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[PMID]:29452653
[Au] Autor:Passeron T
[Ad] Endereço:Service de dermatologie, CHU Nice, France; INSERM U1065, équipe 12, C3M, Nice, France. Electronic address: thierry.passeron@unice.fr.
[Ti] Título:[Post-inflammatory hyperpigmentation].
[Ti] Título:L'hyperpigmentation post-inflammatoire..
[So] Source:Ann Dermatol Venereol;143 Suppl 2:S15-S19, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Post-inflammatory hyperpigmentation (PIH) is a hyperpigmentation of the skin occurring after and sometimes during an inflammatory process. Although more frequent in dark skinned individuals, PIH can be observed in any type of skin and at all ages. In most case a strong impact on the quality of life of affected individuals is observed. The pathophysiology of PIH remains largely unknown. The activation of the melanocytes occurs in the first week following the inflammation emphasizing the crucial role of early preventive measures. Photoprotection with balanced UVA and UVB protection is required. Visible light could also play a role in PIH but this remains to be demonstrated. Healing topics with anti-inflammatory properties are of interest after a skin procedure. When the risk of PIH is high or when PIH occurs, topical steroids remains the gold standard approach.
[Mh] Termos MeSH primário: Dermatite/fisiopatologia
Hiperpigmentação/fisiopatologia
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Dermatite/prevenção & controle
Seres Humanos
Hiperpigmentação/prevenção & controle
Melanócitos/efeitos dos fármacos
Melanócitos/fisiologia
Pigmentação da Pele/efeitos dos fármacos
Pigmentação da Pele/fisiologia
Protetores Solares/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Sunscreening Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180218
[St] Status:MEDLINE


  2 / 9706 MEDLINE  
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[PMID]:28467382
[Au] Autor:Chang NF; Chen YS; Lin YJ; Tai TH; Chen AN; Huang CH; Lin CC
[Ad] Endereço:Department of Cosmetic Science, Providence University, 200, Sec. 7, Taiwan Boulevard, Shalu Dist., Taichung 43301, Taiwan. nfchang@pu.edu.tw.
[Ti] Título:Study of Hydroquinone Mediated Cytotoxicity and Hypopigmentation Effects from UVB-Irradiated Arbutin and DeoxyArbutin.
[So] Source:Int J Mol Sci;18(5), 2017 May 03.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Arbutin (Arb) and deoxyArbutin (dA) are both effective hypopigmentation agents. However, they are glucoside derivatives of hydroquinone (HQ), which may be decayed into HQ under higher energy environments. Therefore, safety and toxicity are very important issues when considering the usage of these compounds. However, no study has verified the properties of Ultra-Violet B (UVB)-irradiated Arb and dA. In this work, we investigated the cytotoxicity and hypopigmentation effects of UVB-irradiated Arb and dA in Detroit 551 human fibroblast cells and B16-F10 mouse melanoma cells. The results showed that UVB-irradiated Arb and dA have strong cytotoxicity for the fibroblast cells, especially for dA, the caspase-3 is also activated by the treatment of UVB-irradiated dA in Detroit 551 cells. The results correlated with the produced HQ. In addition, UVB-irradiated Arb and dA suppressed the production of melanin in melanoma cells; this is due to the release of HQ that compensates for the UVB triggered Arb and dA decomposition.
[Mh] Termos MeSH primário: Arbutina/análogos & derivados
Sobrevivência Celular/efeitos dos fármacos
Hidroquinonas/toxicidade
Hipopigmentação/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Arbutina/efeitos da radiação
Arbutina/toxicidade
Caspase 3/efeitos dos fármacos
Células Cultivadas
Fibroblastos/efeitos dos fármacos
Glucosídeos
Seres Humanos
Hidroquinonas/efeitos da radiação
Melaninas/antagonistas & inibidores
Melanócitos/efeitos dos fármacos
Melanoma Experimental
Camundongos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Hydroquinones); 0 (Melanins); C5INA23HXF (Arbutin); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3); RG969BY5EN (deoxyarbutin); XV74C1N1AE (hydroquinone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  3 / 9706 MEDLINE  
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[PMID]:29186240
[Au] Autor:Ramos MG; Ramos DG; Ramos CG
[Ad] Endereço:College of Human, Social, and Health Sciences, Universidade Fumec - Belo Horizonte (MG), Brazil.
