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[PMID]:28712777
[Au] Autor:Hartman DJ; Borczuk A; Dacic S; Krasinskas A
[Ad] Endereço:Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213. Electronic address: hartmandj@upmc.edu.
[Ti] Título:Reproducibility for histologic parameters in peritoneal mesothelioma.
[So] Source:Hum Pathol;67:54-59, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histologic subtype is recognized as a prognostic factor in malignant pleural mesothelioma. Specifically, epithelial morphology is associated with a better prognosis than other subtypes, and the same association is observed in peritoneal malignant mesothelioma. Recently, prognostic differences based on morphologic subtypes of epithelial peritoneal malignant mesothelioma were reported. Herein, we report the interobserver variability across four pathologists at three institutions. The authors independently reviewed 67 cases of malignant peritoneal epithelioid mesotheliomas and subclassified them according to their epithelial subtype: papillary, tubulopapillary, trabecular, micropapillary, solid and/or pleomorphic. The cases were also evaluated by each author for several other histopathologic parameters including depth of invasion, nuclear grade, lymphocytic host response, mitotic count/index, presence of lymphovascular invasion, and stromal desmoplasia. The interobserver agreement for histopathologic parameters was highest for mitotic rate (κ=0.36) and primary epithelial subtype (κ=0.32). The interobserver variability for solid subtype pattern was moderate (κ=0.49). We found that the interobserver variability for most histopathologic parameters is poor.
[Mh] Termos MeSH primário: Células Epiteliais/patologia
Células Epitelioides/patologia
Mesotelioma/patologia
Neoplasias Peritoneais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biópsia
Células Epiteliais/química
Células Epitelioides/química
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Mesotelioma/química
Mesotelioma/classificação
Meia-Idade
Índice Mitótico
Gradação de Tumores
Invasividade Neoplásica
Variações Dependentes do Observador
Neoplasias Peritoneais/química
Neoplasias Peritoneais/classificação
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE


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[PMID]:28325364
[Au] Autor:Abdelkader A; Lam CA; Shahir KS; Christians K; Suster SM
[Ad] Endereço:Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
[Ti] Título:Retroperitoneal lymphangioleiomyoma with lymph node involvement: A pathologic-radiologic correlation of a rare form of myomelanocytic tumor.
[So] Source:Ann Diagn Pathol;27:69-73, 2017 Apr.
[Is] ISSN:1532-8198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphangioleiomyomatosis (LAM) is a rare and slowly progressive disorder that usually arises in the lung, affects exclusively women in their childbearing years, and typically presents with progressive dyspnea on exertion and pneumothorax. Infrequently, extra-pulmonary LAM can occur in the retroperitoneum, uterine wall, mediastinum and intraperitoneal lymph nodes. Histologically, LAM is characterized by a proliferation of perivascular epithelioid cells (PEC) that express markers for both melanocytes and smooth muscle cells. We report a case of a peripancreatic retroperitoneal mass that was incidentally discovered on magnetic resonance image (MRI) scan of a 38-year-old female. The morphologic findings and the immunohistochemical staining were consistent with a lymphangioleiomyoma. The radiologic and pathologic correlation along with differential diagnosis of this rare entity is discussed.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Células Epitelioides/patologia
Neoplasias Pulmonares/patologia
Linfonodos/patologia
Linfangioleiomiomatose/patologia
Linfangiomioma/patologia
Neoplasias Retroperitoneais/patologia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
Imuno-Histoquímica/métodos
Neoplasias Pulmonares/diagnóstico por imagem
Linfangioleiomiomatose/diagnóstico por imagem
Linfangiomioma/diagnóstico por imagem
Neoplasias Retroperitoneais/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28121626
[Au] Autor:Hsieh CH; Hsiung SC; Yeh CT; Yen CF; Chou YW; Lei WY; Pang ST; Chuang CK; Liao SK
[Ad] Endereço:Division of Uro-oncology, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
[Ti] Título:Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells.
