Base de dados : MEDLINE
Pesquisa : A11.436.265.531 [Categoria DeCS]
Referências encontradas : 885 [refinar]
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  1 / 885 MEDLINE  
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[PMID]:28381426
[Au] Autor:Semenova I; Gupta D; Usui T; Hayakawa I; Cowan A; Rodionov V
[Ad] Endereço:R. D. Berlin Center for Cell Analysis and Modeling and Department of Cell Biology, UConn Health, Farmington, CT 06030.
[Ti] Título:Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules.
[So] Source:Mol Biol Cell;28(11):1418-1425, 2017 Jun 01.
[Is] ISSN:1939-4586
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microtubule (MT)-based transport can be regulated through changes in organization of MT transport tracks, but the mechanisms that regulate these changes are poorly understood. In melanophores, aggregation of pigment granules in the cell center involves their capture by the tips of MTs growing toward the cell periphery, and granule aggregation signals facilitate capture by increasing the number of growing MT tips. This increase could be explained by stimulation of MT nucleation either on the centrosome or on the aggregate of pigment granules that gradually forms in the cell center. We blocked movement of pigment granules to the cell center and compared the MT-nucleation activity of the centrosome in the same cells in two signaling states. We found that granule aggregation signals did not stimulate MT nucleation on the centrosome but did increase MT nucleation activity of pigment granules. Elevation of MT-nucleation activity correlated with the recruitment to pigment granules of a major component of MT-nucleation templates, γ-tubulin, and was suppressed by γ-tubulin inhibitors. We conclude that generation of new MT transport tracks by concentration of the leading pigment granules provides a positive feedback loop that enhances delivery of trailing granules to the cell center.
[Mh] Termos MeSH primário: Melanóforos/metabolismo
Microtúbulos/metabolismo
[Mh] Termos MeSH secundário: Animais
Transporte Biológico
Técnicas de Cultura de Células
Centrossomo/metabolismo
Grânulos Citoplasmáticos/metabolismo
Vesículas Citoplasmáticas/metabolismo
Dineínas/metabolismo
Modelos Biológicos
Movimento/fisiologia
Transdução de Sinais/fisiologia
Tubulina (Proteína)/metabolismo
Xenopus/metabolismo
Xenopus laevis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tubulin); EC 3.6.4.2 (Dyneins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1091/mbc.E16-08-0571


  2 / 885 MEDLINE  
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[PMID]:28209639
[Au] Autor:Eom DS; Parichy DM
[Ad] Endereço:Department of Biology, University of Washington, Seattle, WA 98195, USA.
[Ti] Título:A macrophage relay for long-distance signaling during postembryonic tissue remodeling.
[So] Source:Science;355(6331):1317-1320, 2017 03 24.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Macrophages have diverse functions in immunity as well as in development and homeostasis. We identified a function for these cells in long-distance communication during postembryonic tissue remodeling. Ablation of macrophages in zebrafish prevented melanophores from coalescing into adult pigment stripes. Melanophore organization depends on signals provided by cells of the yellow xanthophore lineage via airinemes, long filamentous projections with vesicles at their tips. We show that airineme extension from originating cells, as well as vesicle deposition on target cells, depend on interactions with macrophages. These findings identify a role for macrophages in relaying long-range signals between nonimmune cells. This signaling modality may function in the remodeling and homeostasis of other tissues during normal development and disease.
[Mh] Termos MeSH primário: Padronização Corporal
Comunicação Celular
Macrófagos/fisiologia
Melanóforos/fisiologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Embrião não Mamífero/citologia
Transdução de Sinais
Pigmentação da Pele
Peixe-Zebra/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1126/science.aal2745


  3 / 885 MEDLINE  
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[PMID]:27882652
[Au] Autor:Kuriyama T; Hasegawa M
[Ad] Endereço:Institute of Natural and Environmental Sciences, University of Hyogo, Sawano 940, Aogaki-cho, Tanba-shi, Hyogo, 669-3842, Japan.
[Ti] Título:Embryonic developmental process governing the conspicuousness of body stripes and blue tail coloration in the lizard Plestiodon latiscutatus.
[So] Source:Evol Dev;19(1):29-39, 2017 Jan.
[Is] ISSN:1525-142X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The combination of body stripes and vivid blue tail color has independently evolved in different lizard families. To understand how and when lizards developed this coloration, we microscopically compared the embryonic development of pigment cells in two island populations of Plestiodon latiscutatus that exhibit either striped and blue tailed or inconspicuously striped and blue tailed juveniles, based on the newly determined 12 normal developmental stages of embryos from shortly after egg laying to just before hatching. We focus on the role of the melanophores in the body stripe and the role of iridophore morphotypes in the extent of blue tail coloration. The melanophore density in the black background region was higher in lizards with vivid stripes than in lizards with drab stripes. Iridophores started to fill the dermal space that was not yet occupied by melanophores, which resulted in a higher iridophore density in stripes than in the inter-stripe regions. We also discovered that iridophores with thin platelets reflecting blue structural coloration appeared at a specific region in the tail at stage 11. The position of the tail where iridophores emerged coincided with the boundary area separating anterior brown and green colored tail from posterior blue colored tail after hatching.
[Mh] Termos MeSH primário: Lagartos/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Embrião não Mamífero/metabolismo
Feminino
Lagartos/embriologia
Lagartos/genética
Melanóforos/metabolismo
Pigmentação
Cauda/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1111/ede.12214


