Base de dados : MEDLINE
Pesquisa : A11.872.677 [Categoria DeCS]
Referências encontradas : 8 [refinar]
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[PMID]:28827310
[Au] Autor:Liu J; Shang D; Xiao Y; Zhong P; Cheng H; Zhou R
[Ad] Endereço:From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
[Ti] Título:Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice.
[So] Source:J Biol Chem;292(39):16003-16013, 2017 Sep 29.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Germline stem cells are essential in the generation of both male and female gametes. In mammals, the male testis produces sperm throughout the entire lifetime, facilitated by testicular germline stem cells. Oocyte renewal ceases in postnatal or adult life in mammalian females, suggesting that germline stem cells are absent from the mammalian ovary. However, studies in mice, rats, and humans have recently provided evidence for ovarian female germline stem cells (FGSCs). A better understanding of the role of FGSCs in ovaries could help improve fertility treatments. Here, we developed a rapid and efficient method for isolating FGSCs from ovaries of neonatal mice. Notably, our FGSC isolation method could efficiently isolate on average 15 cell "strings" per ovary from mice at 1-3 days postpartum. FGSCs isolated from neonatal mice displayed the string-forming cell configuration at mitosis ( a "stringing" FGSC (sFGSC) phenotype) and a disperse phenotype in postnatal mice. We also found that sFGSCs undergo vigorous mitosis especially at 1-3 days postpartum. After cell division, the sFGSC membranes tended to be connected to form sFGSCs. Moreover, F-actin filaments exhibited a cell-cortex distribution in sFGSCs, and E-cadherin converged in cell-cell connection regions, resulting in the string-forming morphology. Our new method provides a platform for isolating FGSCs from the neonatal ovary, and our findings indicate that FGCSs exhibit string-forming features in neonatal mice. The sFGSCs represent a valuable resource for analysis of ovary function and an model for future clinical use to address ovarian dysfunction.
[Mh] Termos MeSH primário: Células-Tronco de Oogônios/citologia
Ovário/citologia
[Mh] Termos MeSH secundário: Citoesqueleto de Actina/efeitos dos fármacos
Citoesqueleto de Actina/metabolismo
Citoesqueleto de Actina/ultraestrutura
Animais
Animais Recém-Nascidos
Biomarcadores/metabolismo
Caderinas/antagonistas & inibidores
Caderinas/genética
Caderinas/metabolismo
Adesão Celular/efeitos dos fármacos
Linhagem Celular
Membrana Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Membrana Celular/ultraestrutura
Proliferação Celular/efeitos dos fármacos
Separação Celular
Células Cultivadas
Técnicas de Cocultura
Feminino
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos ICR
Microscopia Eletrônica de Varredura
Inibidores da Síntese de Ácido Nucleico/farmacologia
Oogênese/efeitos dos fármacos
Células-Tronco de Oogônios/efeitos dos fármacos
Células-Tronco de Oogônios/metabolismo
Células-Tronco de Oogônios/ultraestrutura
Ovário/crescimento & desenvolvimento
Ovário/metabolismo
Ovário/ultraestrutura
Interferência de RNA
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cadherins); 0 (E-cadherin protein, mouse); 0 (Nucleic Acid Synthesis Inhibitors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.799403


  2 / 8 MEDLINE  
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[PMID]:28396508
[Au] Autor:Matsuoka S; Armstrong AR; Sampson LL; Laws KM; Drummond-Barbosa D
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland.
[Ti] Título:Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in .
[So] Source:Genetics;206(2):953-971, 2017 Jun.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nutrients affect adult stem cells through complex mechanisms involving multiple organs. Adipocytes are highly sensitive to diet and have key metabolic roles, and obesity increases the risk for many cancers. How diet-regulated adipocyte metabolic pathways influence normal stem cell lineages, however, remains unclear. has highly conserved adipocyte metabolism and a well-characterized female germline stem cell (GSC) lineage response to diet. Here, we conducted an isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis to identify diet-regulated adipocyte metabolic pathways that control the female GSC lineage. On a rich (relative to poor) diet, adipocyte Hexokinase-C and metabolic enzymes involved in pyruvate/acetyl-CoA production are upregulated, promoting a shift of glucose metabolism toward macromolecule biosynthesis. Adipocyte-specific knockdown shows that these enzymes support early GSC progeny survival. Further, enzymes catalyzing fatty acid oxidation and phosphatidylethanolamine synthesis in adipocytes promote GSC maintenance, whereas lipid and iron transport from adipocytes controls vitellogenesis and GSC number, respectively. These results show a functional relationship between specific metabolic pathways in adipocytes and distinct processes in the GSC lineage, suggesting the adipocyte metabolism-stem cell link as an important area of investigation in other stem cell systems.