[So] Source:Oncotarget;8(9):15593-15609, 2017 Feb 28.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epithelioid and fibroblastoid subsets coexist in the human sarcomatoid renal cell carcinoma (sRCC) cell line, RCC52, according to previous clonal studies. Herein, using monoclonal antibodies to CD44 and CD24 markers, we identified and isolated these two populations, and showed that CD44bright/CD24dim and CD44bright/CD24bright phenotypes correspond to epithelioid and fibroblastoid subsets, respectively. Both sorted subsets displayed different levels of tumorigenicity in xenotransplantation, indicating that each harbored its own cancer stem cells (CSCs). The CD44bright/CD24bright subset, associated with higher expression of MMP-7, -8 and TIMP-1 transcripts, showed greater migratory/invasive potential than the CD44bright/CD24dim subset, which was associated with higher expression of MMP-2, -9 and TIMP-2 transcripts. Both subsets differentially expressed stemness gene products c-Myc, Oct4A, Notch1, Notch2 and Notch3, and the RCC stem cell marker, CD105 in 4-5% of RCC52 cells. These results suggest the presence of CSCs in both sRCC subsets for the first time and should therefore be considered potential therapeutic targets for this aggressive malignancy.
[Mh] Termos MeSH primário: Antígeno CD24/metabolismo
Fibroblastos Associados a Câncer/metabolismo
Carcinoma de Células Renais/metabolismo
Células Epitelioides/metabolismo
Receptores de Hialuronatos/metabolismo
Neoplasias Renais/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores Tumorais/metabolismo
Fibroblastos Associados a Câncer/patologia
Carcinoma de Células Renais/genética
Carcinoma de Células Renais/patologia
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Células Epitelioides/patologia
Feminino
Citometria de Fluxo
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Imuno-Histoquímica
Neoplasias Renais/genética
Neoplasias Renais/patologia
Metaloproteinases da Matriz/genética
Camundongos Endogâmicos NOD
Camundongos SCID
Células-Tronco Neoplásicas/metabolismo
Células-Tronco Neoplásicas/patologia
Receptores Notch/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Inibidores Teciduais de Metaloproteinases/genética
Fator de Crescimento Transformador beta1/secreção
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CD24 Antigen); 0 (CD44 protein, human); 0 (Hyaluronan Receptors); 0 (Receptors, Notch); 0 (Tissue Inhibitor of Metalloproteinases); 0 (Transforming Growth Factor beta1); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14777


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[PMID]:28103910
[Au] Autor:Yamada S; Kirishima M; Hiraki T; Higashi M; Hatanaka K; Tanimoto A
[Ad] Endereço:Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. sohsuke@m.kufm.kagoshima-u.ac.jp.
[Ti] Título:Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review.
[So] Source:Diagn Pathol;12(1):11, 2017 Jan 19.
[Is] ISSN:1746-1596
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma. CASE PRESENTATION: A 65-year-old female presented with a history of a flat and slightly elevated firm and tan plaque accompanied by occasional tenderness, measuring 10 × 8 mm, in the right joint of her hand 1 year before resection. A gross examination of a locally resected specimen revealed an encapsulated nodular lesion, yellow-whitish in color, partly filled with blood. A microscopic examination showed that the tumor predominantly consisted of a solid proliferation of epithelioid cells having mildly enlarged and round to partially spindled nuclei and abundant vacuolated or clear cytoplasm with very few mitotic figures and modest nuclear size variation, associated with focal hyalinized, cystic and hemorrhagic degeneration. This well-demarcated tumor was surrounded by dense, hyalinized and layered fibrocollagenous stroma. Immunohistochemically, these tumor cells were diffusely positive for S-100 protein and had a very low MIB-1 labeling index, and type IV collagen was strongly reactive with reduplicated basal lamina of them. We ultimately made a diagnosis of cutaneous epithelioid schwannoma. CONCLUSION: We should be aware that, since pathologists might misinterpret epithelioid schwannoma as other soft tissue tumors, including its malignant counterpart, a wide panel of immunohistochemical antibodies can be powerful supplementary tools for identifying a very rare entity of conventional schwannoma.
