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Pesquisa : A11.690 [Categoria DeCS]
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[PMID]:28411376
[Au] Autor:Rooper LM; Onenerk M; Siddiqui MT; Faquin WC; Bishop JA; Ali SZ
[Ad] Endereço:Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
[Ti] Título:Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
[So] Source:Cancer;125(8):627-634, 2017 Aug.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases. RESULTS: Twelve cases of oncocytosis were identified from 11 patients, including 11 parotid FNA specimens and 1 submandibular FNA specimen. On the original diagnoses, 6 specimens were classified as benign, 4 as atypical, and 2 as nondiagnostic. Oncocytosis was listed in the differential diagnosis in only 1 case. Among diagnostic aspirates, 8 demonstrated low cellularity and 2 demonstrated moderate cellularity. All 10 cases demonstrated oncocytic cells in small to medium groups, with single cells in just 1 case. Spindled and squamous morphology were each noted in 3 cases. Four cases demonstrated cystic change and 1 showed background mucin without goblet cells. No necrosis or mitoses were observed. CONCLUSIONS: Although oncocytosis demonstrates some overlap with Warthin tumor and oncocytoma, it lacks the diagnostic findings specific to oncocytic salivary gland malignancies such as salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma, and mucoepidermoid carcinoma. Despite current limitations in the understanding of oncocytic salivary gland lesions, the presence of a paucicellular specimen comprised of small groups of oncocytic cells should raise the possibility of oncocytosis in the differential diagnosis and can favor it in elderly patients with multiple salivary nodules. Cancer Cytopathol 2017;125:627-34. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Células Oxífilas/patologia
Doenças Parotídeas/patologia
Doenças da Glândula Submandibular/patologia
[Mh] Termos MeSH secundário: Adenolinfoma/diagnóstico
Adenolinfoma/patologia
Adenoma Oxífilo/diagnóstico
Adenoma Oxífilo/patologia
Idoso
Idoso de 80 Anos ou mais
Biópsia por Agulha Fina
Carcinoma/diagnóstico
Carcinoma/patologia
Carcinoma de Células Acinares/diagnóstico
Carcinoma de Células Acinares/patologia
Carcinoma Mucoepidermoide/diagnóstico
Carcinoma Mucoepidermoide/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Parotídeas/diagnóstico
Doenças das Glândulas Salivares/diagnóstico
Doenças das Glândulas Salivares/patologia
Neoplasias das Glândulas Salivares/diagnóstico
Neoplasias das Glândulas Salivares/patologia
Doenças da Glândula Submandibular/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21865


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[PMID]:28407624
[Au] Autor:Mahajan S; Srinivasan R; Rajwanshi A; Radotra B; Panda N; Dey P; Gupta N; Nijhawan R
[Ad] Endereço:Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Título:Risk of Malignancy and Risk of Neoplasia in the Bethesda Indeterminate Categories: Study on 4,532 Thyroid Fine-Needle Aspirations from a Single Institution in India.
[So] Source:Acta Cytol;61(2):103-110, 2017.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine the frequency of category 3 (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS]), category 4 (follicular neoplasm), and category 5 (suspicious for malignancy) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the risk of malignancy (ROM) and the risk of neoplasia (RON) in these categories. STUDY DESIGN: A retrospective 6-year audit of 4,532 thyroid fine-needle aspirations (FNA) reported as per the TBSRTC from a single institution with cytohistological correlation in 335 cases. RESULTS: The frequency of categories 3, 4, and 5 was 2.5, 3.9, and 0.5%, respectively; the upper and lower bound estimates of ROM being 58.3, 23.6, 75% and 5.1, 5, and 12.5%, respectively. AUS/FLUS (n = 116) cases were subcategorized as AUS, AUS-HC (Hürthle cell), AUS-PTC (AUS-papillary thyroid carcinoma not excluded), FLUS, FLUS-FH (favor hyperplasia), FLUS-HC, and FLUS-PTC. The AUS/FLUS malignancy ratio was 1:3.8. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of FNA thyroid was 80.5, 85.9, 80.7, 85.7, and 82.4%, respectively. CONCLUSION: Implementation of TBSRTC aided in achieving internal quality control in reporting thyroid FNA cytology. The AUS/FLUS frequency was 2.5%, which is at the lower range of the recommended rate and was associated with a higher than recommended upper bound estimate, but a comparable lower bound estimate of ROM.
[Mh] Termos MeSH primário: Biópsia por Agulha Fina
Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/diagnóstico
Nódulo da Glândula Tireoide/diagnóstico
[Mh] Termos MeSH secundário: Biópsia por Agulha Fina/normas
Núcleo Celular/patologia
Seres Humanos
Índia
Auditoria Médica
Células Oxífilas/patologia
Valor Preditivo dos Testes
Prognóstico
Indicadores de Qualidade em Assistência à Saúde
Reprodutibilidade dos Testes
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Neoplasias da Glândula Tireoide/classificação
Neoplasias da Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/terapia
Nódulo da Glândula Tireoide/classificação
Nódulo da Glândula Tireoide/patologia
Nódulo da Glândula Tireoide/terapia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1159/000470825