  4 / 885 MEDLINE  
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[PMID]:26858001
[Au] Autor:Guangming G; Tao Z; Chao L; Moyan Z
[Ad] Endereço:Department of Genetics and Developmental Biology, Southeast University Medical School, Nanjing, 210009, Jiangsu, China. ganguangm@seu.edu.cn.
[Ti] Título:Different morphologic formation patterns of dark patches in the black-spotted frog (Pelophylax nigromaculata) and the Asiatic toad (Bufo gargarizans).
[So] Source:Anat Sci Int;92(1):130-141, 2017 Jan.
[Is] ISSN:1447-073X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The black-spotted frog (Pelophylax nigromaculata) and Asiatic toad (Bufo gargarizans), two relatively distantly related species, live in different habitats with different adaptive dark patches. To explain the formation of dark patches, the distribution patterns of melanin granules were examined with light microscopy and transmission electron microscopy. Melanin granules were produced and gathered into the "cap" structures on top of the nuclei in most epidermal cells. The "cap" structures may play a role in forming the dorsal dark patches coupled with three-layer melanophores, which can give rise to three layers of interconnected melanin networks in the dorsal dermis in P. nigromaculata. Epidermal melanocytes are rare and do not have a definitive role in forming dorsal dark patches in either P. nigromaculata or B. gargarizans. In B. gargarizans, the dermal melanophores only give rise to a single-layered melanin network, which hardly results in dark patches in the dorsal skin. However, the dermal melanophores migrate twice and form into pseudostratified networks, leading to dark patch formation in the ventral skin in B. gargarizans. The melanin granules precisely coregulate dark patches in the dermis and/or epidermis in P. nigromaculata and B. gargarizans. The dark patch formation depends on melanin granules in the epidermis or/and dermis in P. nigromaculata and B. gargarizans.
[Mh] Termos MeSH primário: Anuros/anatomia & histologia
Epiderme/metabolismo
Melaninas/metabolismo
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/metabolismo
Derme/citologia
Derme/metabolismo
Epiderme/citologia
Melaninas/biossíntese
Melaninas/química
Melanóforos/metabolismo
Melanóforos/ultraestrutura
Microscopia
Microscopia Eletrônica de Transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Melanins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE


  5 / 885 MEDLINE  
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[PMID]:27832141
[Au] Autor:Guillot R; Muriach B; Rocha A; Rotllant J; Kelsh RN; Cerdá-Reverter JM
[Ad] Endereço:Department of Fish Physiology and Biotechnology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Científicas, (IATS-CSIC), Ribera de Cabanes, Castellón, Spain, 12595.
[Ti] Título:Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner.
[So] Source:PLoS One;11(11):e0166152, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zebrafish embryos are treated with anti-thyroidal compounds, such as phenylthiourea, to inhibit melanogenesis. However, the mechanism whereby the thyroidal system controls melanin synthesis has not been assessed in detail. In this work, we tested the effect of the administration of diets supplemented with T3 (500µg/g food) on the pigment pattern of adult zebrafish. Oral T3 induced a pronounced skin paling in both adult female and male zebrafish that was reversible upon cessation of treatment. The number of visible melanophores was significantly reduced in treated fish. Accordingly, treatment down-regulated expression of tyrosinase-related protein 1 in both sexes. We also found sexually dimorphic regulation of some melanogenic genes, such as Dct/Tyrp2 that was dramatically up-regulated in females after T3 treatment. Thus, we demonstrated that melanogenesis is reversibly inhibited by thyroid hormones in adult zebrafish and make the discovery of gender-specific differences in the response of melanogenic gene expression. Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis.
[Mh] Termos MeSH primário: Melaninas/metabolismo
Melanóforos/efeitos dos fármacos
Tri-Iodotironina/farmacologia
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Feminino
Expressão Gênica/efeitos dos fármacos
Masculino
Melanóforos/metabolismo
Oxirredutases/genética
Pigmentação/efeitos dos fármacos
Pigmentação/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Fatores Sexuais
Tri-Iodotironina/administração & dosagem
Tri-Iodotironina/sangue
Peixe-Zebra/genética
Proteínas de Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Melanins); 0 (Zebrafish Proteins); 06LU7C9H1V (Triiodothyronine); EC 1.- (Oxidoreductases); EC 1.14.18.- (tyrosinase-related protein-1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0166152