[Mh] Termos MeSH primário: Células Epitelioides/patologia
Neurilemoma/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Feminino
Seres Humanos
Imuno-Histoquímica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1186/s13000-017-0604-9


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[PMID]:27986325
[Au] Autor:Yu Q; Li M
[Ad] Endereço:Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
[Ti] Título:Effects of transient receptor potential canonical 1 (TRPC1) on the mechanical stretch-induced expression of airway remodeling-associated factors in human bronchial epithelioid cells.
[So] Source:J Biomech;51:89-96, 2017 Jan 25.
[Is] ISSN:1873-2380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research has shown that mechanical stress stimulation can cause airway remodeling. We investigate the effects of mechanical stretch on the expression of the airway remodeling-associated factors interleukin-13 (IL-13) and matrix metalloprotein-9 (MMP-9) and signaling pathways in human bronchial epithelioid (16HBE) cells under mechanical stretch. A Flexcell FX-4000 Tension System with a flexible substrate was applied to stretch 16HBE cells at a 15% elongation amplitude and 1Hz frequency, with stretching for 0.5h, 1h, 1.5h and 2h. The experimental group with higher IL-13, MMP-9, and TRPC1 expression and higher Ca levels was selected for performing intervention experiment. These cells were pretreated with the transient receptor potential canonical 1 (TRPC1) channel antagonist SKF96365 and TRPC1-specific siRNA, and then mechanical stretch was applied. Our results provided evidences that mechanical pressure significantly increased IL-13, MMP-9, and TRPC1 protein and mRNA expression levels and intracellular Ca fluorescence intensity at 4 time points compared with the control group. The peak IL-13, MMP-9, and TRPC1 expression levels were observed at 0.5h after exposure to mechanical pressure. IL-13 and MMP-9 expression levels and Ca fluorescence intensity in the stretch+SKF96365 group and in the stretch+TRPC1 siRNA group were significantly lower than those were in the mechanical stretch group. By incubating the cells with the intracellular calcium chelator BAPTA-AM, the expression of IL-13 and MMP9 was significantly decreased, and the expression level of TRPC1 remained unchanged. These observations suggest that mechanical stretch may induce an influx of Ca and up-regulation of IL-13 and MMP-9 expression in 16HBE cells via activation of TRPC1.
[Mh] Termos MeSH primário: Células Epitelioides/metabolismo
Interleucina-13/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Canais de Cátion TRPC/metabolismo
[Mh] Termos MeSH secundário: Remodelação das Vias Aéreas/fisiologia
Brônquios/citologia
Cálcio/metabolismo
Linhagem Celular
Quelantes/farmacologia
Ácido Egtázico/análogos & derivados
Ácido Egtázico/farmacologia
Células Epitelioides/efeitos dos fármacos
Seres Humanos
Imidazóis/farmacologia
Interleucina-13/genética
Metaloproteinase 9 da Matriz/genética
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/genética
Transdução de Sinais
Estresse Mecânico
Canais de Cátion TRPC/antagonistas & inibidores
Canais de Cátion TRPC/genética
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Imidazoles); 0 (Interleukin-13); 0 (RNA, Messenger); 0 (RNA, Small Interfering); 0 (TRPC Cation Channels); 0 (transient receptor potential cation channel, subfamily C, member 1); 139890-68-9 (1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester); 526U7A2651 (Egtazic Acid); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); I61V87164A (1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


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[PMID]:27769872
[Au] Autor:Alikhan MB; Pease G; Watkin W; Grogan R; Krausz T; Antic T
[Ad] Endereço:Department of Pathology, University of Chicago Medicine, Chicago, IL, USA. Electronic address: Mir.Alikhan@uchospitals.edu.