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[PMID]:28035705
[Au] Autor:Reddy SP; Chong K; Cassarino DS
[Ad] Endereço:School of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois.
[Ti] Título:A rare case of cutaneous oncocytic hidradenoma.
[So] Source:J Cutan Pathol;44(3):289-291, 2017 Mar.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 mm erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged and bland-appearing epithelioid cells. Cytokeratin 7 (CK7), epithelial membrane antigen (EMA) and monoclonal carcinoembryonic antigen (mCEA) immunohistochemical stains were positive, consistent with adnexal differentiation. Phosphotungstic acid-hematoxylin (PTAH) and Luxol fast blue (LFB) stains highlighted the cytoplasmic granules, consistent with mitochondria. The overall findings were consistent with an oncocytic nodular hidradenoma. Oncocytic hidradenoma is a very rare entity, with only 1 previously reported case in the literature.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Células Oxífilas/patologia
Neoplasias das Glândulas Sudoríparas/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Carcinoma Basocelular/patologia
Seres Humanos
Imuno-Histoquímica
Masculino
Segunda Neoplasia Primária/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12883


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[PMID]:28009314
[Au] Autor:Tsagareli Z; Kvachadze T; Melikadze E; Metreveli L; Nikobadze E; Gogiashvili L
[Ad] Endereço:I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
[Ti] Título:HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA.
[So] Source:Georgian Med News;(Issue):42-46, 2016 Nov.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specimens (tissue fragments) collected from TG surgery (thyroidectomy) for mollecular (receptor) diagnosis of Hǘrtle cells activities using routine histological and immunohistochemical samples. 89 cases were selected in Hashimoto thyroiditis diagnosis with Hǘrtle cells history (adenoma and adenomatous grouth of oncocytes). Markers as: TSH receptors, TTF-1, S-100 protein, also anti-TPO and anti-TG levels in blood plasm were detected. It was shown that solid cell claster-nests like agregation of oncocytes and adenomatous growth foci in parafollicular areas with anti-TPO and anti-TG antibodies levels arising while Riedel´s struma shown only large intra- and extra glandular inflammatory proliferative fibrosing process. Large positive expression of TTF-1 and S-100 protein and the negative reaction of TSH receptor factor suggest that Thyroid parenchyma disorganization and mollecular biological atypia with Hǘrtle cells are proceses due to hypothyreoidismus, as well as neuroectodermal cells prominent activities in 70% of Hashimoto cases.
[Mh] Termos MeSH primário: Doença de Hashimoto/metabolismo
Células Oxífilas/metabolismo
Tecido Parenquimatoso/metabolismo
Glândula Tireoide/metabolismo
[Mh] Termos MeSH secundário: Adulto
Autoanticorpos/sangue
Autoantígenos/imunologia
Feminino
Fibrose
Doença de Hashimoto/patologia
Seres Humanos
Iodeto Peroxidase/imunologia
Proteínas de Ligação ao Ferro/imunologia
Masculino
Meia-Idade
Proteínas Nucleares/metabolismo
Tecido Parenquimatoso/patologia
Receptores da Tireotropina/metabolismo
Proteínas S100/metabolismo
Glândula Tireoide/patologia
Fator Nuclear 1 de Tireoide
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Autoantigens); 0 (Iron-Binding Proteins); 0 (NKX2-1 protein, human); 0 (Nuclear Proteins); 0 (Receptors, Thyrotropin); 0 (S100 Proteins); 0 (Thyroid Nuclear Factor 1); 0 (Transcription Factors); 0 (anti-thyroglobulin); EC 1.11.1.7 (TPO protein, human); EC 1.11.1.8 (Iodide Peroxidase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE


