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[PMID]:29231166
[Au] Autor:Gasser M; Lissner R; Waaga-Gasser AM
[Ti] Título:Effect of polyvalent immunoglobulins on the cytokine cascade in monocytes from colorectal cancer patients: Basis for a new adjuvant therapy
.
[So] Source:Int J Clin Pharmacol Ther;56(1):34-37, 2018 Jan.
[Is] ISSN:0946-1965
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias Colorretais/tratamento farmacológico
Citocinas/biossíntese
Imunoglobulinas/uso terapêutico
Monócitos/imunologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Colecalciferol/administração & dosagem
Neoplasias Colorretais/imunologia
Colostro/imunologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Immunoglobulins); 1C6V77QF41 (Cholecalciferol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.5414/CP203163


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[PMID]:29391014
[Au] Autor:Torsein M; Lindberg A; Svensson C; Jensen SK; Berg C; Waller KP
[Ad] Endereço:Farm & Animal Health, Uddetorp Röda huset, 532 96, Skara, Sweden. maria.torsein@gardochdjurhalsan.se.
[Ti] Título:α-Tocopherol and ß-carotene concentrations in feed, colostrum, cow and calf serum in Swedish dairy herds with high or low calf mortality.
[So] Source:Acta Vet Scand;60(1):7, 2018 Feb 01.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A study of herd-level risk factors for calf mortality in large Swedish dairy herds showed low serum concentrations of α-tocopherol and ß-carotene in 1-7 day old calves to be more common in high mortality herds. Therefore, we aimed to investigate if calf mortality risk at herd level is associated with concentrations of α-tocopherol and/or ß-carotene at individual level in feed, colostrum, cow and calf serum, while controlling for herd level covariates. Inclusion criteria were affiliation to the Swedish official milk recording scheme, herd size of ≥ 120 milking cows/year, calf mortality risk (day 1-90) of at least 6% (high mortality; HM) or less than 1% (low mortality; LM) and located within one of two regions in southern Sweden. This cross-sectional study was performed in 2010 in 19 (n = 9; n = 10) dairy herds. Questionnaires were used to collect information about feed and routines for colostrum feeding. Feed (n = 57), colostrum (n = 162), cow serum (n = 189) and calf serum samples (n = 187) were collected and analysed for α-tocopherol and ß-carotene. Other analyses e.g. total serum protein, fat content, and total solids in colostrum were also performed. Linear regression models with vitamin concentrations in feed, colostrum, cow and calf serum as outcome were performed. RESULTS: Calves in HM herds had lower concentrations of α-tocopherol in serum than calves in LM herds, but the effect depended on total protein status in serum of the calf (P = 0.036). Calves from herds that fed transition milk for 3 days or more had higher α-tocopherol concentrations in serum than calves from herds feeding transition milk up to 2 days (P = 0.013). Fat percentage in colostrum was positively associated with α-tocopherol (P < 0.001) and ß-carotene concentrations in colostrum (P < 0.001). A diet containing ≥ 20% (in kg dry matter) maize silage of the total ration was negatively associated with ß-carotene concentration in cow serum (P = 0.001). CONCLUSIONS: High calf mortality risks were associated with lower concentrations of α-tocopherol in calf serum for calves with failure of passive transfer. Feeding transition milk longer was associated with higher concentrations of α-tocopherol in calf serum. In HM herds, evaluation of the calves' α-tocopherol status is recommended.
[Mh] Termos MeSH primário: Ração Animal
Colostro/química
Indústria de Laticínios/estatística & dados numéricos
Mortalidade
alfa-Tocoferol/análise
beta Caroteno/análise
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Bovinos/sangue
Bovinos/metabolismo
Estudos Transversais
Feminino
Modelos Lineares
Suécia
alfa-Tocoferol/sangue
beta Caroteno/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
01YAE03M7J (beta Carotene); H4N855PNZ1 (alpha-Tocopherol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0361-0


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[PMID]:29351333
[Au] Autor:Ramírez-Ramírez A; Sánchez-Serrano E; Loaiza-Flores G; Plazola-Camacho N; Rodríguez-Delgado RG; Figueroa-Damián R; Domínguez-Castro M; López-Martínez M; Flores-García Z; Hernández-Pineda J
[Ad] Endereço:Departement of Infectology and Immunology, National Institute of Perinatology, Mexico City, Mexico.
[Ti] Título:Simultaneous quantification of four antiretroviral drugs in breast milk samples from HIV-positive women by an ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method.
