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[PMID]:28669846
[Au] Autor:Butovich IA
[Ad] Endereço:Department of Ophthalmology and the Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9057, United States. Electronic address: igor.butovich@utsouthwestern.edu.
[Ti] Título:Meibomian glands, meibum, and meibogenesis.
[So] Source:Exp Eye Res;163:2-16, 2017 Oct.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Meibum is a lipid-rich secretion that is produced by fully differentiated meibocytes in the holocrine Meibomian glands (MG) of humans and most mammals. The secretion is a part of a defense mechanism that protects the ocular surface from hazardous environmental factors, and from desiccation. Meibomian lipids that have been identified in meibum are very diverse and unique in nature. The lipid composition of meibum is different from virtually any other lipid pool found in the human body. In fact, meibum is quite different from sebum, which is the closest secretion that is produced by anatomically, physiologically, and biochemically related sebaceous glands. However, meibum of mice have been shown to closely resemble that of humans, implying similar biosynthetic mechanisms in MG of both species. By analyzing available genomic, immunohistochemical, and lipidomic data, we have envisioned a unifying network of enzymatic reactions that are responsible for biosynthesis of meibum, which we call meibogenesis. Our current theory is based on an assumption that most of the biosynthetic reactions of meibogenesis are catalyzed by known enzymes. However, the main features that make meibum unique - the ratio of identified classes of lipids, the extreme length of its components, extensive ω-hydroxylation of fatty acids and alcohols, iso- and anteiso-branching of meibomian lipids (e.g. waxes), and the presence of rather unique complex lipids with several ester bonds - make it possible that either the activity of known enzymes is altered in MG, or some unknown enzymes contribute to the processes of meibogenesis, or both. Studies are in progress to elucidate meibogenesis on molecular level.
[Mh] Termos MeSH primário: Lipídeos/biossíntese
Glândulas Tarsais/secreção
Lágrimas/química
[Mh] Termos MeSH secundário: Secreções Corporais
Seres Humanos
Lipídeos/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Lipids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


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[PMID]:28584964
[Au] Autor:Nenadic M; Ljaljevic-Grbic M; Stupar M; Vukojevic J; Ciric A; Tesevic V; Vujisic L; Todosijevic M; Vesovic N; Zivkovic N; Curcic S
[Ad] Endereço:Institute of Zoology, Faculty of Biology, University of Belgrade, Studentski Trg 16, 11000 Belgrade, Serbia.
[Ti] Título:Antifungal activity of the pygidial gland secretion of Laemostenus punctatus (Coleoptera: Carabidae) against cave-dwelling micromycetes.
[So] Source:Naturwissenschaften;104(5-6):52, 2017 Jun.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The antifungal potential of the pygidial gland secretion of the troglophilic ground beetle Laemostenus punctatus from a cave in Southeastern Serbia against cave-dwelling micromycetes, isolated from the same habitat, has been investigated. Eleven collected samples were analyzed and 32 isolates of cave-dwelling fungi were documented. A total of 14 fungal species were identified as members of the genera Aspergillus, Penicillium, Alternaria, Cladosporium, Rhizopus, Trichoderma, Arthrinium, Aureobasidium, Epicoccum, Talaromyces, and Fusarium. Five isolates were selected for testing the antifungal activity of the pygidial gland secretion: Talaromyces duclauxi, Aspergillus brunneouniseriatus, Penicillium sp., Rhizopus stolonifer, and Trichoderma viride. The microdilution method has been applied to detect minimal inhibitory concentrations (MICs) and minimal fungicidal concentrations (MFCs). The most sensitive isolate was Penicillium sp., while the other isolates demonstrated a high level of resistance to the tested agent. L. punctatus has developed a special mechanism of producing specific compounds that act synergistically within the secretion mixture, which are responsible for the antifungal action against pathogens from the cave. The results open opportunities for further research in the field of ground beetle defense against pathogens, which could have an important application in human medicine, in addition to the environmental impact, primarily.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Coleópteros/química
Fungos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antifúngicos/isolamento & purificação
Secreções Corporais/química
Secreções Corporais/microbiologia
Cavernas
Coleópteros/microbiologia
Testes de Sensibilidade Microbiana
Sérvia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1474-4


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[PMID]:28541462
[Au] Autor:Flores M; Crippen TL; Longnecker M; Tomberlin JK
[Ad] Endereço:Malcom Randall VAMC, Research Department, 1601 SW Archer Rd. (151), Gainesville, FL 32608.