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[PMID]:27631263
[Au] Autor:Xiao H; Wen T; Liu X
[Ad] Endereço:aDepartment of Pathology bCollege of Basic Medical Sciences, Gannan Medical University cDepartment of Stomatology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, P.R. China.
[Ti] Título:Submandibular oncocytic carcinoma: A case report and literature review.
[So] Source:Medicine (Baltimore);95(37):e4897, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism. At its most severe, the tumor may invade into the surrounding tissues, including intravascular, lymphatic, or perineural invasion, and lead to regional nodal or distant metastasis. METHODS: The current study describes a novel OC case in a 46-year-old male, the youngest case of the review. The patient presented with a 5-month history of an intermittently painful mass. RESULTS: Following magnetic resonance imaging, excisional biopsy, hematoxylin-eosin staining, phosphotungstic acid-hematoxylin staining, and immunohistochemical examination, an OC of the submandibular gland was diagnosed. CONCLUSION: The current study summarizes the pathogenesis, diagnosis, therapeutics, and the prognosis of OC. The literature review regarding this rare disease is also presented to emphasize the lack of specific markers of OC and the risk of cervical lymph metastasis.
[Mh] Termos MeSH primário: Carcinoma/patologia
Células Oxífilas
Neoplasias da Glândula Submandibular/patologia
Glândula Submandibular/patologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004897


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[PMID]:27376649
[Au] Autor:Meister P; Vorländer C; Hartmann S; Hansmann ML
[Ad] Endereço:Dr. Senckenbergisches Institut für Pathologie, Klinikum der J. W. Goethe Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
[Ti] Título:[Paratracheal lymph node with suspicion of carcinoma].
[Ti] Título:Paratrachealer Knoten mit Karzinomverdacht..
[So] Source:Pathologe;37(5):473-6, 2016 Sep.
[Is] ISSN:1432-1963
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Three paratracheal lymph nodes of a 20-year-old patient were submitted for examination, of which one showed numerous thyrocytes with large void nuclei and was suspected of being metastatic papillary thyroid carcinoma. The simultaneously resected thyroid gland, which was subsequently submitted showed findings consistent with Hashimoto's autoimmune thyroiditis (AIT). In the context of the resected goiter tissue, the suspected lymph node metastasis was identified as a hyperplastic ectopic (so-called parasitic) goiter nodule with thyrocytic changes typically seen in Hashimoto's AIT, such as oxyphilic cell alterations and a high plasma cell content. The re-examination of the suspicious lymph node revealed complete lack of a marginal sinus, thus excluding the diagnosis of a lymph node as well as the diagnosis of thyroid carcinoma metastasis.
[Mh] Termos MeSH primário: Linfonodos/patologia
Metástase Linfática/patologia
Neoplasias da Traqueia/patologia
[Mh] Termos MeSH secundário: Núcleo Celular/patologia
Coristoma/patologia
Diagnóstico Diferencial
Bócio
Doença de Hashimoto/patologia
Seres Humanos
Masculino
Células Oxífilas/patologia
Plasmócitos/patologia
Células Epiteliais da Tireóide/patologia
Glândula Tireoide
Tireoidectomia
Doenças da Traqueia/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE
[do] DOI:10.1007/s00292-016-0181-9


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[PMID]:27346570
[Au] Autor:Boland JM; Folpe AL
[Ad] Endereço:Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
[Ti] Título:Oncocytic variant of malignant gastrointestinal neuroectodermal tumor: a potential diagnostic pitfall.
[So] Source:Hum Pathol;57:13-16, 2016 Nov.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cells with a moderate amount of lightly eosinophilic cytoplasm, round nuclei and small nucleoli, often in association with osteoclast-like giant cells. By immunohistochemistry, these tumors show expression of S100 protein and SOX10, in the absence of expression of more specific melanocytic markers (eg, HMB45, Melan A). Genetically, malignant gastrointestinal neuroectodermal tumors are characterized by rearrangements of the EWSR1 or FUS genes with CREB1 or ATF1. We report a case of gastric malignant gastrointestinal neuroectodermal tumor occurring in a 46-year-old woman and showing striking oncocytic cytoplasmic change, a previously undescribed potential diagnostic pitfall. An initial needle biopsy showed large, eosinophilic cells with S100 protein and SOX10 expression and lacking expression of KIT, DOG1, Melan A, keratin, chromogranin, or smooth muscle actin, and was interpreted as representing a granular cell tumor. The subsequent excision specimen showed similar-appearing areas, but also contained small more primitive-appearing areas, lacking oncocytic change and having high nuclear grade and brisk mitotic activity. This resection specimen was initially diagnosed as a malignant granular cell tumor. However subsequent gene expression profiling studies showed an EWSR1-ATF1 fusion, confirmed with fluorescence in situ hybridization for EWSR1, and a final diagnosis of MGNET with oncocytic change was made. This case highlights a previously undescribed pitfall in the diagnosis of MGNET, oncocytic change, and suggests that MGNET should be included in the differential diagnosis for unusual oncocytic neoplasms of the gastrointestinal tract.
[Mh] Termos MeSH primário: Tumores Neuroectodérmicos Primitivos Periféricos/patologia
Células Oxífilas/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia por Agulha
Feminino
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Meia-Idade
Tumores Neuroectodérmicos Primitivos Periféricos/química
Tumores Neuroectodérmicos Primitivos Periféricos/genética
Tumores Neuroectodérmicos Primitivos Periféricos/cirurgia
Proteínas de Fusão Oncogênicas/genética
Células Oxífilas/química
Valor Preditivo dos Testes
Neoplasias Gástricas/química
Neoplasias Gástricas/genética
Neoplasias Gástricas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (EWSR1-ATF1 fusion protein, human); 0 (Oncogene Proteins, Fusion)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE


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[PMID]:27234487
[Au] Autor:Hong JH; Yi HS; Yi S; Kim HW; Lee J; Kim KS
[Ad] Endereço:Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea.
[Ti] Título:Implications of oncocytic change in papillary thyroid cancer.
[So] Source:Clin Endocrinol (Oxf);85(5):797-804, 2016 Nov.
[Is] ISSN:1365-2265
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Although the presence of oncocytic change in less than 75% of a tumour is not considered to indicate oncocytic variants of papillary thyroid carcinoma (PTC), we frequently observe partial oncocytic change, especially in obese PTC patients. Thus, we sought to investigate the relationship between the presence of oncocytic change of PTC and its prognosis. DESIGN, SETTING AND PARTICIPANTS: We retrospectively studied 142 patients with PTC who had undergone surgery between 2000 and 2005, and re-evaluated their PTC slides to record the proportion of oncocytic change in 10% increments from 0% to 100%. MAJOR OUTCOME MEASURE: We analysed the relationship between the proportion of oncocytic change and clinicopathological prognostic factors. RESULTS: Oncocytic change was found in 45·8% (65/142) of PTC patients. The proportion of patients with oncocytic change was higher in obese patients than in lean patients and showed a significant correlation with the BMI (r = 0·195, P = 0·020). The PTC patients with oncocytic change showed a higher recurrence rate than PTC patients without oncocytic change (30·8% vs 11·7%, respectively; P = 0·005). The presence of oncocytic change in PTC patients was associated with a shorter disease-free survival in a Kaplan-Meier analysis after a mean follow-up of 8·9 years. CONCLUSION: The patients with PTC with oncocytic change presented with a higher recurrence rate and were more likely to be obese. These findings suggest that presence of oncocytic change is a poor prognostic factor in PTC patients, even if the oncocytic change involves less than 75% of a tumour.
[Mh] Termos MeSH primário: Carcinoma/patologia
Células Oxífilas/patologia
Neoplasias da Glândula Tireoide/patologia
[Mh] Termos MeSH secundário: Adulto
Carcinoma/mortalidade
Carcinoma Papilar
Contagem de Células
Intervalo Livre de Doença
Feminino
Seres Humanos
Masculino
Meia-Idade
Obesidade
Prognóstico
Estudos Retrospectivos
Neoplasias da Glândula Tireoide/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160529
[St] Status:MEDLINE
[do] DOI:10.1111/cen.13115