[Mh] Termos MeSH primário: Linhagem da Célula/genética
Células Germinativas/crescimento & desenvolvimento
Redes e Vias Metabólicas/genética
Proteômica
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Animais
Dieta
Drosophila melanogaster/genética
Drosophila melanogaster/crescimento & desenvolvimento
Ácidos Graxos/genética
Ácidos Graxos/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Células Germinativas/metabolismo
Hexoquinase/biossíntese
Hexoquinase/genética
Células-Tronco de Oogônios/metabolismo
Fosfatidiletanolaminas/biossíntese
Fosfatidiletanolaminas/genética
Vitelogênese/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Phosphatidylethanolamines); 39382-08-6 (phosphatidylethanolamine); EC 2.7.1.1 (Hexokinase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.117.201921


  3 / 8 MEDLINE  
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[PMID]:28245464
[Au] Autor:Ye H; Li X; Zheng T; Hu C; Pan Z; Huang J; Li J; Li W; Zheng Y
[Ti] Título:The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells.
[So] Source:Cell Physiol Biochem;41(3):1051-1062, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To improve the separation, identification and cultivation of ovarian germline stem cells (OGSCs), to clarify the relationship between the Hippo signaling pathway effector YAP1 and the proliferation and differentiation of OGSCs in vitro and to identify the major contribution of Hippo signaling to ovarian function. METHODS: Two-step enzymatic separation processes and magnetic separation were used to isolate and identify OGSCs by determining the expression of Mvh, Oct4, Nanog, Fragilis and Stella markers. Then, YAP1, as the main effector molecule in the Hippo signaling pathway, was chosen as the target gene of the study. Lentivirus containing overexpressed YAP1 or a YAP1-targeted shRNA was transduced into OGSCs. The effects of modulating the Hippo signaling pathway on the proliferation, differentiation, reproduction and endocrine function of ovaries were observed by microinjecting the lentiviral vectors with overexpressed YAP1 or YAP1 shRNA into infertile mouse models or natural mice of reproductive age. RESULTS: (1) The specific expression of Mvh, Oct4, Nanog, Fragilis and Stella markers was observed in isolated stem cells. Thus, the isolated cells were preliminarily identified as OGSCs. (2) The co-expression of LATS2, MST1, YAP1 and MVH was observed in isolated OGSCs. Mvh and Oct4 expression levels were significantly increased in OGSCs overexpressing YAP1 compared to GFP controls. Consistently, Mvh and Oct4 levels were significantly decreased in cells expressing YAP1-targeted shRNA. (3) After 14-75 days of YAP1 overexpression in infertile mouse models, we detected follicle regeneration in ovaries, the activation of primordial follicles and increased birth rate, accompanied by increasing levels of E2 and FSH. (4) However, we detected decreasing follicles in ovaries, lower birth rate, and decreasing E2 and FSH in serum from healthy mice of reproductive age following YAP1 shRNA expression. CONCLUSION: Methods for the isolation, identification and culture of OGSCs were successfully established. Further results indicate that isolated OGSCs can specifically recognize Hippo signaling molecules and that manipulation of YAP1 expression can be used to regulate the proliferation and differentiation of OGSCs, as well as ovarian function in mice. This study suggests that the Hippo signaling pathway may represent a new molecular target for the regulation of mouse ovarian functional remodeling.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/genética
Separação Celular/métodos
Regulação da Expressão Gênica
Células-Tronco de Oogônios/metabolismo
Folículo Ovariano/metabolismo
Fosfoproteínas/genética
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores
Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Animais
Diferenciação Celular
Proliferação Celular
RNA Helicases DEAD-box/genética
RNA Helicases DEAD-box/metabolismo
Feminino
Genes Reporter
Vetores Genéticos/química
Vetores Genéticos/metabolismo
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Lentivirus/genética
Lentivirus/metabolismo
Imãs
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Camundongos
Proteína Homeobox Nanog/genética
Proteína Homeobox Nanog/metabolismo
Fator 3 de Transcrição de Octâmero/genética