[So] Source:PLoS One;13(1):e0191236, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The primary strategy to avoid mother-to-child transmission of human immunodeficiency virus (HIV) through breastfeeding is administration of highly active antiretroviral therapy (HAART) to HIV-positive pregnant women. Because significant changes in the pharmacokinetics of antiretroviral (ARV) drugs occur during pregnancy, quantifying HAART and the viral load in breast milk in this population is essential. Here, we developed an analytical assay for the simultaneous quantification of four ARV drugs in breast milk using ultra-performance liquid chromatography coupled to tandem mass spectrometry. We validated this method following Mexican and international guidelines. ARV drugs. We extracted the ARV drugs from 200 µL samples of breast milk and detected these drugs in a triple quadrupole mass spectrometer with positive electrospray ionization. The validated concentration ranges (ng/mL) for zidovudine, lamivudine, lopinavir, and ritonavir were 12.5-750, 50-2500, 100-5000 and 5 to 250, respectively. Additionally, the absolute recovery percentages (and matrix effects) were 91.4 (8.39), 88.78 (28.75), 91.38 (11.77) and 89.78 (12.37), respectively. We determined that ARV drugs are stable for 24 h at 8°C and 24°C for 15 days at -80°C. This methodology had the capacity for simultaneous detection; separation; and accurate, precise quantification of ARV drugs in human breast milk samples according to Mexican standard laws and United States Food and Drug Administration guidelines.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/análise
Terapia Antirretroviral de Alta Atividade
Infecções por HIV/complicações
Infecções por HIV/tratamento farmacológico
Leite Humano/química
Complicações Infecciosas na Gravidez/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Fármacos Anti-HIV/normas
Aleitamento Materno
Calibragem
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia Líquida de Alta Pressão/normas
Colostro/química
Feminino
Infecções por HIV/prevenção & controle
Seres Humanos
Recém-Nascido
Transmissão Vertical de Doença Infecciosa/prevenção & controle
Lamivudina/análise
Lopinavir/análise
Gravidez
Complicações Infecciosas na Gravidez/metabolismo
Padrões de Referência
Reprodutibilidade dos Testes
Ritonavir/análise
Espectrometria de Massas em Tandem/métodos
Espectrometria de Massas em Tandem/normas
Adulto Jovem
Zidovudina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anti-HIV Agents); 2494G1JF75 (Lopinavir); 2T8Q726O95 (Lamivudine); 4B9XT59T7S (Zidovudine); O3J8G9O825 (Ritonavir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191236


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[PMID]:28464792
[Au] Autor:Hou J; An X; Song Y; Cao B; Yang H; Zhang Z; Shen W; Li Y
[Ad] Endereço:Animal Engineering Branch, Yangling Vocational & Technical College, No. 10 Xinong Road, Yangling, Shaanxi, 712100, People's Republic of China.
[Ti] Título:Detection and comparison of microRNAs in the caprine mammary gland tissues of colostrum and common milk stages.
[So] Source:BMC Genet;18(1):38, 2017 05 02.
[Is] ISSN:1471-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: MicroRNAs (miRNAs) have a great influence on various physiological functions. A lot of high-throughput sequencing (HTS) research on miRNAs has been executed in the caprine mammary gland at different lactation periods (common milk lactation and dry period), but little is known about differentially expressed miRNAs in the caprine mammary gland of colostrum and peak lactation periods. RESULT: This study identified 131 differentially expressed miRNAs (P < 0.05 and log colostrum normalized expression (NE)/peak lactation NE > 1 or log colostrum NE/peak lactation NE < -1), including 57 known miRNAs and 74 potential novel miRNAs in the colostrum and peak lactation libraries. In addition, compared with differentially expressed miRNAs in the peak lactation period, 45 miRNAs in the colostrum lactation period were remarkably upregulated, whereas 86 miRNAs were markedly downregulated (P < 0.05 and log colostrum NE/peak lactation NE > 1 or log colostrum NE/peak lactation NE < -1). The expressions of 10 randomly selected miRNAs was analyzed through stem-loop real-time quantitative PCR (RT-qPCR). Their expression patterns were the same with Solexa sequencing results. Pathway analysis suggested that oestrogen, endocrine, adipocytokine, oxytocin and MAPK signalling pathways act on the development of mammary gland and milk secretion importantly. In addition, the miRNA-target-network showed that the bta-miR-574 could influence the development of mammary gland and lactation by leptin receptor (LEPR), which was in the adipocytokine signalling pathway. Chr5_3880_mature regulated mammary gland development and lactation through Serine/threonine-protein phosphatase (PPP1CA), which was in the oxytocin signalling pathway. CONCLUSIONS: Our finding suggested that the profiles of miRNAs were related to the physiological functions of mammary gland in the colostrum and peak lactation periods. The biological features of these miRNAs may help to clarify the molecular mechanisms of lactation and the development of caprine mammary gland.