[Ti] Título:Nonconsumptive Effects of Predatory Chrysomya rufifacies (Diptera: Calliphoridae) Larval Cues on Larval Cochliomyia macellaria (Diptera: Calliphoridae) Growth and Development.
[So] Source:J Med Entomol;54(5):1167-1174, 2017 Sep 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Forensic entomologists often rely on development data associated with a given species to estimate when it colonized human or other vertebrate remains. In most instances, these development studies are based on single species reared in isolation in the laboratory. This study examined the impact of excretions and secretions (ES) associated with third-instar Chrysomya rufifacies (Macquart), a predator, on the development of its prey, Cochliomyia macellaria (F.). Not surprisingly, Ch. rufifacies ES did not impact the development of first- or second-instar C. macellaria, which are typically not preyed on by Ch. rufifacies. However, development of third-instar C. macellaria, which do experience predation, was impacted. First, larvae were longer than those in the control (deionized water, dH2O). Filtering the ES and removing the associated bacteria and byproducts >0.2 µm dampened the previous impact observed by the unfiltered ES on third-instar C. macellaria. Second, third-instar C. macellaria treated with unfiltered ES completed pupariation 8 h quicker than the controls. Filtering the ES lessened this effect by 50%. And finally, third-instar C. macellaria treated with filtered or unfiltered Ch. rufifacies ES reached adulthood ∼5 h faster than controls treated with dH2O. In summary, these data have large ramifications for forensic entomology, as multiple species being present on decomposing remains is not uncommon. Understanding the impact of associated ES produced by interspecific cohorts on associated development could lead to more precise estimates of the minimum postmortem interval for forensic investigation of decomposing remains.
[Mh] Termos MeSH primário: Dípteros/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Secreções Corporais
Sinais (Psicologia)
Ciências Forenses
Larva/crescimento & desenvolvimento
Comportamento Predatório
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjx104


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[PMID]:28446157
[Au] Autor:Hamilton KD; Brooks PR; Ogbourne SM; Russell FD
[Ad] Endereço:Inflammation and Healing Research Cluster, Faculty of Science, Health, Education and Engineering, School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, QLD, 4558, Australia.
[Ti] Título:Natural products isolated from Tetragonula carbonaria cerumen modulate free radical-scavenging and 5-lipoxygenase activities in vitro.
[So] Source:BMC Complement Altern Med;17(1):232, 2017 Apr 26.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Propolis and cerumen are plant-derived products found in honeybees and stingless bees, respectively. Although propolis is an ancient folk medicine, the bioactivities of cerumen obtained from Australian native stingless bees (Tetragonula carbonaria) have not been widely studied. Therefore, we investigated selected anti-oxidant and anti-inflammatory properties of T. carbonaria cerumen. METHODS: A methanolic extract was prepared from the combined cerumen of 40 T. carbonaria hives, and HPLC was used to screen for chemical constituents that scavenged 2,2-azobis(2-methylpropionamidine) dihydrochloride (AAPH). The ability of cerumen extracts to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) and to interfere with leukotriene B (LTB ) production in ionomycin-stimulated human neutrophils was also examined. RESULTS: The extract dose-dependently scavenged DPPH (EC = 27.0 ± 2.3 µg/mL); and inhibited the 5-lipoxygenase (5-LOX)-mediated oxidation of linoleic acid (IC = 67.1 ± 9.6 µg/mL). Pre-treatment of isolated human neutrophils with the methanolic cerumen extract additionally inhibited the ionomycin-stimulated production of LTB from these cells (IC = 13.3 ± 5.3 µg/mL). Following multi-solvent extraction, the free radical-scavenging and 5-LOX-inhibiting activities of the initial cerumen extract were retained in a polar, methanol-water extract, which contained gallic acid and a range of flavonone and phenolic natural products. CONCLUSIONS: The findings identify free radical scavenging activity, and interference by extracts of T. carbonaria cerumen in 5-LOX-LTB signaling. Further investigation is needed to determine whether the extracts will provide therapeutic benefits for medical conditions in which oxidative stress and inflammation are implicated, including cardiovascular disease and impaired wound healing.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Apiterapia
Araquidonato 5-Lipoxigenase/metabolismo
Abelhas
Produtos Biológicos/farmacologia
[Mh] Termos MeSH secundário: Adulto
Animais
Produtos Biológicos/química
Secreções Corporais/química
Cerume
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Ácido Gálico/isolamento & purificação
Ácido Gálico/farmacologia
Seres Humanos
Ionomicina
Leucotrieno B4/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Neutrófilos/metabolismo
Fenóis/isolamento & purificação
Fenóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biological Products); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phenols); 1HGW4DR56D (Leukotriene B4); 56092-81-0 (Ionomycin); 632XD903SP (Gallic Acid); EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1748-6


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[PMID]:28287360
[Au] Autor:Brock C; Cooper S; Herndon CM
[Ti] Título:An Educational Intervention to Decrease Drug Costs Related to Terminal Secretions in a Hospice Organization.