[Ti] Título:Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo.
[So] Source:An Bras Dermatol;92(3):312-318, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. OBJECTIVES: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. METHODS: Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months. RESULTS: Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area. STUDY LIMITATIONS: Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.
[Mh] Termos MeSH primário: Queratinócitos/transplante
Melanócitos/transplante
Vitiligo/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Transplante Autólogo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  4 / 9706 MEDLINE  
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[PMID]:29273566
[Au] Autor:Antunes F; Pereira GJ; Jasiulionis MG; Bincoletto C; Smaili SS
[Ad] Endereço:Universidade Federal de São Paulo, Escola Paulista de Medicina Department of Pharmacology (EPM/UNIFESP), São Paulo, SP, Brazil.
[Ti] Título:Nutritional shortage augments cisplatin-effects on murine melanoma cells.
[So] Source:Chem Biol Interact;281:89-97, 2018 Feb 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Melanoma incidence increases every year worldwide and is responsible for 80% of skin cancer deaths. Due to its metastatic potential and resistance to almost any treatments such as chemo, radio, immune and targeted-therapy, the patients still have a poor prognosis, especially at metastatic stage. Considering that, it is crucial to find new therapeutic approaches to overcome melanoma resistance. Here we investigated the effect of cisplatin (CDDP), one of the chemotherapeutic agents used for melanoma treatment, in association with nutritional deprivation in murine melanoma cell lines. Cell death and autophagy were evaluated after the treatment with cisplatin, nutritional deprivation and its association using an in vitro model of murine melanocytes malignant transformation to metastatic melanoma. Our results showed that nutritional deprivation augmented cell death induced by cisplatin in melanoma cells, especially at the metastatic subtype, with slight effects on melanocytes. Mechanistic studies revealed that although autophagy was present at high levels in basal conditions in melanoma cells, was not essential for cell death process that involved mitochondrial damage, reactive oxygen species production and possible glycolysis inhibition. In conclusion, nutritional shortage in combination with chemotherapeutic drugs as cisplatin can be a valuable new therapeutic strategy to overcome melanoma resistance.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Cisplatino/farmacologia
[Mh] Termos MeSH secundário: Animais
Proteína 7 Relacionada à Autofagia/antagonistas & inibidores
Proteína 7 Relacionada à Autofagia/genética
Proteína 7 Relacionada à Autofagia/metabolismo
Linhagem Celular
Glucose/metabolismo
Macrolídeos/farmacologia
Melanócitos/citologia
Melanócitos/efeitos dos fármacos
Melanócitos/metabolismo
Melanoma/metabolismo
Melanoma/patologia
Potenciais da Membrana/efeitos dos fármacos
Camundongos
Microscopia de Fluorescência
Proteínas Associadas aos Microtúbulos/metabolismo
Interferência de RNA
RNA Interferente Pequeno/metabolismo
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Atg7 protein, mouse); 0 (MAP1LC3 protein, mouse); 0 (Macrolides); 0 (Microtubule-Associated Proteins); 0 (RNA, Small Interfering); 0 (Reactive Oxygen Species); 88899-55-2 (bafilomycin A1); EC 6.2.1.45 (Autophagy-Related Protein 7); IY9XDZ35W2 (Glucose); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  5 / 9706 MEDLINE  
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[PMID]:27771125
[Au] Autor:Jegou MH; Huet P; Penchet I
[Ad] Endereço:Cabinet de dermatologie, 8, rue Jules-Ferry, 33290 Blanquefort, France. Electronic address: mh.jegou@free.fr.
[Ti] Título:[Nested melanoma].
[Ti] Título:Mélanome en thèques..