[Mh] Termos MeSH primário: Colostro/química
Cabras/genética
Lactação/genética
Glândulas Mamárias Animais/crescimento & desenvolvimento
MicroRNAs/análise
Leite/química
[Mh] Termos MeSH secundário: Animais
Feminino
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Cabras/metabolismo
Sequenciamento de Nucleotídeos em Larga Escala
Glândulas Mamárias Animais/citologia
Glândulas Mamárias Animais/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12863-017-0498-2


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[PMID]:28541500
[Au] Autor:Savarino SJ; McKenzie R; Tribble DR; Porter CK; O'Dowd A; Cantrell JA; Sincock SA; Poole ST; DeNearing B; Woods CM; Kim H; Grahek SL; Brinkley C; Crabb JH; Bourgeois AL
[Ad] Endereço:Naval Medical Research Center, Silver Spring, Maryland.
[Ti] Título:Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial.
[So] Source:J Infect Dis;216(1):7-13, 2017 Jul 01.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Tip-localized adhesive proteins of bacterial fimbriae from diverse pathogens confer protection in animal models, but efficacy in humans has not been reported. Enterotoxigenic Escherichia coli (ETEC) commonly elaborate colonization factors comprising a minor tip adhesin and major stalk-forming subunit. We assessed the efficacy of antiadhesin bovine colostral IgG (bIgG) antibodies against ETEC challenge in volunteers. Methods: Adults were randomly assigned (1:1:1) to take oral hyperimmune bIgG raised against CFA/I minor pilin subunit (CfaE) tip adhesin or colonization factor I (CFA/I) fimbraie (positive control) or placebo. Two days before challenge, volunteers began a thrice-daily, 7-day course of investigational product administered in sodium bicarbonate 15 minutes after each meal. On day 3, subjects drank 1 × 109 colony-forming units of colonization factor I (CFA/I)-ETEC strain H10407 with buffer. The primary efficacy endpoint was diarrhea within 120 hours of challenge. Results: After enrollment and randomization, 31 volunteers received product, underwent ETEC challenge, and were included in the per protocol efficacy analysis. Nine of 11 placebos developed diarrhea, 7 experiencing moderate to severe disease. Protective efficacy of 63% (P = .03) and 88% (P = .002) was observed in the antiadhesin bIgG and positive control groups, respectively. Conclusions: Oral administration of anti-CFA/I minor pilin subunit (CfaE) antibodies conferred significant protection against ETEC, providing the first clinical evidence that fimbrial tip adhesins function as protective antigens.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/uso terapêutico
Colostro/imunologia
Diarreia/tratamento farmacológico
Escherichia coli Enterotoxigênica
Infecções por Escherichia coli/tratamento farmacológico
Imunoglobulina G/uso terapêutico
[Mh] Termos MeSH secundário: Adesinas Bacterianas/imunologia
Administração Oral
Adulto
Animais
Antígenos de Bactérias/imunologia
Bovinos
Contagem de Colônia Microbiana
Diarreia/microbiologia
Método Duplo-Cego
Feminino
Proteínas de Fímbrias/imunologia
Fímbrias Bacterianas/genética
Fímbrias Bacterianas/metabolismo
Seres Humanos
Masculino
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Immunoglobulin G); 147680-16-8 (Fimbriae Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix144


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[PMID]:28513788
[Au] Autor:Bertoldo BB; Silva CBD; Rodrigues DBR; Geraldo-Martins VR; Ferriani VPL; Nogueira RD
[Ad] Endereço:Universidade de Uberaba - Uniube, School of Dentistry, Department of Dentistry, Uberaba, MG, Brazil.
[Ti] Título:Comparisons of IgA response in saliva and colostrum against oral streptococci species.