[So] Source:J Pain Palliat Care Pharmacother;31(1):66-70, 2017 Mar.
[Is] ISSN:1536-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Terminal secretions is a common symptom seen in hospice patients. Antimuscarinic drugs are commonly used to treat this symptom despite a lack of supporting data. Wide variability in cost exists among these treatments. Hospice program data were assessed to identify high-use and high-cost medications. An educational intervention (EI) was developed to target one such medication, transdermal scopolamine. The EI focused on efficacy, safety, and actual cost (by unit and total expenditure) for each possible treatment of terminal secretions. Following the EI, drug utilization data was re-evaluated. Prior to the deployment of the EI, total monthly hospice drug costs averaged $91,405 (SD 1,444) with an average drug cost per patient per day of $11.42 (SD 0.54). Monthly costs of drugs frequently employed to treat terminal secretions averaged $7,187.67 (SD 2,253) pre-intervention. Following the EI, monthly drug costs decreased 22.5%, average daily patient drug costs decreased 11.1%, and total anti-secretion costs decreased 28.5% after adjusting for difference in census. Education regarding the use and cost of medications to treat symptoms at end-of-life in hospice patients can be an intervention used to lead to significant cost savings to hospice organizations while maintaining appropriate symptom management for patients. Future interventions to target additional high-cost medications are warranted.
[Mh] Termos MeSH primário: Secreções Corporais/efeitos dos fármacos
Redução de Custos/métodos
Custos de Medicamentos/estatística & dados numéricos
Uso de Medicamentos
Pessoal de Saúde/educação
Cuidados Paliativos na Terminalidade da Vida/economia
Assistência Terminal/economia
[Mh] Termos MeSH secundário: Administração Cutânea
Redução de Custos/estatística & dados numéricos
Uso de Medicamentos/estatística & dados numéricos
Seres Humanos
Internet
Hidrobrometo de Escopolamina/administração & dosagem
Hidrobrometo de Escopolamina/efeitos adversos
Hidrobrometo de Escopolamina/economia
Hidrobrometo de Escopolamina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451IFR0GXB (Scopolamine Hydrobromide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1080/15360288.2016.1276997


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[PMID]:28263321
[Au] Autor:Rieckmann JC; Geiger R; Hornburg D; Wolf T; Kveler K; Jarrossay D; Sallusto F; Shen-Orr SS; Lanzavecchia A; Mann M; Meissner F
[Ad] Endereço:Experimental Systems Immunology, Max Planck Institute of Biochemistry, Bayern, Germany.
[Ti] Título:Social network architecture of human immune cells unveiled by quantitative proteomics.
[So] Source:Nat Immunol;18(5):583-593, 2017 May.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology.
[Mh] Termos MeSH primário: Células Sanguíneas/fisiologia
Imunidade Celular
Mapas de Interação de Proteínas
Proteoma
Proteômica
[Mh] Termos MeSH secundário: Animais
Secreções Corporais
Comunicação Celular
Simulação por Computador
Seres Humanos
Espectrometria de Massas
Apoio Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1038/ni.3693


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[PMID]:28137508
[Au] Autor:Arunagiri K; Sangeetha G; Sugashini PK; Balaraman S; Showkath Ali MK
[Ad] Endereço:Central Leprosy Teaching & Research Institute, Chengalpattu, Tamil Nadu, India.
[Ti] Título:Nasal PCR assay for the detection of Mycobacterium leprae pra gene to study subclinical infection in a community.