  6 / 885 MEDLINE  
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[PMID]:27453500
[Au] Autor:Singh AP; Dinwiddie A; Mahalwar P; Schach U; Linker C; Irion U; Nüsslein-Volhard C
[Ad] Endereço:Max Planck Institute for Developmental Biology, Spemannstraße 35, Tübingen 72076, Germany.
[Ti] Título:Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis.
[So] Source:Dev Cell;38(3):316-30, 2016 Aug 08.
[Is] ISSN:1878-1551
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to diverse cell types in adults via intermediate progenitors. The in vivo cell-fate potential and lineage segregation of these postembryonic progenitors is poorly understood, and it is unknown if and when the progenitors become fate restricted. We investigate the fate restriction in the neural crest-derived stem cells and intermediate progenitors in zebrafish, which give rise to three distinct adult pigment cell types: melanophores, iridophores, and xanthophores. By inducing clones in sox10-expressing cells, we trace and quantitatively compare the pigment cell progenitors at four stages, from embryogenesis to metamorphosis. At all stages, a large fraction of the progenitors are multipotent. These multipotent progenitors have a high proliferation ability, which diminishes with fate restriction. We suggest that multipotency of the nerve-associated progenitors lasting into metamorphosis may have facilitated the evolution of adult-specific traits in vertebrates.
[Mh] Termos MeSH primário: Embrião não Mamífero/citologia
Desenvolvimento Embrionário/fisiologia
Metamorfose Biológica/fisiologia
Células-Tronco Multipotentes/citologia
Pigmentação/fisiologia
Peixe-Zebra/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Diferenciação Celular
Linhagem da Célula
Embrião não Mamífero/fisiologia
Regulação da Expressão Gênica no Desenvolvimento
Melanóforos/citologia
Melanóforos/fisiologia
Células-Tronco Multipotentes/fisiologia
Crista Neural/citologia
Crista Neural/fisiologia
Fenótipo
Peixe-Zebra/genética
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


  7 / 885 MEDLINE  
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[PMID]:27294411
[Au] Autor:Jensen BH
[Ad] Endereço:The College of Saint Rose , Albany, New York.
[Ti] Título:Zebrafish Melanophores: A Model for Teaching Second Messenger Systems.
[So] Source:Zebrafish;13(4):305-9, 2016 Aug.
[Is] ISSN:1557-8542
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A strong literature base supports the notion that active learning improves retention in the science classroom. To that end, a course was designed to allow students to develop their own experiments around a central biological question. The model system used in this particular course is control of melanosome dispersal via second messenger systems in zebrafish (Danio rerio) scales. Students start by applying agonists and antagonists to the cAMP and Ca(2+) second messenger systems, and then can progress to more refined questions with the model system. This project is advantageous because it could be easily adapted to fit the needs of many different courses and ability levels; it is relatively easy to perform; it is enjoyable to teach; and students can be largely given a free reign to decide upon the design of their experiments.
[Mh] Termos MeSH primário: Biologia/educação
Melanóforos/fisiologia
Ciência/educação
Sistemas do Segundo Mensageiro
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE
[do] DOI:10.1089/zeb.2015.1181


  8 / 885 MEDLINE  
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[PMID]:27224945
[Au] Autor:Wang FM
[Ti] Título:Hop to It: Add Blue to Your Blues.
[So] Source:J Pediatr Ophthalmol Strabismus;53(3):138-9, 2016 May 01.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Melanóforos/metabolismo
Células Ganglionares da Retina/metabolismo
Opsinas de Bastonetes/fisiologia
[Mh] Termos MeSH secundário: Animais
Axônios/fisiologia
Seres Humanos
Transtornos do Humor/fisiopatologia
Transtorno Afetivo Sazonal/fisiopatologia
Transtornos do Sono-Vigília/fisiopatologia
Vias Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20160328-02