Fator 3 de Transcrição de Octâmero/metabolismo
Células-Tronco de Oogônios/citologia
Folículo Ovariano/citologia
Fosfoproteínas/antagonistas & inibidores
Fosfoproteínas/metabolismo
Cultura Primária de Células
RNA Interferente Pequeno/genética
RNA Interferente Pequeno/metabolismo
Proteínas Repressoras/genética
Proteínas Repressoras/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Dppa3 protein, mouse); 0 (Membrane Proteins); 0 (Nanog Homeobox Protein); 0 (Nanog protein, mouse); 0 (Octamer Transcription Factor-3); 0 (Phosphoproteins); 0 (Pou5f1 protein, mouse); 0 (RNA, Small Interfering); 0 (Repressor Proteins); 0 (Yap protein, mouse); 0 (fragilis protein, mouse); 147336-22-9 (Green Fluorescent Proteins); EC 3.6.1.- (Ddx4 protein, mouse); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1159/000464113


  4 / 8 MEDLINE  
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[PMID]:28040471
[Au] Autor:Asadi-Azarbaijani B; Santos RR; Jahnukainen K; Braber S; van Duursen MB; Toppari J; Saugstad OD; Nurmio M; Oskam IC
[Ad] Endereço:Women and Children's Division, Oslo University Hospital, Rikshospitalet, Oslo, Norway; University of Oslo, Oslo, Norway. Electronic address: basad@ous-hf.no.
[Ti] Título:Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary.
[So] Source:Reprod Biol;17(1):25-33, 2017 Mar.
[Is] ISSN:2300-732X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Imatinib mesylate is an anti-cancer agent that competitively inhibits several receptor tyrosine kinases (RTKs). RTKs play important roles in the regulation of primordial follicle formation, the recruitment of primordial follicles into the pool of growing follicles and maturation of the follicles. In the present study, we investigated the effects of the tyrosine kinase inhibitor imatinib on primordial follicle assembly and early folliculogenesis in postnatal rats. Female Sprague-Dawley rats were treated with either imatinib (150mg/kg) or placebo (water) on postnatal days 2-4. Bilateral ovariectomy was performed on postnatal day 2 and 5. Histology, immunohistochemistry, and mRNA analysis were performed. Imatinib treatment was associated with increased density of the multi-oocyte follicles (P<0.01), oogonia (p<0.01) and germline clusters (P<0.05), decreased activation of primordial follicles, increased expression of c-Kit and AMH, and decreased protein expression of Kit-ligand and GDF9 when compared to age-matched controls. In conclusion, imatinib affects folliculogenesis in postnatal rat ovaries by delaying the cluster breakdown, follicular assembly and early activation of the primordial follicle pool.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Mesilato de Imatinib/farmacologia
Oogênese/efeitos dos fármacos
Células-Tronco de Oogônios/efeitos dos fármacos
Folículo Ovariano/efeitos dos fármacos
Inibidores de Proteínas Quinases/farmacologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Hormônio Antimülleriano/química
Hormônio Antimülleriano/genética
Hormônio Antimülleriano/metabolismo
Apoptose/efeitos dos fármacos
Biomarcadores/metabolismo
Feminino
Fator 9 de Diferenciação de Crescimento/antagonistas & inibidores
Fator 9 de Diferenciação de Crescimento/genética
Fator 9 de Diferenciação de Crescimento/metabolismo
Imuno-Histoquímica
Oogônios/citologia
Oogônios/efeitos dos fármacos
Oogônios/metabolismo
Células-Tronco de Oogônios/citologia
Folículo Ovariano/citologia
Folículo Ovariano/crescimento & desenvolvimento
Proteínas Proto-Oncogênicas c-kit/agonistas
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Proto-Oncogênicas c-kit/metabolismo
RNA Mensageiro/metabolismo
Ratos Sprague-Dawley
Fator de Células-Tronco/antagonistas & inibidores
Fator de Células-Tronco/genética
Fator de Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers); 0 (Growth Differentiation Factor 9); 0 (Protein Kinase Inhibitors); 0 (RNA, Messenger); 0 (Stem Cell Factor); 80497-65-0 (Anti-Mullerian Hormone); 8A1O1M485B (Imatinib Mesylate); EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


  5 / 8 MEDLINE  
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[PMID]:27465593
[Au] Autor:Zhang XL; Wu J; Wang J; Shen T; Li H; Lu J; Gu Y; Kang Y; Wong CH; Ngan CY; Shao Z; Wu J; Zhao X
[Ad] Endereço:Shanghai Center for Systems Biomedicine, Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
[Ti] Título:Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells.