  9 / 217 MEDLINE  
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[PMID]:27221817
[Au] Autor:Pathak KA; Klonisch T; Nason RW; Leslie WD
[Ad] Endereço:Division of Surgical Oncology, Cancer Care Manitoba, University of Manitoba, ON2048, 675 McDermot Avenue, Winnipeg, R3E 0V9, Canada. apathak@cancercare.mb.ca.
[Ti] Título:FDG-PET characteristics of Hürthle cell and follicular adenomas.
[So] Source:Ann Nucl Med;30(7):506-9, 2016 Aug.
[Is] ISSN:1864-6433
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Follicular (FN) and Hürthle cell neoplasms (HCN) are considered indeterminate on thyroid fine needle aspiration cytology and are preoperative diagnostic challenges. The role of [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) in characterizing indeterminate thyroid nodules remains equivocal, because of the increased FDG uptake by some benign thyroid nodules. The objective of this study was to compare the FDG positron emission tomography/computerized tomography (PET/CT) characteristics of follicular (FA) and Hürthle cell adenomas (HCA). METHODS: Twenty-nine patients with 31 thyroid nodules underwent FDG-PET/CT scans of the neck and superior mediastinum for indeterminate FN/HCN, and were later found to have benign adenomas on final histopathology. All scans were reported by a single observer, who was blinded to the surgical and pathology findings. Receiver operating characteristic (ROC) curve analysis of maximum standardized uptake value (SUVmax) and the area under the curve (AUROC) were used to assess discrimination between FA and HCA. Youden index was used to identify the optimal cut-off SUVmax. Sensitivity, specificity, predictive values and overall accuracy were used as measures of performance. RESULTS: The mean age of our study cohort was 60.7 ± 12.6 years and 77 % of the patients were females. Age of the patients (p = 0.48), their gender (p = 0.52), and the size of thyroid nodules (p = 0.79) were similar for FA and HCA. Increased focal FDG uptake was observed in 100 % of HCA and 52 % of FA (p = 0.02). SUVmax of HCA was significantly higher (p < 0.001) than that of FA. SUVmax of 5 was the best cut-off for discrimination between HCA and FA, with AUROC of 0.90 (95 % CI, 0.79-1.00; p = 0.001). With this cut-off, FDG-PET/CT had sensitivity of identifying HCA of 88 % (95 % CI 47-99 %), specificity of 87 % (95 % CI 65-97 %), positive predictive value of 70 % (95 % CI 35-92 %), and negative predictive value of 95 % (95 % CI 74-99 %). The overall accuracy was 87 %. CONCLUSIONS: HCA shows significantly higher focal FDG uptake as compared to FA and should always be considered in the differential diagnosis of FDG-PET positive thyroid nodules.
[Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem
Adenoma/patologia
Células Oxífilas/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
[Mh] Termos MeSH secundário: Adenoma/metabolismo
Transporte Biológico
Reações Falso-Positivas
Feminino
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
Neoplasias da Glândula Tireoide/diagnóstico por imagem
Neoplasias da Glândula Tireoide/metabolismo
Neoplasias da Glândula Tireoide/patologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE
[do] DOI:10.1007/s12149-016-1087-6


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[PMID]:27097337
[Au] Autor:Elbendary A; Cochran E; Xie Q; Kabigting F; Pereira L; Elston DM; Heilman E
[Ad] Endereço:*Ackerman Academy of Dermatopathology, New York, NY; †Department of Dermatology, Kasr Alainy Faculty of Medicine, Cairo University, Egypt; ‡Kings County Hospital Center, SUNY Downstate Medical Center, New York, NY; §Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, SC; and ¶Department of Dermatology, SUNY Downstate Medical Center, New York, NY.
[Ti] Título:Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study.
[So] Source:Am J Dermatopathol;38(6):444-7, 2016 Jun.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hidradenoma papilliferum is a benign cutaneous adnexal neoplasm, commonly occurring in the vulva and perianal region of adult women. It has characteristic histopathological features composed of anastomosing and branching tubules, lined by columnar cells, and a basal layer of myoepithelial cells. A 39-year-old woman was evaluated for 2 asymptomatic labial masses. The histopathological examination revealed a Bartholin's cyst and a hidradenoma papilliferum. The latter contains a distinct area of oncocytic/oxyphilic metaplasia. Immunohistochemical stains revealed positive staining for gross cystic disease fluid protein (GCDFP)-15 and androgen receptor. GATA-3, a protein expressed in sweat glands, highlights a similar positive staining pattern with weaker staining in areas of oncocytic metaplasia. P63 highlighted the myoepithelial differentiation. In situ hybridization for Human Papilloma Virus 6, 11, 16, and 18 was negative. P53 was negative and Ki-67 was low, confirming its benign nature. Oncocytes are enlarged epithelial cells with voluminous eosinophilic granular cytoplasm resulting from staining of nonribosomal cytoplasmic components. Few reports documented it in hidradenoma papilliferum. Our case demonstrated a florid distinct appearance of this metaplasia. The immunoprofiles of this oncocytic metaplasia such as p53 negativity and positivity for androgen receptor and GCDFP-15 demonstrates similarity to apocrine metaplasia in the breast. The authors' case demonstrates the benign nature of oncocytic metaplasia and supports the common origin of oncocytic cells and columnar cells in hidradenoma papilliferum.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Células Oxífilas/patologia
Neoplasias das Glândulas Sudoríparas/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Feminino
Seres Humanos
Imuno-Histoquímica
Metaplasia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000599



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