  9 / 885 MEDLINE  
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[PMID]:27080548
[Au] Autor:Kobayashi Y; Hamamoto A; Takahashi A; Saito Y
[Ad] Endereço:Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan.
[Ti] Título:Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder.
[So] Source:Gen Comp Endocrinol;230-231:103-9, 2016 05 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vertebrates produce α-melanocyte-stimulating hormone (α-MSH), which contains an N-terminal acetyl group, and desacetyl-α-MSH, which does not contain an N-terminal acetyl group. In teleosts and amphibians, α-MSH-related peptides stimulate pigment dispersion via melanocortin receptors 1-5 (MC1R-MC5R), which are members of the G-protein-coupled receptor (GPCR) family. We previously reported an interesting phenomenon associated with physiological color changes in the skin of a flatfish, barfin flounder (bf). Specifically, pigments in xanthophores expressing only the bfMC5R gene were dispersed by both α-MSH and desacetyl-α-MSH, whereas those in melanophores expressing both the bfMC1R and bfMC5R genes were dispersed by desacetyl-α-MSH, but not by α-MSH. In this study, we examined whether heterodimers of bfMC1R and bfMC5R can act as significant inhibitory receptors for the N-terminal acetylation of α-MSH in mammalian Chinese hamster ovary cells. Immunofluorescence analyses showed that bfMC1R and bfMC5R were localized together at the plasma membrane when expressed in the same cells. Indeed, after coexpression of Flag-bfMC1R and HA-bfMC5R, immunoprecipitation with anti-Flag antibodies resulted in the presence of anti-HA immunoreactivity in the precipitate, and vice versa. Importantly, cyclic AMP assays showed that cotransfection of bfMC1R with bfMC5R inhibited the cyclic AMP accumulation induced by α-MSH to a greater extent than that observed after transfection of bfMC1R alone. Of note, this inhibitory response was not caused by desacetyl-α-MSH. Thus, we show a ligand-dependent signaling through functional heterodimerization of MC1R and MC5R in mammalian cells. The ligand-selective receptor complex also provide the first mechanistic implication that may play a role in the control of color change in teleosts.
[Mh] Termos MeSH primário: Linguado/fisiologia
Multimerização Proteica
Receptor Tipo 1 de Melanocortina/metabolismo
Receptores de Melanocortina/metabolismo
Pigmentação da Pele
[Mh] Termos MeSH secundário: Animais
Células CHO
Cricetinae
Cricetulus
AMP Cíclico/metabolismo
Linguado/genética
Linguado/metabolismo
Ligantes
Melanóforos/metabolismo
Ligação Proteica/genética
Multimerização Proteica/genética
Receptor Tipo 1 de Melanocortina/genética
Receptores de Melanocortina/genética
Transdução de Sinais/genética
Pigmentação da Pele/genética
alfa-MSH/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Receptor, Melanocortin, Type 1); 0 (Receptors, Melanocortin); 0 (melanocortin 5 receptor); 581-05-5 (alpha-MSH); E0399OZS9N (Cyclic AMP)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE


  10 / 885 MEDLINE  
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[PMID]:27053658
[Au] Autor:Nord H; Dennhag N; Muck J; von Hofsten J
[Ad] Endereço:Umeå Centre for Molecular Medicine, Umeå University, 90187 Umeå, Sweden.
[Ti] Título:Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos.
[So] Source:Mol Biol Cell;27(11):1853-62, 2016 Jun 01.
[Is] ISSN:1939-4586
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The pigment pattern of many animal species is a result of the arrangement of different types of pigment-producing chromatophores. The zebrafish has three different types of chromatophores: black melanophores, yellow xanthophores, and shimmering iridophores arranged in a characteristic pattern of golden and blue horizontal stripes. In the zebrafish embryo, chromatophores derive from the neural crest cells. Using pax7a and pax7b zebrafish mutants, we identified a previously unknown requirement for Pax7 in xanthophore lineage formation. The absence of Pax7 results in a severe reduction of xanthophore precursor cells and a complete depletion of differentiated xanthophores in embryos as well as in adult zebrafish. In contrast, the melanophore lineage is increased in pax7a/pax7b double-mutant embryos and larvae, whereas juvenile and adult pax7a/pax7b double-mutant zebrafish display a severe decrease in melanophores and a pigment pattern disorganization indicative of a xanthophore- deficient phenotype. In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells.
[Mh] Termos MeSH primário: Fator de Transcrição PAX2/genética
Fator de Transcrição PAX2/metabolismo
Pigmentação/genética
Proteínas de Peixe-Zebra/genética
Proteínas de Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Padronização Corporal/genética
Padronização Corporal/fisiologia
Diferenciação Celular/genética
Cromatóforos
Embrião não Mamífero/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Melanóforos/metabolismo
Crista Neural/metabolismo
Pigmentação/fisiologia
Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PAX2 Transcription Factor); 0 (Pax7 protein, zebrafish); 0 (Zebrafish Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE
[do] DOI:10.1091/mbc.E15-12-0821



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