[So] Source:Braz Oral Res;31:e39, 2017 May 15.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study compared IgA specificity against oral streptococci in colostrum and saliva samples. Sixty-two mother-and-child pairs were included; samples of colostrum (C) and saliva (MS) were collected from the mothers and saliva samples were collected from babies (BS). The specificity of IgA against Streptococcus mutans and S. mitis were analyzed by western blot. Only 30% of babies' samples presented IgA reactivity to S. mutans, while 74 and 80% of MS and C, respectively, presented this response. IgA reactivity to S. mutans virulence antigens (Ag I/II, Gtf and GbpB) in positive samples showed differences between samples for Gtf and especially for GbpB (p < 0.05), but responses to Ag I/II were similar (p > 0.05). The positive response of Gtf-reactive IgA was different between C (90%) and MS (58%) samples (p < 0.05), but did not differ from BS (p > 0.05). GbpB was the least detected, with 48 and 26% of C and MS, and only 5% of BS samples presenting reactivity (p > 0.05). Eight percent of MS and C samples presented identical bands to SM in the same time-point. In conclusion, the differences of IgA response found between C and MS can be due to the different ways of stimulation, proliferation and transportation of IgA in those secretions. The colostrum has high levels of IgA against S. mutans virulence antigens, which could affect the installation and accumulation process of S. mutans, mainly by supplying anti-GbpB IgA to the neonate.
[Mh] Termos MeSH primário: Colostro/imunologia
Imunoglobulina A Secretora/análise
Imunoglobulina A Secretora/imunologia
Saliva/imunologia
Streptococcus mitis/imunologia
Streptococcus mutans/imunologia
[Mh] Termos MeSH secundário: Análise de Variância
Formação de Anticorpos/imunologia
Antígenos de Bactérias/análise
Antígenos de Bactérias/imunologia
Proteínas de Bactérias/análise
Proteínas de Bactérias/imunologia
Western Blotting
Colostro/microbiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Glucosiltransferases/análise
Glucosiltransferases/imunologia
Glicoproteínas/análise
Glicoproteínas/imunologia
Seres Humanos
Recém-Nascido
Mães
Saliva/microbiologia
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (Glycoproteins); 0 (IDG-60 protein, Streptococcus mutans); 0 (Immunoglobulin A, Secretory); EC 2.4.1.- (Glucosyltransferases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


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[PMID]:28443527
[Au] Autor:McGovern FM; Sweeney T; Ryan MT; Lott S; Campion FP; Boland TM
[Ad] Endereço:1School of Agriculture and Food Science,Lyons Research Farm,University College Dublin (UCD),Newcastle,Co. Kildare,W23 ENY2,Republic of Ireland.
[Ti] Título:An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum.
[So] Source:Br J Nutr;117(7):951-963, 2017 Apr.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An experiment was conducted to determine: (1) the effect of excess maternal I supplementation on the thyroid hormone status of the ewe and her progeny; (2) potential mechanisms underpinning the failure of passive transfer associated with excess I and (3) the growing lambs' response to natural gastrointestinal infection. Twin-bearing ewes received one of two treatments (n 32/treatment group): basal diet (C) or C plus 26·6 mg of iodine/ewe per d (I), supplied as calcium iodate. Ewes were individually fed from day 119 of gestation to parturition. Progeny of I ewes had lower (P<0·01) serum IgG concentrations from 24 h to 28 d postpartum but higher serum IgG concentrations at day 70 postpartum (P<0·05). I supplementation increased the relative expression of Fc receptor, IgA, IgM high affinity and polymeric Ig receptor in the ileum of the lamb at 24 h postpartum; however, thyroid hormone receptor-ß (THRB) and ß-2-microglobulin (B2M) expression declined (P<0·05). Progeny of I ewes had higher growth rates to weaning (P<0·05) and lower faecal egg count (FEC) for Nematodirus battus (P<0·05) between weeks 6 and 10 postpartum. In conclusion, excess maternal I supplementation negatively affected the thyroid hormone status, serum IgG concentration, ileal morphology and the gene expression of THRB and B2M in the ileum and ras-related protein (RAB) RAB25 and the mucin gene (MUC) MUC1 in the duodenum of the lamb postpartum. These effects were followed by an enhancement of average daily gain and lower N. battus FEC in the pre-weaning period of I-supplemented lambs.