[So] Source:Microb Pathog;104:336-339, 2017 Mar.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Identification of Mycobacterium leprae is difficult in part due to the inability of the leprosy bacillus to grow in vitro. A number of diagnostic methods for leprosy diagnosis have been proposed. Both serological tests and molecular probes have shown certain potential for detection and identification of Mycobacterium leprae in patients. In this study, we have investigated whether Mycobacterium leprae DNA from the nasal secretion of healthy household contacts and the non contacts could be detected through PCR amplification as a method to study the sub clinical infection in a community. A total of 200 samples, 100 each from contacts and non contacts representing all age groups and sex were included in this study. The M. leprae specific primer (proline-rich region) of pra gene was selected and PCR was performed using extracted DNA from the sample. A total of 13 samples were found to be positive for nasal PCR for pra gene among the male and female contacts out of which 7% were males and 6% were females. Even though several diagnostic tools are available to detect the cases of leprosy, they lack the specificity and sensitivity. PCR technology has demonstrated the improved diagnostic accuracy for epidemiological studies and requires minimal time. Although nasal PCR studies have been reported from many countries it is not usually recommended due to the high percentage of negative results in the contact.
[Mh] Termos MeSH primário: Infecções Assintomáticas/epidemiologia
Secreções Corporais/microbiologia
Hanseníase/diagnóstico
Hanseníase/epidemiologia
Mycobacterium leprae/isolamento & purificação
Nariz/microbiologia
Reação em Cadeia da Polimerase/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
DNA Bacteriano/análise
DNA Bacteriano/genética
Feminino
Seres Humanos
Lactente
Hanseníase/microbiologia
Masculino
Meia-Idade
Técnicas de Diagnóstico Molecular/métodos
Mycobacterium leprae/genética
Sensibilidade e Especificidade
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:27722993
[Au] Autor:Li J; Yu T; Zhang F; Wang X; Zhou J; Gao X; Gao S; Liu X
[Ad] Endereço:Key lab of Avian Bioproducts Development, Ministry of Agriculture, Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, People's Republic of China.
[Ti] Título:Inactivated chimeric porcine circovirus (PCV) 1-2 vaccines based on genotypes 2b and 2d exhibit similar immunological effectiveness in protecting pigs against challenge with PCV2b strain 0233.
[So] Source:Arch Virol;162(1):235-246, 2017 Jan.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Porcine circovirus type 2 (PCV2) is subdivided into four genotypes: PCV2a, PCV2b, PCV2c and PCV2d. Here, for the first time, we compared the efficacy of two experimental inactivated chimeric PCV1-2 vaccines based on genotypes 2b and 2d. Seventeen 3-week-old pigs were divided randomly into four groups. Group 1 and 2 pigs were inoculated with genotype 2b- and 2d-based inactivated vaccines, respectively. At 28 days post-vaccination (DPV), pigs in groups 1-3 were challenged with the PCV2b 0233 strain. All experimental pigs were necropsied at 21 days post-challenge (DPC). Pigs vaccinated with the genotype 2b- or 2d-based vaccine had high antibody titres and lower PCV2b copy numbers in samples of sera, faeces and nasal secretions compared with pigs in the unvaccinated challenge group. Interestingly, we detected no DNA from the challenge strain in the superficial inguinal lymph nodes of the pigs immunized with the PCV2b vaccine, while one pig in the PCV2d- immunized group had detectable DNA from the challenge strain at 21 DPC. We found no significant differences in the humoral immune response, PCV2b load, or PCV-related microscopic lesions between the two vaccinated groups post-challenge. Therefore, both vaccines were equally effective at inducing immunity against challenge with PCV2b strain 0233.
[Mh] Termos MeSH primário: Infecções por Circoviridae/veterinária
Circovirus/imunologia
Genótipo
Doenças dos Suínos/prevenção & controle
Vacinas Virais/administração & dosagem
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Secreções Corporais/virologia
Infecções por Circoviridae/prevenção & controle
Infecções por Circoviridae/virologia
Circovirus/classificação
Circovirus/genética
Fezes/virologia
Soro/virologia
Suínos
Doenças dos Suínos/virologia
Resultado do Tratamento
Vacinas de Produtos Inativados/administração & dosagem
Vacinas de Produtos Inativados/imunologia
Vacinas Sintéticas/administração & dosagem
Vacinas Sintéticas/imunologia
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Vaccines, Inactivated); 0 (Vaccines, Synthetic); 0 (Viral Vaccines)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3099-x


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[PMID]:27646066
[Au] Autor:von Byern J; Cyran N; Klepal W; Nödl MT; Klinger L
[Ad] Endereço:Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200 Vienna, Austria; Core Facility Cell Imaging and Ultrastructural Research, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Aus
[Ti] Título:Characterization of the adhesive dermal secretion of Euprymna scolopes Berry, 1913 (Cephalopoda).