[So] Source:Ann Dermatol Venereol;144(1):60-64, 2017 Jan.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:BACKGROUND: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype. CASE REPORT: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour. Dermatoscopically, the lesion was chaotic and characterized by a black, structureless, eccentric area with some peripheral globules as well as some segmental radial lines. Histopathological examination revealed the presence of an asymmetric lesion with large junctional melanocytic nests showing a focal tendency to gathering and some cytological atypia. A diagnosis of nested melanoma was ultimately made. DISCUSSION: Nested melanoma of the elderly represents a distinct anatomoclinical variant of superficial spreading melanoma. Clinically, the lesion is usually large and occurs in photodamaged skin. We would stress that the "elderly" criterion is not mandatory given the numerous cases reported in people under 60 years. The main dermatoscopic feature is a globular pattern, but several features characteristic of superficial spreading melanoma may also be present. Histological diagnosis may be difficult because of the mainly nested pattern, and the condition may be confused histologically with a benign junctional nevus. But these large junctional nests of different sizes, with bridging and cytonuclear atypias, together with asymmetry of the lesions are the hallmark of this special kind of melanoma.
[Mh] Termos MeSH primário: Dermoscopia
Melanócitos/patologia
Melanoma/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Dermoscopia/métodos
Diagnóstico Diferencial
Seres Humanos
Masculino
Melanoma/patologia
Meia-Idade
Neoplasias Cutâneas/patologia
Tórax/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 9706 MEDLINE  
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[PMID]:27739313
[Au] Autor:Urban P; Rabajdová M; Veliká B; Spaková I; Bolerázska B; Mareková M
[Ti] Título:[The Importance of MITF Signaling Pathway in the Regulation of Proliferation and Invasiveness of Malignant Melanoma].
[Ti] Título:Význam signálnej dráhy MITF pri regulácii proliferácie a invazivity malígneho melanómu..
[So] Source:Klin Onkol;29(5):347-350, 2016.
[Is] ISSN:0862-495X
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:BACKGROUND: Malignant melanoma is one of the most aggressive types of cancers. Melanoma is derived from pigment-producing cells, melanocytes, which are characterized by a specific survival mechanism. Microphthalmia-associated transcription factor (MITF-M) plays a role in the metabolism of melanoma and is involved in the regulation of the expression of multiple genes mediating processes such as melanogenesis, proliferation, differentiation, and melanocyte survival. The expression of this transcription factor in melanocytes is activated by several signaling pathways, and reduced expression or function of MITF-M can cause the dysregulation of anti-apoptotic mechanisms. MITF-M is also involved in matrix metalloproteinase 14 (MMP14) activity, which is responsible for shape changes in melanocytes and increases in their motility and invasiveness. Very low levels of expression of MITF-M are found in human melanocytes with an invasive phenotype, indicating that this transcription factor acts as a suppressor of the metastatic process. Cancer cells with low expression of cytosolic/nuclear ß-catenin have a small amount of MITF-M 14 that is insufficient to inhibit MMP transcription. The enzyme catalyzes the degradation of laminin and fibronectin, thereby changing the shape of melanocytes, which leads to their increased mobility and invasiveness. AIMS: This review describes the regulatory pathway of MITF-M activation, its involvement in the proliferation of transformed melanocytes, and its role in increasing the invasiveness of malignant melanoma. A detailed understanding of the MITF-M signaling pathway is highly topical and could help to develop new diagnostic and therapeutic applications for patients with malignant melanoma.Key words: neoplastic cell transformation - melanoma - MITF transcription factorThis work was supported by grant projects VEGA 1/0115/14 and VEGA 1/0873/16.The authors declare they have no potential confl icts of interest concerning drugs, products, or services used in the study.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 4. 12. 2015Accepted: 14. 6. 2016.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Proliferação Celular
Melanócitos/patologia
Melanoma/patologia
Fator de Transcrição Associado à Microftalmia/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Melanócitos/metabolismo
Melanoma/metabolismo
Invasividade Neoplásica
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Microphthalmia-Associated Transcription Factor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE


  7 / 9706 MEDLINE  
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[PMID]:27777206
[Au] Autor:Deng Y; Lv L; Yang G; Sui YK
[Ad] Endereço:School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. E-mail: 362186548@qq.com.