[Ti] Título:Primary epithelioid sarcoma of the kidney and adrenal gland: report of 2 cases with immunohistochemical and molecular cytogenetic studies.
[So] Source:Hum Pathol;61:158-163, 2017 Mar.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epithelioid sarcoma (ES) is a malignant mesenchymal neoplasm with some morphologic or immunophenotypic evidence of epithelial differentiation. The "classic" subtype occurs in younger patients, often in distal extremities as compared with the "proximal" type. Tumors of the proximal type primarily arising in solid organs are rare with only few case reports in the literature. We report 2 cases of primary ES in the kidney of a 27-year-old woman and the adrenal gland of a 73-year-old man. Clinical examination and imaging, including computed tomography and positron-emission tomography, did not reveal tumor elsewhere in both cases. Histologic features were those of ES, proximal type with epithelioid/rhabdoid phenotype. Immunohistochemical study in both cases showed strong, diffuse expression of epithelial markers, CD34, and CD31. Nuclear expression of SMARCB1 protein was lost, but fluorescence in situ hybridization analysis was negative for SMARCB1 deletion. We believe that these are the first reports of primary kidney and adrenal gland ES.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/diagnóstico
Biomarcadores Tumorais
Células Epitelioides
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Neoplasias Renais/diagnóstico
Sarcoma/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/química
Neoplasias das Glândulas Suprarrenais/genética
Neoplasias das Glândulas Suprarrenais/patologia
Neoplasias das Glândulas Suprarrenais/terapia
Adulto
Idoso
Antígenos CD34/análise
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Células Epitelioides/química
Células Epitelioides/patologia
Evolução Fatal
Feminino
Deleção de Genes
Seres Humanos
Neoplasias Renais/química
Neoplasias Renais/genética
Neoplasias Renais/patologia
Neoplasias Renais/terapia
Masculino
Molécula-1 de Adesão Celular Endotelial de Plaquetas/análise
Valor Preditivo dos Testes
Proteína SMARCB1/análise
Proteína SMARCB1/genética
Sarcoma/química
Sarcoma/genética
Sarcoma/patologia
Sarcoma/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (Biomarkers, Tumor); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (SMARCB1 Protein); 0 (SMARCB1 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:27765170
[Au] Autor:Vigneswaran WT; Kircheva DY; Ananthanarayanan V; Watson S; Arif Q; Celauro AD; Kindler HL; Husain AN
[Ad] Endereço:Section of Cardiac and Thoracic Surgery, Department of Surgery, University of Chicago Medicine, Chicago, Illinois. Electronic address: wickii.vigneswaran@lumc.edu.
[Ti] Título:Amount of Epithelioid Differentiation Is a Predictor of Survival in Malignant Pleural Mesothelioma.
[So] Source:Ann Thorac Surg;103(3):962-966, 2017 Mar.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Macroscopic complete surgical resection with adjuvant chemotherapy can provide a survival advantage in patients with malignant pleural mesothelioma (MPM). Patients with nonepithelioid histology are largely excluded from such radical operations even though they might benefit. The degree of epithelioid differentiation varies in biphasic histology. We report the outcomes of pleurectomy and decortication and the effect of epithelioid differentiation on overall survival of patients with MPM. METHODS: This report is based on the outcomes of 144 patients who underwent pleurectomy and decortication at a single institution between 2008 and 2015. The variables assessed were age, gender, histology, and pathologic T and N stage. No patients with pure sarcomatoid histology were included. Two independent pathologists estimated the percentage of epithelioid histology. A Cox regression model was used to identify significant predictors of survival. The Kaplan-Meier method was used to summarize overall and subgroup survival. RESULTS: Included were 116 men and 28 women with a median age of 69 years (range, 43 to 88 years). The 2-year survival from pleurectomy and decortication was 20%. Median survival overall was 13.34 months and was 20.1 months for the 100% epithelioid subgroup (n = 77), 11.8 months for the 51% to 99% epithelioid subgroup (n = 39), and 6.62 months for the less than 50% epithelioid subgroup (n = 28). The amount of epithelioid differentiation was a significant predictor of survival (p < 0.001). Differences in survival based on the T, but N stage, were not statistically significant. CONCLUSIONS: The percentage of epithelioid differentiation is an independent predictor of survival in MPM and should be taken into careful consideration when recommending surgical treatment for patients with biphasic MPM.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/patologia
Mesotelioma/mortalidade
Mesotelioma/patologia
Neoplasias Pleurais/mortalidade
Neoplasias Pleurais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Células Epitelioides/patologia
Feminino
Seres Humanos
Neoplasias Pulmonares/cirurgia
Masculino
Mesotelioma/cirurgia
Meia-Idade
Neoplasias Pleurais/cirurgia
Pneumonectomia
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Taxa de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27304998
[Au] Autor:Chokoeva AA; Maximov GK; Wollina U; Patterson JW; Tchernev G
[Ad] Endereço:Department of Dermatology, "Onkoderma" - Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
[Ti] Título:Solitary Cutaneous Epithelioid Angiomatous Nodule Associated with Unilateral Capillary Malformation.