[So] Source:Zoology (Jena);120:73-82, 2017 Feb.
[Is] ISSN:1873-2720
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Bio-adhesion is a common and crucial process in nature and is used by several different species for camouflage, prey capture, hatching or to avoid drifting. Four genera of cephalopods belonging to four different families (Euprymna, Sepiolidae; Idiosepius, Idiosepiidae; Nautilus, Nautilidae; and Sepia, Sepiidae) produce glue for temporary attachment. Euprymna species live in near-shore benthic habitats of the Indo-Pacific Ocean, are nocturnal and bury into the seafloor during the day. The animals secrete adhesives through their epithelial glands to completely coat themselves with sand. In cases of danger, they instantaneously release the sandy coat as a sinking decoy to deflect predators. Earlier morphological investigations have shown that the adhesive gland cells of Euprymna scolopes are scattered on the dorsal epidermis. It has been proposed that neutral mucopolysaccharides, secreted by one gland type (goblet cells), are responsible for adhesion, whereas the release of the glue could be caused by acidic mucoproteins produced by ovate cells in the ventral epidermis. The ultrastructural re-investigation of the Euprymna epithelium in this study has indicated the presence of a new gland type (named flask cell), exclusively located in the dorsal epithelium and always neighboured to the known goblet cells. Based on our histochemical observations, the secretory material of the ovate cells does not display a strong reaction to tests for acidic groups, as had been previously assumed. Within the dermis, a large muscle network was found that was clearly distinctive from the normal mantle musculature. Based on our data, an antagonistic gland system, as previously proposed, seems to be unlikely for Euprymna scolopes. We hypothesize that the adhesive secretion is formed by two gland types (goblet and flask cells). The release of the sand coat may occur mechanically, i.e. by contraction of the dermal mantle muscle, and not chemically through the ovate cells.
[Mh] Termos MeSH primário: Secreções Corporais/química
Secreções Corporais/fisiologia
Cefalópodes/fisiologia
Fenômenos Fisiológicos da Pele
Pele/ultraestrutura
[Mh] Termos MeSH secundário: Adesividade
Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27344923
[Au] Autor:Schmuck RB; Reutzel-Selke A; Raschzok N; Morgul HM; Struecker B; Lippert S; de Carvalho Fischer C; Schmelzle M; Boas-Knoop S; Bahra M; Pascher A; Pratschke J; Sauer IM
[Ad] Endereço:a General, Visceral and Transplantation Surgery, Experimental Surgery and Regenerative Medicine , Charité - Universitätsmedizin Berlin , Campus Virchow Klinikum , Berlin , Germany.
[Ti] Título:Bile: miRNA pattern and protein-based biomarkers may predict acute cellular rejection after liver transplantation.
[So] Source:Biomarkers;22(1):19-27, 2017 Feb.
[Is] ISSN:1366-5804
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Bile rather than blood depicts the local inflammation in the liver and may improve prediction and diagnosis of acute cellular rejection (ACR) after liver transplantation (OLT). METHODS: Secretome and miRNAs were analyzed during the first two weeks and on clinical suspicion of ACR in the bile of 45 OLT recipients. RESULTS: Levels of CD44, CXCL9, miR-122, miR-133a, miR-148a and miR-194 were significantly higher in bile of patients who developed ACR within the first 6 months after OLT and during ACR. CONCLUSION: Analysis of secretome and miRNA in bile could improve our understanding of the local inflammatory process during rejection.
[Mh] Termos MeSH primário: Bile/química
Rejeição de Enxerto/diagnóstico
Transplante de Fígado/efeitos adversos
[Mh] Termos MeSH secundário: Biomarcadores/análise
Secreções Corporais/química
Seres Humanos
MicroRNAs/análise
Valor Preditivo dos Testes
Proteínas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (MicroRNAs); 0 (Proteins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE
[do] DOI:10.1080/1354750X.2016.1201538



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