[Ti] Título:[Role of serotoninergic/melatoninergic system in melanin metabolism in melanocytes exposed to serum of rabbits fed with Liuwei Dihuang decoction].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1401-1405, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the effects of Liuwei Dihuang (LWDH) decoction on serotonine (5-HTs), melatonin and the activity of the rate-limiting enzymes ANNAT and HIOMT in cultured human melanocytes and in melanocytes co-cultured with keratinocytes. METHODS: CCK-8 assay was used to assess the proliferation of melanocytes and melanocytes co-cultured with keratinocytes after treatment with the serum from rabbits fed with LWDH decoction. High-performance liquid chromatography was used to determine 5-HT and melatonin contents, and real-time fluorescent PCR was employed to evaluate the ANNAT and HIOMT activities in the cell cultures. RESULTS: The serum from rabbits fed with LWDH Decoction at low doses did not affect the proliferation of melanocytes co-cultured with keratinocytes, but at the concentrations of 20%-40%, the serum significantly inhibited the proliferation of melanocytes, and the effect was optimal with a concentration of 40% (P<0.05). 5-HT and melatonin contents in the cell culture decreased as the serum concentration increased (P<0.05), which was the most obvious with a serum concentration of 40% (P<0.01). Exposure of the cells to low and moderate doses of the serum caused a dose-dependent decrease in AANAT activity (P<0.05), but the serum produced no significant changes in the level of HIOMT mRNA expression in the cells. COUCLUSIONS: The serotoninergic/melatoninergic system mediate the regulation of melanin metabolism by LWDH Decoction, the mechanism of which may involve 5-HTs, melatonin and ANNAT.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Melaninas/metabolismo
Melanócitos/efeitos dos fármacos
Soro/química
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Técnicas de Cocultura
Seres Humanos
Queratinócitos
Melanócitos/metabolismo
Melatonina/metabolismo
Coelhos
Serotonina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Liuwei Dihuang Decoction); 0 (Melanins); 333DO1RDJY (Serotonin); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  8 / 9706 MEDLINE  
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[PMID]:29059311
[Au] Autor:Mori T; Sukeda A; Sekine S; Shibata S; Ryo E; Okano H; Suzuki S; Hiraoka N
[Ad] Endereço:Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
[Ti] Título:SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5445-5451, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Adenocarcinomas or adenomas derived from pigmented ciliary epithelium (APCE) are exceptionally rare ocular tumors. These tumors have pigmented and epithelioid features, and some APCEs are negative for keratin markers and positive for melanocytic markers. It is especially difficult to distinguish APCEs from uveal melanoma (UM). Accordingly, we examined protein expression and genetic mutations associated with APCE to facilitate diagnosis. Methods: Five APCE and 11 UM samples were obtained from patients during surgical resection at our institute. APCE and UM ocular structures were compared comprehensively. Protein expression and genetic alterations involved in malignant melanoma were evaluated. Results: SOX10 was expressed diffusely in all 11 UMs and in surrounding uveal or choroidal melanocytes, but not in the APCEs or nontumorous pigmented epithelia. Additionally, the expression patterns of cytokeratins and melanocytic markers differed between UMs and APCEs. We identified BRAF V600E mutations in four of five APCE samples, but not in the 11 UM samples. Moreover, GNAQ or GNA11 mutations were found in 10 of the 11 UM samples, but not in APCE samples. NRAS mutations were not observed in either tumor group examined. Conclusions: APCE is a separate entity distinguished from UM by the absence of SOX10 expression and presence of the BRAF V600E mutation. These results have implications for diagnosis, providing a means to distinguish between UM and APCE.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Corpo Ciliar/patologia
Melanoma/genética
Mutação
Proteínas de Neoplasias/genética
Epitélio Pigmentado Ocular/patologia
Neoplasias Uveais/genética
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico
Adenocarcinoma/genética
Adenoma/diagnóstico
Adenoma/genética
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Análise Mutacional de DNA
Feminino
Subunidades alfa de Proteínas de Ligação ao GTP/genética
Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/genética
Regulação Neoplásica da Expressão Gênica/fisiologia
Seres Humanos
Imuno-Histoquímica
Masculino
Melanócitos/metabolismo
Melanoma/diagnóstico
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Microscopia Eletrônica de Transmissão
Meia-Idade
Reação em Cadeia da Polimerase
Proteínas Proto-Oncogênicas B-raf/genética
Fatores de Transcrição SOXE/genética
Neoplasias Uveais/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (GNA11 protein, human); 0 (GNAQ protein, human); 0 (GTP-Binding Protein alpha Subunits); 0 (Neoplasm Proteins); 0 (SOXE Transcription Factors); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf); EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gq-G11)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22362


  9 / 9706 MEDLINE  
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[PMID]:29016654
[Au] Autor:Jasinska-Konior K; Pochylczuk K; Czajka E; Michalik M; Romanowska-Dixon B; Swakon J; Urbanska K; Elas M
[Ad] Endereço:Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Cracow, Poland.
[Ti] Título:Proton beam irradiation inhibits the migration of melanoma cells.
[So] Source:PLoS One;12(10):e0186002, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In recent years experimental data have indicated that low-energy proton beam radiation might induce a difference in cellular migration in comparison to photons. We therefore set out to compare the effect of proton beam irradiation and X-rays on the survival and long-term migratory properties of two cell lines: uveal melanoma Mel270 and skin melanoma BLM. MATERIALS AND METHODS: Cells treated with either proton beam or X-rays were analyzed for their survival using clonogenic assay and MTT test. Long-term migratory properties were assessed with time-lapse monitoring of individual cell movements, wound test and transpore migration, while the expression of the related proteins was measured with western blot. RESULTS: Exposure to proton beam and X-rays led to similar survival but the quality of the cell colonies was markedly different. More paraclones with a low proliferative activity and fewer highly-proliferative holoclones were found after proton beam irradiation in comparison to X-rays. At 20 or 40 days post-irradiation, migratory capacity was decreased more by proton beam than by X-rays. The beta-1-integrin level was decreased in Mel270 cells after both types of radiation, while vimentin, a marker of EMT, was increased in BLM cells only. CONCLUSIONS: We conclude that proton beam irradiation induced long-term inhibition of cellular motility, as well as changes in the level of beta-1 integrin and vimentin. If confirmed, the change in the quality, but not in the number of colonies after proton beam irradiation might favor tumor growth inhibition after fractionated proton therapy.
[Mh] Termos MeSH primário: Movimento Celular/efeitos da radiação
Integrina beta1/genética
Melanócitos/efeitos da radiação
Prótons/uso terapêutico
Vimentina/genética
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular/efeitos da radiação
Células Clonais
Expressão Gênica/efeitos da radiação
Seres Humanos
Integrina beta1/metabolismo
Melanócitos/metabolismo
Melanócitos/patologia
Especificidade de Órgãos
Imagem com Lapso de Tempo
Vimentina/metabolismo
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Integrin beta1); 0 (Protons); 0 (Vimentin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186002


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[PMID]:28979623
[Au] Autor:Debbarh FZ; Mernissi FZ
[Ad] Endereço:Service de Dermatologie, CHU Hassan II, Fès, Maroc.
[Ti] Título:[Piebaldisme: a rare genodermatosis].
[Ti] Título:Piebaldisme: une génodermatose rare..
[So] Source:Pan Afr Med J;27:221, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Piebaldism is a rare autosomal dominant genodermatosis. It is due to congenital absence of melanocytes in the affected areas. We report a case. A 5 year old girl born to consanguineous parents and with similar cases in her mother's; she presented since birth achromic lesions on the legs with a steady evolution. clinical examination showed confluent achromic macules and poliosis (A) with no contrast enhancement under Wood lamp and several coffee-with-milk colored spots on the trunk and thighs(B). The diagnosis of piebaldism was made. Piebaldism is a rare genodermatosis. Its incidence is estimated at less than 1/20000 newborns. It is characterized by the congenital absence of melanocytes in the areas affected by mutation of the c-kit gene and by symmetrical achromic macules appeared at birth with a steady and persistent evolution. A white lock of hair on the forehead could be seen in 80% of cases The differential diagnosis includes vitiligo, albinism and Waardenburg syndrome. Associations have been described with neurofibromatosis type I. However, isolated coffee-with-milk colored spots can be observed; as the case of our patient. The treatment is based on split-thickness skin graft. Piebaldism is a rare genodermatosis. This study aims to discuss its clinical aspects and differential diagnoses.
[Mh] Termos MeSH primário: Melanócitos/patologia
Piebaldismo/diagnóstico
Proteínas Proto-Oncogênicas c-kit/genética
[Mh] Termos MeSH secundário: Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Mutação
Piebaldismo/genética
Piebaldismo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.221.4961



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