[Mh] Termos MeSH primário: Colostro/imunologia
Suplementos Nutricionais
Imunidade Materno-Adquirida
Iodo/uso terapêutico
Fenômenos Fisiológicos da Nutrição Materna
Doenças dos Ovinos/prevenção & controle
Infecções por Strongylida/veterinária
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Colostro/química
Suplementos Nutricionais/efeitos adversos
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Íleo/crescimento & desenvolvimento
Íleo/imunologia
Íleo/metabolismo
Íleo/patologia
Imunoglobulina G/análise
Imunoglobulina G/biossíntese
Mucosa Intestinal/crescimento & desenvolvimento
Mucosa Intestinal/imunologia
Mucosa Intestinal/metabolismo
Mucosa Intestinal/patologia
Iodo/efeitos adversos
Masculino
Nematodirus/imunologia
Nematodirus/isolamento & purificação
Contagem de Ovos de Parasitas/veterinária
Gravidez
Distribuição Aleatória
Ovinos
Doenças dos Ovinos/imunologia
Doenças dos Ovinos/metabolismo
Doenças dos Ovinos/parasitologia
Carneiro Doméstico
Infecções por Strongylida/imunologia
Infecções por Strongylida/parasitologia
Infecções por Strongylida/prevenção & controle
Receptores beta dos Hormônios Tireóideos/genética
Receptores beta dos Hormônios Tireóideos/metabolismo
Ganho de Peso
Microglobulina-2 beta/genética
Microglobulina-2 beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Thyroid Hormone Receptors beta); 0 (beta 2-Microglobulin); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000575


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[PMID]:28419655
[Au] Autor:Fujimori M; França EL; Morais TC; Fiorin V; de Abreu LC; Honório-França AC
[Ad] Endereço:Department of Maternal and Child Health, School of Public Health, University of São Paulo (USP), São Paulo, SP, Brazil.
[Ti] Título:Cytokine and adipokine are biofactors can act in blood and colostrum of obese mothers.
[So] Source:Biofactors;43(2):243-250, 2017 Mar.
[Is] ISSN:1872-8081
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Breast milk contains bioactive components that contribute to newborn development. However, colostrum may undergo biochemical and immunological changes as a function of maternal overweight and obesity. To investigate this hypothesis, this study determined the levels of hormones and immunological markers in the serum and colostrum of overweight and obese mothers. Colostrum and serum samples were collected from 15 normoweight, 15 overweight, and 15 obese women for determination of leptin, adiponectin, cytokines (TNF-α, IL-6, IL-10), and C-reactive protein (CRP). Obese mothers exhibited higher levels of serum TNF-α, IL-6, and CRP, serum and colostrum leptin and colostrum adiponectin and lower levels of serum adiponectin. Leptin levels in maternal serum and colostrum were positively correlated, as was pre-pregnancy BMI and serum TNF-α, IL-6, CRP, and leptin. Adiponectin levels in colostrum and serum were negatively correlated. The results suggest that obesity changes hormonal and immunological components of maternal serum and colostrum. The modifications can have short-term and long-term effects on newborn development. © 2016 BioFactors, 43(2):243-250, 2017.
[Mh] Termos MeSH primário: Colostro/metabolismo
Mães
Obesidade/sangue
Sobrepeso/sangue
[Mh] Termos MeSH secundário: Adiponectina/sangue
Adulto
Índice de Massa Corporal
Proteína C-Reativa/metabolismo
Feminino
Seres Humanos
Interleucina-10/sangue
Interleucina-6/sangue
Leptina/sangue
Obesidade/patologia
Sobrepeso/patologia
Gravidez
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Interleukin-6); 0 (Leptin); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1002/biof.1339


  9 / 5458 MEDLINE  
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[PMID]:28410426
[Au] Autor:Sinanoglou VJ; Cavouras D; Boutsikou T; Briana DD; Lantzouraki DZ; Paliatsiou S; Volaki P; Bratakos S; Malamitsi-Puchner A; Zoumpoulakis P
[Ad] Endereço:Laboratory of Chemistry, Analysis & Design of Food Processes, Instrumental Food Analysis, Department of Food Technology, Technological Educational Institution of Athens, Greece.
[Ti] Título:Factors affecting human colostrum fatty acid profile: A case study.