[So] Source:Genome Biol;17(1):162, 2016 Jul 27.
[Is] ISSN:1474-760X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Germline stem cells play an essential role in establishing the fertility of an organism. Although extensively characterized, the regulatory mechanisms that govern the fundamental properties of mammalian female germline stem cells remain poorly understood. RESULTS: We generate genome-wide profiles of the histone modifications H3K4me1, H3K27ac, H3K4me3, and H3K27me3, DNA methylation, and RNA polymerase II occupancy and perform transcriptome analysis in mouse female germline stem cells. Comparison of enhancer regions between embryonic stem cells and female germline stem cells identifies the lineage-specific enhancers involved in germline stem cell features. Additionally, our results indicate that DNA methylation primarily contributes to female germline stem cell unipotency by suppressing the somatic program and is potentially involved in maintenance of sexual identity when compared with male germline stem cells. Moreover, we demonstrate down-regulation of Prmt5 triggers differentiation and thus uncover a role for Prmt5 in maintaining the undifferentiated status of female germline stem cells. CONCLUSIONS: The genome-wide epigenetic signatures and the transcription regulators identified here provide an invaluable resource for understanding the fundamental features of mouse female germline stem cells.
[Mh] Termos MeSH primário: Células-Tronco Germinativas Adultas/metabolismo
Metilação de DNA/genética
Epigenômica
Fertilidade/genética
[Mh] Termos MeSH secundário: Animais
Linhagem da Célula/genética
Cromatina/genética
Cromatina/metabolismo
Feminino
Genoma
Histonas/genética
Histonas/metabolismo
Masculino
Camundongos
Células-Tronco Embrionárias Murinas
Células-Tronco de Oogônios/metabolismo
Transcriptoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Histones)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1186/s13059-016-1023-z


  6 / 8 MEDLINE  
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[PMID]:26597936
[Au] Autor:Ravel C; Kazdar N; Leveque J
[Ad] Endereço:Laboratoire de biologie de la reproduction, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes, France; Faculté de médecine, université Rennes 1, 35043 Rennes, France; Inserm, IRSET U1085, 263, avenue du Général-Leclerc, 35042 Rennes cedex, France. Electronic address: celia.ravel@chu-rennes.fr.
[Ti] Título:[Ovarian failure: New treatments in perspective?].
[Ti] Título:Fertilité et insuffisance ovarienne: de nouveaux traitements en perspective ?.
[So] Source:Gynecol Obstet Fertil;44(1):56-62, 2016 Jan.
[Is] ISSN:1769-6682
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The premature loss of ovarian function may have physical and psychological consequences. A better understanding of its mechanism is therefore needed. Because they are affecting the oocyte quality, the decline of the ovarian reserve and high maternal age are implicated in many defects leading to chromosomal defects, modifications of gene expression or alterations of the mitochondrial pattern of the oocyte. However, cellular therapies such as ovarian follicle activation or isolation of ovarian stem cells are promising treatments of ovarian failure.
[Mh] Termos MeSH primário: Insuficiência Ovariana Primária/terapia
[Mh] Termos MeSH secundário: Adulto
Doenças Autoimunes
Feminino
Seres Humanos
Idade Materna
Mutação
Oócitos
Células-Tronco de Oogônios
Folículo Ovariano
Insuficiência Ovariana Primária/etiologia
Insuficiência Ovariana Primária/genética
Técnicas de Reprodução Assistida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE


  7 / 8 MEDLINE  
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[PMID]:26567266
[Au] Autor:Oktay K; Baltaci V; Sonmezer M; Turan V; Unsal E; Baltaci A; Aktuna S; Moy F
[Ad] Endereço:Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, New York, NY, USA Innovation Institute for Fertility Preservation and IVF, New York, NY, USA GenArt Women's Health and Reproductive Biotechnology Centre, Ankara, Turkey
[Ti] Título:Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation.