[So] Source:Acta Derm Venereol;97(1):135-136, 2017 01 04.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Mh] Termos MeSH primário: Capilares/patologia
Células Epitelioides/patologia
Hemangioendotelioma Epitelioide/patologia
Neoplasias Cutâneas/patologia
Malformações Vasculares/patologia
[Mh] Termos MeSH secundário: Adulto
Hemangioendotelioma Epitelioide/cirurgia
Seres Humanos
Masculino
Neoplasias Cutâneas/cirurgia
Malformações Vasculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-2487


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[PMID]:28174805
[Au] Autor:Stanculescu RV; Bausic V; Vladescu TC; Vasilescu F; Bratila E
[Ad] Endereço:Department of Obstetrics and Gynecology, Department of Histology, "Carol Davila" University of Medicine and Pharmacy, "St. Pantelimon" Emergency Clinical Hospital, Bucharest, Romania; ruxandra_v_stanculescu@yahoo.com, valibausic@gmail.com.
[Ti] Título:Epithelioid trophoblastic tumor: a case report and literature review.
[So] Source:Rom J Morphol Embryol;57(4):1365-1370, 2016.
[Is] ISSN:1220-0522
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:Epithelioid trophoblastic tumor (ETT) is a very rare case of malignant trophoblastic tumor, which can occur particularly during the fertile age of women with a long history of abortion and delivery. ETT originates from the intermediate trophoblastic cells of chorion laeve. The main features of this tumor include lack of vessels within the tumor, nuclear hyperchromasia and pleomorphism and a large zone of necrosis and hyalinization. The clinical features of ETT are specific to each case and often consist of vaginal bleeding or amenorrhea in the absence of other complains. The beta-human chorionic gonadotropin (ß-hCG) serum level cannot be an absolute criterion useful in defining diagnosis. The right diagnosis can only be established by a histopathological examination of the tissue picked-up via intrauterine curettage. This paper describes the case of a 35-year-old woman who required gynecological investigation for amenorrhea. The diagnosis established by biopsic curettage and the clinical evolution have influenced the physician's decision to perform hysterectomy. The only method to differentiate between the microscopic diagnosis of ETT and choriocarcinoma was the immunohistochemical staining of trophoblastic cells for cytokeratin AE1÷AE3, p63, Ki67. Despite the diagnosis of malignity, this tumor does not usually require a recommendation for chemotherapy and does not seem to have a bad prognostic. However, these data do not rule out that clinical behavior is sometimes difficult to predict. We analyzed the clinical and histology criteria in line with the data published in literature.
[Mh] Termos MeSH primário: Células Epitelioides/patologia
Neoplasias Trofoblásticas
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Neoplasias Trofoblásticas/patologia
Neoplasias Trofoblásticas/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE



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