[So] Source:PLoS One;12(4):e0175817, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The role of maternal colostrum to infant development has been extensively studied and presented. Among the main factors which contribute to breast milk composition are maternal diet, age and body mass index, parity, duration of pregnancy and stage of lactation. This study aims to investigate the potential impact of several factors including demographic (i.e. maternal age and nationality) on the colostrum fatty acid profile. Colostrum was collected the third day postpartum in a Greek maternity hospital. Certain lipid quality indices and fatty acid ratios were estimated and results were statistically processed. The main identified fatty acids were palmitic (C16:0), oleic (C18:1ω-9), and linoleic (C18:2ω-6) acids. Among fatty acids, saturated fatty acids predominated (47.61%), followed by monounsaturated fatty acids (39.26%), while polyunsaturated fatty acids had the lowest proportion (13.13%). Values of lipid quality indices were within the reported in the literature ranges. Maternal body mass index, nationality, age, mode of delivery, gender and fetal weight percentile were studied in respect to their potential influence on the fatty acid profile of colostrum fat. Results suggest that colostrum fatty acid profile was mainly dependent on maternal nationality and age rather than mode of delivery and maternal BMI. Regarding the effect of maternal nationality, significant differences were found for saturated and monounsaturated fatty acids. Of the most interesting findings is that colostrum fat from older (≥35 years) mothers had less saturated fat and more appropriate LQIs values. Finally, a reversed correlation was observed between the customized centile of the infants and the colostrum fat content.
[Mh] Termos MeSH primário: Colostro/metabolismo
Ácidos Graxos/análise
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Índice de Massa Corporal
Cromatografia Gasosa
Colostro/química
Ácidos Graxos Monoinsaturados/análise
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Ácido Linoleico/análise
Masculino
Ácido Oleico/análise
Ácido Palmítico/análise
Gravidez
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 2UMI9U37CP (Oleic Acid); 2V16EO95H1 (Palmitic Acid); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175817


  10 / 5458 MEDLINE  
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[PMID]:28397754
[Au] Autor:Halasa M; Maciejewska D; Baskiewicz-Halasa M; Machalinski B; Safranow K; Stachowska E
[Ad] Endereço:Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin 70-204, Poland. maciupam@op.pl.
[Ti] Título:Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes.
[So] Source:Nutrients;9(4), 2017 Apr 08.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Increased intestinal permeability has been implicated in various pathologies, has various causes, and can develop during vigorous athletic training. Colostrum bovinum is a natural supplement with a wide range of supposed positive health effects, including reduction of intestine permeability. We assessed influence of colostrum supplementation on intestinal permeability related parameters in a group of 16 athletes during peak training for competition. This double-blind placebo-controlled study compared supplementation for 20 days with 500 mg of colostrum bovinum or placebo (whey). Gut permeability status was assayed by differential absorption of lactulose and mannitol (L/M test) and stool zonulin concentration. Baseline L/M tests found that six of the participants (75%) in the colostrum group had increased intestinal permeability. After supplementation, the test values were within the normal range and were significantly lower than at baseline. The colostrum group Δ values produced by comparing the post-intervention and baseline results were also significantly lower than the placebo group Δ values. The differences in stool zonulin concentration were smaller than those in the L/M test, but were significant when the Δ values due to intervention were compared between the colostrum group and the placebo group. Colostrum bovinum supplementation was safe and effective in decreasing of intestinal permeability in this series of athletes at increased risk of its elevation.
[Mh] Termos MeSH primário: Produtos Biológicos/uso terapêutico
Colostro/química
Suplementos Nutricionais
Fármacos Gastrointestinais/uso terapêutico
Gastroenteropatias/prevenção & controle
Mucosa Intestinal/metabolismo
Estresse Fisiológico
[Mh] Termos MeSH secundário: Adulto
Animais
Atletas
Produtos Biológicos/efeitos adversos
Bovinos
Permeabilidade da Membrana Celular/efeitos dos fármacos
Toxina da Cólera/análise
Toxina da Cólera/antagonistas & inibidores
Toxina da Cólera/metabolismo
Toxina da Cólera/toxicidade
Estudos Cross-Over
Suplementos Nutricionais/efeitos adversos
Método Duplo-Cego
Fezes/química
Liofilização
Fármacos Gastrointestinais/efeitos adversos
Gastroenteropatias/induzido quimicamente
Gastroenteropatias/metabolismo
Gastroenteropatias/fisiopatologia
Seres Humanos
Absorção Intestinal/efeitos dos fármacos
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/fisiologia
Mucosa Intestinal/fisiopatologia
Masculino
Artes Marciais
Venenos/análise
Venenos/química
Venenos/metabolismo
Venenos/toxicidade
Polônia
Toxicocinética
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biological Products); 0 (Gastrointestinal Agents); 0 (Poisons); 0 (zonulin); 9012-63-9 (Cholera Toxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE



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