[So] Source:Reprod Sci;22(12):1612-7, 2015 Dec.
[Is] ISSN:1933-7205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mitochondrial dysfunction has been suggested as a major cause of age-induced decline in oocyte quality. In the past, donor oocyte cytoplasmic transfer showed some success but was abandoned due to the concerns with heteroplasmy. Recent studies indicated presence of oogonial precursor cells (OPCs) in the human ovary, which could be an autologous source of "healthy mitochondria." We sought to investigate the clinical efficacy of OPC-derived autologous mitochondrial injection (AMI) to improve oocyte quality in women with multiple in vitro fertilization (IVF) failures. METHODS: The OPCs were isolated from laparoscopically obtained ovarian cortical pieces by cell sorting using a monoclonal anti-vasa homolog (anti-DDX) antibody. They were then disrupted and mitochondria were isolated. Reconstituted mitochondria were injected into each oocyte during intracytoplasmic sperm injection. Paired comparisons were made between the first failed cycles and the post-AMI cycles. RESULTS: Of the 15 women undergoing ovarian stimulation, 2 were canceled and 3 decided to pool oocytes for later AMI. In remaining 10 (mean age 34.7 ± 4.1), AMI significantly improved fertilization rates (49.7 ± 31.3 vs 78.3 ± 18.9; P = .03) with a trend for better embryo grades (2.3 ± 0.3 vs 3.1 ± 0.7; P = .08). Four of 10 women conceived after single frozen embryo transfer and 3 after confirmation of diploidy via array comparative genomic hybridization (aCGH) (clinical pregnancy/embryo transfer = 4/10). CONCLUSION: These data show encouraging results for AMI in comparison to previous failed IVF cycles.
[Mh] Termos MeSH primário: Fertilidade
Fertilização In Vitro
Infertilidade/terapia
Mitocôndrias/transplante
Oócitos/patologia
Células-Tronco de Oogônios/transplante
[Mh] Termos MeSH secundário: Adulto
Blastocisto/patologia
Hibridização Genômica Comparativa
Feminino
Testes Genéticos
Seres Humanos
Infertilidade/diagnóstico
Infertilidade/fisiopatologia
Gravidez
Taxa de Gravidez
Diagnóstico Pré-Natal/métodos
Transferência de Embrião Único
Injeções de Esperma Intracitoplásmicas
Transplante Autólogo
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151115
[St] Status:MEDLINE
[do] DOI:10.1177/1933719115612137


  8 / 8 MEDLINE  
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[PMID]:25897831
[Au] Autor:Garg N; Sinclair DA
[Ad] Endereço:Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.
[Ti] Título:Oogonial stem cells as a model to study age-associated infertility in women.
[So] Source:Reprod Fertil Dev;27(6):969-74, 2015 Jul.
[Is] ISSN:1031-3613
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Fertility is the first biological process to break down during aging, thereby making it a useful tool to understand fundamental processes of aging. Reproductive aging in females is associated with a loss of ovarian function characterised by a reduction in the number and quality of oocytes. The central dogma, namely that females are born with a fixed pool of oocytes that progressively decline with increasing maternal age, has been challenged by evidence supporting postnatal oogenesis in mammals. Reports demonstrating formation of new oocytes from newly discovered germline stem cells, referred to as oogonial stem cells (OSCs), has opened new avenues for treatment of female infertility. In this review we discuss why the OSCs possibly lose their regenerative potential over time, and focus specifically on the aging process in germline stem cells as a possible mechanism for understanding female age-related infertility and how we can slow or delay ovarian aging.
[Mh] Termos MeSH primário: Células-Tronco Germinativas Adultas/metabolismo
Envelhecimento/metabolismo
Infertilidade Feminina/etiologia
Meiose/genética
Oócitos/metabolismo
Oogênese/fisiologia
Células-Tronco de Oogônios/metabolismo
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Infertilidade Feminina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150422
[St] Status:MEDLINE
[do] DOI:10.1071/RD14461



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde